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Basic research for the production of human hepatocytes and the transplantation of hepatic tissues

Research Project

Project/Area Number 21390365
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionSapporo Medical University

Principal Investigator

MITAKA Toshihiro  札幌医科大学, 医学部, 教授 (50231618)

Co-Investigator(Kenkyū-buntansha) TANIMIZU Naoki  札幌医科大学, 医学部, 講師 (00333386)
OOE Hidekazu  札幌医科大学, 医学部, 助教 (90452979)
ICHINOHE Norihisa  札幌医科大学, 医学部, 研究員 (80452978)
MIZUGUCHI Toru  札幌医科大学, 医学部, 准教授 (30347174)
HIRATA Koichi  札幌医科大学, 医学部, 教授 (50136959)
KIKKAWA Yamato  東京薬科大学, 薬学部, 准教授 (20274227)
TANISHITA Kazuo  慶應義塾大学, 理工学部, 教授 (10101776)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2009: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Keywords肝再生 / 肝幹・前駆細胞 / 細胞移植 / 増殖 / 分化 / 肝組織形成 / 肝発生 / 人工肝臓 / 小型肝細胞 / 成熟化 / CD44 / 胆管形成 / 3次元培養 / 肝臓 / 幹・前駆細胞 / 移植 / 組織形成 / 再生医学 / 遺伝子導入 / 組織化 / 細胞相互作用
Research Abstract

We aimed to develop the methods of producing a large number of small hepatocytes(SHs), hepatic progenitor cells, and to establish the methods of hepatic organoid formation in vitro. In addition, we examined how cells and tissues could be transplanted into liver. Unlike mature hepatocytes the growth of rat SHs was regulated by Follistatin/Activin system. Although oval cells, hepatic stem cells, differentiated into hepatocytes via SHs, they could not completely mature. The transplanted hepatic stem/progenitor cells could not survive for a long term in the recipient liver and disappeared by cellular senescence. Thus, the role of hepatic stem/progenitor cells in severe liver failure may be to compensate for the lost hepatic functions transiently. To use the model of hepatic sinusoids constituting rat SHs, stellate cells, and endothelial cells, we clarified that quiescent stellate cells might regulate the capillary formation of endothelial cells and maturation of SHs.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (161 results)

All 2012 2011 2010 2009 Other

All Journal Article (50 results) (of which Peer Reviewed: 42 results) Presentation (101 results) Book (5 results) Remarks (4 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Spatio-temporal Control of Hepatic Stellate Cell-Endothelial Cell Interactions for Reconstruction of Liver Sinusoids in vitro2012

    • Author(s)
      Kasuya J, Sudo R, Mitaka T, Ikeda M, Tanishita K
    • Journal Title

      Tissue Engineer A

      Volume: 18 Pages: 1045-1056

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Growth ability and repopulation efficiency of transplanted hepatic stem, progenitor cells, and mature hepatocytes in retrorsine-treated rat livers2012

    • Author(s)
      Ichinohe N, Kon J, Sasaki K, Nakamura Y, Ooe H, Tanimizu N, Mitaka T
    • Journal Title

      Cell Transplant

      Volume: 21 Issue: 1 Pages: 11-22

    • DOI

      10.3727/096368911x580626

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proliferation of rat small hepatocytes depends on follistatin expression2012

    • Author(s)
      Ooe H, Chen Q, Kon J, Sasaki K, Miyoshi H, Ichinohe N, Tanimizu N, Mitaka T
    • Journal Title

      J Cell Physiol

      Volume: 227 Issue: 6 Pages: 2363-2370

    • DOI

      10.1002/jcp.22971

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Isolation of hepatic progenitor cells from the galactosamine-treated rat liver2012

    • Author(s)
      Ichinohe N, Kon J, Mitaka T
    • Journal Title

      Methods Mol Biol

      Volume: 826 Pages: 49-58

    • DOI

      10.1007/978-1-61779-468-1_5

    • ISBN
      9781617794674, 9781617794681
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reconstruction of 3D stacked-up hepatocyte tissues by degradation of microporous poly(D, L-lactide-co-glycolide acids) membranes2012

    • Author(s)
      Kasuya J, Sudo R, Tamogami R, Masuda G, Mitaka T, Tanishita K
    • Journal Title

      Biomaterials

      Volume: 33(9) Pages: 2693-2700

    • URL

      http://dx.doi.org/10.1016/j.biomaterials.2011.12.039

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Spatio-temporal Control of Hepatic Stellate Cell-Endothelial Cell Interactions for Reconstruction of Liver Sinusoids in vitro2012

    • Author(s)
      Kasuya J, et al
    • Journal Title

      Tissue Engineering A

      Volume: (in press) Issue: 9-10 Pages: 1045-1056

    • DOI

      10.1089/ten.tea.2011.0351

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low-dose steroid pretreatment ameliorates the transient impairment of liver regeneration2012

    • Author(s)
      Shibata T, et al
    • Journal Title

      World Journal of Gastroenterology

      Volume: 18 Issue: 9 Pages: 905-914

    • DOI

      10.3748/wjg.v18.i9.905

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reconstruction of 3D stacked-up hepatocyte tissues by degradation of microporous poly (D,L-lactide-co-glycolide acids) membranes2012

    • Author(s)
      Kasuya J, et al
    • Journal Title

      Biomaterials

      Volume: 33 Issue: 9 Pages: 2693-2700

    • DOI

      10.1016/j.biomaterials.2011.12.039

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum Antithrombin III Level is Well Correlated with Multiple Indicaters for Assessment of Liver Function and Diagnostic Accuracy for Predicting Postoperative Liver Failure in Hepatocellular Carcinoma Patients2012

