The Research of the bioreactor that can promote the cell differentiation from bone marrow stem cells to osteogenic cells

• Project/Area Number: 21390419
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Nagoya University
• Principal Investigator: ISHIGURO Naoki 名古屋大学, 大学院・医学系研究科, 教授 (20212871)
• Co-Investigator(Kenkyū-buntansha): KITOH Hiroshi 名古屋大学, 医学部附属病院, 講師 (40291174) ; SAKAI Tadahiro 名古屋大学, 医学部附属病院, 病院講師 (60378198) ; 光山 浩人 名古屋大学, 大学院・医学系研究科, 特任助教 (80467282)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000); Fiscal Year 2011: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
• Keywords: SOX9 / VEGF / ATDC5 / バイオリアクター / 脚延長 / 細胞培養 / 骨髄間系細胞 / 骨芽細胞 / 細胸培養 / 骨髄間葉系細胞

Research Abstract

We used ATDC5 cell and bone marrow stem cells(BMC) in the experiments. The expression of SOX9mRNA(chondorogenic marker) and RUNX2mRNA(osteogenic marker) was respectively demonstrated in the process of cell differentiation with suitable condition. The both mRNA expression were increased with the mechanical stimuli applied in this process of cell differentiation. The strength and cyclic rate were important for this process. The cell differentiation and matrix synthesis was exaggerated when the strong stimuli were applied. We could not obtained the VEGF producing cells from BMC with the hypoxia condition and mechanical stimuli.

Research Products

• [Journal Article] Cartilage mplantation for the bone and cartilage destruction in rheumatoid arthritis (2012)
  • Author(s): Sakai T, Ishiguro N
  • Journal Title: Clin Calcium Volume: 22(2) Pages: 245-9
  • Peer Reviewed
• [Journal Article] Chondroblastoma of the femoral neck as a cause of hip synovitis (2012)
  • Author(s): Kaneko H, Kitoh H, Wasa J, Nishida Y, Ishiguro N
  • Journal Title: J Pediatr Orthop B Volume: 21(2) Pages: 179-82
  • Peer Reviewed
• [Journal Article] Cartilage implantation for the bone and cartilage destruction in rheumatoid arthritis (2012)
  • Author(s): Sakai T, Ishiguro N
  • Journal Title: Clin Calcium Volume: 22(2) Pages: 245-9
  • Peer Reviewed
• [Journal Article] Spondylometaphysealdysplasiawithcone-roddystrophy (2011)
  • Author(s): Kitoh H, Kaneko H, Kondo M, YamamotoT, Ishiguro N Nishimura
  • Journal Title: Am J Med Genet A Volume: 155A(4) Pages: 845-9
  • Peer Reviewed
• [Journal Article] Anti-tumor necrosis factor therapy in rheumatoid arthritis patients with a history of deep prosthetic joint infecti on : a report of four cases (2011)
  • Author(s): Hirano Y, Kojima T, Kanayama Y, Shioura T, Hayashi M, Tsuboi S, Ishiguro N
  • Journal Title: Mod Rheumatol Volume: 21(5) Pages: 542-7
  • Peer Reviewed
• [Journal Article] Study protocol of a multicenter registry of patients with rheumatoid arthritis starting biologic therapy in Japan : TsurumaiBiologicsCommunication Registry(TBCR) Study (2011)
  • Author(s): Kojima T, Kaneko A, Hirano Y, Ishikawa H, Miyake H, Oguchi T, Takagi H, YabeY, Kato T, Ito T, Terabe K, FukayaN, Kanayama Y, Shioura T, FunahashiK, Hayashi M, Kato D, MatsubaraH, Fujibayashi T, Kojima M, Ishiguro N
  • Journal Title: Mod Rheumatol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Early aggressive intervention with tocilizumab for rheumatoid arthritis increases remission rate defined using a Boolean approach in clinical practice (2011)
