Tripartite relationship between osteoclasts, osteoblasts and osteocytes in bone remodeling

• Project/Area Number: 21390425
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Keio University
• Principal Investigator: MATSUO Koichi 慶應義塾大学, 医学部, 教授 (40229422)
• Co-Investigator(Kenkyū-buntansha): TAKADA Yasunari 慶應義塾大学, 医学部, 講師 (40407086)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000); Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2010: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000); Fiscal Year 2009: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
• Keywords: 破骨細胞 / 骨芽細胞 / 骨細胞 / 骨リモデリング / 骨吸収 / ephrin / Eph

Research Abstract

Bone remodeling is a process in which osteoclastic bone resorption is followed by bone formation by osteoblasts/osteocytes. In this study, we found that ephrinA2 produced by osteoclasts is a coupling inhibitor, which suppresses bone mineralization. Furthermore, Fra-1 transgenic mice, which show overproduction of bone matrix due to impaired bone remodeling exhibit pulmonary fibrosis.

Research Products

• [Journal Article] Osteocytes Communicate with Osteoclast Lineage Cells via RANKL (2012)
  • Author(s): Koichi Matsuo
  • Journal Title: IBMS BoneKEy 9 Volume: 39
  • DOI: 10.1038/bonekey.2012.36
  • Peer Reviewed
• [Journal Article] Interstitial lung disease induced by gefitinib and Toll-like receptor ligands is mediated by Fra-1 (2011)
  • Author(s): Yasunari Takada, Lionel Gresh, Aline Bozec, Eiji Ikeda, Kazunori Kamiya, Masazumi Watanabe, Koichi Kobayashi, Koichiro Asano, Yoshiaki Toyama, Erwin F. Wagner, Koichi Matsuo
  • Journal Title: Oncogene Volume: 30 Pages: 3821-3832
  • Peer Reviewed
• [Journal Article] 骨の破壊と再生 (2011)
  • Author(s): 松尾光一
  • Journal Title: 臨床検査 Volume: 55巻 Pages: 1497-1502
• [Journal Article] Interstitial lung disease induced by gefitinib and toll-like receptor ligands is mediated by Fra-1 (2011)
  • Author(s): Takada Y, Gresh L, Bozec A, Ikeda E, Kamiya K, Watanabe M, Kobayashi K, Asano K, Toyama Y, Wagner EF, Matsuo K
  • Journal Title: Oncogene Volume: 30 Issue: 36 Pages: 3821-32
  • DOI: 10.1038/onc.2011.101
  • Peer Reviewed
• [Journal Article] Impaired vibration of auditory ossicles in osteopetrotic mice (2011)
  • Author(s): Kanzaki S, et al.
  • Journal Title: Am J Pathol. Volume: 178 Pages: 1270-1278
  • Peer Reviewed
• [Journal Article] Interstitial lung disease induced by gefitinib and Toll-like receptor ligands is mediated by Fra-1 (2011)
  • Author(s): Takada Y., et al.
  • Journal Title: Oncogene Volume: (inpress)
  • Peer Reviewed
• [Presentation] The osteocyte canaliculi are the basis of mineral metabolism in cortical bone studied by a multi-scan method of X-ray microscope (2012)
  • Author(s): Nango, N., Kubota, S., Yashiro, W., Momose, A., Takada Y., Matsuo, K
  • Organizer: International Workshop on X-ray and Neutron Phase Imaging with Gratings(XNPIG)
  • Place of Presentation: Tokyo, Japan
• [Presentation] The osteocyte canaliculi are the basis of mineral metabolism in cortical bone studied by a multi-scan method of X-ray microscope (2012)
  • Author(s): Nango, N., Kubota, S., Yashiro, W., Momose, A., Takada Y., Matsuo, K.
  • Organizer: International Workshop on X-ray and Neutron Phase Imaging with Gratings (XNPIG)
  • Place of Presentation: 日本科学未来館(東京)