    • Author(s)
      Mizuguchi T, et al
    • Journal Title

      Hepatogastroenterology

      Volume: 59 Pages: 551-557

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The molecular pathogenesis and clinical implications of hepatocellular carcinoma2012

    • Author(s)
      Meguro M, et al
    • Journal Title

      International Journal of Hepatology

      Volume: 2011 Pages: 818672-818672

    • DOI

      10.4061/2011/818672

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An antibody to the lutheran glycoprotein(Lu) recognizing the LU4 blood type variant inhibits cell adhesion to laminin alpha52011

    • Author(s)
      Kikkawa Y, et al
    • Journal Title

      PLoS One

      Volume: 6(8) Issue: 8 Pages: e23329-e23329

    • DOI

      10.1371/journal.pone.0023329

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hepatic stellate cell-mediated 3D tri-culture model of hepatocytes and endothelial cells2011

    • Author(s)
      Kasuya J, Sudo R, Mitaka T, Ikeda M, Tanishita K
    • Journal Title

      Tissue Eng A

      Volume: 17 Issue: 3-4 Pages: 361-370

    • DOI

      10.1089/ten.tea.2010.0033

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Liver stem/progenitor cells : their characteristics and regulatory mechanisms.2011

    • Author(s)
      Tanaka M, Itoh T, Tanimizu N, Miyajima A
    • Journal Title

      J Biochem

      Volume: 149(3) Issue: 3 Pages: 231-239

    • DOI

      10.1093/jb/mvr001

    • NAID

      10030583627

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 障害肝と肝細胞移植2011

    • Author(s)
      中村幸雄、水口徹, 三高俊広, 平田公一
    • Journal Title

      Surgery Frontier

      Volume: 18 Pages: 288-291

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Cluster analysis of indicators of liver functional and preoperative low branched-chain amino acid tyrosine ration indicate a high risk of early recurrence in analysis of 165 hepatocellular carcinoma patients after initial hepatectomy2011

    • Author(s)
      Nakamura Y, et al
    • Journal Title

      Surgery

      Volume: 150 Issue: 2 Pages: 250-262

    • DOI

      10.1016/j.surg.2011.06.001

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic impact of preoperative the branched-chain amino acid to the tyrosine ratio in hepatocellular carcinoma patients after initial hepatectomy2011

    • Author(s)
      Mizuguchi T, et al
    • Journal Title

      Journal of Gastrointestinal Surgery

      Volume: 15 Issue: 8 Pages: 1433-1439

    • DOI

      10.1007/s11605-011-1566-y

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Maintenance of hepatic differentiation by hepatocyte attachment peptides derived from laminin chains2011

    • Author(s)
      Kikkawa Y, et al
    • Journal Title

      Journal of Biomedical Material Research

      Volume: 99 Issue: 2 Pages: 203-210

    • DOI

      10.1002/jbm.a.33176

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum antithrombin III level is well correlated with multiple in dicators for assessment of liver function and diagnostic accuracy for predicting postoperative liver failure in hepatocellular carcinoma patients2011

    • Author(s)
      Mizuguchi T, et al
    • Journal Title

      Hepatogastroenterology

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic impact of preoperative branched-chain amino acids to the tyrosine ratio level in hepatocellular carcinoma patients after initial hepatectomy2011

    • Author(s)
      Mizuguchi T, et al
    • Journal Title

      J Gastroint Surg

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Liver stem/progenitor cells : their characteristics and regulatory mechanisms2011

    • Author(s)
      Tanaka M, et al
    • Journal Title

      J Biochem

      Volume: 149 Pages: 231-239

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Laparoscopic hepatectomy : a systematic review, meta-analysis and power analysis2011

    • Author(s)
      Mizuguchi T, et al
    • Journal Title

      Surg Today

      Volume: 41 Pages: 39-47

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Drug Metabolism Reviews focusing on drug transporter interactions in the liver : Characterization of hepatic-organoid cultures2010

    • Author(s)
      Mitaka T, Ooe H
    • Journal Title

      Drug Metab Rev

      Volume: 42 Issue: 3 Pages: 472-481

    • DOI

      10.3109/03602530903492020

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 消化器外科と再生医療-肝細胞移植研究の現状と将来展望-2010

    • Author(s)
      水口徹、三高俊広、平田公一、他
    • Journal Title

      消化器外科

      Volume: 33巻3号 Pages: 373-380

    • Related Report
      2011 Final Research Report
  • [Journal Article] The influence of Tribenoside on expression and deposition of epidermal laminins in HaCaT cells2010

    • Author(s)
      Kikkawa Y, et al
    • Journal Title

      Biol Pharm Bull

      Volume: 33 Pages: 307-310

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] せん断応力に依存した血管内皮細胞の3次元ネットワーク形成2010

    • Author(s)
      阿部順紀, 他
    • Journal Title

      日本機械学会論文集(B編)

      Volume: 76 Pages: 51-57

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reviews focusing on drug transporter interactions in the liver : Characterization of hepatic-organoid cultures2010

    • Author(s)
      Mitaka T, et al
    • Journal Title

      Drug Metab Rev

      Volume: 42 Pages: 472-481

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 力学的刺激による血管形成のバイオニックデザイン2010

    • Author(s)
      須藤亮, 他
    • Journal Title

      血管医学

      Volume: 11 Pages: 55-61

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 消化器外科と再生医療-肝細胞移植研究の現状と将来展望-2010

