Development of high spatial resolution molecular imaging system

• Project/Area Number: 21390339
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kitasato University
• Principal Investigator: TAKEDA Tohoru 北里大学, 医療衛生学部, 教授 (10197311)
• Co-Investigator(Kenkyū-buntansha): YUASA Tetsuya 山形大学, 大学院・理工学研究科, 教授 (30240146)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000); Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2009: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
• Keywords: エックス線 / CT / 蛍光X線CT / 分子イメージング / 高速撮像 / シートビーム / 放射光

Research Abstract

High spatial molecular imaging system with fluorescent X-ray technique is being developed. In this system, fluorescent X-ray signal of target elements is obtained by exiting the monochromatic sheet X-ray beam together with absorption X-ray image. Good CT images were obtained from 25 keV to 52 keV X-ray energy in phantom and biological objects within less than 1 min. The positioning of small animal and the anatomical structure of object can be imaged using this new detector system. CT image will be obtained shortly for in-vivo study.

Research Products

• [Journal Article] In vivo physiological saline-infused hepatic vessel imaging using two-crystal-interferometer-based phase-contrast X-ray technique (2012)
  • Author(s): Takeda T, Yoneyama Y, Wu J, Thet-Thet-Lwin, Momose A, Hyodo K.
  • Journal Title: J. Synchrotron Rad Volume: 19 Pages: 252-256
• [Journal Article] Fluorescent X-ray computed tomography using synchrotron radiation towards molecular imaging (2012)
  • Author(s): Yuasa T, Takeda T
  • Journal Title: InTech-Molecular imaging : ISBN 978-953-51-0359-2(edited by Bernhard Schaller) Volume: 1 Pages: 39-70
• [Journal Article] In vivo physiological saline-infused hepatic vessel imaging using two-crystal-interferometer-based phase-contrast X-ray technique (2012)
  • Author(s): Takeda T, Yoneyama Y, Wu J, Thet-Thet-Lwin, Momose A, Hyodo K
  • Journal Title: J.Synchrotron Rad. Volume: 19 Pages: 252-256
  • Peer Reviewed
• [Journal Article] Sequential imaging analysis using MIBG scintigraphy revealed progressive degeneration of cardiac sympathetic nerve in Parkinson's disease (2011)
  • Author(s): Watanabe M, Takeda T, Nakamagoe K, Tamaoka A
  • Journal Title: Eur J Neuro Volume: 18 Pages: 1010-1013
• [Journal Article] Nondestructive imaging of anomalously preserved methane clathrate hydrate by phase contrast X-ray imaging (2011)
  • Author(s): Takeya S, Yoneyama A, Ueda K, Takeda T, et al
  • Journal Title: J Phys Chem Volume: 115 Pages: 16193-16199
• [Journal Article] Synchrotron-based x-ray fluorescence, imaging and elemental mapping from biological samples (2011)
  • Author(s): Rao D. V, Swapna M, Cesareo R, Brunetti A, Akatsuka T, Yuasa T, Takeda T, G. E. Gigante
  • Journal Title: PRAMANA-J Phys Volume: 76 Pages: 261-2697
• [Journal Article] Use of synchrotron-based diffraction-enhanced imaging for visualization of soft tissues in invertebrates (2011)
  • Author(s): Rao DV, Swapna M, Cesareo R, Brunetti A, Zhong Z, Akatsuka T, Yuasa T, Takeda T, Gigante GE
  • Journal Title: Appl. Rad & Isotop Volume: 68 Pages: 1987-1993
• [Journal Article] Phase I clinical study of NMK36 : a new PET tracer with synthetic amino acid analogue anti-[18F] FACBC (2011)
  • Author(s): Asano Y, Inoue Y, Ikeda Y, Kikuchi K, Hara T, Taguchi C, Tokushige H, Maruo H, Takeda T, Nakamura T, Fujita T, Kumagai Y, Hayakawa K