  • Author(s): Kojima T, Kaneko A, Hirano Y, IshikawaH, Miyake H, Takagi H, Yabe Y, Kato T, Terabe K, Fukaya N, Tsuchiya H, Shioura T, Funahashi K, Hayashi M, Kato D, Matsubara H, Ishiguro N
  • Journal Title: Mod Rheumatol Volume: (in press)
  • NAID: 10030782171
  • Peer Reviewed
• [Journal Article] Anti-tumor necrosis factor therapy in rheumatoid arthritis patients with a history of deep prosthetic joint infection : a report of four cases (2011)
  • Author(s): Hirano Y, Kojima T, Kanayama Y, Shioura T, Hayashi M, Tsuboi S, Ishiguro N
  • Journal Title: Mod Rheumatol Volume: 21(5) Issue: 5 Pages: 542-7
  • DOI: 10.1007/s10165-011-0437-4
  • NAID: 10030205867
  • Peer Reviewed
• [Journal Article] Study protocol of a multicenter registry of patients with rheumatoid arthritis starting biologic therapy in Japan : Tsurumai Biologics Communication Registry (TBCR) Study (2011)
  • Author(s): Kojima T, Kaneko A, Hirano Y, Ishikawa H, Miyake H, Oguchi T, Takagi H, Yabe Y, Kato T, Ito T, Terabe K, Fukaya N, Kanayama Y, Shioura T, Funahashi K, Hayashi M, Kato D, Matsubara H, Fujibayashi T, Kojima M, Ishiguro N
  • Journal Title: Mod Rheumatol Volume: 22(3) Issue: 3 Pages: 339-45
  • DOI: 10.1007/s10165-011-0518-4
  • NAID: 10030782076
  • Peer Reviewed
• [Journal Article] Early aggressive intervention with tocilizumab for rheumatoid arthritis increases remission rale defined using a Boolean approach in clinical practice (2011)
  • Author(s): Kojima T, Kaneko A, Hirano Y, Ishikawa H, Miyake H, Takagi H, Yabe Y, Kato T, Terabe K, Fukaya N, Tsuchiya H, Shioura T, Funahashi K, Hayashi M, Kato D, Matsubara H, Ishiguro N
  • Journal Title: Mod Rheumatol Volume: 22 Issue: 3 Pages: 370-375
  • DOI: 10.1007/s10165-011-0528-2
  • Peer Reviewed
• [Journal Article] Inflammatory effect of advanced glycation end products on human meniseal cells from osteoarthritic knees (2011)
  • Author(s): Hiraiwa H, Sakai T, Mitsuyama H, Hamada T, Yamamoto R, Omachi T, Ohno Y, Nakashima M, Ishiguro N
  • Journal Title: Inflamm Res Volume: 60(11) Issue: 11 Pages: 1039-48
  • DOI: 10.1007/s00011-011-0365-y
  • Peer Reviewed
• [Journal Article] Geranylgeranylacetone suppresses hydrogen peroxide-induced apoptosis of osteoarthritic chondrocytes (2011)
  • Author(s): Yoda M, Sakai T, Mitsuyama H, Hiraiwa H, Ishiguro N
  • Journal Title: J Orthop Sci Volume: 16(6) Issue: 6 Pages: 791-8
  • DOI: 10.1007/s00776-011-0138-z
  • Peer Reviewed
• [Journal Article] Spatial and temporal distribution of growth factors receptors in the call us : implications for improvement of distraction osteogenesis (2011)
  • Author(s): Siwicka KA, Kitoh H, Kawasumi M, Ishiguro N
  • Journal Title: Nagoya J Med Sci Volume: 73(3-4) Pages: 117-27
  • Peer Reviewed
• [Journal Article] Hyperuricemia cosegregating with osteogenesis imperfecta is associated with a mutation in GPATCH8 (2011)
  • Author(s): Kaneko H, Kitoh H, Matsuura T, Masuda A, Ito M, Mottes M, Rauch F, Ishiguro N, Ohno K
  • Journal Title: Hum Genet Volume: 130 Issue: 5 Pages: 671-683
  • DOI: 10.1007/s00439-011-1006-9
  • Peer Reviewed
• [Journal Article] Early clinical and radiographic characteristics in fibrodysplasia ossificans progressiva : a report of two cases (2011)
  • Author(s): Mishima K, Kitoh H, Katagiri T, Kaneko H, Ishiguro N