    • Author(s)
      水口徹, 他
    • Journal Title

      消化器外科

      Volume: 33 Pages: 373-380

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proliferation and osteogenic differentiation of rat bone-marrow stromal cells on bio-apatite with different crystalline facets2010

    • Author(s)
      Ichinohe N, et al
    • Journal Title

      J Biomed Mat Res A

      Volume: 93 Pages: 646-655

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 腹腔鏡下肝癌手術における新しいエネルギーデバイス2010

    • Author(s)
      水口徹, 他
    • Journal Title

      臨床外科

      Volume: 65 Pages: 1544-1552

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 最新の肝予備能評価2010

    • Author(s)
      平田公一, 他
    • Journal Title

      臨床雑誌「外科」

      Volume: 72 Pages: 356-362

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Drug Metabolism Reviews focusing on drug transporter interactions in the liver : Characterization of hepatic-organoid cultures2010

    • Author(s)
      Mitaka T, et al.
    • Journal Title

      Drug Metab Rev 42

      Pages: 472-481

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum antithrombin III level is well correlated with multiple indicators for assessment of liver function and diagnostic accuracy for predicting postoperative liver failure in hepatocellular carcinoma patients2010

    • Author(s)
      水口徹, et al.
    • Journal Title

      Hepatogastroenterology (In Press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 消化器外科と再生医療-肝細胞移植研究の現状と将来展望-. 消化器外科2010

    • Author(s)
      水口徹, 他
    • Journal Title

      消化器外科 33

      Pages: 373-380

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Proliferation and osteogenic differentiation of rat bone-marrow stromal cells on bio-apatite with different crystalline facets2010

    • Author(s)
      市戸義久, et al.
    • Journal Title

      J Biomed Mat Res A 93

      Pages: 646-655

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impaired liver regeneration with humoral and genetic disturbances in urinary trypsin inhibitor-deficient mice2009

    • Author(s)
      Nobuoka T, Mizuguchi T, Mitaka T, Hirata K
    • Journal Title

      Liver Int

      Volume: 29 Issue: 7 Pages: 979-987

    • DOI

      10.1111/j.1478-3231.2009.01990.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thyroid hormone is necessary for expression of constitutive androstane receptor in rat hepatocytes2009

    • Author(s)
      Ooe H, Kon J, Oshima H, Mitaka T
    • Journal Title

      Drug Metabol Dispos

      Volume: 37 Issue: 9 Pages: 1963-1969

    • DOI

      10.1124/dmd.108.022905

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thy1-positive cells have bipotential ability to differentiate into hepatocytes and biliary epithelial cells in galactosamine-induced rat liver regeneration2009

    • Author(s)
      Kon J, Ichinohe N, Ooe H, Chen Q, Sasaki K, Mitaka T
    • Journal Title

      Am J Pathol

      Volume: 175(6) Pages: 2362-2371

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 肝臓における幹細胞2009

    • Author(s)
      市戸義久、今純子、大栄秀和、三高俊広
    • Journal Title

      肝胆膵

      Volume: 59巻4号 Pages: 573-580

    • Related Report
      2011 Final Research Report
  • [Journal Article] Matrix metalloproteinase-2 expression in stromal tissues is a consistent prognostic factor in stage II colon cancer2009

    • Author(s)
      Inafuku Y, et al.
    • Journal Title

      Cancer Sci 100

      Pages: 852-858

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 肝臓における幹細胞2009

    • Author(s)
      市戸義久, 他
    • Journal Title

      肝胆膵 59

      Pages: 573-580

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Thy1-positive cells have bipotential ability to differentiate into hepatocytes and biliary epithelial cells in galactosamine-induced rat liver regeneration2009

    • Author(s)
      Kon J, et al.
    • Journal Title

      Am J Pathol 175

      Pages: 2362-2371

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thyroid hormone is necessary for expression of constitutive androstane receptor in rat hepatocytes2009

    • Author(s)
      Ooe H, et al.
    • Journal Title

      Drug Metabol Dispos 37

      Pages: 1963-1969

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impaired liver regeneration with humoral and genetic disturbances in urinary trypsin inhibitor-deficient mice2009

    • Author(s)
      Nobuoka T, et al.
    • Journal Title

      Liver Int 29

      Pages: 979-987

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The influence of synthetic peptides derived from the laminin alphal chain on he patocyte adhesion and gene expression2009

    • Author(s)
      Kikkawa Y, et al.
    • Journal Title

      Biomaterials 30

      Pages: 6888-6895

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic impact of surgical complications and preoperative serum hepatocyte growth factor in hepatocellular carcinoma patients after initial hepatectomy2009

    • Author(s)
      水口徹, et al.
    • Journal Title

      J Gastrointest Surg 13

      Pages: 325-333

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 今日の再生医学・再生医療の現状2009

    • Author(s)
      平田公一, 他
    • Journal Title

      Surgery Frontier 16

      Pages: 275-282

    • Related Report
      2009 Annual Research Report
  • [Journal Article] ショックと臓器障害対策 ショック肝の発生メカニズムと対策は?2009

    • Author(s)
      平田公一, 他
    • Journal Title

      救急・集中治療 21

      Pages: 1083-1087

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 熱焼灼デバイスが及ぼす肝切除後の血清サイトカインの変動と肝再生への影響2009

    • Author(s)
      柴田稔人, 他
    • Journal Title

      日本外科学会雑誌 110

      Pages: 292-292

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 肝切除後の敗血症作成モデルにおける肝循環不全にプロテアーゼインヒビターは有効か2009

