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Regulation of the delayed-type xenograft rejection and pig retrovirus

Research Project

Project/Area Number 21390361
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionOsaka University

Principal Investigator

MIYAGAWA Syuji  大阪大学, 医学系・研究科, 准教授 (90273648)

Co-Investigator(Renkei-kenkyūsha) NAGASHIMA Hiroshi  明治大学, 農学部生命科学科, 教授 (50318664)
OKABE Masaru  大阪大学, 微生物病研究所, 教授 (30089875)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2010: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Keywords糖鎖抗原 / レクチン・アレ / ブタ血管内皮 / PAI-2 / Dol-P-Mannosidase / N型糖鎖 / REPV / PERV
Research Abstract

For the purpose of the regulating the rejections in xenotransplantation, the carbohydrate antigens and the cellular factors was analyzed. In addition, porcine endogenous retrovirus was also studied.
1. The carbohydrate antigen of pig islets was compared with those of humans.
2. Pig CMAH gene was cloned, and the targeting vector was prepared.
3. Pig PAI-2 gene was cloned, and human modified-FasL gene was also established. The effect of the knockdown of the related gene to glycosylation on PERV was studied.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (82 results)

All 2012 2011 2010 2009 Other

All Journal Article (28 results) (of which Peer Reviewed: 25 results) Presentation (51 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Cloning of Homozygousα1, 3-Galactosyltransferase Gene Knock-Out Pigs Somatic Cell Nuclear Transfer2012

    • Author(s)
      Hitomi Matsunari, Masahito Watanabe, Kazuhiro Umeyama, Kazuaki Nakano, Yuka Ikezawa, Mayuko Kurome, Barbara Kessler, Eckhard Wolf, Shuji Miyagawa and Hiroshi Nagashima.
    • Journal Title

      Open access Publisher INTECH

      Pages: 37-54

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Takehisa Ueno and Masahiro Fukuzawa Carbohydrate antigens2012

    • Author(s)
      Shuji Miyagawa, Yuichi Takama, Hiroshi Nagashima
    • Journal Title

      Curr Opin Organ Transplant

      Volume: 17 Pages: 174-9

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A study of the glycoantigens of neonatal porcine islet-like cell clusters(NPCC) using a lectin microarray2012

    • Author(s)
      Shino Nakatsu, Yuichi Takama, Takehisa Ueno, Chikako Inuinaka, Shunsaku Takeishi, Akihiro Kondo, Teru Okitsu, Hiroshi Nagashima, Masahiro Fukuzawa and Shuji Miyagawa
    • Journal Title

      Transplant Proc

      Volume: (In press)

    • Related Report
      2011 Final Research Report
  • [Journal Article] A cloning of cytidine monophospho-N-acetylneuraminic acid(CMP-NeuAc) hydroxylase from porcine endothelial cell2012

    • Author(s)
      uke Ikeda, Aki Yamamoto, Akiko Nanjo, Chikako Inuinaka, Yuichi Takama, Takehisa Ueno, Masahiro Fukuzawa, Kazuaki Nakano, Hitomi Matsunari, Hiroshi Nagashima and Shuji Miyagawa.
    • Journal Title

      Transplant Proc

      Volume: (In press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The blocking of CCR5 and CXCR3 suppresses the infiltration of macrophages in acute renal allograft rejection2012

    • Author(s)
      Yoichi Kakuta, Masayoshi Okumi, Shuji Miyagawa, Koichi Tsutahara, Toyofumi Abe, Koji Yazawa, Katsuyoshi Matsunami, Hideaki Otsuka, Shiro Takahara, Norio Nonomura.
    • Journal Title

      Transplantation

      Volume: 93 Pages: 24-31

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The blocking of CCR5 and CXCR3 suppresses the infiltration of macrophages in acute renal allograft rejection2012

    • Author(s)
      Yoichi Kakuta, Masayoshi Okumi, Shuji Miyagawa, Koichi Tsutahara, Toyofumi Abe, Koji Yazawa, Katsuyoshi Matsunami, Hideaki Otsuka, Shiro Takahara, Norio Nonomura
    • Journal Title

      Transplantation

      Volume: (In press)(印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A cloning of cytidine monophospho-N-acetylneuraminic acid (CMP-NeuAc) hydroxylase from porcine endothelial cell2012

    • Author(s)
      Kosuke Ikeda, Aki Yamamoto, Akiko Nanjo, Chikako Inuinaka, Yuichi Takama, Takehisa Ueno, Masahiro Fukuzawa, Kazuaki Nakano, Hitomi Matsunari, Hiroshi Nagashima, Shuji Miyagawa
    • Journal Title

