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Therapeutic strategy for the chronic pain through the neurogenesis of the central nervous system in enriched environment

Research Project

Project/Area Number 21390431
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionUniversity of Toyama

Principal Investigator

YAMAZAKI Mitsuaki  富山大学, 大学院・医学薬学研究部(医学), 教授 (70158145)

Co-Investigator(Kenkyū-buntansha) NARITA Minoru  星薬科大学, 薬学部, 教授 (40318613)
HATAKEYAMA Noboru  愛知医科大学, 医学部, 教授 (70251907)
Project Period (FY) 2009 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2009: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
Keywordsneuropathic pain / enriched environment / neurogenesis / central nervous system / 豊かな環境 / エピジェネティクス修飾 / 神経新生 / 海馬 / セルソーティング / マイクログリア / エピジェネティクス / ヒストン / メチル化 / 神経障害性疼痛 / ファンクショナルMRI / ダイノルフィンA / オピオイド受容体
Research Abstract

Our results indicate that exposure to an enriched environment enhances neurogenesis and regulates emotionality. Enriched environment increases BDNF mRNA expression via sustained epigenetic modification in the mouse hippocampus. The chronic pain process promotes astrogliosis in the cingulate cortex through the dysfunction of cortical □-opioid receptors. Furthermore, chronic pain suppressed enriched environment mediated induction of both DCX- and NeuroD-labeled cells. These results suggest that chronic pain has stress-like damaging modulatory effects on hippocampal neurogenesis.

Report

(5 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (22 results)

All 2012 2011 2010 2009 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (11 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Usefulness of olanzapine as an adjunct to opioid treatment and for the treatment of neuropathic pain2012

    • Author(s)
      Torigoe K, Nakahara K, Rahmadi M, Yoshizawa K, Horiuchi H, Hirayama S, Ima S, Kuzumaki N, Itoh T, Yamashita A, Shakunaga K, Yamazaki M, Nagase H, Matbba M, Suzuki T, Narita M
    • Journal Title

      Anesthesiology

      Volume: 116 Pages: 159-169

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Upregulation of bradykinin receptors is implicated in the pain associated with caerulein-induced acute pancreatitis.2011

    • Author(s)
      Takemura Y, Furuta S, Hirayama S, Miyashita K, Imai S, Narita M, Kuzumaki N, Tsukiyama Y, Yamazaki M, Suzuki T, Narita M
    • Journal Title

      Synapse

      Volume: 65 Pages: 608-616

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of gabapentin on brain hyperactivity related to pain and sleep disturbance under a neuropathic pain-like state using fMRI and brain wave analysis.2011

    • Author(s)
      Takemura Y, Yamashita A, Horiuchi H, Furuya M, Yanase M, Niikura K, Imai S, Hatakeyama N, Kinoshita H, Tsukiyama Y, Senba E, Matoba M, Kuzumaki N, Yamazaki M, Suzuki T, Narita M.
    • Journal Title

      Synapse

      Volume: 65 Pages: 668-676

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of glutamatergic transmission in the cingulate cortex in response to mild noxious stimuli under a neuropathic pain-like state.2011

    • Author(s)
      Niikura K, Furuya M, Narita M, Torigoe K, Kobayashi Y, Takemura Y, Yamazaki M, Horiuchi H, Enomoto T, Iseki M, Kinoshita H, Tomiyasu S, Imai S, Kuzumaki N, Suzuki T, Narita M.
    • Journal Title

      Synapse

      Volume: 65 Pages: 424-432

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Upregvdation of bradykinin receptors is implicated in the pain associated with caerulein-induced acute pancreatitis2011

    • Author(s)
      Takemura Y, Furuta S, Hirayama S, Miyasita K, Imai S, Narita M, Kuzumaki N, Tsukiyama Y, Yamazaki M, Suzuki T, Naita M
    • Journal Title

      Synapse

      Volume: 65 Pages: 608-616

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of gabapentin on brain hyperactivity related to pain and sleep disturbance under a neuropathic pain-like state using fMRI and brain wave analysis2011

    • Author(s)
      Takemura Y, Yamashita A, Horiuchi H, Furuya M, Yanase M, Niikura K, Imai S, Hatakeyama N, Kinoshita H, Tsukiyama Y, Senba E, Matoba M, Kuzumaki N, Yamazaki M, Suzuki T, Narita M
    • Journal Title

      Synapse

      Volume: 65 Pages: 668-76

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct evidence for the ongoing brain activation by enhanced dynorphinergic system in the spinal cord under inflammatory noxious stimuli.2010

    • Author(s)
      Taketa Y, Niikura K, Kobayashi Y, Furuya M, Shimizu T, Narita M, Imai S, Kuzumaki N, Maitani Y, Yamazaki M, Inada E, Iseki M, Suzuki T, Narita M.
    • Journal Title

