| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2010: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2009: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Research Abstract |
(1) We reported OSNA-based diagnosis of lymph node metastasis of colorectal cancer in 2010, and Ministry of Health, Labour and Welfare permitted its usage in diagnosis.(2) We produced the C4. 4A specific antibody that recognizes only invasive cancer cells. We also found that C4. 4A promotes EMT.(3) We found that hypoxia-induced gene JMJD1A promotes EMT in colon cancer.(4) We found that carbonate apatite containing specific siRNA showed a tumor shrinkage when it is injected into the tail vein of nude mice.(5) We found inhibition of both VEGF and Ang2 led to a tumor shrinkage in nude mice.
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