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Development of New Strategy of Immunological Tolerance Inductionby Intraportal administration of donor specific Mesenchymal hepatic stem cell in OrganTransplantation

Research Project

Project/Area Number 21390356
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionNiigata University

Principal Investigator

SATO Yoshinobu  新潟大学, 医歯学系, 講師 (20313538)

Co-Investigator(Kenkyū-buntansha) ABO Toru  新潟大学, 医歯学系, 教授 (30005079)
MATSUDA Yasunobu  新潟大学, 医歯学系, 准教授 (40334669)
TOMIYAMA Chikako  新潟大学, 医歯学系, 准教授 (80359702)
Project Period (FY) 2009 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2011: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2009: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Keywords移植・再生医療 / 免疫学 / 外科 / 免疫寛容 / ドナー特異的抗原 / 肝幹細胞 / 移植 / 臓器移植 / 拒絶反応 / ドナー特異的抗原門脈内投与 / 調節性T細胞 / shear stress
Research Abstract

The purpose of this study was to analyze the mechanisms of theinduction of operational tolerance in clinical liver transplantation by the intra-portaladministration of donor specific antigen and make the new method of induction of toleranceby hepatic stem cell. In the basic examination, the CD133+ NCAM+ human hepaticstem/progenitor cell was recognized around the region with existence of ductular reactionin the human liver with chronic or acute hepatitis. Especially, its existence was moreclearly in the human liver with higher hepatic injury. However, it was not recognizedin the normal human liver. In the immunological analysis of intra-portal administrationof super donor antigens, the population of FoxP3^+/CD4^+CD25^+ regulatory T cells increasedin the transplant patients with no immunosuppressants.
Treg. cells increased in the patients above MELD score 20. It was proved that the graspof preoperative immunological situation of transplant patients take the betteradministration of immunosuppressants.

Report

(5 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (36 results)

All 2013 2012 2011 2010 2009

All Journal Article (25 results) (of which Peer Reviewed: 16 results) Presentation (9 results) Book (2 results)

  • [Journal Article] Perioperative immunological differentiation in liver cirrhotic patients who underwent living related liver transplantation.2013

    • Author(s)
      Sato Y, Tomiyama C, Yamamoto S
    • Journal Title

      Hepatogastroenterology

      Volume: 60 Pages: 1156-1162

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Perioperativeimmunological differentiation in livercirrhotic patients who underwent livingrelated liver transplantation2012

    • Author(s)
      Sato Y, Tomiyama C, Yamamoto S, Oya H,Kobayashi T, Kokai H, Miura K, Hirose Y,Hatakeyama K
    • Journal Title

      Hepatogastroenterology

      Volume: Dec21;60 (Epub ahead of print) Pages: 124-124

    • Related Report
      2012 Final Research Report
  • [Journal Article] Regulatory Tcells activation in the patients whodisplased operational tolerance inIntra-Portal Administration of DonorSpecific Antigens in Living-Donor LiverTransplantation2012

    • Author(s)
      Yoshinobu Sato, Hiroshi Oya, SatoshiYamamoto, Hidenaka Kokai, Miura Kohei,Katsuyoshi Hatakeyama
    • Journal Title

      Transplant Proc

      Volume: 44 Pages: 560-564

    • Related Report
      2012 Final Research Report
  • [Journal Article] Livertransplantation surgical techniques forextensive retroperitoneal tumor withmajor blood vessel involvement: A casereport2012

    • Author(s)
      K.Miura, Y.Sato, Kokai H, Hara Y, Oya H,Yamamoto S, Hatakeyama K
    • Journal Title

      Transplant Proc

      Volume: 44 Pages: 579-580

    • Related Report
      2012 Final Research Report
  • [Journal Article] Isolated dissection of thesuperior mesenteric artery after livingdonor liver transplantation: a casereport2012

    • Author(s)
      Kokai H, Sato Y, Yamamoto S, Oya H,Kobayashi T, Watanabe T, Miura K,Hatakeyama K
    • Journal Title

      Transpl Proc

      Volume: 44 Pages: 588-589

    • Related Report
      2012 Final Research Report
  • [Journal Article] Regulatory T cells activation in the patients who displased operational tolerance in Intra-Portal Administration of Donor Specific Antigens in Living-Donor Liver Transplantation.2012

    • Author(s)
      Yoshinobu Sato, Hiroshi Oya, Satoshi Yamamoto
    • Journal Title

      Transplant Proc

      Volume: 44 Pages: 560-564

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Liver transplantation surgical techniques for extensive retroperitoneal tumor with major blood vessel involvement: A case report.2012

    • Author(s)
      K.Miura, Y.Sato, Kokai H
    • Journal Title

      Transplant Proc.

      Volume: 44 Pages: 579-580

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isolated dissection of the superior mesenteric artery after living donor liver transplantation: a case report.2012

    • Author(s)
      Kokai H, Sato Y, Yamamoto S,
    • Journal Title

      Transpl Proc.

