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Preclinical study for tolerance induction in lung transplantation

Research Project

Project/Area Number 21390386
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research Institution公益財団法人田附興風会 (2011)
Kyoto University (2009-2010)

Principal Investigator

SHOJI Tsuyoshi  公益財団法人田附興風会, 医学研究所第1研究部, 研究員 (80402840)

Co-Investigator(Kenkyū-buntansha) DATE Hiroshi  京都大学, 医学研究科, 教授 (60252962)
BANDO Toru  京都大学, 医学研究科, 准教授 (20293954)
SAKAI Hiroaki  京都大学, 医学研究科, 講師 (50362489)
小柴 貴明  京都大学, 医学研究科, 准教授 (60362521)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2011: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Keywords呼吸器外科学 / 肺移植 / 免疫寛容 / 前臨床研究 / ミニブタ / 慢性拒絶
Research Abstract

In the study of lung allograft using miniature swine as preclinical model, an adoptive transfer of ex vivo donor alloantigen-stimulated CD4^+CD25^+FoxP3^+Tregs combined with low dose tacrolimus ameliorates rejection of immunogenic lung transplantation and prolonged lung allograft survival in clinically relevant miniature swine.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (8 results)

All 2010 2009 Other

All Presentation (5 results) Remarks (3 results)

  • [Presentation] 肺移植における移植免疫研究~大動物実験から臨床応用へ~2010

    • Author(s)
      庄司剛、阪井宏彰、板東徹、伊達洋至ら11名
    • Organizer
      第46回日本移植学会総会
    • Place of Presentation
      京都市
    • Year and Date
      2010-10-22
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Adoptive Trasfer of Ex Vivo Donor Alloantigen-Stimulated CD4^+CD25^+FoxP3^+Regulatory T Cells Ameriorates Rejection of Lung Transplantation between Fully Mismatched Miniature Swine2010

    • Author(s)
      Koshiba T, Date Hら11名
    • Organizer
      American Transplant Congress(米国移植学会)
    • Place of Presentation
      米国カリフォルニア州サンディエゴ
    • Year and Date
      2010-05-01
    • Related Report
      2011 Final Research Report
  • [Presentation] Adoptive transfer of ex vivo donor alloantigen-stimulated CD4+CD25++regulatory T cells ameliorates rejection of Lung Transplantation between Fully Mismatched Miniature Swine2009

    • Author(s)
      Satoda N, Shoji T, Bando T, Date H, ほか10名
    • Organizer
      European Society for Organ Transplantation(欧州臓器移植学会)
    • Place of Presentation
      フランス、パリ
    • Year and Date
      2009-08-31
    • Related Report
      2011 Final Research Report
  • [Presentation] Adoptive Trasfer of Ex Vivo Donor Alloantigen-Stimulated CD4^+CD25^+FoxP3^+Regulatory T Cells Ameriorates Rejection of Lung Transplantation between Fully Mismatched Miniature Swine2009

    • Author(s)
      Shoji Tら11名
    • Organizer
      American Transplant Congress(米国移植学会), Late Breaking Oral Session
    • Place of Presentation
      米国マサチューセッツ州ボストン
    • Year and Date
      2009-06-03
    • Related Report
      2011 Final Research Report
  • [Presentation] Adoptive Trasfer of Ex Vivo Donor Alloantigen-Stimulated CD4^+CD25^+FoxP3^+ Regulatory T Cells Ameriorates Rejection of Lung Transplantation between Fully Mismatched Miniature Swine2009

    • Author(s)
      庄司剛
    • Organizer
      American Transplant Congress (米国移植学会)
    • Place of Presentation
      Hynes Convention Center (米国 ボストン)
    • Year and Date
      2009-06-03
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.thoracic-kyoto-u.gr.jP/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.thoracic-kyoto-u.gr.jp/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.thoracic-kyoto-u.gr.jp/

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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