Molecular mechanisms of regulation in locomotive tissues

• Project/Area Number: 21390423
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Saitama Medical University
• Principal Investigator: KATAGIRI Takenobu 埼玉医科大学, 医学部, 教授 (80245802)
• Co-Investigator(Kenkyū-buntansha): FUKUDA Toru 慶應大学, 医学部, 助教 (20301492) ; OHTE Satoshi 埼玉医科大学, 医学部, 助教 (00547979) ; SASANUMA Hiroki 埼玉医科大学, 医学部, 研究員 (30571707) ; YONEYAMA Katsumi 埼玉医科大学, 医学部, 助手 (20571574) ; SHIN Masashi 埼玉医科大学, 医学部, 研究員 (70549261) ; JIMI Eijiro 九州歯科大学, 歯学部, 教授 (40276598)
• Co-Investigator(Renkei-kenkyūsha): AKITA Masumi 埼玉医科大学, 医学部, 教授 (60105905)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000); Fiscal Year 2011: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2009: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
• Keywords: 再生 / 蛋白質 / 筋芽細胞 / 細胞・組織 / 骨形成 / 骨芽細胞 / 分化 / 筋 / 骨組織

Research Abstract

We studied molecular mechanisms of heterotopic bone formation induced by bone morphogenetic protein(BMP) signaling in C2C12 myoblasts. The Smad-dependent pathway plays critical roles for both an induction of osteoblast differentiation and inhibition of myogenesis. The Smad-dependent signaling was suppressed by Zranb2 or DRAGON. In patients with fibrodysplasia ossificans progressiva(FOP), one of BMP receptors, ALK2, was genetically mutated and activated the Smad-dependent signaling regardless of the binding to BMPs.

Research Products

• [Journal Article] Recent topics in fibrodysplasia ossificans progressiva (2012)
  • Author(s): Katagiri T
  • Journal Title: J Oral Biosci Volume: (in press)
  • Peer Reviewed
• [Journal Article] Identification and functional analysis of Zranb2 as a novel Smad-binding protein that suppresses BMP signaling (2012)
  • Author(s): Ohte S
  • Journal Title: J Cell Biochem Volume: 113 Issue: 3 Pages: 808-814
  • DOI: 10.1002/jcb.23408
  • Peer Reviewed
• [Journal Article] Disease-causing allele specific silencing against the ALK2 mutants, R206H and G356D, in Fibrodysplasia Ossificans Progressiva (2012)
  • Author(s): Takahashi M
  • Journal Title: Gene Ther Volume: 31 Issue: 7 Pages: 3019-3028
  • DOI: 10.1038/gt.2011.193
  • Peer Reviewed
• [Journal Article] BMP3 suppresses osteoblast differentiation of bone marrow stromal cells via interaction with Acvr2b (2012)
  • Author(s): Kokabu S
  • Journal Title: Mol Endocrinol Volume: 26 Issue: 1 Pages: 87-94
  • DOI: 10.1210/me.2011-1168
  • Peer Reviewed
• [Journal Article] Accumulation of p100, a precursor of NF-κB2, enhances osteoblastic differentiation in vitro and bone formation in vivo in aly/aly mice (2012)
  • Author(s): Seo Y
  • Journal Title: Mol Endocrinol Volume: 26 Issue: 3 Pages: 414-422
  • DOI: 10.1210/me.2011-1241
  • Peer Reviewed
• [Journal Article] Identification and functional analysis of Zranb2 as a novel Smad-binding protein that suppresses BMP signaling (2011)
  • Author(s): Ohte S, Kokabu S, Iemura S, Sasanuma H, Yoneyama K, Shin M, Suzuki S, Fukuda T, Nakamura Y, Jimi E, Natsume T, and Katagiri T
  • Journal Title: J Cell Biochem Volume: 113 Pages: 808-814
  • Peer Reviewed
• [Journal Article] A novel mutation of ALK2, L196P, found in the most benign case of fibrodysplasia ossificans progressiva activates BMP-specific intracellular signaling equivalent to a typical mutation, R206H (2011)
  • Author(s): Ohte S, Shin M, Sasanuma H, Yoneyama K, Akita M, Ikebuchi K, Jimi E, Maruki Y, Matsuoka M, Nanba A, Tomoda H, Okazaki Y, Ohtake A, Oda H, Owan I, Yoda T, Furuya H, Kamizono J, Kitoh H, Nakashima Y, Susami T, Haga N, Komori T and Katagiri T
  • Journal Title: Biochem Biophys Res Commun Volume: 407 Pages: 213-218
  • Peer Reviewed
• [Journal Article] Suppression of BMP-Smad axis-induced osteoblastic differentiation by small C-terminal domain phosphatase 1, a Smad phosphatase (2011)
  • Author(s): Kokabu S, Ohte S, Sasanuma H, Shin M, Yoneyama K, Murata E, Kanomata K, Nojima J, Ono Y, Yoda T, Fukuda T, and Katagiri T
  • Journal Title: Mol Endocrinol Volume: 25 Pages: 474-481
  • Peer Reviewed
• [Journal Article] Chondrocyte-Specific MicroRNA-140 Regulates endochondral bone development and targets Dnpep to modulate BMP signaling (2011)
  • Author(s): Nakamura Y
  • Journal Title: Mol Cell Biol Volume: 31 Issue: 14 Pages: 3019-3028
  • DOI: 10.1128/mcb.05178-11
  • Peer Reviewed
• [Journal Article] BMP signaling permits population expansion by preventing premature myogenic differentiation in muscle satellite cells. (2011)
  • Author(s): Ono Y.
