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Novel radiation therapy with regulation of immune response

Research Project

Project/Area Number 21390340
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionThe University of Tokyo

Principal Investigator

KAKIMI Kazuhiro  東京大学, 医学部附属病院, 特任准教授 (80273358)

Co-Investigator(Kenkyū-buntansha) NAKAGAWA Keiichi  東京大学, 医学部附属病院, 准教授 (80188896)
Co-Investigator(Renkei-kenkyūsha) SHIRAISHI Kenshiro  東京大学, 医学部附属病院, 助教 (40447404)
YAMASHITA Hideomi  東京大学, 医学部附属病院, 助教 (70447407)
YOSHIDA Yukihiro  東京大学, 医学部附属病院, 助教 (00529050)
UEHA Satoshi  東京大学, 医学部附属病院, 助教 (00447385)
KURACHI Makoto  東京大学, 医学部附属病院, 助教 (00396722)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Keywords放射線治療 / 免疫細胞治療 / 腫瘍免疫 / 免疫抑制 / 電子線照射 / 細胞傷害性T細胞 / MDSC / 骨髄性抑制細胞 / TAM / B16 / 免疫 / 腫瘍内微小環境 / 骨髄性免疫抑制細胞 / 免疫制御 / 抑制性T細胞 / Tadalafil / Cyclophosphamide
Research Abstract

The objective of this study is to develop novel effective radiation therapy(RT) based on Radiation Immunobiology. In addition to the induction of apoptosis, we investigate the secondary anti-tumor activity of ionizing radiation mediated by the immune response to the irradiated tumor and host. When RT was followed with cytotoxic T lymphocyte therapy(CTL), antitumor activity of CTLs was markedly enhanced by prior RT, because RT inhibited the recruitment of myeloid derived suppressor cells. We demonstrated that the regulation of anti-tumor immune response contributed to the improvement of RT.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (64 results)

All 2011 2010 2009 Other

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (46 results) Remarks (1 results)

  • [Journal Article] γδT-cell immunotherapy for lung cancer2011

    • Author(s)
      Yoshida Y, Nakajima J, Wada H, Kakimi K
    • Journal Title

      Surgery today

      Volume: 41(5) Issue: 5 Pages: 606-11

    • DOI

      10.1007/s00595-010-4478-7

    • NAID

      10029047060

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] UV irradiation of immunized mice induces type 1 regulatory T cells that suppress tumor antigen specific cytotoxic T lymphocyte responses2011

    • Author(s)
      Toda M, Wang L, Ogura S, Torii M, Kurachi M, Kakimi K, Nishikawa H, Matsushima K, Shiku H, Kuribayashi K, Kato T
    • Journal Title

      International journal of cancer

      Volume: 129(5) Issue: 5 Pages: 1126-36

    • DOI

      10.1002/ijc.25775

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adoptive immunotherapy for advanced non-small cell lung cancer using zoledronate-expandedγδT cells : a phase I clinical study2011

    • Author(s)
      Sakamoto M, Nakajima J, Murakawa T, Fukami T, Yoshida Y, Murayama T, Takamoto S, Matsushita H, Kakimi K
    • Journal Title

      Journal of immunotherapy

      Volume: 34(2) Issue: 2 Pages: 202-11

    • DOI

      10.1097/cji.0b013e318207ecfb

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exploring immune therapy for renal cancer2011

    • Author(s)
      Matsushita H, Kakimi K
    • Journal Title

      International journal of urology : official journal of the Japanese Urological Association

      Volume: 18(6) Issue: 6 Pages: 412-13

    • DOI

      10.1111/j.1442-2042.2011.02762.x

    • NAID

      10030822756

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chemokine receptor CXCR3 facilitates CD8(+) T cell differentiation into short-lived effector cells leading to memory degeneration2011