• [Presentation] Tks5-dependent formation of circumferential podosomes mediates cell. cell fusion (2011)
  • Author(s): Oikawa, T., Oyama, M., Kozuka-Hata, H., Uehara, S., Udagawa, N., Saya, H., and Matsuo, K
  • Organizer: Podosomes, Invadopodia and Focal Adhesions in Physiology and Pathology
  • Place of Presentation: Madrid, Spain
• [Presentation] Coupling factors : Lessons from Ephs and Ephrins (2011)
  • Author(s): Matsuo, K
  • Organizer: 33^<rd> Annual Meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: San Diego, USA
• [Presentation] Osteoclast-dependent canalicular formation in cortical bone that mediates bone remodeling (2011)
  • Author(s): Nango, N., Kubota, S., Yashiro, W., Momose, A., Takada, Y., Matsuo, K
  • Organizer: 33^<rd> Annual Meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: San Diego, USA
• [Presentation] Osteoprotegerin prevents infection-induced bone loss (2011)
  • Author(s): Takada, Y., Matsuo, K
  • Organizer: 33rd Annual Meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: San Diego, USA
• [Presentation] 3D visualization of osteocyte lacunae in the entire long bone (2011)
  • Author(s): Takeda, Y., Takada, Y., Omote, K., Matsuo, K
  • Organizer: 33^<rd> Annual Meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: San Diego, USA
• [Presentation] In vivo effect of bone-specific ephB4 overexpression in mice on subchondral bone and cartilage during osteoarthritis (2011)
  • Author(s): Valverde-Franco, G., Kapoor, M., Hum, D., Matsuo, K. Lussier, B. Pelletier, J.-P., Martel-Pelletier, J
  • Organizer: 33^<rd> Annual Meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: San Diego, USA
• [Presentation] 骨細胞による骨溶解について (2011)
  • Author(s): 松尾光一
  • Organizer: 第29回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
• [Presentation] Osteoprotegerinによる感染性骨破壊の抑制 (2011)
  • Author(s): 高田康成、松尾光一
  • Organizer: 第29回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
• [Presentation] 破骨細胞は骨細管形成に関与し、骨細管は皮質骨リモデリングへ関与する (2011)
  • Author(s): 南郷脩史、久保田省吾、矢代航、百生敦、松尾光一
  • Organizer: 第29回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
• [Presentation] Tks5によるポドソーム形成と破骨細胞融合メカニズム (2011)
  • Author(s): 及川司、尾山大明、秦裕子、佐谷秀行、松尾光一
  • Organizer: 第29回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
• [Presentation] Tks5-dependent formation of circumferential podosome mediates cell-cell fusion (2011)
  • Author(s): 及川司、尾山弘明、羽田裕子、佐谷秀行、松尾光一
  • Organizer: 第63回日本細胞生物学会大会
  • Place of Presentation: 札幌
• [Presentation] Osteoclasts affect hearing function and auditory ossicles (2011)
  • Author(s): Kanzaki, S., Takada, Y., Ogawa, K., Matsuo, K
  • Organizer: 10th international symposium : Recent Advances in Otitis Media
  • Place of Presentation: New Orleans, USA
• [Presentation] In vivo protective effect of EphB4 receptor overexpression on the pathophysiology of osteoarthritis (2011)
  • Author(s): Valverde-Franco, G., Kapoor, M., Hum, D., Matsuo, K., Lussier, B., Pelletier, J.-P., Martel-Pelletier, J
  • Organizer: EULAR-the European league against rheumatism-2011
  • Place of Presentation: London, UK
• [Presentation] In vivo protective effect of EphB4 receptor overexpression on the patho physiology of osteoarthritis (2011)
  • Author(s): G.Valverde-Franco, M.Kapoor, D.Hum, K.Matsuo, B.Lussier, J.-P.Pelletier, J.Martel-Pelletier
  • Organizer: EULAR-the European league against rheumatism