  • Journal Title: Cell Death Differ Volume: 18 Pages: 222-234
  • Peer Reviewed
• [Journal Article] Early clinical and radiological characteristics in fibrodysplasia ossificans progressiva. A report of two cases. (2011)
  • Author(s): Mishima K.
  • Journal Title: J Bone Joint Surg Volume: (In press)
  • Peer Reviewed
• [Journal Article] Suppression of BMP-Smad axis-induced osteoblastic differentiation by small C-terminal domain phosphatase 1, a Smad phosphatase. (2011)
  • Author(s): Kokabu S.
  • Journal Title: Mol Endocrinol Volume: 25 Pages: 474-481
  • Peer Reviewed
• [Journal Article] A novel mutation of ALK2, L196P, found in the most benign case of fibrodysplasis ossificans progressiva activates BMP-specific intracellular signaling equivalent to a typical mutation, R206H. (2011)
  • Author(s): Ohte S.
  • Journal Title: Biochem Biophys Res Commun Volume: 407 Pages: 213-128
  • Peer Reviewed
• [Journal Article] Lactacystin, a proteasome inhibitor, enhances BMP-induced osteoblastic differentiation by increasing active Smads. (2011)
  • Author(s): Ito Y.
  • Journal Title: Biochem Biophys Res Commun Volume: 407 Pages: 225-229
  • Peer Reviewed
• [Journal Article] Canonical Wnts and BMPs cooperatively induce osteoblastic differentiation through a GSK3・-dependent but a・-catenin-independent mechanism (2010)
  • Author(s): Fukuda T, Kokabu S, Ohte S, Sasanuma H, Kanomata K, Yoneyama K, Kato H, Akita M, Oda H, and Katagiri T
  • Journal Title: Differentiation Volume: 80 Pages: 46-52
  • Peer Reviewed
• [Journal Article] Dual roles of Smad proteins in the conversion from myoblasts to osteoblastic cells by bone morphogenetic proteins (2010)
  • Author(s): Nojima J, Kanomata K, Takada Y, Fukuda T, Kokabu S, Ohte S, Takada T, Tsukui T, Yamamoto TS, SasanumaH, Yoneyama K, Ueno N, Okazaki Y, Kamijo R, Yoda T, and Katagiri T
  • Journal Title: J Biol Chem Volume: 285 Pages: 15577-15586
  • Peer Reviewed
• [Journal Article] Protein phosphatase magnesium-dependent 1Amediated inhibition of BMP signaling is independent of Smaddephosphorylation (2010)
  • Author(s): Kokabu S, Nojima J, Kanomata K, Ohte S, Yoda T, Fukuda T and Katagiri T
  • Journal Title: J Bone Miner Res Volume: 25 Pages: 653-660
  • Peer Reviewed
• [Journal Article] Heterotopic bone formation induced by bone morphogenetic protein signaling : fibrodysplasia ossificans progressiva (2010)
  • Author(s): Katagiri T
  • Journal Title: J Oral Biosci Volume: 52 Pages: 33-41
  • NAID: 10027105268
  • Peer Reviewed
• [Journal Article] Protein phosphatase magnesium-dependent 1A-mediated inhibition of BMP signaling is independent of Smad-dephosphorylation (2010)
  • Author(s): Kokabu S.
  • Journal Title: J Bone Miner Res Volume: 25 Pages: 653-660
  • Peer Reviewed
• [Journal Article] Dual roles of Smad proteins in the conversion from myoblasts to osteoblastic cells by bone morphogenetic proteins. (2010)
  • Author(s): Nojima J.
  • Journal Title: J Biol Chem Volume: 285 Pages: 15577-15586
  • Peer Reviewed
• [Journal Article] Canonical Wnts and BMPs cooperatively induce osteoblastic differentiation through a GSK3β-dependent but a β-catenin-independent mechanism. (2010)
  • Author(s): Fukuda T.