  • Journal Title: J Bone Joint Surg Am Volume: 93(10) Issue: 10 Pages: e52(1)-e52(5)
  • DOI: 10.2106/jbjs.j.01443
  • Peer Reviewed
• [Journal Article] Spondylometaphyseal dysplasia with cone-rod dystrophy (2011)
  • Author(s): Kitoh H, Kaneko H, Kondo M, Yamamoto T, Ishiguro N, Nishimura G
  • Journal Title: Am J Med Genet A Volume: 155A(4) Issue: 4 Pages: 845-9
  • DOI: 10.1002/ajmg.a.33898
  • Peer Reviewed
• [Journal Article] Factors related to surgical outcome after posterior decompression and fusion for craniocervical junction lesions associated with osteogenesis imperfecta (2011)
  • Author(s): Imagama S, Wakao N, Kitoh H, Matsuyama Y, Ishiguro N
  • Journal Title: Eur Spine J Volume: 20 Suppl 2 Issue: S2 Pages: 320-5
  • DOI: 10.1007/s00586-011-1734-5
  • Peer Reviewed
• [Journal Article] Influences of anti-tumour necrosis factor agents on postoperative recovery in patients with rheumatoid arthritis (2010)
  • Author(s): Hirano Y, Kojima T, Kanayama Y, Shioura T, Hayashi M, Kida D, Kaneko A, Eto Y, Ishiguro N
  • Journal Title: Clin Rheumatol Volume: 29(5) Pages: 495-500
  • Peer Reviewed
• [Journal Article] Deformity of the great to e in fibrodysplasia ossificans progressiva (2010)
  • Author(s): Nakashima Y, Haga N, Kitoh H, Kamizono J, Tozawa K, Katagiri T, Susami T, Fukushi J, Iwamoto Y
  • Journal Title: J Orthop Sci Volume: 15(6) Pages: 804-9
  • Peer Reviewed
• [Journal Article] Novel and recurrent TRPV4 mutations and their association with distinct phenotypes with in theTRPV4 dysplasia family (2010)
  • Author(s): Dai J, Kim OH, Cho TJ, Schmidt-RimplerM, Tonoki H, Takikawa K, Haga N, Miyoshi K, Kitoh H, Yoo WJ, Choi IH, Song HR, Jin DK, Kim HT, Kamasaki H, Bianchi P, Grigelioniene G, NampoothiriS, Minagawa M, Miyagawa S, Fukao T, Marcelis C, Jansweijer MCE, HennekamRCM, Bedeschi F, Mustonen A, Jiang Q, Ohashi H, Furuichi T, Unger S, Zabel B, Lausch E, Superti-Furga A, NishimuraN, Ikegawa S
  • Journal Title: J Med Genet Volume: 47(10) Pages: 704-709
  • Peer Reviewed
• [Journal Article] Spondylo-epiphyseal dysplasia, Maroteaux type(pseudo-Morquio syndrome type 2) and parastremmatic dy splasia are caused by TRPV4 mutations (2010)
  • Author(s): Nishimura G, Dai J, Lausch E, Unger S, Megarbane A, Kitoh H, OH Kim, ChoTJ, Bedeschi F, Benedicenti F, Mendoza-Londono R, Silengo M, Schmidt-Rimpler M, Spranger J, Zabel B, Ikegawa S
  • Journal Title: J Med Genet Volume: 152A(6) Pages: 1443-1449
  • Peer Reviewed
• [Journal Article] Radiographic progression of cervical lesions in patients with rheumatoid arthritis receiving infliximab treatment. (2010)
  • Author(s): Kanayama Y, Kojima T, Hirano Y, Shioura T, Hayashi M, Funahashi K, Ishiguro N
  • Journal Title: Mod Rheumatol Volume: 20(3) Pages: 273-279
  • NAID: 10027169366
  • Peer Reviewed
• [Journal Article] Influences of anti-tumour necrosis factor agents on postoperative recovery in patients with rheumatoid arthritis. (2010)
  • Author(s): Hirano Y, Kojima T, Kanayama Y, Shioura T, Hayashi M, Kida D, Kaneko A, Eto Y, Ishiguro N
  • Journal Title: Clin Rheumatol. Volume: 29(5) Pages: 495-500
  • Peer Reviewed
• [Journal Article] Exploring the link between depression and rheumatoid arthritis : prospects for optimal therapeutic success. (2010)
  • Author(s): Kojima M, Kojima T, Ishiguro N, Furukawa T.