      Transplant Proc

      Volume: (In press)(印刷中)

    • Related Report
      2011 Annual Research Report
  • [Journal Article] A study of the glycoantigens of neonatal porcine islet-like cell clusters (NPCC) using a lectin microarray2012

    • Author(s)
      Shino Nakatsu, Yuichi Takama, Takehisa Ueno, Chikako Inuinaka, Shunsaku Takeishi, Akihiro Kondo, Teru Okitsu, Hiroshi Nagashima, Masahiro Fukuzawa, Shuji Miyagawa
    • Journal Title

      Transplant Proc

      Volume: (In press)(印刷中)

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Carbohydrate antigens2012

    • Author(s)
      Shuji Miyagawa, Yuichi Takama, Hiroshi Nagashima, Takehisa Ueno, Masahiro Fukuzawa
    • Journal Title

      Current Opinion on Organ Transplanat

      Volume: (In press)(印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cloning of Homozygous α1,3-Galactosyltransferase Gene Knock-Out Pigs Somatic Cell Nuclear Transfer2012

    • Author(s)
      Hitomi Matsunari, Masahito Watanabe, Kazuhiro Umeyama, Kazuaki Nakano, Yuka Ikezawa, Mayuko Kurome, Barbara Kessler, Eckhard Wolf, Shuji Miyagawa, Hiroshi Nagashima
    • Journal Title

      [Xenotransplantation]INTECH

      Volume: 1 Pages: 37-54

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of a calcineurin inhibitor, FK506, and a CCR5/ CXCR3 antagonist, TAK-779, in a rat small intestinal transplantation model2011

    • Author(s)
      Yuichi Takama, Shuji Miyagawa, Aki Yamamoto, Sabere Firdawes, Takehisa Ueno, Yoshiyuki Ihara, Akihiro Kondo, Katsuyoshi Matsunami, Hideaki Otsuka, and Masahiro Fukuzawa.
    • Journal Title

      Transplant Immunology

      Volume: 25 Pages: 49-55

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of a calcineurin inhibitor, FK506, and a CCR5/CXCR3 antagonist, TAK-779, in a rat small intestinal transplantation model2011

    • Author(s)
      Yuichi Takama, Shuji Miyagawa, Aki Yamamoto, Sabere Firdawes, Takehisa Ueno, Yoshiyuki Ihara, Akihiro Kondo, Katsuyoshi Matsunami, Hideaki Otsuka, Masahiro Fukuzawa
    • Journal Title

      Transplant Immunology

      Volume: 25 Pages: 49-55

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of complement regulatory protein on porcine endogenous retrovirus(PERV) depends on molecular size2010

    • Author(s)
      Aki Yamamoto, Chizuko Kobayashi, Saya Yamashita, Takayuki Miyazawa, Masaru Okabe, Masahiro Fukuzawa, Shuji Miyagawa
    • Journal Title

      Transplant Immunology

      Volume: 23 Pages: 71-6

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Newly cloned pig dolichyl-phosphate mannosyltransferase for preventing the transmission of porcine endogenous retrovirus to human cells2010

    • Author(s)
      Aki Yamamoto, Shino Nakatsu, Akihiro Kondo, Tetsuya Asato, Masaru Okabe, Masahiro Fukuzawa, Shuji Miyagawa.
    • Journal Title

      Transplant International

      Volume: 23 Pages: 424-31

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Survey of glycoantigens in cells from a1-3galactosyltransferase knockout pig using a lectin microarray2010

    • Author(s)
      Shuji Miyagawa, Shunsaku Takeishi, Aki Yamamoto, Kosuke Ikeda, Hitomi Matsunari, Masao Yamada, Masaru Okabe, Eiji Miyoshi, Masahiro Fukuzawa, Hiroshi Nagashima.
    • Journal Title

      Xenotransplantation

      Volume: 17 Pages: 61-70

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Complement regulation in the GalT KO era2010

    • Author(s)
      Shuji Miyagawa, Aki Yamamoto, Katsuyoshi Matsunami, Dandan Wang, Yuichi Takama, Takehisa Ueno, Masaru Okabe, Hiroshi Nagashima, Masahiro Fukuzawa.
    • Journal Title

      Xenotransplantation

      Volume: 17 Pages: 11-25

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Complement regulation in the GalT KO era.2010

    • Author(s)
      Shuji Miyagawa, Aki Yamamoto, Katsuyoshi Matsunami, Dandan Wang, Yuichi Takama, Takehisa Ueno, Masaru Okabe, Hiroshi Nagashima, Masahiro Fukuzawa
    • Journal Title

      Xenotransplantation.

