Tyrosine kinase gene mutation and chemotherapy sensitivity in lung cancers.
| Project/Area Number |
21390394
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Nagoya City University |
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Principal Investigator |
FUJII Yoshitaka 名古屋市立大学, 大学院・医学研究科, 教授 (40156831)
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| Co-Investigator(Kenkyū-buntansha) |
SASAKI Hidefumi 名古屋市立大学, 大学院・医学研究科, 准教授 (00336695)
YANO Motoki 名古屋市立大学, 大学院・医学研究科, 准教授 (40315883)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2010: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
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| Keywords | 肺癌 / ERCC1 / NRF2 / KIF5B/RET / RET阻害剤 / FISH / MRP3 / EGFR / KIF5B / RET / 遺伝子転座 / FGFR1 / コピー数 / Kras / AKT2 / MEK1 / NFE2L2 / 扁平上皮癌 / βチュブリン / MCL1 / BCL2L1 |
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| Research Abstract |
ERCC1 C8092A and codon118C/T gene polymorphism statuses were evaluated for lung cancer patients who recieved adjuvant chemotherapy. We have investigated NRF2 gene mutation statuses in lung squamous cell carcinomas and compared with copy number, MRP3(multi-drug resistance-associated protein 3) expression and other clinico-pathological backgrounds. Novel KIF5B/RET translocation was found in lung cancer using a next-generation sequencing assay. KIF5B/RET transfected cells were sensitive to anti-RET drugs. We have developed fluorescence in situ hybridization(FISH) assay to detect KIF5B/RET transfusion gene.
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Report
(4 results)
Research Products
(32 results)
