| Project/Area Number |
21390387
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Chiba University |
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Principal Investigator |
MATSUMIYA Goro 千葉大学, 大学院・医学研究院, 教授 (20314312)
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| Co-Investigator(Kenkyū-buntansha) |
SAWA Yoshiki 大阪大学, 医学系研究科, 教授 (00243220)
KURATANI Toru 大阪大学, 医学系研究科, 准教授 (90448035)
UENO Takayoshi 大阪大学, 医学系研究科, 講師 (60437316)
SAKAGUCHI Taichi 大阪大学, 医学系研究科, 寄附講座准教授 (10467574)
SHIRAKAWA Yukitoshi 大阪大学, 医学系研究科, 助教 (20457013)
MATSUYAMA Akifumi 大阪大学, 医学部附属病院, 特任准教授 (10423170)
MIYAGAWA Shigeru 大阪大学, 医学系研究科, 助教 (70544237)
ISHIZAKA Toru 千葉大学, 医学部附属病院, 講師 (10372616)
KOHNO Hiroki 千葉大学, 医学部附属病院, 助教 (40375803)
ISHIDA Keiichi 千葉大学, 医学部附属病院, 助教 (40375671)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2010: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2009: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Keywords | iPS細胞 / 心筋細胞 / 細胞シート / 心不全 / 心筋梗塞 / Teratoma |
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| Research Abstract |
iPS cell-derived cardiomyocyte cell-sheet was successfully generated by iPS cells of mouse and human origin by means of thermoresponsive dishes. Transplantation of this iPS cell-sheet into the heart having ischemic pathology was feasible, safe and therapeutically effective in both rodent and porcine model, warranting clinical study of this strategy.
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