      Volume: 17巻 Pages: 11-25

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Survey of glycoantigens in cells from al-3galactosyltransferase knockout pig using a lectin microarray.2010

    • Author(s)
      Shuji Miyagawa, Shunsaku Takeishi, Aki Yamamoto, Kosuke Ikeda, Hitomi Matsunari, Masao Yamada, Masaru Okabe, Eiji Miyoshi, Masahiro Fukuzawa, Hiroshi Nagashima
    • Journal Title

      Xenotransplantation.

      Volume: 17巻 Pages: 61-70

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Newly cloned pig dolichyl-phosphate mannosyltransferase for preventing the transmission of porcine endogenous retrovirus to human cells.2010

    • Author(s)
      Aki Yamamoto, Shino Nakatsu, Akihiro Kondo, Tetsuya Asato, Masaru Okabe, Masahiro Fukuzawa, Shuji Miyagawa
    • Journal Title

      Transplant International

      Volume: 23巻 Pages: 424-431

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of complement regulatory protein on porcine endogenous retrovirus (PERV) depends on molecular size.2010

    • Author(s)
      Aki Yamamoto, Chizuko Kobayashi, Saya Yamashita, Takayuki Miyazawa, Masaru Okabe, Masahiro Fukuzawa, Shuji Miyagawa
    • Journal Title

      Transplant Immunology

      Volume: 23巻 Pages: 71-76

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Construction of the Plasmid, Overexpression by Chinese Hamster Ovary Cell, Purification, and Characterization of the First Three Short Consensus Repeat Modules of Human Complement Receptor Type 12009

    • Author(s)
      Atsushi Yamaguchi, Hiroaki Takagawa, Hirofumi Iwakaji, Shuji Miyagawa, Pi-Chao Wang, and Noriyuki Ishii.
    • Journal Title

      J B

      Volume: 145 Pages: 533-42

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Successful Treatment of Cardiogenic Shock Caused by Humoral Cardiac Allograft Rejecti2009

    • Author(s)
      Saito S, Matsumiya G, Fukushima N, Sakaguchi T, Fujita T, Ueno T, Miyagawa S, Yamauchi A, Sawa Y.
    • Journal Title

      Circ J

      Volume: 73 Pages: 970-3

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Construction of the Plasmid, Overexpression by Chinese Hamster Ovary Cell, Purification, and Characterization of the First Three Short Consensus Repeat Modules of Human Complement Receptor Type 1.2009

    • Author(s)
      Atsushi Yamaguchi, Shuji Miyagawa, Pi-Chao Wang, Noriyuki Ishii.
    • Journal Title

      JB 145

      Pages: 533-42

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Successful Treatment of Cardiogenic Shock Caused by Humoral Cardiac Allograft Rejection.2009

    • Author(s)
      Saito S, Miyagawa S, Yamauchi A, Sawa Y.
    • Journal Title

      Circ J. 73

      Pages: 970-3

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Complement regulation in the GalT KO era.

    • Author(s)
      Shuji Miyagawa, Masahiro Fukuzawa.
    • Journal Title

      Xenotransplantation (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C A Newly cloned pig dolichyl-phosphate mannosyltransferase for preventing the transmission of porcine endogenous retrovirus to human cells.

    • Author(s)
      Aki Yamamoto, Shuji Miyagawa.
    • Journal Title

      Transplant Interanational (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Survey of glyvoantigens in cells from α1-3galactosyltransferase knock out pig using a lectin microarray.

    • Author(s)
      Shuji Miyagawa, Hiroshi Nagashima.
    • Journal Title

      Xenotransplantation (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of complement regulatory protein on porcine endogenous retrovirus (PERV) depends on molecular size

    • Author(s)
      Aki Yamamoto, Shuji Miyagawa.
    • Journal Title

      Transplant Immunology (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] バイオ人工細胞・臓器の世界の現況2012

    • Author(s)
      宮川周士
    • Organizer
      第2回公開シンポジウム・先進医用ブタの開発と前臨床研究拠点形成プロジェクト
    • Place of Presentation
      鹿児島大学
    • Year and Date
      2012-03-22
    • Related Report
      2011 Final Research Report
  • [Presentation] ブタ膵島の糖鎖抗原について2012