      Volume: 44 Pages: 588-589

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Magnetic compression anastomosis for bile duct stenosis after donor left hepatectomy: a case report2012

    • Author(s)
      Oya H, Sato Y
    • Journal Title

      Transpl Proc.

      Volume: 44 Pages: 806-809

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Total pancreatectomy combined with partial pancreas autotransplantation for recurrent pancreatic cancer, a case report.2012

    • Author(s)
      T. Kobayashi, Y. Sato
    • Journal Title

      Transplant Proc

      Volume: 44 Pages: 1176-1179

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Successful laparoscopic assisted hemostasis of intrathoracic massive variceal rupture during living related liver transplant operation.2012

    • Author(s)
      Yoshinobu Sato, Hiroshi Oya
    • Journal Title

      Transpl Proc.

      Volume: 44 Pages: 820-821

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulatory T cells activation in the patients who displased operational tolerance in Intra-Portal Administration of Donor Specific Antigens in Living-Donor Liver Transplantation2012

    • Author(s)
      Yoshinobu Sato, et al
    • Journal Title

      Transplantation Proceedings

      Volume: 44 Pages: 560-564

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Successful laparoscopic assisted hemostasis of intrathoracic massive variceal rupture during living related liver transplant operation2012

    • Author(s)
      Yoshinobu Sato, Hiroshi OYa, et al.
    • Journal Title

      Transplantation Proceedings

      Volume: 44 Pages: 820-821

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A New Technique ofLateral Approach forLaparoscopy-Assisted Donor LeftHepatectomy2011

    • Author(s)
      Oya H, Sato Y, Yamamoto S, Hara Y,Kobayashi T, Watanabe T, Kokai H, MiuraK, Hatakeyama K
    • Journal Title

      Hepatogastroenterology

      Volume: 58 Pages: 110-111

    • Related Report
      2012 Final Research Report
  • [Journal Article] A New Technique of Lateral Approach for Laparoscopy-Assisted Donor Left Hepatectomy2011

    • Author(s)
      Oya H, Sato Y, et al.
    • Journal Title

      Hepatogastroenterology

      Volume: 58 Pages: 110-111

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Method for spontaneousconstriction and closure of porto-cavalshunt using a ligamentum teres hepatis insmall-for-size graft livertransplantation2010

    • Author(s)
      Yoshinobu Sato, Hiroshi Oya, SatoshiYamamoto, Takashi Kobayashi, YoshiakiHara, Hidenaka Kokai, and Katsuyoshi Hatakeyama
    • Journal Title

      Transplantation

      Volume: 90 Pages: 1200-1203

    • Related Report
      2012 Final Research Report
  • [Journal Article] Method for spontaneous constriction and closure of porto-caval shunt using a ligamentum teres hepatis in small-for-size graft liver transplantation2010

    • Author(s)
      Yoshinobu Sato, et al
    • Journal Title

      Transplantation

      Volume: 90 Pages: 1200-1203

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Auxuliary partial orthotopic living donor liver transplantation for fulminant hepatic failure with flat electroencephalogram : A case of report2010

    • Author(s)
      Kobayashi T, et al
    • Journal Title

      Transplantation Proceedings

      Volume: 42 Pages: 990-993

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 肝移植と門脈圧亢進症-shear stress理論と過小グラフトへの対策の変遷-2010

    • Author(s)
      佐藤好信, 他
    • Journal Title

      日本門脈圧充進症学会誌

      Volume: 16 Pages: 19-25

    • NAID

      130003378776

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinicopathological analysis of CD133(+) and NCAM(+) humanhepatic stem/progenitor cells in damagedlivers and hepatocellular carcinomas2009

    • Author(s)
      Tsuchiya A, Kamimura H, Takamura M,Yamagiwa S, Matsuda Y, Sato Y, Nomoto M,Ichida T, Aoyagi Y
    • Journal Title

      Hepatol Res

      Volume: 39 Pages: 1080-1090

    • Related Report
      2012 Final Research Report
  • [Journal Article] Intra portal donorspecific antigen transfusion mightprevent re-infection of hepatitis Cvirus after living related livertransplantation in hepatitis C hepaticcirrhosis2009

    • Author(s)
      Sato Y, Oya H, Yamamoto S, Kobayashi T,Watanabe T, Kokai H, Yamagiwa S,Hatakeyama K
    • Journal Title

      Hepatogastroenterology

      Volume: 56 Pages: 205-207

    • Related Report
      2012 Final Research Report
  • [Journal Article] Impact of intraportaldonor-specific leukocyte transfusionfor adult ABO-incompatible livertransplantation2009

    • Author(s)
      Oya H, Sato Y, Yamamoto S, Nakatsuka H,Kobayashi T, Watanabe T, Hara Y, Kokai H,Hatakeyama K
    • Journal Title

