Mechanisms of cerebral aneurysmal occurrence, growth and rupture and development of new treatments
Project/Area Number |
21390411
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Cerebral neurosurgery
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Research Institution | Shiga University of Medical Science |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
JITO Junya 滋賀医科大学, 医学部, 助教 (50534161)
NISHIMURA Masaki 京都大学, 医学研究科, 助教 (60452348)
YOKOI Toshihiro 滋賀医科大学, 医学部, 助教 (20573182)
INUBUSHI Toshiro 滋賀医科大学, MR医学総合研究センター, 教授 (20213142)
MORIKAWA Shigehiro 滋賀医科大学, 医学部, 教授 (60220042)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2011: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2009: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
|
Keywords | 脳動脈瘤 / 動物モデル / 薬物治療 / MR画像 / 分子イメージング |
Research Abstract |
In order to elucidate the mechanisms of cerebral aneurysmal development, growth, rupture, we conducted molecular an histological analyses in induced aneurismal models of rats and monkeys. Induced aneurysms were successfully checked using 7T-MRA and the administration of statins, TNF-αinhibitors suppressed the development of cerebral aneurysms by inhibiting inflammatory processes.
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Report
(4 results)
Research Products
(62 results)
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[Presentation] 脳動脈瘤 基礎と臨床2011
Author(s)
野崎和彦
Organizer
第34回香川脳血管障害研究会
Place of Presentation
全日空ホテル クレメント高松(香川)(特別講演)
Year and Date
2011-03-04
Related Report
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[Presentation] 脳動脈瘤 基礎と臨床2010
Author(s)
野崎和彦
Organizer
第38回大阪大学脳神経外科同窓会
Place of Presentation
千里ライフサイエンスセンター(大阪)(特別講演)
Year and Date
2010-07-03
Related Report
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[Presentation] 脳動脈瘤2010
Author(s)
野崎和彦
Organizer
山口脳卒中セミナー
Place of Presentation
山口大学(山口)(特別講演)
Year and Date
2010-05-29
Related Report
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[Presentation] 脳動脈瘤2009
Author(s)
野崎和彦
Organizer
第4回城山ニューロフォーラム
Place of Presentation
大阪
Year and Date
2009-11-25
Related Report
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