  • Journal Title: Ann Nucl Med Volume: 25 Pages: 414-418
  • NAID: 10029284616
• [Journal Article] Development of 30-picoradian-picoradian positioning system for X-ray interferometer and Its application for phase-contrast X-ray imaging (2011)
  • Author(s): Yoneyama A, Takeya S, Hyodo K, Ueda K, Takeda T
  • Journal Title: Microscope Volume: 46 Pages: 71-74
• [Journal Article] Use of synchrotron-based diffraction-enhanced imaging for visualization of soft tissues in invertebrates (2011)
  • Author(s): Rao DV, Swapna M, Cesareo R, Brunetti A, Zhong Z, Akatsuka T, Yuasa T, Takeda T, Gigante GE
  • Journal Title: Appl.Rad & Isotop Volume: 68 Pages: 1987-1993
  • Peer Reviewed
• [Journal Article] Phase-contrast X-ray imaging of the gas diffusion layer of fuel cells (2010)
  • Author(s): Takeya S, Yoneyama A, Miyamoto J, Gotoh Y, Ueda K, Kyodo K, Takeda T
  • Journal Title: J. Synchrotron Rad Volume: 17 Pages: 813-816
• [Journal Article] A practical method of determining cross-calibration factors of PET scanners by moving a point-like 22 Na radioactive source (2010)
  • Author(s): Hasegawa T, Oda K, Wada Y, Sato Y, Yamada T, Yoshida E, Murayama H, Saito K, Takeda T, Kikuchi K
  • Journal Title: Ann Nucl Med Volume: 24 Pages: 655-661
  • NAID: 10027659516
• [Journal Article] Increased cerebral blood flow in primary somatosensory region related to somatichal lucination in the elderly (2010)
  • Author(s): Nemoto K, Mizukami K, Hori T, Kawai N, Kawanishi Y, Ota M. Takeda T, Sato N, Ohnishi T, Matsuda H, Asada T
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 64 Pages: 341-445
• [Journal Article] X-ray imaging studies using synchrotron radiation (2010)
  • Author(s): Takeda T, Yoneyama A, Yuasa T, Akatsuka T, Wu J
  • Journal Title: Proc International Conference on Nanotechnology & Medical Sciences Pages: 24-25
• [Journal Article] Synchrotron-based scattered radiation from phantom materials used in X-ray CT (2010)
  • Author(s): Rao DV, Swapna M, Cesareo R, Brunetti A, Akatsuka T, Yuasa T, Takeda T, Gigante GE
  • Journal Title: J. X-Ray Sci & Tech Volume: 18 Pages: 327-337
• [Journal Article] Cork embedded internal features and contrast mechanisms with dei using 18, 20, 30, 36, and 40keV synchrotron X-Ray (2010)
  • Author(s): Rao DV, Cesareo R, Brunetti A, Zhong Z, Yuasa T, Akatsuka T, Takeda T, Gigante G. E
  • Journal Title: Res Nondestructive Evaluation Volume: 21 Pages: 171-183
• [Journal Article] Synchrotron based diffraction-enhanced imaging to visualize the embedded physiology, soft-anatomy and contrast mechanisms of invertebrates (2010)
  • Author(s): Rao DV, Swapna M., Cesareo R, Brunetti A, Zhong Z, Akatsuka T, Yuasa T, Takeda T, and Gigante G. E
  • Journal Title: Applied Radiation and Isotopes Volume: 68 Pages: 1687-1693
• [Journal Article] Phase-contrast X-ray imaging of the gas diffusion layer of fuel cells. (2010)
  • Author(s): Takeya S, Yoneyama A, Miyamoto J, Gotoh Y, Ueda K, Hyodo K, Takeda T.
  • Journal Title: J.Synchrotron Rad. Volume: 17巻 Pages: 813-816
  • Peer Reviewed
• [Journal Article] A practical method of determining cross-calibration factors of PET scanners by moving a point-like 22 Na radioactive source. (2010)
  • Author(s): Hasegawa T, Oda K, Wada Y, Sato Y, Yamada T, Yoshida E, Murayama H, Saito K, Takeda T, Kikuchi K.