    • Author(s)
      Kurachi Makoto
    • Journal Title

      The Journal of Experimental Medicine

      Volume: 208 Issue: 8 Pages: 1605-1620

    • DOI

      10.1084/jem.20102101

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expansion of human peripheral bloodγδT cells using zoledronate2011

    • Author(s)
      Kondo M, Izumi T, Fujieda N, Kondo A, Morishita T, Matsushita H, Kakimi K
    • Journal Title

      Journal of visualized experiments : JoVE

      Volume: 55 Issue: 55 Pages: 3182-3182

    • DOI

      10.3791/3182

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A phase i study of vaccination with NY-ESO-1f peptide mixed with Picibanil OK-432 and Montanide ISA-51 in patients with cancers expressing the NY-ESO-1 antigen2011

    • Author(s)
      Kakimi K, Isobe M, Uenaka A, Wada H, Sato E, Doki Y, Nakajima J, Seto Y, Yamatsuji T, Naomoto Y, Shiraishi K, Takigawa N, Kiura K, Tsuji K, Iwatsuki K, Oka M, Pan L, Hoffman EW, Old LJ, Nakayama E
    • Journal Title

      International journal of cancer Journal international du cancer

      Volume: 129 Issue: 12 Pages: 2836

    • DOI

      10.1002/ijc.25955

    • URL

      https://pure.teikyo.jp/en/publications/58759438-4771-4be4-89b5-4cf95da8afd3

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adoptive Immunotherapy for Advanced Non-small CellLung Cancer Using Zoledronate-expanded gammadeltaTCells : APhase I Clinical Study.2011

    • Author(s)
      Sakamoto M
    • Journal Title

      J Immunother

      Volume: 34 Pages: 202-211

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A phase I study of vaccination with NY-ESO-1f peptide mixed with Picibanil OK-432 and Montanide ISA-51 in patients with cancers exnressing the NY-ESO-1 antigen.2011

    • Author(s)
      Kakimi K
    • Journal Title

      Int J Cancer.

      Volume: (掲載確定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A phase I study of adoptive immunotherapy for recurrent non-small-cell lung cancer patients with autologousγδT cells2010

    • Author(s)
      Nakajima J, Murakawa T, Fukami T, Goto S, Kaneko T, Yoshida Y, Takamoto S, Kakimi K
    • Journal Title

      European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

      Volume: 37(5) Issue: 5 Pages: 1191-7

    • DOI

      10.1016/j.ejcts.2009.11.051

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficient cross-presentation of soluble exogenous antigens introduced into dendritic cells using a weak-based amphiphilic peptide2010

    • Author(s)
      Ikeuchi N, Futami J, Hosoi A, Noji S, Kurachi M, Ueha S, Fujii S, Yamada H, Matsushima K, Moriyasu F, Kakimi K
    • Journal Title

      Biochemical and biophysical research communications

      Volume: 392(2) Issue: 2 Pages: 217-22

    • DOI

      10.1016/j.bbrc.2010.01.019

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A phase I study of adoptive immunotherapy for recurrent non-small-cell lung cancer patients with autologous gammadelta T cells2010

    • Author(s)
      Nakajima J
    • Journal Title

      Eur J Cardiothorac Surg

      Volume: 37 Pages: 1191-1197

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] UV irradiation of immunized mice induces type 1 regulatory T cells that suppress tumor antigen specific cytotoxic T lymp hocyte responses.2010

    • Author(s)
      Toda M
    • Journal Title

      Int J Cancer

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A phase I study of adoptive immunotherapy for recurrent non-small-cell lung cancer patients with autologous gammadelta Tcells.2010

    • Author(s)
      Nakaiima J
    • Journal Title

      Eur J Cardiothorac Surg. (Epub)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of culture medium on the expansion of T cells for immunotherapy2009

    • Author(s)
      Sato K, Kondo M, Sakuta K, Hosoi A, Noji S, Sugiura M, Yoshida Y, Kakimi K
    • Journal Title