    • Author(s)
      日黒誠, 他
    • Journal Title

      日本腹部救急医学会雑誌 29

      Pages: 342-342

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Hepatic Progenitor Cell Transplantation for Improving Survival after Liver Resection of Rat Non-alcoholic Steatocirrhotic Liver Model2012

    • Author(s)
      Nakamura Y, et al
    • Organizer
      7^<th> Annual Academic Surgical Congress, Quick shot oral presentation
    • Place of Presentation
      Las Vegas, NV, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] estricted differentiation of hepatic stem/progenitor cells isolated from D-galactosamine-treated rat livers2011

    • Author(s)
      Mitaka T
    • Organizer
      Liver Down Under : Liver development, diseases & regeneration
    • Place of Presentation
      Perth, Australia
    • Year and Date
      2011-11-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 転写因子Grhl2は上皮バリア機能および上皮細胞の形態形成を制御する2011

    • Author(s)
      千賀一徳
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2011-09-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 発生過程における胆管上皮細胞の肝細胞分化能の変化2011

    • Author(s)
      谷水直樹
    • Organizer
      第44回北海道病理談話会
    • Place of Presentation
      旭川市国際会議場
    • Year and Date
      2011-09-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] ラット肝硬変モデルに対する肝細胞移植の影響についての検討2011

    • Author(s)
      中村幸雄
    • Organizer
      第66回日本消化器外科学会総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-07-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] 肝前駆細胞移植治療におけるレシピエントラット肝再生機序の解析2011

    • Author(s)
      市戸義久, 他
    • Organizer
      第18回肝細胞研究会
    • Place of Presentation
      東京都
    • Year and Date
      2011-06-24
    • Related Report
      2011 Final Research Report
  • [Presentation] ラミニン111の機能を模倣する肝細胞接着ペプチドの探索と初代肝細胞の培養2011

    • Author(s)
      吉川大和
    • Organizer
      第43回日本結合組織学会学術大会・第58回マトリックス研究会大会合同学術集会
    • Place of Presentation
      別府市
    • Year and Date
      2011-06-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 乳酸-グリコール酸共重合体薄膜を用いた小型肝細胞、星細胞および血管内皮細胞の3次元複合体組織の再構築2011

    • Author(s)
      益田源太
    • Organizer
      第18回肝細胞研究会
    • Place of Presentation
      東京ガーデンパレス
    • Year and Date
      2011-06-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 肝細胞癌における細胞接着分子ルテランの発現とshedding2011

    • Author(s)
      濱窪亨行
    • Organizer
      第18回肝細胞研究会
    • Place of Presentation
      東京ガーデンパレス
    • Year and Date
      2011-06-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] ラット小型肝細胞の増殖機序2011

    • Author(s)
      大栄秀和
    • Organizer
      第18回肝細胞研究会
    • Place of Presentation
      東京ガーデンパレス
    • Year and Date
      2011-06-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 胆管上皮細胞に肝細胞分化能の検討2011

    • Author(s)
      谷水直樹
    • Organizer
      第18回肝細胞研究会
    • Place of Presentation
      東京ガーデンパレス
    • Year and Date
      2011-06-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 胆管上皮細胞に特異的な転写因子Grhl2の機能解析2011

    • Author(s)
      千賀一徳
    • Organizer
      第18回肝細胞研究会
    • Place of Presentation
      東京ガーデンパレス
    • Year and Date
      2011-06-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 肝前駆細胞移植治療におけるレシピエントラット肝再生機序の解析2011

    • Author(s)
      市戸義久
    • Organizer
      第18回肝細胞研究会
    • Place of Presentation
      東京ガーデンパレス
    • Year and Date
      2011-06-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 星細胞-血管内皮細胞肝接触による血管形態形成の制御2011

    • Author(s)
      粕谷淳一
    • Organizer
      第18回肝細胞研究会
    • Place of Presentation
      東京ガーデンパレス
    • Year and Date
      2011-06-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 細胞移植治療における肝幹・前駆細胞の有用性2011

    • Author(s)
      市戸義久
    • Organizer
      第47回日本肝臓学会総会
    • Place of Presentation
      ホテルグランパシフィックLE DAIBA
    • Year and Date
      2011-06-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 肝前駆細胞治療における再生機序の解析2011

    • Author(s)
      市戸義久
    • Organizer
      第100回日本病理学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-04-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 肝幹・前駆細胞移植におけるドナー細胞増殖機序の解析2011

    • Author(s)
      市戸義久, 他
    • Organizer
      第10回日本再生医療学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-03-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胆管上皮細胞の肝細胞分化能の検討2011

    • Author(s)
      谷水直樹, 他
    • Organizer
      第10回日本再生医療学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-03-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラット肝障害モデルに対する肝細胞移植の影響についての検討2011

    • Author(s)
      中村幸雄, 他
    • Organizer
      第10回日本再生医療学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-03-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 誘電泳動による細胞パターニング技術の開発と組織工学への応用2011

    • Author(s)
      小林哲也, 他
    • Organizer
      日本再生医療学会
    • Place of Presentation
      東京
    • Year and Date
      2011-03-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] マイクロ流体デバイスにおける血管内皮細胞-肝細胞組織間相互作用の定量的解析-2011

    • Author(s)
      辻知宏, 他
    • Organizer
      日本再生医療学会
    • Place of Presentation
      東京
    • Year and Date
      2011-03-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Hepatic Progenitor Cell Transplantation for Improving Survival after Liver Resection of Rat Non-alcoholic Steatocirrhotic Liver Model2011