  • Journal Title: Differentiation Volume: 80 Pages: 46-52
  • Peer Reviewed
• [Journal Article] Id4, a new candidate gene for senile osteoporosis acts as a molecular switch promoting osteoblast differentiation. (2010)
  • Author(s): Tokuzawa Y.
  • Journal Title: PLoS Genet Volume: 6
  • Peer Reviewed
• [Journal Article] Deformity of the great toe in fibrodysplasia ossificans progressiva (2010)
  • Author(s): Nakashima Y.
  • Journal Title: J Orthop Sci Volume: 15 Pages: 804-809
  • Peer Reviewed
• [Journal Article] 進行性骨化性線維異形成症の歯科治療について (2010)
  • Author(s): 松崎哲
  • Journal Title: 歯界展望 Volume: 115 Pages: 556-557
• [Journal Article] 進行性骨化性線維異形成症(FOP)の発症メカニズム (2010)
  • Author(s): 片桐岳信
  • Journal Title: Clin Neurosci Volume: 28 Pages: 480-481
• [Journal Article] 進行性骨化性線維異形成症(FOP)の病態生理部門と新規治療法の開発 (2010)
  • Author(s): 片桐岳信
  • Journal Title: クリニカルカルシウム Volume: 20 Pages: 1204-1211
• [Journal Article] BMPと進行性骨化性線維異形成症 (2010)
  • Author(s): 片桐岳信
  • Journal Title: クリニカルカルシウム Volume: 20 Pages: 1510-1517
• [Journal Article] Heterotopic bone formation induced by bone morphogenetic protein signaling : fibrodysplasia ossificans progressiva (2010)
  • Author(s): 片桐岳信
  • Journal Title: J Oral Biosci 52 Pages: 33-41
  • NAID: 10027105268
  • Peer Reviewed
• [Journal Article] Protein phosphatase magnesium-dependent 1A-mediated inhibition of BMP signaling is independent of Smad-dephosphorylation (2010)
  • Author(s): Kokabu S.
  • Journal Title: J Bone Miner Res (In press)
  • Peer Reviewed
• [Journal Article] 進行性骨化性線維異形成症の歯科治療について (2010)
  • Author(s): 松崎哲
  • Journal Title: 歯界展望 (印刷中)
• [Journal Article] FOP(進行性骨化性線維異形成症) (2010)
  • Author(s): 片桐岳信
  • Journal Title: Arthritis 7 Pages: 158-163
• [Journal Article] 進行性骨化性線維異形成症(FOP)の発症メカニズムの解明と治療法 (2010)
  • Author(s): 片桐岳信
  • Journal Title: 日本未熟児新生児学会雑誌 22 Pages: 30-32
  • NAID: 10026440106
• [Journal Article] 進行性骨化性線維異形成症(FOP)の発症メカニズム (2010)
  • Author(s): 片桐岳信
  • Journal Title: Clin Neurosci (印刷中)
• [Journal Article] Constitutively activated ALK-2 and increased Smad1/5 cooperatively induce BMP signaling in fibrodysplasia ossificans progressiva (2009)
  • Author(s): Fukuda T, Kohda M, Kanomata K, Nojima J, Nakamura A, Kamizono J, Noguchi Y, Iwakiri K, Kondo T, Kurose J, Endo K, Awakura T, Fukushi J, Nakashima Y, Chiyonobu T, Kawara A, Nishida Y, Wada I, Akita M, Komori T, Nakayama K, Nanba A, Maruki Y, Yoda T, Tomoda H, Yu PB, Shore EM, Kaplan FS, Miyazono K, Matsuoka M, Ikebuchi K, Ohtake A, Oda H, Jimi E, Owan I, Okazaki Y, and Katagiri T
  • Journal Title: J Biol Chem Volume: 284 Pages: 7149-7156
  • Peer Reviewed
• [Journal Article] The fibrodysplasia ossificans progressiva R206H ACVR1 mutation activates BMP-independent chondrogenesis and zebrafish embryo ventralization (2009)
  • Author(s): Shen Q, Little SC, Xu M, Haupt J, Ast C, Katagiri T, Mundlos S, Seemann P, Kaplan FS, Mullins MC and Shore EM
  • Journal Title: J Clin Invest Volume: 119 Pages: 3462-3472
  • Peer Reviewed
• [Journal Article] DRAGON, a GPI-anchored membrane protein, inhibits BMP signaling in C2C12 myoblasts (2009)
  • Author(s): Kanomata K, Kokabu S, Nojima J, Fukuda T and Katagiri T
  • Journal Title: Genes Cells Volume: 14 Pages: 695-702
  • Peer Reviewed
• [Journal Article] Constitutively activated ALK-2 and increased Smad1/5 cooperatively induce BMP signaling in fibrodysplasia ossificans progressiva (2009)
  • Author(s): Fukuda T.
