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Development of a novel prophylaxis for the post-cardiopulmonary bypass lung injury by a pharmacological leukocyte control

Research Project

Project/Area Number 21390384
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionUniversity of Tsukuba

Principal Investigator

GOTO Yukinobu  筑波大学, 医学医療系, 講師 (20451700)

Co-Investigator(Kenkyū-buntansha) HIRAMATSU Yuji  筑波大学, 医学医療系, 准教授 (30302417)
AGEYAMA Naohide  独立行政法人医薬基盤研究所, 霊長類研究所, 研究員 (50399458)
SAKAKIBARA Yuzuru  筑波大学, 医学医療系, 教授 (60192085)
TOKUNAGA Chiho  筑波大学, 医学医療系, 講師 (30451701)
Project Period (FY) 2009 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords呼吸器外科 / 心臓血管外科 / 病態生理学 / 体外循環 / 肺傷害 / 白血球 / 骨髄 / 肺障害
Research Abstract

We have applied a well-established method to assess the BM reactionin vivo in monkeys. This method proved to be a model relevant for humans by showing the release of PMN and monocytes from the BM to be quantified and their T_<1/2> in the circulation pool to be estimated. Using this technique, we confirmed that CPB accelerates the release of leukocytes (PMN and monocytes) from the BM and showed their delayed recruitment to the lungs. We postulate that the behavior of BM-derived leukocytes following CPB, rather than of circulating leukocytes, plays an important role in the pathogenesis of post-CPB lung injury as a part of a whole-body inflammatory reaction.

Report

(5 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (10 results)

All 2012 2011 2010 Other

All Presentation (6 results) Remarks (4 results)

  • [Presentation] Cardiopulmonary Bypass Accelerates Bone-marrow Leukocyte Release And Recruitment Into The Lung In Primate Model.2012

    • Author(s)
      Goto Y, Hiramatsu Y, Ageyama N, Sato S, Kobayashi N, Suzuki H, Sakai M, Kanemoto S, Onizuka M., Sato Y., Sakakibara Y
    • Organizer
      American Thoracic Society International Conference. 2012;169:K83
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2012-05-20
    • Related Report
      2012 Final Research Report
  • [Presentation] Bone-marrow-derived Leukocyte Induced by Cardiopulmonary Bypass Recruit into the Lung in Our Established Primate Model2011

    • Author(s)
      Goto Y, Hiramatsu Y, Ageyama N, Kobayashi N, Sakai M, Onizuka M, Sato Y, Kanemoto S, Sakakibara Y
    • Organizer
      General Thoracic and Cardiovascular Surgery 2011;59:171 (Outstasnding Works).
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-10-10
    • Related Report
      2012 Final Research Report
  • [Presentation] Bone-marrow-derived Leukocytes Induced by Cardiopulmonary Bypass Recruit into the Lung in Our Established Primate Model2011

    • Author(s)
      後藤行延
    • Organizer
      第64回日本胸部外科学会定期学術集会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-10-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] A novel primate model to study bone-marrow-derived leukocyte kinetics induced by cardiopulmonary bypass2010

    • Author(s)
      Goto Y., Hiramatsu Y., Ageyama N., Sato S., Sakai M., Onizuka M., Sato Y., Sakakibara Y
    • Organizer
      Chest. 2010; 138: 580A.
    • Place of Presentation
      VANCOUVER,BC,CANADA
    • Year and Date
      2010-11-03
    • Related Report
      2012 Final Research Report
  • [Presentation] A Novel Primate Model to Study Bone-marrow-derived Leukocyte Kinetics Induced by Cardiopulmonary Bypass2010

    • Author(s)
      後藤行延
    • Organizer
      CHEST2010
    • Place of Presentation
      VANCOUVER, BC, CANADA
    • Year and Date
      2010-11-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cardiopulmonary Bypass Accelerates Bone-marrow Leukocyte Release And Recruitment Into The Lung In Primate Model

    • Author(s)
      後藤行延
    • Organizer
      American Thoracic Society International Conference. 2012
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.md.tsukuba.ac.jp/clinical-med/respiratory/

    • Related Report
      2012 Final Research Report
  • [Remarks] 筑波大学呼吸器外科ホームページ

    • URL

      http://www.md.tsukuba.ac.jp/clinical-med/respiratory/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.md.tsukuba.ac.jp/clinical-med/respiratory/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.md.tsukuba.ac.jp/clinical-med/respiratory/

    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2019-07-29  

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