    • Author(s)
      Nakamura Y
    • Organizer
      7^<th> Annual Academic Surgical Congress
    • Place of Presentation
      Las Vegas, USA
    • Year and Date
      2011-02-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cluster analysis of liver functional indicators and ALB-BTR classification to predict postoperative prognosis in 165 HCC patients2011

    • Author(s)
      Mizuguchi T, et al
    • Organizer
      6^<th> Annual Academic Surgical Congress
    • Place of Presentation
      Huntington Beach, USA
    • Year and Date
      2011-02-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 誘電泳動による細胞パターニング技術の開発と組織工学への応用2011

    • Author(s)
      小林哲也, 他
    • Organizer
      日本機械学会 バイオエンジニアリング講演会
    • Place of Presentation
      熊本県
    • Year and Date
      2011-01-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Differentiation potential of cholangiocytes2011

    • Author(s)
      Tanimizu N, et al
    • Organizer
      Liver Down Under : Liver development, diseases & regeneration
    • Place of Presentation
      Perth, Australia
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Restricted differentiation of hepatic stem/progenitor cells isolated from D-galactosamine-treated rat livers2011

    • Author(s)
      Mitaka T, et al
    • Organizer
      Liver Down Under : Liver development, diseases & regeneration
    • Place of Presentation
      Perth, Australia
    • Related Report
      2011 Final Research Report
  • [Presentation] Role of laminin in bile duct morphogenesis. Epithelial plasticity and epithelial to mesenchymal transition2011

    • Author(s)
      Tanimizu N, et al
    • Organizer
      Keystone Symposia on Molecular and Cellular Biology
    • Place of Presentation
      Vancouver, Canada
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 胆管様ネットワーク再形成に関する組織工学2010

    • Author(s)
      谷下一夫, 他
    • Organizer
      第37回日本胆道閉鎖症研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-12-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肝細胞癌の細胞外マトリックス環境:異所的なラミニンα5鎖とその受容体ルテランによる細胞接着の解明2010

    • Author(s)
      吉川大和, 他
    • Organizer
      第83回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 上皮細胞による組織構造形成を制御する因子についての研究2010

    • Author(s)
      谷水直樹, 他
    • Organizer
      第83回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 最善の肝切除術を目指した基本技術と新しい工夫2010

    • Author(s)
      水口徹, 他
    • Organizer
      第72回日本臨床外科学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2010-11-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腹腔鏡下肝切除術の幕開けとこれまでの成績からSSI対策の見直し2010

    • Author(s)
      水口徹, 他
    • Organizer
      第23回日本外科感染症学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] A Bioengineering Approach to Liver Tissue Engineering2010

    • Author(s)
      Ryo Sudo, et al
    • Organizer
      Biofrontier Syposium 2010
    • Place of Presentation
      石川県金沢市
    • Year and Date
      2010-11-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラット肝障害モデルに対する肝細胞移植の効果についての検討2010

    • Author(s)
      中村幸雄, 他
    • Organizer
      第99回北海道癌談話会例会(第90回北海道医学大会腫瘍系分科会)
    • Place of Presentation
      札幌
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肝臓の胆管上皮細胞の分化や胆管構造形成を制御する因子についての研究2010

    • Author(s)
      谷水直樹, 他
    • Organizer
      第43回北海道病理談話会例会(第90回北海道医学大会病理系分科会)
    • Place of Presentation
      札幌
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Intrahepatic distribution, preservation and transplantation of hepatocyte progenitor cells isolated from adult liver in human and rat2010

    • Author(s)
      Hirata K, et al
    • Organizer
      18^<th> United European Gastroenterology Week
    • Place of Presentation
      Barceona, Spain
    • Year and Date
      2010-10-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腹腔鏡下肝切除術は低侵襲と言えるのか-検出力解析からの検証2010

    • Author(s)
      水口徹, 他
    • Organizer
      第23回日本内視鏡外科学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2010-10-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] ワークショップ16肝胆膵疾患と組織幹細胞/progenitor cell :病態解析と治療戦略「肝幹・前駆細胞の分化誘導因子の解析」2010

    • Author(s)
      市戸義久, 他
    • Organizer
      JDDW2010
    • Place of Presentation
      横浜市
    • Year and Date
      2010-10-14
    • Related Report
      2011 Final Research Report
  • [Presentation] 肝幹・前駆細胞の分化誘導因子の解析2010

    • Author(s)
      市戸義久, 他
    • Organizer
      JDDW2010
    • Place of Presentation
      横浜
    • Year and Date
      2010-10-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] パネルディスカッション4肝臓の再生機構を考える:今後の肝再生医療への展望:「肝幹・前駆細胞の分化・再生能力」2010

    • Author(s)
      三高俊広、他
    • Organizer
      JDDW2010
    • Place of Presentation
      横浜市
    • Year and Date
      2010-10-13
    • Related Report
      2011 Final Research Report
  • [Presentation] 肝幹・前駆細胞の分化・再生能力2010

    • Author(s)
      三高俊広, 他
    • Organizer
      JDDW2010
    • Place of Presentation
      横浜
    • Year and Date
      2010-10-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肝硬変ラットモデルにおける肝細胞移植の有用性についての検討2010

    • Author(s)
      中村幸雄, 他
    • Organizer
      JDDW2010
    • Place of Presentation
      横浜
    • Year and Date
      2010-10-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラミニンα5鎖との結合を阻止する抗ルテランモノクローナル抗体のエピトープ探索2010

