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Signal source of functional MRI under heavy diffusion weighting

Research Project

Project/Area Number 21390352
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionNational Institute of Radiological Sciences

Principal Investigator

OBATA Takayuki  独立行政法人放射線医学総合研究所, 重粒子医科学センター, チームリーダー (00285107)

Co-Investigator(Kenkyū-buntansha) MASAMOTO Kazuto  電気通信大学, 先端領域教育研究センター, 特任准教授 (60455384)
Co-Investigator(Renkei-kenkyūsha) AOKI Ichio  独立行政法人放射線医学総合研究所, 分子イメージング研究センター, チームリーダー (10319519)
IKEHIRA Hiroo  独立行政法人放射線医学総合研究所, 分子イメージング研究センター, サブグループリーダ (50150313)
OHBAYASHI Shigeru  独立行政法人放射線医学総合研究所, 分子イメージング研究センター, チームリーダー (90318246)
KIMURA Yuichi  独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 室長 (60205002)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2009: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Keywords水拡散 / MRI / 機能イメージング / 分子イメージング / magnetic resonance imaging(MRI) / 脳機能計測 / レーザー顕微鏡 / マルチモーダルイメージング
Research Abstract

This project aimed to make clear the mechanism of functional magnetic resonance imaging under heavy diffusion weighting(DfMRI). Our results from human and animal MRI indicated that the main source of DfMRI signal is BOLD related, but the signal changes were different from usual BOLD. The human data also included some diffusion related signal contribution to DfMRI. Taking in vitro aquaporin data into consideration, DfMRI may reflect intracellular BOLD and water diffusion changes.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (19 results)

All 2011 2010 2009 Other

All Journal Article (7 results) (of which Peer Reviewed: 4 results) Presentation (12 results)

  • [Journal Article] High b-value diffusion-weighted fMRI in a rat forepaw electrostimulation model at 7 T2011

    • Author(s)
      Autio JA, Kershaw J, Shibata S, Obata T, Kanno I, Aoki I
    • Journal Title

      Neuroimage

      Volume: 57 Issue: 1 Pages: 140-8

    • DOI

      10.1016/j.neuroimage.2011.04.006

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Spatial frequency-based analysis of mean red blood cell speed in single microvessels : investigation of microvascular perfusion in rat cerebral cortex2011

    • Author(s)
      Autio J, Kawaguchi H, Saito S, Aoki I, Obata T, Masamoto K, Kanno I
    • Journal Title

      PLoS ONE

      Volume: 6 Issue: 8 Pages: e24056-e24056

    • DOI

      10.1371/journal.pone.0024056

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reproducibility and variance of a stimulation-induced hemody namic response in barrel cortex of awake behaving mice2011

    • Author(s)
      Takuwa H, Autio J, Nakayama H, Matsuura T, Obata T, Okada E, Masamoto K, Kanno I
    • Journal Title

      Brain Research

      Volume: 1369 Pages: 103-111

    • DOI

      10.1016/j.brainres.2010.11.007

    • Related Report
      2011 Final Research Report
  • [Journal Article] Reproducibility and variance of a stimulation-induced hemody namic response in barrel cortex of awake behaving mice2011

    • Author(s)
      Takuwa H, et al.
    • Journal Title

      Brain Research

      Volume: 19;1369 Pages: 103-111

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contribution of nitric oxide to cerebral blood flow regulation under hypoxia in rats2010

    • Author(s)
      Takuwa H, Matsuura T, Bakalova R, Obata T, Kanno I
    • Journal Title

      Journal of Physiological Sciencese

      Volume: 60 Issue: 6 Pages: 399-406

    • DOI

      10.1007/s12576-010-0108-9

    • NAID

      10027712229

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] A multi-compartmental SE-BOLD interpretation for stimulus-related signal changes in diffusion-weighted functional MRI2009