  • Journal Title: J Biol Chem 284 Pages: 7149-7156
  • Peer Reviewed
• [Journal Article] DRAGON, a GPI-anchored membrane protein, inhibits BMP signaling in C2C12 myoblasts (2009)
  • Author(s): Kanomata K.
  • Journal Title: Genes Cells 14 Pages: 695-702
  • Peer Reviewed
• [Journal Article] Fibrodysplasia ossificans progressiva ACVR1 R206H mutation activates ligand-in dependent and ligand-sensitive chondrogenesis and regulates zebrafish dorso-ventral patterning (2009)
  • Author(s): Shen Q.
  • Journal Title: J Clin Invest 119 Pages: 3462-3472
  • Peer Reviewed
• [Presentation] 筋肉が骨になるメカニズム (2011)
  • Author(s): 片桐岳信
  • Organizer: 第9回RCGMフロンティアシンポジウム
  • Place of Presentation: 埼玉県日高市
  • Year and Date: 2011-11-03
• [Presentation] 筋肉が骨になるメカニズム (2011)
  • Author(s): 片桐岳信
  • Organizer: 第9回RCGMフロンティアシンポジウム
  • Place of Presentation: 埼玉県日高市(招待講演)
  • Year and Date: 2011-11-03
• [Presentation] 進行性骨化性線維異形成症で同定されたALK2変異体とII型BMP受容体の相互作用解析 (2011)
  • Author(s): 大手聡
  • Organizer: 第9回RCGMフロンティアシンポジウム
  • Place of Presentation: 埼玉県日高市
  • Year and Date: 2011-11-03
• [Presentation] 筋サテライト細胞はBMPシグナルにより骨芽細胞様細胞へ分化する (2011)
  • Author(s): 笹沼寛樹
  • Organizer: 第9回RCGMフロンティアシンポジウム
  • Place of Presentation: 埼玉県日高市
  • Year and Date: 2011-11-03
• [Presentation] BMP初期応答遺伝子Id2,Id3におけるBMP応答配列の解析 (2011)
  • Author(s): 進正史
  • Organizer: 第9回RCGMフロンティアシンポジウム
  • Place of Presentation: 埼玉県日高市
  • Year and Date: 2011-11-03
• [Presentation] 構成的活性型Smad5及びSmad8の構築 (2011)
  • Author(s): 片桐岳信
  • Organizer: 第9回RCGMフロンティアシンポジウム
  • Place of Presentation: 埼玉県日高市
  • Year and Date: 2011-11-03
• [Presentation] 骨格筋組織の再生過程に関する組織学的研究 (2011)
  • Author(s): 米山克美
  • Organizer: 第9回RCGMフロンティアシンポジウム
  • Place of Presentation: 埼玉県日高市
  • Year and Date: 2011-11-03
• [Presentation] Smadの新規転写抑制因子Zranb2の同定と機能解析 (2011)
  • Author(s): 片桐岳信, 他
  • Organizer: 第53回歯科基礎医学会学術大会演
  • Place of Presentation: 岐阜県岐阜市
  • Year and Date: 2011-10-01
• [Presentation] BMPによる骨形成機序の解明と難病研究への展開 (2011)
  • Author(s): 片桐岳信
  • Organizer: 第53回歯科基礎医学会学術大会・総会ライオン学術賞受賞講演
  • Place of Presentation: 岐阜県岐阜市(招待講演)
  • Year and Date: 2011-10-01
• [Presentation] 初期応答遺伝子のIdファミリーにおけるBMP応答領域の同定 (2011)
  • Author(s): 進正史
  • Organizer: 第53回歯科基礎医学会学術大会演
  • Place of Presentation: 岐阜県岐阜市
  • Year and Date: 2011-10-01
• [Presentation] BMP3はAcvr2bを介して骨髄間質細胞の骨芽細胞分化を制御する (2011)
  • Author(s): 古株彰一郎
  • Organizer: 第53回歯科基礎医学会学術大会演
  • Place of Presentation: 岐阜県岐阜市
  • Year and Date: 2011-10-01
• [Presentation] NF-kB非古典的経路による骨形成の抑制 (2011)
  • Author(s): 妹尾吉訓
  • Organizer: 第53回歯科基礎医学会学術大会演
  • Place of Presentation: 岐阜県岐阜市
  • Year and Date: 2011-10-01
• [Presentation] 新規Smad結合分子Zranb2はBMPシグナル抑制因子である (2011)
  • Author(s): 大手聡, 他
  • Organizer: 第18回BMP研究会
  • Place of Presentation: 大阪府大阪市
  • Year and Date: 2011-07-31
• [Presentation] 筋が骨化する難病進行性骨化性線維異形成症 (2011)
  • Author(s): 片桐岳信
  • Organizer: 第29回日本骨代謝学会学術集会
  • Place of Presentation: 大阪府大阪市
  • Year and Date: 2011-07-29
• [Presentation] 筋が骨化する難病進行性骨化性線維異形成症 (2011)
  • Author(s): 片桐岳信
  • Organizer: 第29回日本骨代謝学会学術集会
  • Place of Presentation: 大阪府大阪市(招待講演)
  • Year and Date: 2011-07-29
• [Presentation] 筋の中に骨ができる (2011)
  • Author(s): 片桐岳信
  • Organizer: 第1回彩の国骨フォーラム