    • Author(s)
      戸原侑希子, 他
    • Organizer
      第54回日本薬学会関東支部大会
    • Place of Presentation
      八王子
    • Year and Date
      2010-10-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] マイクロ流体デバイスにおける毛細血管の再生2010

    • Author(s)
      須藤亮, 他
    • Organizer
      酸素ダイナミクス研究会
    • Place of Presentation
      東京都千代田区
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラミニンβ1鎖およびγ1鎖由来細胞接着ペプチドライブラリーを用いた肝細胞接着ペプチドの探索と肝細胞培養2010

    • Author(s)
      片岡輝, 他
    • Organizer
      第42回日本結合組織学会学術大会・第57回マトリックス研究会大会合同学術集会
    • Place of Presentation
      秋田
    • Year and Date
      2010-08-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Hepatic Stellate Cell-mediated Three-dimensional Hepatocyte and Endothelial Cell Tri-culture Model for a Physiological Liver Experimental Model2010

    • Author(s)
      Kasuya J, et al
    • Organizer
      World Congress of Biomechanics 2010
    • Place of Presentation
      Singapore
    • Year and Date
      2010-08-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effect of Extracellular Matrix Stiffness on Ductular Formation of Biliary Epithelial Cells2010

    • Author(s)
      Komatsu N, et al
    • Organizer
      World Congress of Biomechanics 2010
    • Place of Presentation
      Singapore
    • Year and Date
      2010-08-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 安全な肝切除術への工夫2010

    • Author(s)
      水口徹, 他
    • Organizer
      第65回日本消化器外科学会
    • Place of Presentation
      下関
    • Year and Date
      2010-07-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Molecular dissection of lutheran binding to laminin alpha5 using a function-blocking antibody2010

    • Author(s)
      Kikkawa Y, et al
    • Organizer
      Symposium on Basement Membranes in Tissue Development and Regeneration
    • Place of Presentation
      Nashville, USA
    • Year and Date
      2010-07-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] A New Door for Tissue Engineering Opened by Microfluidic Devices2010

    • Author(s)
      Ryo Sudo, 他
    • Organizer
      日本生体医工学会
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2010-06-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effect of pulsatile flow on three-dimensional microvessel network formation2010

    • Author(s)
      阿部順紀, 他
    • Organizer
      日本生体医工学会
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2010-06-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 3D Stacked-up structure by rat small hepatocytes and endothelial cells on PLGA (poly lactic-glycolic acid) membrane2010

    • Author(s)
      益田源太, 他
    • Organizer
      日本生体医工学会
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2010-06-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Development of Dielectrophoretic Cell Patterning for Tissue Engineering2010

    • Author(s)
      小林哲也, 他
    • Organizer
      日本生体医工学会
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2010-06-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] PLGA membrane sandwich culture model of biliary epithelial cells for reconstruction of bile duct2010

    • Author(s)
      松尾薫, 他
    • Organizer
      日本生体医工学会
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2010-06-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Hepatic stellate cell-mediated three-dimensional hepatocyte and endothelial cell tri-culture model2010

    • Author(s)
      粕谷淳一, 他
    • Organizer
      日本生体医工学会
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2010-06-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肝前駆細胞移植におけるドナー細胞増殖機序の解析2010

    • Author(s)
      市戸義久, 他
    • Organizer
      第17回肝細胞研究会
    • Place of Presentation
      秋田
    • Year and Date
      2010-06-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] 生体吸収性薄膜による胆管上皮細胞の管腔構造形成2010

    • Author(s)
      松尾薫, 他
    • Organizer
      第17回肝細胞研究会
    • Place of Presentation
      秋田
    • Year and Date
      2010-06-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラミニンβ1およびγ1鎖由来の合成ペプチドを基質に用いたラット肝細胞の培養2010

    • Author(s)
      片岡輝, 他
    • Organizer
      第17回肝細胞研究会
    • Place of Presentation
      秋田
    • Year and Date
      2010-06-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胆管上皮細胞特異的な転写因子Grhl2の機能解析2010

    • Author(s)
      千賀一徳, 他
    • Organizer
      第17回肝細胞研究会
    • Place of Presentation
      秋田
    • Year and Date
      2010-06-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胆管の構造形成を制御する因子についての研究2010

    • Author(s)
      谷水直樹, 他
    • Organizer
      第17回肝細胞研究会
    • Place of Presentation
      秋田
    • Year and Date
      2010-06-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 食餌により作成した肝障害ラットモデルにおける肝細胞移植の有用性についての検討2010

    • Author(s)
      中村幸雄, 他
    • Organizer
      第17回肝細胞研究会
    • Place of Presentation
      秋田
    • Year and Date
      2010-06-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 血管内皮細胞の3次元ネットワーク形成に及ぼす定常及び拍動せん断応力の影響2010

    • Author(s)
      阿部順紀, 他
    • Organizer
      日本バイオレオロジー学会
    • Place of Presentation
      埼玉県和光市
    • Year and Date
      2010-06-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 誘電泳動による細胞パターニング技術の開発と組織工学への応用2010

    • Author(s)
      小林哲也, 他
    • Organizer
      日本バイオレオロジー学会
    • Place of Presentation
      埼玉県和光市
    • Year and Date
      2010-06-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] マイクロ流体デバイスによる微小細胞環境の制御と多細胞組織化の検討2010

    • Author(s)
      須藤亮, 他
    • Organizer
      日本バイオレオロジー学会
    • Place of Presentation
      埼玉県和光市
    • Year and Date
      2010-06-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肝前駆細胞の分化機構の解析2010