  • Journal Title: Int. J. Clin Volume: 5 Pages: 273-275
  • Peer Reviewed
• [Journal Article] Radiographic analysis of movements of the acetabulum and the femoral head after Salter innominate osteotomy (2009)
  • Author(s): Kitoh H, Kaneko H, Ishiguro N
  • Journal Title: J Pediatr Orthop Volume: 29(8) Pages: 879-84
  • Peer Reviewed
• [Journal Article] Psychosocial factors, disease status, and quality of life in patients with rheumatoid arthritis (2009)
  • Author(s): Kojima M, Kojima T, Ishiguro N, OguchiT, Oba M, Tsuchiya H, Sugiura F, Furukawa TA, Suzuki S, Tokudome S
  • Journal Title: J Psychosom Res Volume: 67(5) Pages: 425-31
  • Peer Reviewed
• [Journal Article] Differential effects of culture-expanded bone marrow cells on the regeneration of bone between the femoral and the tibial lengthenings (2009)
  • Author(s): Kitoh H, Kawasumi M, Kaneko H, Ishiguro N
  • Journal Title: J Pediatr Orthop Volume: 29(6) Pages: 643-9
  • Peer Reviewed
• [Journal Article] Predictive factors for unsuccessful treatment of developmental dysplasia of the hip by the Pavlik harness (2009)
  • Author(s): Kitoh H, Kawasumi M, Ishiguro N
  • Journal Title: J Pediatr Orthop Volume: 29(6) Pages: 552-7
  • Peer Reviewed
• [Journal Article] Radiographic analysis of movements of the acetabulum and the femoral head after Salter innominate osteotomy (2009)
  • Author(s): Kitoh H, Kaneko H, Ishiguro N
  • Journal Title: J Pediatr Orthop. 29(8) Pages: 879-884
  • Peer Reviewed
• [Journal Article] Differential effects of culture-expanded bone marrow cells on the regeneration of bone between the femoral and the tibial lengthenings (2009)
  • Author(s): Kitoh H, Kawasumi M, Kaneko H, Ishiguro N.
  • Journal Title: J Pediatr Orthop 29(6) Pages: 643-649
  • Peer Reviewed
• [Journal Article] A case of lung tuberculosis in a patient with rheumatoid arthritis treated with infliximab after anti-tuberculosis chemoprophylaxis with isoniazid (2009)
  • Author(s): Yuji Hirano, Toshihisa Kojima, Yasuhide Kanayama, Hisato Ishikawa, Naoki Ishiguro
  • Journal Title: Modern Rheumatology 19(3) Pages: 323-328
  • NAID: 10025113203
  • Peer Reviewed
• [Presentation] 十字靭帯再建用ガイドシステムBullseye(r)を用いた解剖学的二重束前十字靭帯再建術の小経験 (2012)
  • Author(s): 平岩秀樹、酒井忠博、濱田恭、大間知孝顕、中島基成、石塚真哉、松川哲也、小田智之、高松晃、山下暁士、石黒直樹
  • Organizer: 第18回東海関節鏡研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-01-21
• [Presentation] 外反ストレステスト陽性を呈した肘関節後内側インピンジメント症候群 (2012)
  • Author(s): 高松晃、酒井忠博、平岩秀樹、濱田恭、大間知孝顕、中島基成、松川哲也、石塚真哉、小田智之、、山下暁士、石黒直樹
  • Organizer: 第18回東海関節鏡研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-01-21
• [Presentation] 滑膜骨軟骨腫症による変形性肩関節症の1例 (2012)
  • Author(s): 大間知孝顕、酒井忠博、平岩秀樹、濱田恭、中島基成、石塚真哉、松川哲也、小田智之、高松晃、山下暁士、石黒直樹
  • Organizer: 第18回東海関節鏡研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-01-21
• [Presentation] 当院における解剖学的後十字靭帯二重束再建術について (2012)