    • Author(s)
      王丹丹、高間勇一、上野豪久、福沢正洋、宮川周士、(東京大学)興津輝、(米ベイラー大)松本慎一、(東北大学)後藤昌史、(明治大学)長嶋比呂志
    • Organizer
      第39回膵・膵島移植研究会
    • Place of Presentation
      旭川医大
    • Related Report
      2011 Final Research Report
  • [Presentation] 異種移植ブタ開発研究の流れ2011

    • Author(s)
      宮川周士・王丹丹・高間勇一・上野豪久・福沢正洋、長嶋比呂志
    • Organizer
      第14回日本異種移植研究会
    • Place of Presentation
      広島大学
    • Year and Date
      2011-12-10
    • Related Report
      2011 Final Research Report
  • [Presentation] αGal-knockoutブタ関連の膵島の糖鎖抗原の解析2011

    • Author(s)
      王丹丹、高間勇一、上野豪久、武石俊作、福沢正洋、宮川周士、(東京大学・生産技術研究所)興津輝、(米ベイラー大)松本慎一、(明治大学・農学部)中野和明、松成ひとみ、長嶋比呂志
    • Organizer
      第14回日本異種移植研究会
    • Place of Presentation
      広島大学
    • Year and Date
      2011-12-10
    • Related Report
      2011 Final Research Report
  • [Presentation] 新生児ブタ膵島の糖鎖について2011

    • Author(s)
      王丹丹、高間勇一、上野豪久、南條明子、乾中智佳子、福沢正洋、武石俊作、宮川周士、(東京大学・生産技術研究所)興津輝、(明治大学・農学部)長嶋比呂志
    • Organizer
      第14回日本異種移植研究会
    • Place of Presentation
      広島大学
    • Year and Date
      2011-12-10
    • Related Report
      2011 Final Research Report
  • [Presentation] In comparison with APIs, NICCs axe very rich in α2,6Neu5NAc, and reduced Fucose/Gore Fucose & high-mannose form, and Lactosamine & Core 1 forms are upregulated, instead, in 5 day cultures2011

    • Author(s)
      Hiroaki Kashiwada, Akiko Nanjyo, Shino Nakatsu, Yuichi Takama, Teru Okitsu, Hiroshi Nagashima, Masahiro Fukuzawa, Shuji Miyagawa
    • Organizer
      The 11th Congress of International Congress for Xenotransplantation (Joint Conference with CST)
    • Place of Presentation
      Miami, USA
    • Year and Date
      2011-10-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] A cloning of cytidine monophospho-N-acetylneuraminic acid (CMP-NeuAc) hydroxylase from porcine endothelial cells2011

    • Author(s)
      Kosuke Ikeda, Akiko Nanjyo, Hiroaki Kashiwada, Yuichi Takama, Takehisa Ueno, Masahiro Fukuzawa, Kazuaki Nakano, Hitomi Matsunari, Hiroshi Nagashima, Shuji Miyagawa
    • Organizer
      12th Congress of the Asian Society of Transplantation
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2011-09-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] A study of the glycoantigens of neonatal porcine islet-like cell clusters using a lectin microarray2011

    • Author(s)
      Hiroaki Kashiwada, Akiko Nanjyo, Shino Nakatsu, Shunsaku Takeishi, Yuichi Takama, Akihiro Kondo, Teru Okitsu, Hiroshi Nagashima, Masahiro Fukuzawa, Shuji Miyagawa
    • Organizer
      12th Congress of the Asian Society of Transplantation
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2011-09-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Complements in transplantation2011

    • Author(s)
      Shuji Miyagawa
    • Organizer
      12th Congress of the Asian Society of Transplantation
    • Place of Presentation
      Seoul, Korea(Invited)(招待講演)
    • Year and Date
      2011-09-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effects of a calcineurin inhibitor, FK506, and a CCR5/CXCR3 antagonist, TAK-779, in a rat small intestinal transplantation model2011

    • Author(s)
      Yuichi Takama, Shuji Miyagawa, Takehisa Ueno, Masahiro Fukuzawa
    • Organizer
      XIIth International Small Bowel Transplant Symposium
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] ラット小腸移植におけるケモカイン阻害剤及びカルシニューリン阻害剤の効果の検討2011

    • Author(s)
      高間勇一, 宮川周士, 山本亜紀, 井原欣幸, 上野豪久, 福澤正洋
    • Organizer
      第23回小腸移植研究会
    • Place of Presentation
      熊本大学
    • Year and Date
      2011-03-11
    • Related Report
      2011 Final Research Report
  • [Presentation] αGal-knockoutブタ関連の膵島の糖鎖抗原の解析2011

