Novel radiation therapy with regulation of immune response
| Project/Area Number |
21390340
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KAKIMI Kazuhiro 東京大学, 医学部附属病院, 特任准教授 (80273358)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAGAWA Keiichi 東京大学, 医学部附属病院, 准教授 (80188896)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIRAISHI Kenshiro 東京大学, 医学部附属病院, 助教 (40447404)
YAMASHITA Hideomi 東京大学, 医学部附属病院, 助教 (70447407)
YOSHIDA Yukihiro 東京大学, 医学部附属病院, 助教 (00529050)
UEHA Satoshi 東京大学, 医学部附属病院, 助教 (00447385)
KURACHI Makoto 東京大学, 医学部附属病院, 助教 (00396722)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
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| Keywords | 放射線治療 / 免疫細胞治療 / 腫瘍免疫 / 免疫抑制 / 電子線照射 / 細胞傷害性T細胞 / MDSC / 骨髄性抑制細胞 / TAM / B16 / 免疫 / 腫瘍内微小環境 / 骨髄性免疫抑制細胞 / 免疫制御 / 抑制性T細胞 / Tadalafil / Cyclophosphamide |
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| Research Abstract |
The objective of this study is to develop novel effective radiation therapy(RT) based on Radiation Immunobiology. In addition to the induction of apoptosis, we investigate the secondary anti-tumor activity of ionizing radiation mediated by the immune response to the irradiated tumor and host. When RT was followed with cytotoxic T lymphocyte therapy(CTL), antitumor activity of CTLs was markedly enhanced by prior RT, because RT inhibited the recruitment of myeloid derived suppressor cells. We demonstrated that the regulation of anti-tumor immune response contributed to the improvement of RT.
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Report
(4 results)
Research Products
(64 results)
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[Journal Article] UV irradiation of immunized mice induces type 1 regulatory T cells that suppress tumor antigen specific cytotoxic T lymphocyte responses2011
Author(s)
Toda M, Wang L, Ogura S, Torii M, Kurachi M, Kakimi K, Nishikawa H, Matsushima K, Shiku H, Kuribayashi K, Kato T
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Journal Title
International journal of cancer
Volume: 129(5)
Issue: 5
Pages: 1126-36
DOI
Related Report
Peer Reviewed
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[Journal Article] A phase I study of vaccination with NY-ESO-1f peptide mixed with Picibanil OK-432 and Montanide ISA-51 in patients with cancers expressing the NY-ESO-1 antigen2011
Author(s)
Kakimi K, Isobe M, Uenaka A, Wada H, Sato E, Doki Y, Nakajima J, Seto Y, Yamatsuji T, Naomoto Y, Shiraishi K, Takigawa N, Kiura K, Tsuji K, Iwatsuki K, Oka M, Pan L, Hoffman EW, Old LJ, Nakayama E
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Journal Title
International journal of cancer Journal international du cancer
Volume: 129(12)
Issue: 12
Pages: 2836-46
DOI
Related Report
Peer Reviewed
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[Journal Article] Efficient cross-presentation of soluble exogenous antigens introduced into dendritic cells using a weak-based amphiphilic peptide2010
Author(s)
Ikeuchi N, Futami J, Hosoi A, Noji S, Kurachi M, Ueha S, Fujii S, Yamada H, Matsushima K, Moriyasu F, Kakimi K
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Journal Title
Biochemical and biophysical research communications
Volume: 392(2)
Issue: 2
Pages: 217-22
DOI
Related Report
Peer Reviewed
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[Presentation] 転移性腎細胞癌に対するsunitinib併用DCワクチン治療2011
Author(s)
松下博和,榎本裕,久米春喜,永田政義,細田千尋,福原浩,藤村哲也,鈴木基文,西松寛明,石川晃,本間之夫,垣見和宏
Organizer
第49回日本癌治療学会総会/学術集会
Place of Presentation
名古屋
Year and Date
2011-10-28
Related Report
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[Presentation] 転移性腎細胞癌に対するsunitinib併用DCワクチン治療2011
Author(s)
松下博和, 榎本裕, 久米春喜, 永田政義, 細田千尋, 福原浩, 藤村哲也, 鈴木基文, 西松寛明, 石川晃, 本間之夫, 垣見和宏
Organizer
第49回日本癌治療学会総会
Place of Presentation
愛知県
Year and Date
2011-10-28
Related Report
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