Novel therapy for aortic aneurysms by targeting a mechanical stress sensor
Project/Area Number |
21390362
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General surgery
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Research Institution | Yamaguchi University |
Principal Investigator |
YOSHIMURA Koichi 山口大学, 大学院・医学系研究科, 准教授(特命) (00322248)
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Co-Investigator(Kenkyū-buntansha) |
AOKI Hiroki 久留米大学, 循環器病研究所, 准教授 (60322244)
IKEDA Yasuhiro 山口大学, 大学院・医学系研究科, 助教 (00260349)
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Co-Investigator(Renkei-kenkyūsha) |
TAKAHASHI Masafumi 自治医科大学, 医学部, 教授 (40296108)
TANIGUCHI Shun' ichiro 信州大学, 大学院・医学系研究科, 教授 (60117166)
|
Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2011: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
|
Keywords | 大動脈瘤 / メカニカルストレス / 炎症 |
Research Abstract |
Abdominal aortic aneurysm(AAA) is characterized by chronic inflammation. Although a mechanical stress may contribute to pathogenesis of AAA, the mechanism that connects mechanical stress to inflammation is not yet understood. In this study, we demonstrated that the mechanical stress caused the activation of inflammatory signaling molecule and the release of inflammatory cytokine in macrophages. In addition, our data suggested that ASC might be critical for the linkage between mechanical stress and inflammatory response.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Tenascin-C is expressed in abdominal aortic aneurysm tissue with active degradation process2011
Author(s)
Kimura T, Yoshimura K, Aoki H, Imanaka-Yoshida K, Yoshida T, Ikeda Y, Morikage N, Endo H, Hamano K, Imaizumi T, Hiroe M, Aonuma K, Matsuzaki M
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Journal Title
Pathol Int
Volume: 61
Pages: 559-564
NAID
Related Report
Peer Reviewed
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[Presentation] Tenascin C Protects Aortic Tissue From Multiple Insults Against The Development of Aortic Aneurysm2009
Author(s)
Aoki H, Kimura T, Yoshimura K, Imanaka-Yoshida K, Yoshida T, Aonuma K, Hiroe M, Imaizumi Y, Matsuzaki M
Organizer
49th American Society for Cell Biology Annual Meeting
Place of Presentation
San Diego, CA, U. S. A.
Related Report
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