Preclinical study for tolerance induction in lung transplantation

• Project/Area Number: 21390386
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: 公益財団法人田附興風会 (2011); Kyoto University (2009-2010)
• Principal Investigator: SHOJI Tsuyoshi 公益財団法人田附興風会, 医学研究所第1研究部, 研究員 (80402840)
• Co-Investigator(Kenkyū-buntansha): DATE Hiroshi 京都大学, 医学研究科, 教授 (60252962) ; BANDO Toru 京都大学, 医学研究科, 准教授 (20293954) ; SAKAI Hiroaki 京都大学, 医学研究科, 講師 (50362489) ; 小柴 貴明 京都大学, 医学研究科, 准教授 (60362521)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000); Fiscal Year 2011: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2009: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
• Keywords: 呼吸器外科学 / 肺移植 / 免疫寛容 / 前臨床研究 / ミニブタ / 慢性拒絶

Research Abstract

In the study of lung allograft using miniature swine as preclinical model, an adoptive transfer of ex vivo donor alloantigen-stimulated CD4^+CD25^+FoxP3^+Tregs combined with low dose tacrolimus ameliorates rejection of immunogenic lung transplantation and prolonged lung allograft survival in clinically relevant miniature swine.

Research Products

• [Presentation] 肺移植における移植免疫研究～大動物実験から臨床応用へ～ (2010)
  • Author(s): 庄司剛、阪井宏彰、板東徹、伊達洋至ら11名
  • Organizer: 第46回日本移植学会総会
  • Place of Presentation: 京都市
  • Year and Date: 2010-10-22
• [Presentation] Adoptive Trasfer of Ex Vivo Donor Alloantigen-Stimulated CD4^+CD25^+FoxP3^+Regulatory T Cells Ameriorates Rejection of Lung Transplantation between Fully Mismatched Miniature Swine (2010)
  • Author(s): Koshiba T, Date Hら11名
  • Organizer: American Transplant Congress(米国移植学会)
  • Place of Presentation: 米国カリフォルニア州サンディエゴ
  • Year and Date: 2010-05-01
• [Presentation] Adoptive transfer of ex vivo donor alloantigen-stimulated CD4+CD25++regulatory T cells ameliorates rejection of Lung Transplantation between Fully Mismatched Miniature Swine (2009)
  • Author(s): Satoda N, Shoji T, Bando T, Date H, ほか10名
  • Organizer: European Society for Organ Transplantation(欧州臓器移植学会)
  • Place of Presentation: フランス、パリ
  • Year and Date: 2009-08-31
• [Presentation] Adoptive Trasfer of Ex Vivo Donor Alloantigen-Stimulated CD4^+CD25^+FoxP3^+Regulatory T Cells Ameriorates Rejection of Lung Transplantation between Fully Mismatched Miniature Swine (2009)
  • Author(s): Shoji Tら11名
  • Organizer: American Transplant Congress(米国移植学会), Late Breaking Oral Session
  • Place of Presentation: 米国マサチューセッツ州ボストン
  • Year and Date: 2009-06-03
• [Presentation] Adoptive Trasfer of Ex Vivo Donor Alloantigen-Stimulated CD4^+CD25^+FoxP3^+ Regulatory T Cells Ameriorates Rejection of Lung Transplantation between Fully Mismatched Miniature Swine (2009)
  • Author(s): 庄司剛
  • Organizer: American Transplant Congress (米国移植学会)
  • Place of Presentation: Hynes Convention Center (米国 ボストン)
  • Year and Date: 2009-06-03
• [Remarks]
  • URL: http://www.thoracic-kyoto-u.gr.jP/
• [Remarks]
  • URL: http://www.thoracic-kyoto-u.gr.jp/
• [Remarks]
  • URL: http://www.thoracic-kyoto-u.gr.jp/