      Cytotherapy

      Volume: 11(7) Issue: 7 Pages: 936-46

    • DOI

      10.3109/14653240903219114

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Active specific immunotherapy and cell-transfer therapy for the treatment of non-small cell lung cancer2009

    • Author(s)
      Kakimi K, Nakajima J, Wada H
    • Journal Title

      Lung cancer

      Volume: 65(1) Issue: 1 Pages: 1-8

    • DOI

      10.1016/j.lungcan.2008.10.018

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of culture medium on the expansion of T cells for immunotherapy.2009

    • Author(s)
      Sato, K
    • Journal Title

      Cytotherapy 11

      Pages: 936-946

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Efficient Cross-presentation of Soluble Exogenous Antigens Introduced into Dendritic Cells2011

    • Author(s)
      Kakimi K
    • Organizer
      HAA-ISHAPD 2011
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2011-11-01
    • Related Report
      2011 Final Research Report
  • [Presentation] Efficient cross-presentation of soluble exogenous antigens introduced into dendritic cells2011

    • Author(s)
      Kakimi K
    • Organizer
      HAA-ISHAPD 2011
    • Place of Presentation
      Sydney(オーストラリア)(招待講演)
    • Year and Date
      2011-11-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] γδT細胞移入治療により末梢血中に蓄積されたγδT細胞の機能評価2011

    • Author(s)
      近藤篤,藤枝奈緒,森下岳晴,近藤真,泉謙道,前川隆司,松下博和,垣見和宏
    • Organizer
      第49回日本癌治療学会総会/学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-29
    • Related Report
      2011 Final Research Report
  • [Presentation] 細胞移入治療により末梢血中に蓄積されたγδT細胞の機能評価2011

    • Author(s)
      近藤篤, 藤枝奈緒, 森下岳晴, 近藤真, 泉謙道, 前川隆司, 松下博和, 垣見和宏
    • Organizer
      第49回日本癌治療学会総会/学術集会
    • Place of Presentation
      愛知県
    • Year and Date
      2011-10-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 転移性腎細胞癌に対するsunitinib併用DCワクチン治療2011

    • Author(s)
      松下博和,榎本裕,久米春喜,永田政義,細田千尋,福原浩,藤村哲也,鈴木基文,西松寛明,石川晃,本間之夫,垣見和宏
    • Organizer
      第49回日本癌治療学会総会/学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-28
    • Related Report
      2011 Final Research Report
  • [Presentation] 転移性腎細胞癌に対するsunitinib併用DCワクチン治療2011

    • Author(s)
      松下博和, 榎本裕, 久米春喜, 永田政義, 細田千尋, 福原浩, 藤村哲也, 鈴木基文, 西松寛明, 石川晃, 本間之夫, 垣見和宏
    • Organizer
      第49回日本癌治療学会総会
    • Place of Presentation
      愛知県
    • Year and Date
      2011-10-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Requirement for comon γ chain cytokines for adoptive transferred γδ T cell function and homeostasis in vivo2011

    • Author(s)
      Kakimi K, Izumi T, Kondo M, Fujieda N, Kondo A, Tamura N, Maekawa R
    • Organizer
      The 2nd Meeting of Asian Cellular Therapy Organizaiton 2011
    • Place of Presentation
      Miyazaki
    • Year and Date
      2011-10-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 抗4-1BB抗体はCTLの増殖・生存ではなく、エフェクター活性に作用して抗腫瘍効果を増強する2011

    • Author(s)
      野地秀一,細井亮宏,竹田和由,松下博和,瀬戸泰之,垣見和宏
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 抗CD137抗体併用による腫瘍特異的CTL移入治療の増強2011

    • Author(s)
      細井亮宏, 野地秀一, 竹田和由, 松下博和, 瀬戸泰之, 垣見和宏
    • Organizer
      第15回日本がん免疫学会総会
    • Place of Presentation
      大阪府
    • Year and Date
      2011-06-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] NY-ESO-1fペプチドワクチン治療経験から見たRECISTガイドラインとimmune-related response cirteria2011

