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Development of novel CT contrast agents with long retention in the vessel

Research Project

Project/Area Number 21390343
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

SAKAHARA Harumi  浜松医科大学, 医学部, 教授 (10187031)

Co-Investigator(Kenkyū-buntansha) MAGATA Yasuhiro  浜松医科大学, メディカルフォトニクス研究センター, 教授 (20209399)
YAMAGUCHI Hiroshi  浜松医科大学, 光量子医学研究センター, 助教 (00450841)
FUCHIGAMI Takeshi  浜松医科大学, 光量子医学研究センター, 助教 (30432206)
OGAWA Mikako  浜松医科大学, メディカルフォトニクス研究センター, 准教授 (20344351)
KOJIMA Chie  大阪府立大学, 21世紀科学研究機構, 講師 (50405346)
SAKAI Toshihiro  浜松医科大学, メディカルフォトニクス研究センター, 特任研究員 (40585098)
TAKASHIMA Misato  浜松医科大学, メディカルフォトニクス研究センター, 助教 (70525592)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
KeywordsX線 / 造影剤 / X線CT / ヨウ素 / アルブミン / T4
Research Abstract

The aim of this study is to develop novel CT contrast agent with a longer retention in blood in order to visualize vascular structure in a target tissue or angiogenesis of tumor. For this purpose, we use iodine or gold as a contrast element and human serum albumin or dendrimer modified with PEG as a carrier compound. Iodine modified agent showed a less enhancement effect in vivo because of its instability in blood. Gold modified agent showed a longer enhancement effect in vivo in comparison with a commercially available iodine contrast agent.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (7 results)

All 2012 2011 2010

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (4 results)

  • [Journal Article] Gold nanoparticle-loaded PEGylated dendrimers for theragnosis.2012

    • Author(s)
      C. Kojima, S.-H. Cho, E. Higuchi
    • Journal Title

      Res. Chem. Intermed.

      Volume: 38 Pages: 1279-1289

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gold Nanoparticle-Loaded PEGylated Dendrimers for Theragnosis2012

    • Author(s)
      C Kojima, S-H Cho, E Higuchi
    • Journal Title

      Res.Chem.Intermed

      Volume: 38 Pages: 1279-1289

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] X-ray computed tomography contrast agents prepared by seeded growth of gold nanoparticle in PEGylated dendrimer2010

    • Author(s)
      C. Kojima, Y. Umeda, M. Ogawa, A. Harada, Y. Magata, K. Kono
    • Journal Title

      Nanotechnology

      Volume: 21 Pages: 245104-245104

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] ナノカプセル化金ナノ粒子の光応答性を利用した診断・治療2011

    • Author(s)
      児島千恵
    • Organizer
      第24回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      堺市
    • Related Report
      2011 Final Research Report
  • [Presentation] ナノカプセル化金ナノ粒子の光応答性を利用した診断・治療2011

    • Author(s)
      児島千恵
    • Organizer
      第24回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      堺
    • Related Report
      2011 Annual Research Report
  • [Presentation] 金ナノ粒子内包PEG修飾デンドリマーを利用したCT造影剤の作製2010

    • Author(s)
      児島千恵、梅田康仁、小川美香子、原田敦史、間賀田泰寛、河野健司
    • Organizer
      第26回日本DDS学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2010-06-18
    • Related Report
      2011 Final Research Report
  • [Presentation] Gold nanoparticles in PEGylated dendrimer as a CT contrast agent for blood pool2010

    • Author(s)
      C. Kojima, Y. Umeda, M. Ogawa, A. Harada, Y. Magata, K. Kono
    • Organizer
      2010 World Molecular Imaging Congress
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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