    • Author(s)
      J.Kershaw, T.Obata, et al
    • Journal Title

      NMR in Biomedicine

      Volume: 22 Pages: 770-788

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regional heterogeneity and age-related change in sub-regions of internal capsule evaluated by diffusion tensor imaging

    • Author(s)
      Kawaguchi H, Obata T, Ota M, Akine Y, Ito H, Ikehira H, Kanno I, Suhara T
    • Journal Title

      Brain Res

      Volume: 2010 Pages: 1-1

    • Related Report
      2011 Final Research Report
  • [Presentation] シンポジウム「機能画像・拡散画像の現状」拡散強調MRIで得られる新たな脳機能信号2011

    • Author(s)
      小畠隆行
    • Organizer
      第23回臨床MR脳機能研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-02-19
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Symposium : Research and Innovation of Molecular Imaging Technology Effect of Cell Membrane Water Permeability on Diffusion-Weighted MR signal Imaging12011

    • Author(s)
      Takayuki Obata
    • Organizer
      11th Asia-Oceania Congress of Medical Physics(AOCMP)
    • Place of Presentation
      福岡
    • Related Report
      2011 Final Research Report
  • [Presentation] Biexponential modeling of diffusion-weighted MRI of rat brain before and after global ischaemia2011

    • Author(s)
      Jeff Kershaw, Takayuki Obata, et al
    • Organizer
      第39回日本磁気共鳴医学会大会
    • Place of Presentation
      北九州
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Aquaporin-4発現細胞を用いた拡散強調MRIの信号源探索2011

    • Author(s)
      小畠隆行
    • Organizer
      第39回日本磁気共鳴医学会大会
    • Place of Presentation
      北九州
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Symposium : Research and Innovation of Molecular Imaging Technology Effect of Cell Membrane Water Permeability on Diffusion-Weighted MR signal Imagingl2011

    • Author(s)
      Takayuki Obata
    • Organizer
      11th Asia-Oceania Congress of Medical Physics (AOCMP)
    • Place of Presentation
      福岡
    • Related Report
      2011 Annual Research Report
  • [Presentation] 脳水拡散に関する最近の(マニアックな)話題2010

    • Author(s)
      小畠隆行
    • Organizer
      第12回東京臨床脳画像解析研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-08
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] シンポジウム「Neurovascular coupling」拡散強調MRIで得られる新たな脳機能信号2010

    • Author(s)
      小畠隆行
    • Organizer
      第12回ヒト脳機能マッピング学会
    • Place of Presentation
      東京
    • Year and Date
      2010-06-20
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] ひげ刺激負荷に対する覚醒マウスの脳血流反応及び自発的運動量との相関2009

    • Author(s)
      田桑弘之、小畠隆行, 他
    • Organizer
      第21回日本脳循環代謝学会
    • Place of Presentation
      大阪
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 共焦点レーザ顕微鏡法を用いたラット体性感覚野における脳血流動態の時空間解析2009

    • Author(s)
      川口拓之、小畠隆行, 他
    • Organizer
      第21回日本脳循環代謝学会
    • Place of Presentation
      大阪
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Diffusion-Weighted TE-dependent fMRI Signal in Rat Somatosensory Cortex at 7 T2009

    • Author(s)
      J. A. Autio, T. Obata, et al
    • Organizer
      17th Scientific Meeting and Exhibition
    • Place of Presentation
      Honolulu, Hawaii
    • Related Report
      2011 Final Research Report
  • [Presentation] Signal Source in Heavily Diffusion-Weighted functional MRI2009

    • Author(s)
      D. Kuroiwa, T. Obata, et al
    • Organizer
      ISMRM 17th Scientific Meeting and Exhibition
    • Place of Presentation
      Honolulu, Hawaii
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Diffusion-Weighted TE-dependent fMRI Signal in Rat Somatosensory Cortex at 7 T2009

    • Author(s)
      J.A.Autio, T.Obata, et al.
    • Organizer
      ISMRM 17th Scientific Meeting and Exhibition
    • Place of Presentation
      Honolulu, Hawaii
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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