  • Place of Presentation: 埼玉県入間郡毛呂山町(招待講演)
  • Year and Date: 2011-06-30
• [Presentation] Heterotopic bone formation and muscle regeneration (2011)
  • Author(s): Katagiri T
  • Organizer: 32nd Annual Meeting of Japanese Society of Inflammation and Regeneration
  • Place of Presentation: 京都府京都市
  • Year and Date: 2011-06-03
• [Presentation] Heterotopic bone formation and muscle regeneration (2011)
  • Author(s): Katagiri T
  • Organizer: 32nd Annual Meeting of Japanese Society of Inflammation and Regeneration
  • Place of Presentation: 京都府京都市(招待講演)
  • Year and Date: 2011-06-03
• [Presentation] BMP signaling inhibits myogenesis and induces osteoblastic differentiation in satellite cells during muscle regeneration (2011)
  • Author(s): Katagiri T, et al.
  • Organizer: ASBMR 2011 Annual Meeting
  • Place of Presentation: San Diego, California, U. S. A.
• [Presentation] BMP type II receptors further stimulate constitutively activated mutant ALK2 found in fibrodysplasia ossificans progressiva (2011)
  • Author(s): Ohte S, et al.
  • Organizer: ASBMR 2011 Annual Meeting
  • Place of Presentation: San Diego, California, U. S. A.
• [Presentation] Molecular mechanisms of heterotopic bone formation in skeletal muscle induced by BMP signaling (2011)
  • Author(s): Katagiri T, et al.
  • Organizer: Gordon Research Conference on Myogenesis
  • Place of Presentation: Waterville Valley, New Hampshire, U. S. A.
• [Presentation] 進行性骨化性線維異形成症(FOP)で同定されたALK2はII型BMP受容体によってさらに活性化される (2011)
  • Author(s): 大手聡, 他
  • Organizer: 第29回日本骨代謝学会学術集会
  • Place of Presentation: 大阪府大阪市
• [Presentation] Characterization of mutant forms of ALK2 found in patients with fibrodysplasia ossificans progressiva (2011)
  • Author(s): Katagiri T
  • Organizer: Gordon Research Conference on Myogenesis
  • Place of Presentation: Les Diablerets, Switzerland
• [Presentation] 骨格筋の再生と異所性骨化におけるサテライト細胞に対するBMPシグナルの役割 (2011)
  • Author(s): 笹沼寛樹
  • Organizer: 第29回日本骨代謝学会学術集会
  • Place of Presentation: 大阪府大阪市
• [Presentation] BMP初期応答遺伝子におけるBMP応答配列の解析 (2011)
  • Author(s): 進正史
  • Organizer: 第29回日本骨代謝学会学術集会
  • Place of Presentation: 大阪府大阪市
• [Presentation] Molecular mechanisms of heterotopic bone formation in skeletal muscle induced by BMP signaling (2011)
  • Author(s): Katagiri T
  • Organizer: Gordon Research Conference on Myogenesis
  • Place of Presentation: Waterville Valley, New Hampshire, U.S.A.
• [Presentation] BMP3 suppresses osteoblast differentiation of bone marrow stromal cells via interacting with Acvr2b (2011)
  • Author(s): Kokabu S
  • Organizer: ASBMR 2011 Annual Meeting
  • Place of Presentation: San Diego, California, U.S.A.
• [Presentation] BMP type II receptors further stimulate constitutively activated mutant ALK2 found in fibrodysplasia ossificans progressiva (2011)
  • Author(s): Ohte S
  • Organizer: ASBMR 2011 Annual Meeting
  • Place of Presentation: San Diego, California, U.S.A.
• [Presentation] BMP signaling inhibits myogenesis and induces osteoblastic differentiation in satellite cells during muscle regeneration (2011)
  • Author(s): Katagiri T
  • Organizer: ASBMR 2011 Annual Meeting
  • Place of Presentation: San Diego, California, U.S.A.
