| Project/Area Number |
21390354
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | National Institute of Biomedical Innovation |
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Principal Investigator |
TOMONAGA Takeshi 独立行政法人医薬基盤研究所, プロテオームリサーチプロジェクト, プロジェクトリーダー (80227644)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUBARA Hisahiro 千葉大学, 大学院・医学研究院, 教授 (20282486)
NOMURA Fumio 千葉大学, 大学院・医学研究院, 教授 (80164739)
NISHIMURA Motoi 千葉大学, 大学院・医学研究院, 助教 (80400969)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2009: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
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| Keywords | プロテオーム / ペプチド / 癌 / 腫瘍マーカー / 診断 / プロテナーム |
|---|
| Research Abstract |
Recent advance of proteomic technology have contributed to identify biomarkers for various disease, however, only a few proteins have been used in practical application. This study was aimed to identify and quantitate low abundant tumor marker candidates in plasma derived from cancer tissue using recent proteomic technologies. About 5000 membrane proteins from colorectal and breast cancer tissues were identified respectively. Among them, about 100 colorectal and 20 breast cancer biomarker candidate proteins were verified by SRM/MRM method. Some of the candidate proteins were detected in human serum.
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