    • Author(s)
      垣見和宏,中島淳,村川知弘,吉田幸弘,坂本美紀,村山智紀,松下博和,和田尚,中山睿一
    • Organizer
      第20回日本癌病態治療研究会
    • Place of Presentation
      東京都
    • Year and Date
      2011-06-18
    • Related Report
      2011 Final Research Report
  • [Presentation] 非小細胞肺癌に対するγδT細胞移入治療により末梢血中に蓄積されたγδT細胞の機能評価2011

    • Author(s)
      近藤篤, 藤枝奈緒, 森下岳晴, 近藤真, 泉謙道, 前川隆司, 松下博和, 垣見和宏
    • Organizer
      第20回日本癌病態治療研究会
    • Place of Presentation
      東京都
    • Year and Date
      2011-06-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] 抗CD137抗体併用による腫瘍特異的CTL移入治療の増強2011

    • Author(s)
      野地秀一, 細井亮宏, 竹田和由, 松下博和, 瀬戸泰之, 垣見和宏
    • Organizer
      第20回日本癌病態治療研究会
    • Place of Presentation
      東京都
    • Year and Date
      2011-06-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] がん免疫エディティングと腫瘍拒絶のメカニズム2011

    • Author(s)
      松下博和, Schreiber RD,垣見和宏
    • Organizer
      第20回日本癌病態治療研究会
    • Place of Presentation
      東京都
    • Year and Date
      2011-06-17
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Requirement for common g chain family cytokines for adoptive transferred gd T cell function and homeostasis in vivo.2011

    • Author(s)
      Kakimi K, Izumi T, Kondo M, Fujieda N, Kondo A, Morishita T, R. Maekawa, Matsushita H
    • Organizer
      Immunology 2011 : 98th Annual Meeting The American Association of Immunologist
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2011-05-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 進行再発非小細胞肺癌に対するγδT細胞移入治療2011

    • Author(s)
      坂本未紀, 村山智紀, 村川知弘, 中島淳, 垣見和宏
    • Organizer
      第28回日本呼吸器外科学会総会
    • Place of Presentation
      大分県
    • Year and Date
      2011-05-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Requirement for common g chain family cytokines for adoptive transferred γδ T cell function and homeostasis in vivo2011

    • Author(s)
      Kakimi K, Izumi T, Kondo M, Fujieda N, Kondo A, Morishita T, R.Maekawa, Matsushita H
    • Organizer
      Immunology 2011 : 98th Annual Meeting The American Association of Immunologist 2011
    • Place of Presentation
      San Francisco(米国)
    • Year and Date
      2011-05-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] 共通γ鎖ファミリーサイトカインによるγδT細胞の増殖に対する影響2011

    • Author(s)
      泉謙道,近藤真,松下博和,近藤篤,森下岳晴,藤枝奈緒,垣見和宏
    • Organizer
      第15回日本がん免疫学会総会
    • Place of Presentation
      大阪市
    • Related Report
      2011 Final Research Report
  • [Presentation] 進行再発非小細胞肺癌に対するγδT細胞移入治療2011

    • Author(s)
      坂本未紀,村山智紀,村川知弘,中島淳,垣見和宏
    • Organizer
      第28回日本呼吸器外科学会総会
    • Place of Presentation
      大分県由布市
    • Related Report
      2011 Final Research Report
  • [Presentation] 抗CD137抗体併用による腫瘍特異的CTL移入治療の増強2011

    • Author(s)
      細井亮宏,野地秀一,竹田和由,松下博和,瀬戸泰之,垣見和宏
    • Organizer
      第15回日本がん免疫学会総会
    • Place of Presentation
      大阪市
    • Related Report
      2011 Final Research Report
  • [Presentation] Antigen imunoselection as a mechanism of cancer immunoediting2011