• [Presentation] Identification of a common BMP-responsive element in the Id1, Id2 and Id3 genes (2011)
  • Author(s): Shin M
  • Organizer: ASBMR 2011 Annual Meeting
  • Place of Presentation: San Diego, California, U.S.A.
• [Presentation] NF-kB, p65サブユニットはSmad4と会合し、SmadのDNA結合を抑制することでBMPシグナルによる骨芽細胞分化を抑制する (2011)
  • Author(s): 自見英治郎
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 神奈川県横浜市
• [Presentation] BMP-Smadによる筋組織での異所性骨化 (2010)
  • Author(s): 片桐岳信
  • Organizer: 第14回九州歯科大学骨分子生物学セミナー
  • Place of Presentation: 福岡
  • Year and Date: 2010-12-30
• [Presentation] BMP-Smadによる細胞分化の制御 (2010)
  • Author(s): 片桐岳信
  • Organizer: 昭和大学歯学部口腔生化学セミナー
  • Place of Presentation: 東京
  • Year and Date: 2010-11-26
• [Presentation] 骨形成を促すBMP細胞内情報伝達系とその制御機構の解明 (2010)
  • Author(s): 片桐岳信
  • Organizer: 第8回RCGMフロンティア国際シンポジウム
  • Place of Presentation: 埼玉県
  • Year and Date: 2010-11-03
• [Presentation] 骨形成を促すBMP細胞内情報伝達系とその制御機構の解明 (2010)
  • Author(s): 片桐岳信
  • Organizer: 骨形成を促すBMP細胞内情報伝達系とその制御機構の解明.第8回RCGMフロンティア国際シンポジウム
  • Place of Presentation: 埼玉
  • Year and Date: 2010-11-03
• [Presentation] 新規Smad結合分子Zranb2はBMPシグナル抑制因子である (2010)
  • Author(s): 大手聡
  • Organizer: 第8回RCGMフロンティア国際シンポジウム
  • Place of Presentation: 埼玉
  • Year and Date: 2010-11-03
• [Presentation] 骨芽細胞分化におけるBMPとWntシグナルの相互作用の解明 (2010)
  • Author(s): 笹沼寛樹
  • Organizer: 第8回RCGMフロンティア国際シンポジウム
  • Place of Presentation: 埼玉
  • Year and Date: 2010-11-03
• [Presentation] SCP1はBMP誘導性の骨芽細胞分化においてSmadの下流因子を抑制する (2010)
  • Author(s): 進正史
  • Organizer: 第8回RCGMフロンティア国際シンポジウム
  • Place of Presentation: 埼玉
  • Year and Date: 2010-11-03
• [Presentation] SmadホスファターゼによるBMP誘導性骨芽細胞分化の抑制機序 (2010)
  • Author(s): 片桐岳信
  • Organizer: 第52回歯科基礎医学会学術大会
  • Place of Presentation: 東京都
  • Year and Date: 2010-09-22
• [Presentation] Smadホスファターゼに夜冷え誘導性骨芽細胞分化の抑制機序 (2010)
  • Author(s): 片桐岳信
  • Organizer: 第52回歯科基礎医学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2010-09-22
• [Presentation] 口腔がん細胞の顎骨浸潤におけるBMPシグナル活性化の役割 (2010)
  • Author(s): 進正史
  • Organizer: 第52回歯科基礎医学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2010-09-21
• [Presentation] 筋の中に骨ができる難病・進行性骨化性線維異形成症 (2010)
  • Author(s): 片桐岳信
  • Organizer: 第39回骨・カルシウム代謝研究会
  • Place of Presentation: 京都
  • Year and Date: 2010-09-03
• [Presentation] 血小板第4因子は血中の新規BMP活性促進因子である (2010)
  • Author(s): 片桐岳信
  • Organizer: 第28回日本骨代謝学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2010-07-22
• [Presentation] 新規Smad結合分子Zranb2の同定とBMPシグナル阻害因子の解析 (2010)
  • Author(s): 大手聡
  • Organizer: 第28回日本骨代謝学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2010-07-21
• [Presentation] 筋組織内での異所性骨化と難病(FOP) (2010)
  • Author(s): 片桐岳信
  • Organizer: 第137回 藤田保健衛生大学医学セミナー
  • Place of Presentation: 愛知
  • Year and Date: 2010-04-23
• [Presentation] Identification of Zranb2, a novel R-Smads binding protein, as a suppressor of BMP signaling (2010)
  • Author(s): Ohte S., et al.
  • Organizer: ASBMR(American Society for Bone and Mineral Research) 2010 annual meeting
  • Place of Presentation: カナダ、トロント
• [Presentation] PPM1A and SCP1, Smad phosphatases, inhibit BMP-induced osteoblastic differentiation by different molecular mechanisms (2010)
  • Author(s): Katagiri T, et al.