  • Place of Presentation: London, UK
• [Presentation] Coupling factors : Lessons from Ephs and Ephrins (2011)
  • Author(s): Matsuo, K
  • Organizer: 33rd Annual Meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: San Diego, USA(招待講演)
• [Presentation] Osteoclast-dependent canalicular formation in cortical bone that mediates bone remodeling (2011)
  • Author(s): Nango, N., Kubota, S., Yashiro, W., Momose, A., Takada, Y., Matsuo, K.
  • Organizer: 33rd Annual Meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: San Diego, USA
• [Presentation] 3D visualization of osteocyte lacunae in the entire long bone (2011)
  • Author(s): Takeda, Y., Takada, Y., Omote, K., Matsuo, K.
  • Organizer: 33rd Annual Meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: San Diego, USA
• [Presentation] In vivo effect of bone-specific ephB4 overexpression in mice on subchondral bone and cartilage during osteoarthritis (2011)
  • Author(s): Valverde-Franco, G., Kapoor, M., Hum, D., Matsuo, K.Lussier, B.Pelletier, J.-R, Martel-Pelletier, J.
  • Organizer: 33rd Annual Meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: San Diego, USA
• [Presentation] Tks5-dependent formation of circumferential podosomes mediates cell-cell fusion (2011)
  • Author(s): Oikawa, T., Oyama, M., Kozuka-Hata, H., Uehara, S., Udagawa, N., Saya, H., Matsuo, K.
  • Organizer: Podosomes, Invadopodia and Focal Adhesions in Physiology and Pathology
  • Place of Presentation: Madrid, Spain
• [Presentation] Tks5-dependent formation of circumferential podosome mediates cell-cell fusion (2011)
  • Author(s): 及川司、尾山大明、秦裕子、佐谷秀行、松尾光一
  • Organizer: 第63回日本細胞生物学会大会
  • Place of Presentation: 北海道大学(北海道)
• [Presentation] 骨細胞による骨溶解について (2011)
  • Author(s): 松尾光一
  • Organizer: 第29回日本骨代謝学会学術集会
  • Place of Presentation: 大阪国際会議場(大阪)(招待講演)
• [Presentation] Osteoprotegerinによる感染性骨破壊の抑制 (2011)
  • Author(s): 高田康成、松尾光一
  • Organizer: 第29回日本骨代謝学会学術集会
  • Place of Presentation: 大阪国際会議場(大阪)
• [Presentation] 破骨細胞は骨細管形成に関与し、骨細管は皮質骨リモデリングへ関与する (2011)
  • Author(s): 南郷脩史、久保田省吾、矢代航、百生敦、松尾光一
  • Organizer: 第29回日本骨代謝学会学術集会
  • Place of Presentation: 大阪国際会議場(大阪)
• [Presentation] Tks5によるポドソーム形成と破骨細胞融合メカニズム (2011)
  • Author(s): 及川司、尾山大明、秦裕子、佐谷秀行、松尾光一
  • Organizer: 第29回日本骨代謝学会学術集会
  • Place of Presentation: 大阪国際会議場(大阪)
• [Presentation] From NFATc1 to the interaction of bone cells. (2010)
  • Author(s): 松尾光一
  • Organizer: 第22回 韓国内分泌学会
  • Place of Presentation: ソウル、韓国
  • Year and Date: 2010-05-15
• [Presentation] Inhibition of EphA-ephrinA interaction induces acute bone formation in an adult bone organ culture and in mice (2010)
  • Author(s): 入江奈緒子・松尾光一
  • Organizer: 第33回 米国骨代謝学会
  • Place of Presentation: トロント、カナダ
• [Presentation] Structural Basis of Osteocytic Osteolysis during Lactation in Mouse Fibula. (2010)
  • Author(s): 松尾光一, 他7名
  • Organizer: 第33回 米国骨代謝学会
  • Place of Presentation: トロント、カナダ
• [Presentation] Structural basis for bone resorption within the cortical bone. (2010)
  • Author(s): 南郷脩史, 他4名
  • Organizer: 第33回 米国骨代謝学会
  • Place of Presentation: トロント、カナダ
• [Presentation] Ephrin-Ephによる細胞間相互作用を介した骨代謝制御 (2009)
  • Author(s): 入江奈緒子
  • Organizer: 第12回骨発生・再生研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-31
• [Remarks]
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• [Remarks]
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