    • Author(s)
      宮川周士、南條明子、柏田紘明、福沢正洋、武石俊作、興津輝、(明治大学・農学部)長嶋比呂志、(米ベイラー大)松本慎一
    • Organizer
      第47回日本移植学会
    • Place of Presentation
      福島県立医大
    • Related Report
      2011 Final Research Report
  • [Presentation] ブタCMAH遺伝子制御による抗原性の変化の検討2011

    • Author(s)
      高間勇一、柏田紘明、南條明子、中津志野、王丹丹、福沢正洋、宮川周士、(明治大学・農学部)長嶋比呂志
    • Organizer
      第47回日本移植学会
    • Place of Presentation
      福島県立医大
    • Related Report
      2011 Final Research Report
  • [Presentation] In comparison with APIs, NICCs are very rich in a2, 6Neu5NAc, and reduced Fucose/ Core Fucose & high-mannose form, and Lactosamine & Core 1 forms are upregulated, instead, in 5 day cultures2011

    • Author(s)
      Hiroaki Kashiwada, Akiko Nanjyo, Shino Nakatsu, Yuichi Takama, Teru Okitsu, Hiroshi Nagashima, Masahiro Fukuzawa, Shuji Miyagawa. P
    • Organizer
      The 11th Congress of International Congress for Xenotransplantation(Joint Conference with CST)
    • Place of Presentation
      Miami, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] study of the glycoantigens of neonatal porcine islet-like cell clusters using a lectin microarray2011

    • Author(s)
      Hiroaki Kashiwada, Akiko Nanjyo, Shino Nakatsu, Shunsaku Takeishi, Yuichi Takama, Akihiro Kondo, Teru Okitsu, Hiroshi Nagashima, Masahiro Fukuzawa, Shuji Miyagawa P
    • Organizer
      2th Congress of the Asian Society of Transplantation
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2011 Final Research Report
  • [Presentation] Trial of knockdown for the H-D antigen of pig cells2011

    • Author(s)
      Akiko Nanjyo, Aki Yamamoto, Hiroaki Kashiwada, Kosuke Ikeda, Yuichi Takama, Takehisa Ueno, Masahiro Fukuzawa, Akihiro Kondo, Hiroshi Nagashima, Shuji Miyagawa P
    • Organizer
      12th Congress of the Asian Society of Transplantation
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] A cloning of cytidine monophospho-N-acetylneuraminic acid(CMP-NeuAc) hydroxylase from porcine endothelial cells2011

    • Author(s)
      Kosuke Ikeda, Akiko Nanjyo, Hiroaki Kashiwada, Yuichi Takama, Takehisa Ueno, Masahiro Fukuzawa, Kazuaki Nakano, Hitomi Matsunari, Hiroshi Nagashima, Shuji Miyagawa P
    • Organizer
      12th Congress of the Asian Society of Transplantation
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2011 Final Research Report
  • [Presentation] (Invited) Complements in transplantation2011

    • Author(s)
      Shuji Miyagawa O
    • Organizer
      12th Congress of the Asian Society of Transplantation
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2011 Final Research Report
  • [Presentation] Effects of a calcineurin inhibitor, FK506, and a CCR5/ CXCR3 antagonist, TAK-779, in a rat small intestinal transplantation model2011

    • Author(s)
      Yuichi Takama, Shuji Miyagawa, Takehisa Ueno, Masahiro Fukuzawa O
    • Organizer
      XIIth International Small Bowel Transplant Symposium
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Multilateral inhibition of complement activation in the GalT KO era2010

    • Author(s)
      Shuji Miyagawa, Dandan Wang, Yuichi Takama, Masahiro Fukuzawa
    • Organizer
      2010 Korean Society for Transplantation (40th)
    • Place of Presentation
      Seoul, (Korea)(招待講演)
    • Year and Date
      2010-11-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] Complement activation on the xeno-cells Seoul Forum on Xenotransplantation2010

    • Author(s)
      Shuji Miyagawa
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2010-11-10
    • Related Report
      2011 Final Research Report
  • [Presentation] Complement activation on the xeno-cells2010

    • Author(s)
      Shuji Miyagawa
    • Organizer
      2010 Seoul Forum on Xenotransplantation
    • Place of Presentation
      Seoul, (Korea)(招待講演)
    • Year and Date
      2010-11-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] レクチンブロット法によるαGal-knockoutブタ膵島の糖鎖抗原の解析2010

    • Author(s)
      宮川周士、山本亜紀、興津輝、長嶋比呂志、高間勇一、井原欣幸、上野豪久、福澤正洋
    • Organizer
      第46回日本移植研究会
    • Place of Presentation
      京都府立医大
    • Year and Date
      2010-10-21
    • Related Report
      2011 Final Research Report
  • [Presentation] ブタCMAH遺伝子ノックダウンによる抗原性の検討2010