  • Author(s): 濱田恭、酒井忠博、平岩秀樹、大間知孝顕、中島基成、松川哲也、石塚真哉、小田智之、高松晃、山下暁士、石黒直樹
  • Organizer: 第18回東海関節鏡研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-01-21
• [Presentation] Ectopic Ossification in the Regenerated Tissue at the Tendon Defect Site (2012)
  • Author(s): Omachi, T; Sakai, T; Hiraiwa, H; Hamada, T; Ohno, Y; Nakashima, M; Ishizuka, S; Matsukawa, T; Oda, T; Takamatsu, A; Yamashita, S; Ishiguro, N
  • Organizer: 2012 Annual Meeting of Orthopaedic Research Society
  • Place of Presentation: サンフランシスコ
• [Presentation] Increased expression of Hypoxia-inducible factor-2α in Osteoarthritic meniscus cells (2012)
  • Author(s): Ishizuka, S; Sakai, T; Hiraiwa, H; Hamada, T; Ohmachi, T; Nakashima, M; Ohno, Y; Matsukawa, T; Oda T; Takamatsu A; Yamashita S; Ishiguro, N
  • Organizer: 2012 Annual Meeting of Orthopaedic Research Society
  • Place of Presentation: サンフランシスコ
• [Presentation] The effects of S100A12 in the pathogenesis of osteoarthritis (2012)
  • Author(s): Nakashima, M, Sakai, T, Hiraiwa, H, Hamada, T, Omachi, T, Ohno, Y, Ishizuka, S, Matsukawa, T, Oda, T, Takamatsu, A, Yamashita S, Ishiguro, N
  • Organizer: 2012 Annual Meeting of Orthopaedic Research Society
  • Place of Presentation: サンフランシスコ
• [Presentation] 人OA細胞におけるMicroRNA-125bによるAggrecanase-1(ADAMTS4)の発現制御 (2012)
  • Author(s): 松川哲也、酒井忠博、平岩秀樹、濱田恭、大間知孝顕、中島基成,石塚真哉、小田智之、高松晃、山下暁士、石黒直樹
  • Organizer: 第25回日本軟骨代謝学会
  • Place of Presentation: 名古屋
• [Presentation] 変形性関節症(OA)半月板細胞におけるHypoxia-inducible facyor-2α(HIF-2α)の発現増加 (2012)
  • Author(s): 石塚真哉、酒井忠博、平岩秀樹、濱田恭、大間知孝顕、中島基成、松川哲也,小田智之, 高松晃、山下暁士、石黒直樹
  • Organizer: 第25回日本軟骨代謝学会
  • Place of Presentation: 名古屋
• [Presentation] microRNA-23b、27bはOAの軟骨細胞においてhypoxia-inducible factor-2α(HIF2-α)及び軟骨内骨化関連遺伝子の発現を制御する (2012)
  • Author(s): 石塚真哉、酒井忠博、平岩秀樹、濱田恭、大間知孝顕、中島基成、松川哲也、小田智之,高松晃、山下暁士、石黒直樹
  • Organizer: 第25回日本軟骨代謝学会
  • Place of Presentation: 名古屋
• [Presentation] 変形性関節症の発生機序におけるS100A12タンパクの影響 (2012)
  • Author(s): 中島基成、酒井忠博、平岩秀樹、濱田恭、大間知孝顕、石塚真哉、松川哲也、小田智之、高松晃、山下暁士、石黒直樹
  • Organizer: 第25回日本軟骨代謝学会
  • Place of Presentation: 名古屋
• [Presentation] 関節リウマチ患者における血中II型コラーゲン分解産物の軟骨破壊マーカーとしての意義 (2011)
  • Author(s): 小嶋俊久、林真利、舟橋康治、加藤大三、松原浩之、石黒直樹、J.S.Mort、A.R.Poole
  • Organizer: 第26回日本整形外科学会基礎学術集会
  • Place of Presentation: 前橋
  • Year and Date: 2011-10-21
• [Presentation] 軟骨無(低)形成症の身体的特徴 (2011)
  • Author(s): 鬼頭浩史、金子浩史、馬渕晃好、三島健一、石黒直樹
  • Organizer: 第26回東海小児整形外科懇話会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-02-19
• [Presentation] 生物学的製剤の種類と外科治療のリスク (2011)
  • Author(s): 石黒直樹,小嶋俊久
  • Organizer: 第55回日本リウマチ学会
  • Place of Presentation: 神戸
• [Presentation] 進行性骨化性線維異形成症における早期(骨化発症前)の臨床的、X線学的特徴 (2011)
  • Author(s): 鬼頭浩史、三島健一、金子浩史、石黒直樹
  • Organizer: 第84回日本整形外科学会
  • Place of Presentation: 横浜
• [Presentation] ペルテス病の治療成績に関連する因子の検討 (2011)
  • Author(s): 鬼頭浩史、金子浩史、北小路隆彦、服部義、石黒直樹.