    • Author(s)
      Matsushita H, Kakimi K, Schreiber RD
    • Organizer
      第40回日本免疫学会総会/学術集会
    • Place of Presentation
      幕張メッセ
    • Related Report
      2011 Final Research Report
  • [Presentation] Requirement for comon g chain cytokines for adoptive transferred gd T cell function and homeostasis in vivo2011

    • Author(s)
      Kakimi K, Izumi T, Kondo M, Fujieda N, Kondo A, Tamura N, Maekawa R
    • Organizer
      The 2nd Meeting of Asian Cellular Therapy Organizaiton
    • Place of Presentation
      Miyazaki, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] CTL therapy-induced accumulation of CD11b+Gr-1+myeloid-derived suppressor cells in tumors2011

    • Author(s)
      Kakimi K, Hosoi A, Matsushita H
    • Organizer
      Keystone Symposia on Molecular and Cellular Biology : Cancer Control by Tumor Suppressors and Immune Effectors
    • Place of Presentation
      Santa Fe, New Mexico, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] The discriminatory activation of tumor specific cytotoxic T lymphocytes localized int he tumor by anti-4-1BB mAB2011

    • Author(s)
      Hosoi A, Shuichi N, Kazuyoshi T, Hirokazu M, Kakimi, K
    • Organizer
      第40回日本免疫学会総会/学術集会
    • Place of Presentation
      幕張メッセ
    • Related Report
      2011 Final Research Report
  • [Presentation] CTL therapy-induced accumulation of CD11b+Gr-1+ myeloid-derived sunnressor cells in tumors.2011

    • Author(s)
      Kazuhiro Kakimi
    • Organizer
      40th Keystone Symposia on Molecular and Cell Biology.
    • Place of Presentation
      Santa Fe, New Mexico, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] γδT細胞治療に用いるγδT細胞とその体内動態2010

    • Author(s)
      有吉直子
    • Organizer
      第14回日本がん免疫学会
    • Place of Presentation
      熊本市
    • Year and Date
      2010-07-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 抗原mRNAとNKTリガンドを提示させたアジュバントベクター細胞による抗腫瘍効果の誘導2010

    • Author(s)
      清水佳奈子
    • Organizer
      第14回日本がん免疫学会
    • Place of Presentation
      熊本市
    • Year and Date
      2010-07-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] がんに対する免疫細胞治療~がんワクチンと細胞移入治療~2010

    • Author(s)
      垣見和宏
    • Organizer
      第19回日本癌病態治療研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-06-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Circumventing immunosuppressive environement in combination with radiation therapy improved the tumor-specific CTL thera py.2010

    • Author(s)
      垣見和宏
    • Organizer
      NIRS-Chiba University G-COE Joint Symposium on Carbon-Ion Therapy and Immunotherapy
    • Place of Presentation
      千葉市
    • Year and Date
      2010-01-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] CTL治療の二面性:免疫抑制活性を持つMDSCを腫瘍内に誘導する2010

    • Author(s)
      細井亮宏,前川隆司,垣見和宏
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪市
    • Related Report
      2011 Final Research Report
  • [Presentation] CTL治療は免疫抑制活性を持つCD11b+Gr1+細胞を腫瘍内に誘導する2010

    • Author(s)
      細井亮宏,前川隆司,垣見和宏
    • Organizer
      第14回日本がん免疫学会総会
    • Place of Presentation
      熊本市
    • Related Report
      2011 Final Research Report
  • [Presentation] がんに対するγδT細胞治療2010

    • Author(s)
      泉謙道,近藤真,垣見和宏
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪市
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 自己活性化γδT細胞による非小細胞肺癌免疫療法2010

    • Author(s)
      吉田幸弘,村山智紀,金子亨,後藤重則,村川知弘,坂本未紀,中島淳,垣見和宏
    • Organizer
      第48回日本癌治療学会学術集会
    • Place of Presentation
      京都市
    • Related Report
      2011 Final Research Report
  • [Presentation] CTL治療の二面性:抗腫瘍効果と抑制性細胞の誘導2010

