| Project/Area Number |
21390430
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Hirosaki University |
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Principal Investigator |
HIROTA Kazuyoshi 弘前大学, 医学(系)研究科(研究院), 教授 (20238413)
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| Co-Investigator(Kenkyū-buntansha) |
KUSHIKATA Tetsuya 弘前大学, 医学部・附属病院, 講師 (80250603)
YOSHIDA Hitoshi 弘前大学, 医学(系)研究科(研究院), 講師 (00374843)
OKAWA Hirobumi 弘前大学, 医学(系)研究科(研究院), 講師 (40322953)
工藤 美穂子 弘前大学, 大学院・医学研究科, 助教 (30003411)
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| Project Period (FY) |
2009 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2011: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 睡眠障害 / 加齢 / ラット / 全身麻酔 / 神経生理活性物質 / 鎮静 / オピオイド |
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| Research Abstract |
In this study, although age-related sleep disorder was confirmed in rats, we could not recognize a difference with the length of each sleep stage between adult and aged rats. Then, we also studied post-anesthesia sleep disorder and determine the difference of sleep disorder after both type(GABA_A receptor activation[GABA type] or NMDA receptor inhibition[NMDA-type]) of anesthetic agent-induced anesthesia. We found that REM sleep significantly increased a few days after ketamine (NMDA-type) anesthesia while no significant differences in each sleep stage between pre- and post propofol anesthesia were observed. Ketamine-induced post-anesthesia sleep disorder is similar to post-surgical sleep disorder that is considered as a main factor of postoperative respiratory and cardiovascular complications. Thus, ketamine-induced post-anesthesia sleep disorder may be used as a post-surgical sleep disorder model. In addition, this post-anesthesia sleep disorder was almost fully antagonized by icv orexin A or neuropeptide S. If prexin A or neuropeptide S analogues that are un-metabolized in the plasma and penetrated into blood brain barrier after their systemic administration will be developed, we may be able to treat post-surgical sleep disorder.
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