| Budget Amount *help |
¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Research Abstract |
For careful interpretation of spatial and temporal changes of electrocorticogram (ECoG) with semantic tasks, we developed a software to visualize semantic-ECoG dynamics on individual brain. Twenty patients underwent implantation of subdural electrodes (more than 80 channels) bilaterally for diagnostic purpose of intractable epilepsy. Semantic-ECoG was recorded with word, figure and face recognition and memory tasks. The ECoG raw data was processed by averaging and time-frequency analysis and the functional profiles were projected on individual brain surface. Acquired ECoG was classified by Support Vector Machine and Sparse Logistic Regression to decode brain signals. Because of variations of electrode locations, we normalized the ECoG elecrtodes using SPM8. The basal temporal-occipital cortex was activated within 250 msec after visual object presentations. Face stimulation evoked significantly higher ECoG amplitudes than other stimuli. The hipocumpus was dominantly activated than other brain areas by the memory task. Prediction rate od ECoG-classification reached 90%, which was sufficient for clinical use. Semantic-ECoG is a powerful technique to detect and decode the human brain functions.
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