  • Organizer: ペルテス病の治療成績に関連する因子の検討
  • Place of Presentation: 諏訪
• [Presentation] 服部義.重度大腿骨頭すべり症に対する創外固定法による骨切り術.プレート法との比較. (2011)
  • Author(s): 鬼頭浩史、金子浩史、馬渕晃好、三島健一、松下雅樹、石黒直樹、北小路隆彦
  • Organizer: 第22回日本小児整形外科学会
  • Place of Presentation: 京都
• [Presentation] Ryuichiro Yamamoto, Naoki Ishiguro, Kinji Ohno (2011)
  • Author(s): Hiroshi Kaneko, Hiroshi Kitoh
  • Organizer: Annual Meeting of the Orthopaedic Research Society
  • Place of Presentation: LongBeach(USA)
• [Presentation] 膝蓋骨不安定症患者と正常人のTT-TG値の比較検討 (2011)
  • Author(s): 平岩秀樹、塚原隆司、酒井忠博、濱田恭、大間知孝顕、山本隆一郎、大野洋平、中島基成、石塚真哉、松川哲也、石黒直樹
  • Organizer: 第3回日本関節鏡・膝・スポーツ整形外科学会
  • Place of Presentation: 札幌
• [Presentation] CTを用いたACL損傷膝における伸展および回旋アライメントの評価 (2011)
  • Author(s): 平岩秀樹、塚原隆司、酒井忠博、濱田恭、大間知孝顕、山本隆一郎、大野洋平、中島基成、石塚真哉、松川哲也、石黒直樹
  • Organizer: 第3回日本関節鏡・膝・スポーツ整形外科学会
  • Place of Presentation: 札幌
• [Presentation] 異常可動性外側半月板の鏡視下縫合術後に外側半月板の断裂を起こした1例 (2011)
  • Author(s): 濱田恭、塚原隆司、河合亮輔、酒井忠博、平岩秀樹、山本隆一郎、大間知孝顕、中島基成、大野洋平、石塚真哉、松川哲也、石黒直樹
  • Organizer: 第3回日本関節鏡・膝・スポーツ整形外科学会
  • Place of Presentation: 札幌
• [Presentation] ポータブルX線透視装置を用いたACL再建術前後の膝伸展位矢状面アライメント評価 (2011)
  • Author(s): 大野洋平、塚原隆司、酒井忠博、平岩秀樹、河合亮輔、濱田恭、山本隆一郎、大間知孝顕、中島基成、石黒直樹
  • Organizer: 第3回日本関節鏡・膝・スポーツ整形外科学会
  • Place of Presentation: 札幌
• [Presentation] MPFL再建+脛骨粗面移行術後の膝蓋骨高位に関するX線学的検討 (2011)
  • Author(s): 松川哲也、平岩秀樹、酒井忠博、濱田恭、山本隆一郎、大間知孝顕、大野洋平、中島基成、石塚真哉、石黒直樹
  • Organizer: 第3回日本関節鏡・膝・スポーツ整形外科学会
  • Place of Presentation: 札幌
• [Presentation] The role of cathepsin K on IL-1-induced degradation of type II collagen in explants culture of human cartilage with measurement of cathepsin K-generated specific site (2011)
  • Author(s): Toshihisa Kojima, Naoki Ishiguro, John S Mort, Anthony R Poole
  • Organizer: 2011 Annual Meeting of the Orthopaedic Research Society
  • Place of Presentation: Long Beach (USA)
• [Presentation] 骨系統疾患に対する培養骨髄細胞移植を併用した骨延長術 (2010)
  • Author(s): 鬼頭浩史、金子浩史、石黒直樹
  • Organizer: 第83回日本整形外科学会
  • Place of Presentation: 東京
  • Year and Date: 2010-05-30
• [Presentation] 培養骨髄細胞移植を併用した骨延長術 (2010)