  • Organizer: 8th International Conference on Bone Morphogenetic Proteins
  • Place of Presentation: ベルギー、ルーベン
• [Presentation] Identification and characterization of a nuclear protein as a co-suppressor of BMP-regulated Smads (2010)
  • Author(s): Ohte S., et al.
  • Organizer: 8th International Conference on Bone Morphogenetic Proteins
  • Place of Presentation: ベルギー、ルーベン
• [Presentation] Potentiation of bone morphogenetic protein activity in the extracellular environment (2010)
  • Author(s): Katagiri T
  • Organizer: Gordon Research Conference on Signal Transduction by Tissue Engineered Extracellular Matrices
  • Place of Presentation: 米国メイン州
• [Presentation] Potentiation of bone morphogenetic protein activity in the extracellular environment. (2010)
  • Author(s): Katagiri T
  • Organizer: Gordon Research Conference on Signal Transduction by Tissue Engineered Extracellular Matrices
  • Place of Presentation: 米国メイン州
• [Presentation] PPM1A and SCP1, Smad phosphatases, inhibit BMP-induced osteoblastic differentiation by different molecular mechanisms. (2010)
  • Author(s): Katagiri T
  • Organizer: 8th International Conference on Bone Morphogenetic Proteins
  • Place of Presentation: ベルギー、ルーベン
• [Presentation] Identification and characterization of a nuclear protein as a co suppressor of BMP-regulated Smads (2010)
  • Author(s): Ohte S.
  • Organizer: 8th International Conference on Bone Morphogenetic Proteins
  • Place of Presentation: ベルギー、ルーベン
• [Presentation] Platelet factor 4 is a novel potentiator of BMP-induced osteoblastic differentiation and bone formation (2010)
  • Author(s): Katagiri T
  • Organizer: ASBMR (American Society for Bone and Mineral Research) 2010 annual meeting
  • Place of Presentation: カナダ、トロント
• [Presentation] Identification of Zranb2, a novel R-Smads binding protein, as a suppressor of BMP signaling (2010)
  • Author(s): Ohte S.
  • Organizer: ASBMR (American Society for Bone and Mineral Research) 2010 annual meeting
  • Place of Presentation: カナダ、トロント
• [Presentation] 難病・進行性骨化性繊維異形成症(FOP)の研究者から (2009)
  • Author(s): 片桐岳信
  • Organizer: FOP講演会
  • Place of Presentation: 福島
  • Year and Date: 2009-12-26
• [Presentation] 筋肉が骨になる難病・進行性骨化性線維異形成症(FOP) (2009)
  • Author(s): 片桐岳信
  • Organizer: 九州歯科大学最新生命科学
  • Place of Presentation: 福岡
  • Year and Date: 2009-12-15
• [Presentation] 筋組織における異所性骨化の機序解明と治療への応用 (2009)
  • Author(s): 片桐岳信
  • Organizer: 第7回RCGMフロンティアシンポジウム
  • Place of Presentation: 埼玉県
  • Year and Date: 2009-11-03
• [Presentation] 筋組織における異所性骨化の機序解明と治療への応用 (2009)
  • Author(s): 片桐岳信
  • Organizer: 第7回RCGMフロンティアシンポジウム
  • Place of Presentation: 埼玉
  • Year and Date: 2009-11-03
• [Presentation] 骨芽細胞におけるSmadとRunx2のクロストーク (2009)
  • Author(s): 大手聡
  • Organizer: 第7回RCGMフロンティアシンポジウム
  • Place of Presentation: 埼玉
  • Year and Date: 2009-11-03
• [Presentation] Smad1の骨芽細胞分化誘導活性はC末端とリンカー領域のリン酸化により制御される (2009)
  • Author(s): 古株彰一郎
  • Organizer: 第7回RCGMフロンティアシンポジウム
  • Place of Presentation: 埼玉
  • Year and Date: 2009-11-03
• [Presentation] 進行性骨化性線維異形成症(FOP)で同定されたALK2変異体の安定発現細胞の樹立 (2009)
  • Author(s): 塚本翔
  • Organizer: 第7回RCGMフロンティアシンポジウム
  • Place of Presentation: 埼玉
  • Year and Date: 2009-11-03
• [Presentation] Fibrodysplasia ossificans progressiva(FOP)で同定された10種類のALK2変異体の機能解析 (2009)
  • Author(s): 福田亨
  • Organizer: 第7回RCGMフロンティアシンポジウム
  • Place of Presentation: 埼玉
  • Year and Date: 2009-11-03