    • Author(s)
      (王丹丹, )山本亜紀, 池田孔佑, 長嶋比呂志, 高間勇一, 上野豪久, 井原欣幸, 福澤正洋, 宮川周士
    • Organizer
      第46回日本移植研究会
    • Place of Presentation
      京都府立医大
    • Year and Date
      2010-10-21
    • Related Report
      2011 Final Research Report
  • [Presentation] ラット小腸移植におけるケモカイン阻害剤TAK-779及びカルシニューリン阻害剤FK506の効果の検討2010

    • Author(s)
      高間勇一, 宮川周士, フルダウス・サビエル, 山本亜紀, 井原欣幸, 上野豪久, 福澤正洋
    • Organizer
      第46回日本移植研究会
    • Place of Presentation
      京都府立医大
    • Year and Date
      2010-10-21
    • Related Report
      2011 Final Research Report
  • [Presentation] A study of the Prevention of PERV Infection by siRNA on Pig Dolichyl-Phosphate Mannosyltransferase2010

    • Author(s)
      Aki Yamamoto, Akihiro Kondo, Shino Nakatsu, Kosuke Ikeda, Sabere Firdawes, Dandan Wang, Yuichi Takama, Takehisa Ueno, Masahiro Fukuzawa, Shuji Miyagawa
    • Organizer
      The XXIII International Congress of Transplantation
    • Place of Presentation
      Vancouver(Canada)
    • Year and Date
      2010-08-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] An analysis of pig cytidine monophospho-N-acetylneuraminic acid (CMP-NeuAc) hydroxylase.2010

    • Author(s)
      Kosuke Ikeda, Aki Yamamoto, Akihiro Kondo, Yuichi Takama, Masahiro Fukuzawa, Hitomi Matsunari, Hiroshi Nagashima, Shuji Miyagawa
    • Organizer
      The XXIII International Congress of Transplantation
    • Place of Presentation
      Vancouver(Canada)
    • Year and Date
      2010-08-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effects of a calcineurin inhibitor, FK506, and a CCR5/CXCR3 antagonist, TAK-779, in a rat small intestinal transplantation model2010

    • Author(s)
      Takama Y, Miyagawa S, Firdawes S, Ueno T, Yamamoto A, Wang D, Ikeda K, Fukuzawa M.
    • Organizer
      The XXIII International Congress of Transplantation
    • Place of Presentation
      Vancouver(Canada)
    • Year and Date
      2010-08-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラット小腸移植におけるケモカイン阻害剤及びカルシニューリン阻害剤の効果の検討2010

    • Author(s)
      高間勇一, 宮川周士, フルダウス・サビエル, 山本亜紀, 池田孔佑, 上野豪久, 福澤正洋
    • Organizer
      第47回日本小児外科学会
    • Place of Presentation
      名古屋保健衛生大学
    • Year and Date
      2010-06-17
    • Related Report
      2011 Final Research Report
  • [Presentation] ブタDolichyl-phosphate mannosyltransferase(DPM) knockdownによるブタ内在性レトロウイルス(PERV)の感染制御2010

    • Author(s)
      山本亜紀, 中津志野, 近藤昭宏, 池田孔佑、間勇一, 上野豪久, 福澤正洋, 宮川周士
    • Organizer
      第13回日本異種移植研究会
    • Place of Presentation
      東京医科歯科大学
    • Year and Date
      2010-03-14
    • Related Report
      2011 Final Research Report
  • [Presentation] ブタCMP-N-acetylneuraminic acid hydroxylase geneの解析2010

    • Author(s)
      池田孔佑、山本亜紀、近藤昭宏、松成ひとみ、長嶋比呂志、高間勇一, 上野豪久, 福澤正洋、宮川周士
    • Organizer
      第13回日本異種移植研究会
    • Place of Presentation
      東京医科歯科大学
    • Year and Date
      2010-03-14
    • Related Report
      2011 Final Research Report
  • [Presentation] α1, 3ガラクトース転移酵素遺伝子ダブルノックアウトブタの体細胞クローニングにおけるScriptaidの効果2010