  • Author(s): 鬼頭浩史、金子浩史、石黒直樹
  • Organizer: 第83回日本整形外科学会
  • Place of Presentation: 東京
• [Presentation] 三角筋拘縮症に合併した反復性肩関節脱臼の1例 (2010)
  • Author(s): 酒井忠博、平岩秀樹、濱田恭、山本隆一郎、大間知孝顕、大野洋平、中島基成、石塚真哉、松川哲也、石黒直樹
  • Organizer: 第37回日本肩関節学会
  • Place of Presentation: 仙台
• [Presentation] 人工関節置換術を施行した関節リウマチ患者の治療状況-全国10000例の横断的疫学調査より- (2010)
  • Author(s): 小嶋俊久,石黒直樹,萩野昇,森美賀子,山本一彦,宮坂信之,山中寿,竹内勤,當間重人
  • Organizer: 第83回日本整形外科学会学術総会
  • Place of Presentation: 東京
• [Presentation] 本邦におけるエタネルセプトの使用状況-関節リウマチ10427例の横断調査より- (2010)
  • Author(s): 小嶋俊久,石黒直樹,萩野昇,後藤美賀子,山本一彦,宮坂信之,山中寿,竹内勤,當間重人
  • Organizer: 第54回日本リウマチ学会総会学術集会
  • Place of Presentation: 神戸
• [Presentation] RAに対するアダリムマブの臨床成績-生物学的製剤未投与例と他製剤からの変更例の比較- (2010)
  • Author(s): 平野裕司,大石幸由,小嶋俊久,石黒直樹,金子敦史
  • Organizer: 第54回日本リウマチ学会総会
  • Place of Presentation: 神戸
• [Presentation] Poole Robin変形性関節症の病態と治療:治療法のup to date (2009)
  • Author(s): 石黒直樹、小嶋俊久
  • Organizer: 第82回日本整形外科学会学術総会
  • Place of Presentation: 福岡
• [Presentation] 培養骨髄細胞移植による仮骨形成促進効果の移植部位による相違:大腿骨延長と骨延長の比較 (2009)
  • Author(s): 鬼頭浩史、川澄本明、石黒直樹
  • Organizer: 第82回日本整形外科学会学術総会
  • Place of Presentation: 福岡
• [Presentation] Perthes病におけるSalter手術 (2009)
  • Author(s): 北小路隆彦、服部義、三島健一、鬼頭浩史、石黒直樹
  • Organizer: 第82回日本整形外科学会学術総会
  • Place of Presentation: 福岡
• [Book] 今日の診断指針第6版II疾患編16運動器疾患変形性膝関節症 (2010)
  • Author(s): 石黒直樹、中村茂, 他
  • Publisher: 医学書院
• [Book] 今日の診断指針第6版 (2010)
  • Author(s): 石黒直樹, 他
  • Total Pages: 2144
  • Publisher: 医学書院
• [Patent(Industrial Property Rights)] 骨形成促進剤及びその用途 (2011)
  • Inventor(s): 大野欽司、石黒直樹、鬼頭浩史、三島健一
  • Industrial Property Rights Holder: 国立大学法人名古屋大学
  • Filing Date: 2011-08-26
  • Overseas
• [Patent(Industrial Property Rights)] 骨形成促進剤及びその用途 (2011)
  • Inventor(s): 大野欽司, 石黒直樹, 鬼頭浩史, 他
  • Industrial Property Rights Holder: 国立大学法人名古屋大学
  • Filing Date: 2011-08-26
• [Patent(Industrial Property Rights)] 生体材料製骨材・セメント複合体及びセメント硬化体 (2010)
  • Inventor(s): 寺岡啓、石黒直樹、松山幸弘
  • Industrial Property Rights Holder: 独立行政法人産業技術総合研究所、石黒直樹, 他
  • Acquisition Date: 2010-06-25