      Anesthesiology

      Volume: 112 Pages: 418-431

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Direct evidence for the ongoing brain activation by enhanced dynorphin ergic system in the spinal cord under inflammatory noxious stimuli2010

    • Author(s)
      Taketa Y, Yamazaki M, Narita M., et al.
    • Journal Title

      Anesthesiology 112

      Pages: 418-431

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 神経障害性疼痛の難治化における脊髄内エピジェネティクス修飾の関与.2012

    • Author(s)
      伊東久勝、池上大悟、山崎光章、成田年
    • Organizer
      日本ペインクリニック学会第46会大会
    • Place of Presentation
      島根
    • Related Report
      2012 Final Research Report
  • [Presentation] 横隔膜下迷走神経機能不全による侵害性知覚神経の感作.2012

    • Author(s)
      伊東久勝、古田貞由、山崎光章、池上大悟、酒井寛泰、成田 年
    • Organizer
      日本麻酔科学会 第59回学術集会
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report
  • [Presentation] 疼痛制御機構に関する研究:慢性疼痛モデルと比較したセルレイン誘発急性膵炎モデルでの疼痛発現機構の検討.2011

    • Author(s)
      竹村佳記, 山下 哲, 堀内 浩, 柳瀬 諒, 大石美緒子, 山崎光章, 成田 年
    • Organizer
      日本臨床麻酔学会第31回大会
    • Place of Presentation
      沖縄
    • Related Report
      2012 Final Research Report
  • [Presentation] Enriched environment 飼育によるエピジェネティクス修飾を伴った海馬神経新生促進機構の解析.2011

    • Author(s)
      長澤阿津実、葛巻直子、成田道子、池上大悟、竹島秀幸、牛島俊和、山崎光章、成田年
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Caerulein 誘発急性膵炎モデルでの疼痛発現機構におけるbradykinin 受容体の関与.2011

    • Author(s)
      竹村佳記, 古田貞由, 平山重人, 宮下和彦, 今井哲司, 成田道子, 葛巻直子, 山崎光章, 鈴木 勉, 成田 年
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] 疼痛制御機構に関する研究:炎症性疼痛下での脳活動の変化や睡眠障害に対するメロキシカム(モービック(R))の影響2010

    • Author(s)
      竹村佳記、山崎光章, ほか
    • Organizer
      日本麻酔科学会 第57回学術集会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Year and Date
      2010-06-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 炎症性疼痛下での脳活動の変化や睡眠障害に対するメロキシカム(モービック)の影響;fMRI および脳波解析による検討.2010

    • Author(s)
      竹村佳記、今井哲司、葛巻直子、山崎光章、鈴木勉、成田年
    • Organizer
      日本麻酔科学会 第57回学術集会
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] Up-regulation of bradykinin receptors function in the dorsal root ganglia under the acute pacreatitis pain-like state.2010

    • Author(s)
      Y. Takemura, M. Narita, S. Furuta, K. Miyashita, S. Imai, M. T-Narita, N. Kuzumaki, M. Yamazaki, and T. Suzuki
    • Organizer
      The International Narcotics Research Conference (INRC)
    • Place of Presentation
      Sweden
    • Related Report
      2012 Final Research Report
  • [Presentation]2009

    • Author(s)
      屋代涼子、成田 年、古田貞由、吉澤一巳、竹村佳記、榎本達也、成田道子、今井哲司、山崎光章、井関雅子、葛巻直子、鈴木 勉
    • Organizer
      第3回日本緩和医療薬学会年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] 疼痛制御機構に関する研究 (第100 報) : Fentanyl によるμ-opioid 受容体代謝回転ならびに中枢性Na+ チャネルに対する影響-Fentanyl が示す特異性の解析-.2009

    • Author(s)
      竹村佳記、尾関あゆみ、橋本敬輔、山崎光章、成田 年、鈴木 勉
    • Organizer
      日本麻酔科学会 第56回学術集会
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report
  • [Presentation] 疼痛制御機構に関する研究 (第105 報) : Caerulein誘発膵炎モデルにおける疼痛発現機構の解析2009

    • Author(s)
      竹村佳記、平山重人、古田貞治、今井哲司、山崎光章、葛巻直子、成田 年 、鈴 木 勉
    • Organizer
      日本ペインクリニック学会 第43回大会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report
  • [Book] メディカルレビュー,オキシコドンの今後の可能性-基礎研究の観点から-. がん患者と対症療法2012

    • Author(s)
      伊藤久勝, 池上大悟, 酒井寛泰, 山崎光章, 成田 年
    • Related Report
      2012 Final Research Report
  • [Book] 痛みの統合的理解と除痛の意義. 臨床麻酔2012

    • Author(s)
      成田 年, 山下 哲, 釈永清志, 山崎光章
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.med.u-toyama.ac.jp/anesth/index.html

    • Related Report
      2012 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2019-07-29  

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