    • Author(s)
      垣見和宏
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪市
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Adoptive gamma/delta T cell for the treatment of cancer2010

    • Author(s)
      Sakuta K, Noguchi A, Ariyoshi N, Nakata J, Maekawa R, Kakimi K
    • Organizer
      14th Inthernational Congress of Immunology
    • Place of Presentation
      Kobe, JAPAN
    • Related Report
      2011 Final Research Report
  • [Presentation] CTL therapy-induced accumulation of CD11b+Gr-1+myeloid-derived suppressor cells in tumors2010

    • Author(s)
      Hosoi A, Maekawa R, Kakimi K
    • Organizer
      14th Inthernational Congress of Immunology
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] CTL治療の二面性;免疫抑制活性を持つMDSCを腫瘍内に誘導する2010

    • Author(s)
      細井亮宏
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪市
    • Related Report
      2010 Annual Research Report
  • [Presentation] Adoptive γδT cell transfer for non-small cell lung cancer.2010

    • Author(s)
      Kazuhiro Kakimi
    • Organizer
      AACR 101st Annual Meeting 2010
    • Place of Presentation
      Washington, DC., USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Adoptive gamma/delta T cell for the treatment of cancer.2010

    • Author(s)
      Sakuta, K
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe
    • Related Report
      2010 Annual Research Report
  • [Presentation] Chemokine receptor CXCR3 regulates the generation of memory CTL.2010

    • Author(s)
      Kurachi
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dynamics of CCR7+ tumor-infiltrating dendritic cells that regulate anti-tumor immune response.2010

    • Author(s)
      Ueha, S
    • Organizer
      14th International Congress of Immunology.
    • Place of Presentation
      Kobe
    • Related Report
      2010 Annual Research Report
  • [Presentation] CTL therapy-induced accumulation of CD11b+Gr-1+ myeloid-derived suppressor cells in tumor.2010

    • Author(s)
      Hosoi, A
    • Organizer
      14th International Congress of Immunology.
    • Place of Presentation
      Kobe
    • Related Report
      2010 Annual Research Report
  • [Presentation] 電子線照射と免疫制御因子阻害剤(PDE-5阻害剤)の併用による抗腫瘍効果2009

    • Author(s)
      細井亮宏
    • Organizer
      日本放射線腫瘍学会第22回学術大会
    • Place of Presentation
      京都市
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Identification of CCR7+MHC class IIhi dendritic cells in mouse tumor2009

    • Author(s)
      上羽悟史
    • Organizer
      第13回日本がん免疫学会総会
    • Place of Presentation
      北九州市
    • Year and Date
      2009-06-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] 抗腫瘍エフェクター細胞免疫抑制因子阻害剤と腫瘍特異的細胞傷害性T細胞移入の併用療法による抗腫瘍効果の検討.2009

    • Author(s)
      細井亮宏
    • Organizer
      第13回日本がん免疫学会総会
    • Place of Presentation
      北九州市
    • Year and Date
      2009-06-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] 抗腫瘍エフェクター細胞免疫抑制因子阻害剤と腫瘍特異的細胞傷害性T細胞移入の併用療法による抗腫瘍効果の検討2009

    • Author(s)
      細井亮宏,前川隆司,吉田幸弘,垣見和宏
    • Organizer
      第13回日本がん免疫学会総会
    • Place of Presentation
      北九州市小倉
    • Related Report
      2011 Final Research Report
  • [Presentation] Cell therapy(細胞療法)の新たなアプローチ:ゾレドロン酸を用いて培養したVγ9Vδ2T細胞による免疫細胞治療2009

    • Author(s)
      垣見和宏
    • Organizer
      第13回日本がん免疫学会総会
    • Place of Presentation
      北九州市小倉
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://immunoth.umin.jp/

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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