      Transplant Proc

      Volume: 41 Pages: 222-225

    • Related Report
      2012 Final Research Report
  • [Journal Article] Clinicopathological analysis of CD133+ and NCAM+ human hepatic stem/proge…2009

    • Author(s)
      Atsunori Tsuchiya, et al
    • Journal Title

      Hepatology Research 39

      Pages: 1080-1090

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of intraportal donor-specific leukocyte transfusion for adult…2009

    • Author(s)
      H Oya, Y Sato, et al.
    • Journal Title

      Transplantion Proceedings 41

      Pages: 222-225

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intra portal donor specific antigen transfusion might prevent re-infecti…2009

    • Author(s)
      Y Sato, H Oya, et al
    • Journal Title

      Hepato-Gastroenterology 56

      Pages: 205-207

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Perioperative immunological differentiation in livercirrhotic patients who underwent livingrelated liver transplantation2012

    • Author(s)
      Sato Y, Tomiyama C, Yamamoto S, OyaH, Kobayashi T, Kokai H, Miura K, HiroseY, Hatakeyama K
    • Organizer
      24^<th> International Congress of TheTransplantation Society
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2012 Final Research Report
  • [Presentation] Perioperative immunological differentiation in liver cirrhotic patients who underwent living related liver transplantation.2012

    • Author(s)
      Sato Y
    • Organizer
      24th International Congress of The Transplantation Society.
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2012 Annual Research Report
  • [Presentation] Regulatory T cells activation in the patients who obtained operational tolerance in Intra-Portal Administration of Donor Specific Antigens in Living-Donor Liver Transplantation2011

    • Author(s)
      Yoshinobu Sato, Chikako Tomiyama, Hiroshi Oya, Satoshi Yamamoto, Kokai Hidenaka, Kohei Miura, Katsuyoshi Hatakeyama
    • Organizer
      12th Congress of the Asian Society of Transplantation
    • Place of Presentation
      Korea (Seoul)
    • Year and Date
      2011-09-26
    • Related Report
      2012 Final Research Report
  • [Presentation] COAGULATION BETWEEN DONOR AND RECIPIENT IN THE EARLY PERIOD AFTER LIVING DONOR LIVER TRANSPLANTATION2011

    • Author(s)
      Sato Y, et al.
    • Organizer
      European Society Organ Transplantation Congress
    • Place of Presentation
      英国グラスゴー,Scottish Exh-ibition & Conference Center
    • Year and Date
      2011-09-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] COAGULATION BETWEEN DONOR AND RECIPIENT IN THE EARLY PERIOD AFTER LIVING DONOR LIVER TRANSPLANTATION2011

    • Author(s)
      Yoshinobu Sato Hiroshi Oya, Satoshi Yamamoto, Yoshiaki Hara, Takashi Kobayashi, Kokai Hidenaka, Kohei Miura, Katsuyoshi Hatakeyama
    • Organizer
      The 15th Congress of the European Society for Organ Transplantation
    • Place of Presentation
      Glasgow, United Kingdom
    • Related Report
      2012 Final Research Report
  • [Presentation] Spontaneous constriction and closure method of porto-caval shunt creation using a ligamentum teres hepatis in small-for-size graft liver transplantation2010

    • Author(s)
      Sato Y, Yamamoto S, Oya H, et al
    • Organizer
      XXIII International Congress of Transplantation
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2010-08-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Induction of operational tolerance and its mechanism by intraportal administration of donor specific antigens in living-donor liver transplantation2010

    • Author(s)
      Sato Y, Yamamoto S, Oya H, et al
    • Organizer
      American Transplant Congress
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-05-03
    • Related Report
      2012 Final Research Report
  • [Presentation] Induction of_Operations to erance an its mec amsm y mtraporta a ministration of donor specific antigens in living -donor liver transplantation2010

    • Author(s)
      Yoshinobu Sato, et al
    • Organizer
      American Transplant Congress
    • Place of Presentation
      San Diego USA
    • Year and Date
      2010-05-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Impact of FoxP3+CD4+CD25+T Cells in the Recipients Acquiring Almost Tolerance2009

    • Author(s)
      Yoshinobu Sato
    • Organizer
      ヨーロッパ移植学会
    • Place of Presentation
      パリ(フランス)
    • Year and Date
      2009-08-31
    • Related Report
      2009 Annual Research Report
  • [Book] Coagulation and Wall Shear Stress in Living Donor Liver Transplantation2012

    • Author(s)
      Yoshinobu Sato, Hideki Nakatsuka, Toru Abo
    • Publisher
      Anett M. Taloyan and David S. Bankiewicz, Nova Science Publishers.
    • Related Report
      2012 Final Research Report
  • [Book] Coagulation: Kinetics, Structure Formation and Disorders , Recent Advances in Hematology Research2012

    • Author(s)
      Yoshinobu Sato
    • Total Pages
      207
    • Publisher
      Nova Science Publishers.
    • Related Report
      2012 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2019-07-29  

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