  • Journal Title: Ann Nucl Med. Volume: 24巻 Pages: 655-661
  • NAID: 10027659516
  • Peer Reviewed
• [Journal Article] Attenuation correction in fluorescent X-ray computed tomography using synchrotron incident sheet-beam. (2010)
  • Author(s): Nakamura S, Yuasa T, Huo Q, Takeda T, F Avrahama Dilmanian.
  • Journal Title: OSA.DIPA. Pages: 1-3
  • Peer Reviewed
• [Journal Article] X-Ray phase-contrast microtomography for visualizing of renal microstuctures in albino-panda-albino hamsters (2009)
  • Author(s): Wu J, Takeda T, Momose A
  • Journal Title: Spring-8 Research Frontiers Pages: 44-45
• [Journal Article] X-ray fluorescent CT imaging of cerebral uptake of stable-iodine perfusion agent iodoamphetamine analog IMP in mice (2009)
  • Author(s): Takeda T, Wu J, Thet-Thet-Lwin
  • Journal Title: J. Synchrotron Rad Volume: 16 Pages: 57-62
• [Journal Article] Imaging renal structures by x-ray phase-contrast microtomography (2009)
  • Author(s): Wu J, Takeda T, Thet-Thet-Lwin, Momose A, Sunaguchi N, Fukami T, Yuasa T, Akatsuka T
  • Journal Title: Kidney International Volume: 75 Pages: 945-951
• [Journal Article] Imaging properties of fluorescent X. ray CT comparison study (2009)
  • Author(s): Huo Q, Sato H, Takeda T, Wu J, Thet-Thet-Lwin, Yuasa T, Hyodo K, Akatsuka T
  • Journal Title: Information and communication Engineers MI 2008-142(2009-01) Pages: 375-379
  • NAID: 110007122890
• [Journal Article] Generation of the map of myocardial wall thickness for evaluation of heart function (2009)
  • Author(s): Sato H, fukami T, Wu J, Thet-Thet-Lwin, Yuasa T, Takeda T, and Akatsuka T
  • Journal Title: MI2008-135
  • NAID: 110007122903
• [Journal Article] First experimental result with fluorescent X-ray CT based on sheet-beam geometry (2009)
  • Author(s): Huo Q, Sato H, Yuasa T, Akatsuka T, Wu J, Thet-Thet-Lwin, Takeda T, Hyodo K
  • Journal Title: X-Ray Spectrometry Volume: 38 Issue: 5 Pages: 439-445
  • DOI: 10.1002/xrs.1190
  • ISSN: 0049-8246, 1097-4539
• [Journal Article] X-ray fluorescent CT imaging of cerebral uptake of stable-iodine perfusion agent iodoamphetamine analog IMP in mice (2009)
  • Author(s): Takeda T, Wu J, Thet-Thet-Lwin
  • Journal Title: J.Synchrotron Rad 16巻 Pages: 57-62
  • Peer Reviewed
• [Journal Article] Imaging renal structures by x-ray phase-contrast microtomography (2009)
  • Author(s): Wu J, Takeda T, Thet-Thet-Lwin, Momose A, Sunaguchi N, Fukami T, Yuasa T, Akatsuka T.
  • Journal Title: Kidney International 75巻 Pages: 945-951
  • Peer Reviewed
• [Journal Article] First experimental result with fluorescent X-ray CT based on sheet-beam geometry (2009)
  • Author(s): Huo Q, Sato H, Yuasa T, Akatsuka T, Wu J, Thet-Thet-Lwin, Takeda T, Hyodo K.
