| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Research Abstract |
Drug delivery system is defined as the method which enables to efficiently bring drugs to target tissues or cells, resulting in therapeutic effects at most and side effects at least. Poly lactic/glycolic acids are harmless and available as a drug carrier. We established the methods to evaluate distribution of drug-incorporated PLGA particles, release of drugs, and effects of drugs on target and non-target cells. Because oral administration of PLGA particles failed to be absorbed in GI mucosa, modif ication of the particle surface may be required.
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