Prediction of Response to Preoperative Chemoradiotherapy in Rectal Cancer By Gene expression Analysis
| Project/Area Number |
21390383
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2010: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
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|---|
| Keywords | 直腸癌 / DNAマイクロアレイ / 照射効果 / 遺伝子発現 / 化学放射線療法 |
|---|
| Research Abstract |
Based on the gene expression of rectal cancer, we aimed to build a predictive model for response to chemoradiotherapy. Using 46 samples as a training set, we examined gene expression by microarray and RT-PCR. We finally selected 4 genes that were used for predictive model. The accuracy rate of prediction was 89.1% among a training set. In an independent test set of 16 samples, we validated the accuracy of a predictive model and the accuracy rate of the predictive model was 81.3%.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Predicting ulcerative colitis-associated colorectal cancer using reverse-transcription polymerase chain reaction analysis2011
Author(s)
Watanabe T, Kobunai T, Yamamoto Y, Ikeuchi H, Matsuda K, Ishihara S, Nozawa K, Iinuma H, Kanazawa T, Tanaka T, Yokoyama T, Konishi T, Eshima K, Ajioka Y, Hibi T, Watanabe M, Muto T, Nagawa H
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Journal Title
Clin Colorectal Cancer
Volume: 10(2)
Pages: 134-141
Related Report
Peer Reviewed
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[Journal Article] Gene expression of vascular endothelial growth factor a, thymidylate synthase, and tissue inhibitor of metalloproteinase 3 in prediction of response to bevacizumab treatment in colorectal cancer patients2011
Author(s)
Watanabe T, Kobunai T, Yamamoto Y, Matsuda K, Ishihara S, Nozawa K, Iinuma H, Shibuya H, Ikeuchi H
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Journal Title
Dis Colon Rectum
Volume: 54(8)
Pages: 1026-35
Related Report
Peer Reviewed
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[Journal Article] RUNX3 copy number predicts the development of UC-associated colorectal cancer2011
Author(s)
Watanabe T, Kobunai T, Ikeuchi H, Yamamoto Y, Matsuda K, Ishihara S, Nozawa K, Iinuma H, Kanazawa T, Tanaka T, Yokoyama T, Konishi T, Eshima K, Ajioka Y, Hibi T, Watanabe M, Muto T, Nagawa H
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Journal Title
Int J Oncol
Volume: 38(1)
Pages: 201-207
Related Report
Peer Reviewed
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[Journal Article] Prediction of liver metastasis after colorectal cancer using reverse transcription-polymerase chain reaction analysis of 10 genes2010
Author(s)
Watanabe T, Kobunai T, Yamamoto Y, Kanazawa T, Konishi T, Tanaka T, Matsuda K, Ishihara S, Nozawa K, Eshima K, Muto T, Nagawa H
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Journal Title
Eur J Cancer
Volume: 46(11)
Pages: 2119-26
Related Report
Peer Reviewed
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