  • Journal Title: X-ray Spectrometry 1190巻 Pages: 1-7
  • Peer Reviewed
• [Journal Article] 30-picoradian stabilization of optical components for X-ray interferometric imaging
  • Author(s): Yoneyama A, Takeya S, Ueda K, Hyodo K, Takeda T
  • Journal Title: Photon Factory Activity Report Volume: 270
• [Presentation] 分離型X線干渉計を用いた生体及び材料イメージングに関する研究 (2011)
  • Author(s): 武田徹、米山明男、上田和浩、竹谷敏、山田重人、兵藤一行
  • Organizer: 第28回PFシンポジウム
  • Place of Presentation: つくば
• [Presentation] 分離型X線干渉計を用いた位相X線イメージングシステムの安定化 (2011)
  • Author(s): 米山明男、上田和浩、竹谷敏、兵藤一行、武田徹
  • Organizer: 第24回日本放射光学会
  • Place of Presentation: つくば
• [Presentation] X-ray imaging studies using synchrotron radiation. (2010)
  • Author(s): Takeda T.Yoneyama A, Yuasa T, Akatsuka T, Jin Wu.
  • Organizer: International Conference on Nanotechnology & Medical Sciences.
  • Place of Presentation: Kolhapur・INDIA
  • Year and Date: 2010-10-21
• [Presentation] Comparison of chest dual-energy subtraction digital tomosynthesis and dual-energy subtraction radiography to detect simulated pulmonary nodules with and without calcifications : evaluation of phantom study (2010)
  • Author(s): Gomi T, Fujiwara H, Nakajima M, Umeda T, Okawa A, Takeda T, Sakaguchi K
  • Organizer: RSNA 2010
  • Place of Presentation: Chicago, IL, USA
• [Presentation] Fluorescent X-ray computed tomography using synchrotron incident sheet-beam (2010)
  • Author(s): Yuasa T, Takeda T, Akatsuka T, Wu J
  • Organizer: International Conference on Nanotechnology & Medical Sciences
  • Place of Presentation: Kolhapur, INDIA
• [Presentation] X-ray imaging studies using synchrotron radiation (2010)
  • Author(s): Takeda T, Yoneyama A, Yuasa T, Akatsuka T, Wu J
  • Organizer: International Conference on Nanotechnology & Medical Sciences
  • Place of Presentation: Kolhapur, INDIA
• [Presentation] 位相X線撮影技術を用いた生体組織観察 (2010)
  • Author(s): 武田徹
  • Organizer: 第42回日本臨床分子形態学会総会
  • Place of Presentation: 静岡
• [Presentation] 生体試料観察のための位相及び蛍光X線イメージングの利用 (2009)
  • Author(s): 武田徹
  • Organizer: 第10回X線結像光学シンポジウム
  • Place of Presentation: つくば国際会議場
  • Year and Date: 2009-11-06
• [Presentation] 生体試料観察のための位相及び蛍光X線イメージングの利用 (2009)
  • Author(s): 武田徹
  • Organizer: 第10回X線結像光学シンポジウム
  • Place of Presentation: つくば
• [Presentation] 特徴点確率モデルに基づく曲面のレジストレーション (2009)
  • Author(s): 渡辺航、本谷秀堅、武田徹、渡辺順久
  • Organizer: 28回日本医用画像工学会大会
  • Place of Presentation: 名古屋
• [Book] Fluorescent X-ray computed tomography using synchrotron radiation towards molecular imaging (2012)
  • Author(s): Yuasa T, Takeda T
  • Publisher: InTech
• [Book] Developmental anatomy of the human embryo-3D-imaging and analytical techniques (2012)
  • Author(s): Yamada S, Nakashima T, Hirose A, Yoneyama A, Takeda T. Takakuwa T
  • Publisher: InTech
• [Book] Phase-contrast X-ray imaging with Bone-Hart type crystal X-ray interferometer handbook of interferometers, research, technology and applications. (2009)
  • Author(s): Takeda T, Yoneyama A, Halsey D. and Raynor W Takeya S, Thet-Thet-Lwin, Wu J
  • Publisher: Nova Science Publishers
• [Book] Phase-contrast X-ray imaging with Bone-Hart type crystal X-ray interferometer (2009)
  • Author(s): Takeda T, Yoneyama A, Takeya S, Thet-Thet-Lwin, Wu J.
  • Total Pages: 12
  • Publisher: NOVA Publishers, New York