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The novel therapeutic approach for emphysema by regeneration of microvessel and alveolus after intrapulmonary arterial administration of gelatin microspheres slowly releasing basic fibroblast growth factor(bFGF-GMS).

Research Project

Project/Area Number 21390393
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionKagawa University

Principal Investigator

YOKOMISE Hiroyasu  香川大学, 医学部, 教授 (80231728)

Co-Investigator(Kenkyū-buntansha) GO Tetsuhiko  香川大学, 医学部附属病院, 助教 (50313656)
CHANG Sunsoo  香川大学, 医学部, 助教 (00419508)
MATURA Natsumi  香川大学, 医学部附属病院, 助教 (20572853)
KASAI Yoshitaka  香川大学, 医学部附属病院, 助教 (40610085)
三崎 伯幸  香川大学, 医学部, 助教 (50452678)
後藤 正司  香川大学, 医学部附属病院, 助教 (40398029)
黄 政龍  香川大学, 医学部, 准教授 (10271511)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2010: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2009: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Keywords再生医学 / 肺気腫 / 肺胞再生
Research Abstract

The prognosis of patients with emphysema is poor, and no truly effective treatment is available. Our previous study showed that the alveolar space was smaller and the microvessel density was higher in a canine emphysema model after intrapulmonary arterial administration of gelatin microspheres slowly releasing basic fibroblast growth factor(bFGF-GMS). We evaluated the functional effect of injection of bFGF-GMS via the pulmonary artery in a canine pulmonary emphysema model. Lung compliance in the total emphysema group was higher than in the control group(p=0. 031), and the bFGF group showed no significant improvement of lung compliance in comparison with the total emphysema group(p=0. 112). PaO_2(partial pressure of oxygen in arterial blood) was improved by administration of bFGF-GMS in the total emphysema model(p=0. 027). In the canine total emphysema model, blood gas parameters were improved by whole pulmonary arterial administration of bFGF-GMS. This method has the potential to be an effective novel therapy for pulmonary emphysema.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report

Research Products

(7 results)

All 2010 2009 2008

All Presentation (7 results)

  • [Presentation] イヌ肺気腫モデルにおけるbFGF徐放ゼラチンマイクロスフェアおよび間葉系幹細胞の肺動脈内投与による肺気腫治療の試み2010

    • Author(s)
      張性洙
    • Organizer
      第63回日本胸部外科学会定期学術集会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2010-10-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] イヌ肺気腫モデルにおけるbFGF徐放ゼラチンマイクロスフェアおよび間葉系幹細胞の肺動脈内投与による肺気腫治療の試み2010

    • Organizer
      第63回日本胸部外科学会総会
    • Related Report
      2011 Final Research Report
  • [Presentation] Basic FGF徐放ゼラチンマイクロスフェア経肺静脈投与による肺気腫治療に関する実験的研究2009

    • Author(s)
      張性洙
    • Organizer
      第26回 日本呼吸器外科学会総会
    • Place of Presentation
      北九州
    • Year and Date
      2009-05-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] 呼吸器外科領域の再生医療basic FGF徐放ゼラチンマイクロスフェア経肺動脈投与による肺気腫治療に関する実験的研究2009

    • Organizer
      第26回日本呼吸器外科学会総会
    • Related Report
      2011 Final Research Report
  • [Presentation] 呼吸器外科領域の再生医療成長因子徐放ゼラチンスポンジを用いた気管軟骨再生2009

    • Organizer
      第26回日本呼吸器外科学会総会
    • Related Report
      2011 Final Research Report
  • [Presentation] イヌ肺気腫モデルにおけるbFGF徐放ゼラチンマイクロスフェアの肺動脈内投与による肺気腫治療の試み2008

    • Organizer
      第61回日本胸部外科学会総会
    • Related Report
      2011 Final Research Report
  • [Presentation] ポリ乳酸カプロラクトン共重合体(PLAC)多孔性足場を用いた自己組織による肺切除後死腔閉鎖の試み2008

    • Organizer
      第108回日本外科学会総会
    • Related Report
      2011 Final Research Report

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Published: 2009-03-31   Modified: 2016-04-21  

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