    • Author(s)
      松成ひとみ、池澤有加、渡邊将人、梅山大、中野和明、藤原主、竹内靖浩、本田香澄、前原美樹、高柳就子、山田和彦、宮川周士、長嶋比呂志
    • Organizer
      第13回日本異種移植研究会
    • Place of Presentation
      東京医科歯科大学
    • Year and Date
      2010-03-14
    • Related Report
      2011 Final Research Report
  • [Presentation] ラット小腸移植におけるケモカイン阻害剤及びカルシニューリン阻害剤の効果の検討2010

    • Author(s)
      高間勇一、宮川周士、フルダウスサビエル、山本亜紀、池田孔佑、上野豪久、福沢正洋
    • Organizer
      第22回小腸移植研究会
    • Place of Presentation
      慶応義塾大学
    • Year and Date
      2010-03-06
    • Related Report
      2011 Final Research Report
  • [Presentation] αGal-knockoutブタ膵島(NICC)の糖鎖抗原の解析2010

    • Author(s)
      山本亜紀、池田孔佑、松成ひとみ、長嶋比呂志、武石俊作、山田正雄、高間勇一、福澤正洋、宮川周士
    • Organizer
      第37回膵・膵島移植研究会
    • Place of Presentation
      独協大学
    • Related Report
      2011 Final Research Report
  • [Presentation] Multilateral inhibition of complement activation in the GalT KO era2010

    • Author(s)
      Shuji Miyagawa, Dandan Wang, Yuichi Takama, Masahiro Fukuzawa
    • Organizer
      Korean Society for Transplantation(40th)
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2011 Final Research Report
  • [Presentation] Effects of a calcineurin inhibitor, FK506, and a CCR5/ CXCR3 antagonist, TAK-779, in a rat small intestinal transplantation model2010

    • Author(s)
      Takama Y, Miyagawa S, Firdawes S, Ueno T, Yamamoto A, Wang D, Ikeda K, Fukuzawa M. P
    • Organizer
      The XXIII International Congress of Transplantation
    • Place of Presentation
      Vancouver, Canada
    • Related Report
      2011 Final Research Report
  • [Presentation] An analysis of pig cytidine monophospho-N-acetylneuraminic acid(CMP-NeuAc) hydroxylase2010

    • Author(s)
      Kosuke Ikeda, Aki Yamamoto, Akihiro Kondo, Yuichi Takama, Masahiro Fukuzawa, Hitomi Matsunari, Hiroshi Nagashima, Shuji Miyagawa Mini O
    • Organizer
      The XXIII International Congress of Transplantation
    • Place of Presentation
      Vancouver, Canada
    • Related Report
      2011 Final Research Report
  • [Presentation] A study of the Prevention of PERV Infection by siRNA on Pig Dolichyl-Phosphate Mannosyltransferase2010

    • Author(s)
      Aki Yamamoto, Akihiro Kondo, Shino Nakatsu, Kosuke Ikeda, Sabere Firdawes, Dandan Wang, Yuichi Takama, Takehisa Ueno, Masahiro Fukuzawa, Shuji Miyagawa O
    • Organizer
      The XXIII International Congress of Transplantation
    • Place of Presentation
      Vancouver, Canada
    • Related Report
      2011 Final Research Report
  • [Presentation] レクチンブロット法によるαGal-knockoutブタの糖鎖抗原の解析2009

    • Author(s)
      山本亜紀、徐恒傑、武石俊作、山田正雄、三善英知、池田孔佑、松成ひとみ、長嶋比呂志、福澤正洋、宮川周士
    • Organizer
      第44回日本移植学会
    • Place of Presentation
      東京女子医大
    • Related Report
      2011 Final Research Report
  • [Presentation] ブタCMP-N-acetylneuraminic acid hydroxylase geneの解析2009

    • Author(s)
      池田孔佑、山本亜紀、松成ひとみ、中野和明、藤原主、長嶋比呂志、福澤正洋、宮川周士
    • Organizer
      第44回日本移植学会
    • Place of Presentation
      東京女子医大
    • Related Report
      2011 Final Research Report
  • [Presentation] ラット小腸移植におけるケモカイン阻害剤及びカルシニューリン阻害剤の効果の検討2009

    • Author(s)
      高間勇一、宮川周士、徐恒傑、フルダウス・サビエル、山本亜紀、池田孔佑、上野豪久、福沢正洋
    • Organizer
      第44回日本移植学会
    • Place of Presentation
      東京女子医大
    • Related Report
      2011 Final Research Report
  • [Presentation] Expression of Complement Regulatory Protein on Porcine Endogenous Retrovirus depends on Molecular Size2009