• [Presentation] BMPのSmad依存的シグナルによる筋芽細胞分化の抑制機構 (2009)
  • Author(s): 片桐岳信
  • Organizer: 第64回日本体力医学会大会
  • Place of Presentation: 新潟
  • Year and Date: 2009-09-19
• [Presentation] 筋組織内に異所性骨化を生じる遺伝性難病(Fibrodysplasia Ossificans Progressiva) (2009)
  • Author(s): 福田亨
  • Organizer: 運動器科学研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-09-18
• [Presentation] Smad1のリン酸化・脱リン酸化による骨芽細胞分化誘導の制御 (2009)
  • Author(s): 片桐岳信
  • Organizer: 第51回歯科基礎医学会学術集会・総会
  • Place of Presentation: 新潟
  • Year and Date: 2009-09-10
• [Presentation] Smad1のリン酸化・脱リン酸化による骨芽細胞分化誘導の制御 (2009)
  • Author(s): 古株彰一郎
  • Organizer: 第16回BMP研究会
  • Place of Presentation: 大阪
  • Year and Date: 2009-07-27
• [Presentation] Fibrodysplasia ossificans progressiva(FOP)で新たに同定されたALK2変異体の解析 (2009)
  • Author(s): 福田亨
  • Organizer: 第16回BMP研究会
  • Place of Presentation: 大阪
  • Year and Date: 2009-07-27
• [Presentation] Smad C末端のホスファターゼPPM1AとSCP1はリンカー領域のMAPKリン酸化部位を介してBMPシグナルを抑制する (2009)
  • Author(s): 古株彰一郎
  • Organizer: 第27回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-07-25
• [Presentation] Fibrodysplasia ossificans progressiva(FOP)で同定されたALK2変異体の解析 (2009)
  • Author(s): 福田亨
  • Organizer: 第27回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-07-25
• [Presentation] 筋肉が骨になる難病・進行性骨化性線維異形成症(FOP) (2009)
  • Author(s): 片桐岳信
  • Organizer: 第20回電顕サマースクール
  • Place of Presentation: 埼玉
  • Year and Date: 2009-07-24
• [Presentation] Roles of Smad pathways in the conversion of myoblasts to osteoblastic cells by BMPs. (2009)
  • Author(s): Katagiri T
  • Organizer: Gordon Research Conference on Bones & Teeth
  • Place of Presentation: 米国メイン州
  • Year and Date: 2009-07-15
• [Presentation] Roles of Smad pathways in the conversion of myoblasts to osteoblastic cells by BMPs (2009)
  • Author(s): 片桐岳信
  • Organizer: Gordon Research Conference on Bones & Teeth
  • Place of Presentation: 米国メイン州
  • Year and Date: 2009-07-15
• [Presentation] R-SmadのホスファターゼPPM1AによるBMP活性の抑制にはSmadの脱リン酸化に依存しない分解が重要である (2009)
  • Author(s): 古株彰一郎
  • Organizer: 第8回松本ボーンフォーラム
  • Place of Presentation: 長野
  • Year and Date: 2009-05-08
• [Presentation] Functional Analysis of Mutant ALK2 Receptors Found in Fibro dysplasia ossificans progressiva(FOP) (2009)
  • Author(s): 福田亨
  • Organizer: 31st ASBMR(American Society for Bone and Mineral Research)annual meeting
  • Place of Presentation: 米国コロラド州
• [Presentation] PPM1A and SCP1 suppress BMP activity via novel mechanism independent of Smad C-terminal dephosphorylation (2009)
  • Author(s): 古株彰一郎
  • Organizer: 31st ASBMR(American Society for Bone and Mineral Research)annual meeting
  • Place of Presentation: 米国コロラド州
• [Remarks]
  • URL: http://www.saitama-med.ac.jp/genome/Div04_PPhysiol/index.html
• [Remarks]
  • URL: http://www.saitama-med.ac.jp/genome/Div04_PPhysiol/index.html
• [Remarks]
  • URL: http://www.saitama-med.ac.jp/genome/Div04_PPhysiol/index.html
• [Remarks]
  • URL: http://www.saitama-med.ac.jp/genome/Div04_PPhysiol/index.html
• [Patent(Industrial Property Rights)] 骨分化阻害剤およびその製造方法 (2010)
  • Inventor(s): 供田洋,他
  • Industrial Property Rights Holder: 学校法人北里研究所、埼玉医科大学
  • Industrial Property Number: 2010-255134
  • Filing Date: 2010-11-15
• [Patent(Industrial Property Rights)] 骨分化阻害剤およびその製造方法 (2010)
  • Inventor(s): 供田洋, 他
  • Industrial Property Rights Holder: 学校法人北里研究所、埼玉医科大学
  • Industrial Property Number: 2010-255134
  • Filing Date: 2010-11-15