    • Author(s)
      市戸義久, 他
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形
    • Year and Date
      2010-05-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肝不全予測因子の多変量解析とクラスター解析による分類2010

    • Author(s)
      水口徹, 他
    • Organizer
      第22回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2010-05-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラウンドチップCUSAによる肝離断法の有用性に関する検討2010

    • Author(s)
      水口徹, 他
    • Organizer
      第64回手術手技研究会
    • Place of Presentation
      大阪
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肝前駆細胞移植におけるドナー細胞増殖機序の解析2010

    • Author(s)
      市戸義久, 他
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肝硬変ラットモデルにおける肝細胞移植の肝機能改善効果についての検討2010

    • Author(s)
      中村幸雄, 他
    • Organizer
      第110回日本外科学会定期学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-04-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肝臓の胆管の組織構造形成を制御する因子についての研究2010

    • Author(s)
      谷水直樹, 他
    • Organizer
      第9回日本再生医療学会総会
    • Place of Presentation
      広島市
    • Year and Date
      2010-03-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Thy1陽性未分化肝幹細胞の分化機序の解析2010

    • Author(s)
      市戸義久, 他
    • Organizer
      第9回日本再生医療学会総会
    • Place of Presentation
      広島市
    • Year and Date
      2010-03-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 特別講演「幹細胞と肝組織再構築」2010

    • Author(s)
      三高俊広
    • Organizer
      第22回代用臓器・再生医学研究会総会
    • Place of Presentation
      札幌市
    • Year and Date
      2010-01-23
    • Related Report
      2011 Final Research Report
  • [Presentation] 幹細胞と肝組織再構築2010

    • Author(s)
      三高俊広
    • Organizer
      第22回代用臓器・再生医学研究会総会
    • Place of Presentation
      札幌市
    • Year and Date
      2010-01-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] マイクロ流体システムによる肝細胞-血管内皮細胞相互作用の解析2010

    • Author(s)
      須藤亮, 他
    • Organizer
      第22回日本機械学会バイオエンジニアリング講演会
    • Place of Presentation
      岡山市
    • Year and Date
      2010-01-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] 細胞外マトリクスの力学特性を利用した生体外胆管様組織の再構築2010

    • Author(s)
      小松那也, 他
    • Organizer
      第22回日本機械学会バイオエンジニアリング講演会
    • Place of Presentation
      岡山市
    • Year and Date
      2010-01-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Intrahepatic distribution, preservation and transplantation of hepatocyte progenitor cells isolated from adult liver in human and rat2010

    • Author(s)
      Hirata K, et al
    • Organizer
      18^<th> United European Gastroenterology Week
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2011 Final Research Report
  • [Presentation] Management of Pancreatic Necrosis2010

    • Author(s)
      Hirata K, et al
    • Organizer
      World Congress of the International Hepato-Pancreatic Biliary Association 2010
    • Place of Presentation
      BuenosAires, Argentina
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肝前駆細胞の3次元培養を用いた転写因子HNF1βの機能解析2009

    • Author(s)
      谷水直樹, 他
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸市
    • Year and Date
      2009-10-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラット小型肝細胞の増殖における Follistatin/Activin の役割2009

    • Author(s)
      大栄秀和, 他
    • Organizer
      第89回北海道医学大会腫瘍系分科会
    • Place of Presentation
      札幌市
    • Year and Date
      2009-09-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] Thy1/CD44両陽性肝前駆細胞の分化機序の解析2009

    • Author(s)
      市戸義久, 他
    • Organizer
      第89回北海道医学大会腫瘍系分科会
    • Place of Presentation
      札幌市
    • Year and Date
      2009-09-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肝臓の胆管の形態形成を制御する分子メカニズムの解析2009

    • Author(s)
      谷水直樹, 他
    • Organizer
      第89回北海道医学大会病理系分科会
    • Place of Presentation
      札幌市
    • Year and Date
      2009-09-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] Easy techniques and procedures for laparoscopic hybrid liver resection : the introduction reading to complete laparoscopic hepatectomy2009

    • Author(s)
      水口徹, et al.
    • Organizer
      The 43th World Congress of the International society of Surgery
    • Place of Presentation
      Adelade, Australia
    • Year and Date
      2009-09-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] The reconstructed tube formation by integrated cellular structure2009

    • Author(s)
      須藤亮, et al.
    • Organizer
      Third Switzerland-Japan Workshop on Biomechanics
    • Place of Presentation
      Engelberg, Switzerland
    • Year and Date
      2009-09-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラウンド型チップCUSAによる肝切離面の新展開と癒着剥離術への応用2009

    • Author(s)
      水口徹, 他
    • Organizer
      第64回日本消化器外科学会
    • Place of Presentation
      大阪市
    • Year and Date
      2009-07-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラウンドチップCUSAの肝切除術への導入-プレリミナリー報告2009

    • Author(s)
      水口徹, 他
    • Organizer
      第45回日本肝癌研究会
    • Place of Presentation
      福岡市
    • Year and Date
      2009-07-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Thy1/CD44両陽性肝前駆細胞の分化機序の解析2009

    • Author(s)
      市戸義久、今純子、大栄秀和、中村幸雄、三高俊広
    • Organizer
      第16回肝細胞研究会
    • Place of Presentation
      山形市
    • Year and Date
      2009-06-27
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] ラミニン-111由来の合成ペプチドA13(RQVFQVAYIIIKA)を基質に用いたラット肝細胞の培養2009