    • Author(s)
      Aki Yamamoto, Chizuko Kobayashi, Saya Yamashita, Kosuke Ikeda, Masahiro Fukuzawa, Shuji Miyagawa O
    • Organizer
      The 10th Congress of International Congress for Xenotransplantation(Joint Conference with IPITA)
    • Place of Presentation
      Venice, Italy
    • Related Report
      2011 Final Research Report
  • [Presentation] Lectin microarray analyses of endothelial cells and fibroblasts from the a1, 3 galactosyltransferase knockout pig2009

    • Author(s)
      Shuji Miyagawa, Aki Yamamoto, Kosuke Ikeda, Hitomi Matsunari, Hiroshi Nagashima, Shunsaku Takeishi, Masao Yamada, Eiji Miyoshi, Masahiro Fukuzawa O
    • Organizer
      pig. The 10th Congress of International Congress for Xenotransplantation(Joint Conference with IPITA),
    • Place of Presentation
      Venice, Italy
    • Related Report
      2011 Final Research Report
  • [Presentation] Complement regulation in the GalT KO era2009

    • Author(s)
      Shuji Miyagawa Plenary
    • Organizer
      The 10th Congress of International Congress for Xenotransplantation(Joint Conference with IPITA)
    • Place of Presentation
      Venice, Italy
    • Related Report
      2011 Final Research Report
  • [Presentation] Effects of a calcineurin inhibitor, FK506, and a CCR5/ CXCR3 antagonist, TAK-779, in a rat small intestinal transplantation model2009

    • Author(s)
      Takama Y, Miyagawa S, Xu H, Ueno T, Firdawes S, Yamamoto A, Ikeda K, Fukuzawa M. P
    • Organizer
      XIth International Small Bowel Transplant Symposium
    • Place of Presentation
      Bologna, Italy
    • Related Report
      2011 Final Research Report
  • [Presentation] Profiles of xeno-glycoantigens of the cell from a1, 3 galactosyltransferase knockout pig2009

    • Author(s)
      Shuji Miyagawa, Shunsaku Takeishi, Aki Yamamoto, Kosuke Ikeda, Hitomi Matsunari, Hiroshi Nagashima, Masao Yamada, Eiji Miyoshi, Masahiro Fukuzawa
    • Organizer
      Joint Conference of CTS(10^<th> biannual) & JSOPMB(36^<th> annul)
    • Place of Presentation
      Okayama
    • Related Report
      2011 Final Research Report
  • [Presentation] Profiles of xeno-glycoantigens of the cell from a1, 3 galactosyltransferase knockout pig2009

    • Author(s)
      Shuji Miyagawa, Masahiro Fukuzawa
    • Organizer
      Joint Conference of CTS (10th biannual) & JSOPMB (36th annul)
    • Place of Presentation
      Okayama
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effects of a calcineurin inhibitor, FK506, and a CCR5/CXCR3 antagonist, TAK-779, in a rat small intestinal transplantation model2009

    • Author(s)
      Takama Y, Miyagawa S, Xu H, Ueno T, Firdawes S, Yamamoto A, Ikeda K, Fukuzawa M.
    • Organizer
      XIth International Small Bowel Transplant Symposium
    • Place of Presentation
      Bologna, Italy
    • Related Report
      2009 Annual Research Report
  • [Presentation] Complement regulation in the GalT KO era2009

    • Author(s)
      Shuji Miyagawa
    • Organizer
      The 10th Congress of International Congress for Xenotransplantation (Joint Conference with IPITA)
    • Place of Presentation
      Venice, Italy
    • Related Report
      2009 Annual Research Report
  • [Presentation] Lectin microarray analyses of endothelial cells and fibroblasts from the a1, 3 galactosyltransferase knockout pig2009

    • Author(s)
      Shuji Miyagawa, Masahiro Fukuzawa
    • Organizer
      The 10th Congress of International Congress for Xenotransplantation (Joint Conference with IPITA)
    • Place of Presentation
      Venice, Italy
    • Related Report
      2009 Annual Research Report
  • [Presentation] Expression of Complement Regulatory Protein on Porcine Endogenous Retrovirus depends on Molecular Size2009

    • Author(s)
      Aki Yamamoto, Shuji Miyagawa
    • Organizer
      The 10th Congress of International Congress for Xenotransplantation (Joint Conference with IPITA)
    • Place of Presentation
      Venice, Italy
    • Related Report
      2009 Annual Research Report
  • [Book] Xenotransplantation2012

    • Author(s)
      Shuji Miyagawa
    • Publisher
      INTECH
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.med.osaka-u.ac.jp/pub/orgtrp/www/index-jp.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.med.osaka-u.ac.jp/pub/orgtrp/www/index-jp.html

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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