    • Author(s)
      片岡輝, 他
    • Organizer
      第16回肝細胞研究会
    • Place of Presentation
      山形市
    • Year and Date
      2009-06-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肝芽細胞から胆管上皮細胞への分化及び胆管の形態形成を制御する分子メカニズムの解析2009

    • Author(s)
      谷水直樹, 他
    • Organizer
      第16回肝細胞研究会
    • Place of Presentation
      山形市
    • Year and Date
      2009-06-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 細胞外マトリックスの力学特性が胆管上皮細胞の管腔構造形成に及ぼす影響2009

    • Author(s)
      小松那也, 他
    • Organizer
      第16回肝細胞研究会
    • Place of Presentation
      山形市
    • Year and Date
      2009-06-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 乳酸-グリコール酸共重合体多孔質薄膜の分解による小型肝細胞の3次元組織化2009

    • Author(s)
      益田源太, 他
    • Organizer
      第16回肝細胞研究会
    • Place of Presentation
      山形市
    • Year and Date
      2009-06-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 小型肝細胞、星細胞、および血管内皮細胞による3次元共培養モデル2009

    • Author(s)
      粕谷淳一, 他
    • Organizer
      第16回肝細胞研究会
    • Place of Presentation
      山形市
    • Year and Date
      2009-06-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肝細胞癌初回肝切除時の肝予備能評価としてのATIIIおよびHGFの合併症予測因子および予後因子としての有用性に関する検討2009

    • Author(s)
      水口徹, 他
    • Organizer
      第21回日本肝胆膵外科学会
    • Place of Presentation
      名古屋市
    • Year and Date
      2009-06-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Thy1/CD44両陽性肝前駆細胞の分化機序の解析2009

    • Author(s)
      市戸義久, 他
    • Organizer
      第45回日本肝臓学会総会
    • Place of Presentation
      神戸市
    • Year and Date
      2009-06-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラット小型肝細胞の増殖機序の解析2009

    • Author(s)
      大栄秀和, 他
    • Organizer
      第45回日本肝臓学会総会
    • Place of Presentation
      神戸市
    • Year and Date
      2009-06-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] Primary Culture of Hepatocytes on A13 Peptide derived from Laminin Alpha1 Chain2009

    • Author(s)
      Kikkawa Y, 他
    • Organizer
      第43回日本結合組織学会学術大会
    • Place of Presentation
      横須賀市
    • Year and Date
      2009-06-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] 特別講演「肝幹細胞と組織再構築:肝再生医療へ向けて2009

    • Author(s)
      三高俊広
    • Organizer
      第35回日本急性肝不全研究会
    • Place of Presentation
      神戸市
    • Year and Date
      2009-06-03
    • Related Report
      2011 Final Research Report
  • [Presentation] 肝幹細胞と組織再構築:肝再生医療へ向けて2009

    • Author(s)
      三高俊広
    • Organizer
      第35回日本急性肝不全研究会
    • Place of Presentation
      神戸市
    • Year and Date
      2009-06-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肝前駆細胞の分化機序の解析2009

    • Author(s)
      市戸義久, 他
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都市
    • Year and Date
      2009-05-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 胆管上皮細胞の管腔形成に与える細胞外マトリクスの影響2009

    • Author(s)
      小松那也, 他
    • Organizer
      日本生体医工学会大会
    • Place of Presentation
      東京都
    • Year and Date
      2009-04-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肝再生を目標とした小型肝細胞と血管内皮細胞による3次元共培養モデルの構築2009

    • Author(s)
      粕谷淳一, 他
    • Organizer
      日本生体医工学会大会
    • Place of Presentation
      東京都
    • Year and Date
      2009-04-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 乳酸-グリコール酸共重合体薄膜の分解に応じた小型肝細胞の積層化2009

    • Author(s)
      益田源太, 他
    • Organizer
      日本生体医工学会大会
    • Place of Presentation
      東京都
    • Year and Date
      2009-04-23
    • Related Report
      2009 Annual Research Report
  • [Book] 「各種肝病態における肝オーバル細胞・小型肝細胞の同定」再生医学叢書第5巻、第5章肝細胞の機能制御・分化誘導2012

    • Author(s)
      市戸義久、大栄秀和、谷水直樹、三高俊広
    • Publisher
      朝倉書店(印刷中)
    • Related Report
      2011 Final Research Report
  • [Book] 再生医学叢書第5巻2012

    • Author(s)
      市戸義久, 他
    • Publisher
      各種肝病態における肝オーバル細胞・小型肝細胞の同定(印刷中)
    • Related Report
      2011 Annual Research Report
  • [Book] Liver Stem Cells : Methods and Protocols2011

    • Author(s)
      Ichinohe N, et al
    • Publisher
      Humana Press(In press)
    • Related Report
      2010 Annual Research Report
  • [Book] 多臓器損傷.腹腔鏡下肝切除術 多臓器損傷2010

    • Author(s)
      水口徹, 他
    • Publisher
      南山堂
    • Related Report
      2010 Annual Research Report
  • [Book] Liver Stem Cells : Methods and Protocols2010

    • Author(s)
      Ichinohe N, et al.
    • Publisher
      Human Press, USA(In Press)
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://web.sapmed.ac.jp/canpath/Tissue_Regeneration/Top_page.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://web.sapmed.ac.jp/canpath/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://web.sapmed.ac.jp/canpath/

    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 結紮具および結紮方法2010

    • Inventor(s)
      水口徹、平田公一, 他
    • Industrial Property Rights Holder
      札幌医科大学
    • Industrial Property Number
      2010-226110
    • Filing Date
      2010-10-05
    • Related Report
      2010 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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