| Project/Area Number |
21390435
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATUNAGA Akira 鹿児島大学, 医歯(薬)学総合研究科, 准教授 (70284883)
YASUDA Tomotugu 鹿児島大学, 医学部・歯学部附属病院, 講師 (80437954)
IMABAYASHI Toru 鹿児島大学, 医学部・歯学部附属病院, 助教 (90404491)
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| Research Collaborator |
YAMASHITA Yutaka 浜松ホトニクス(株), 中央研究所・第7研究室
ODA Motoki 浜松ホトニクス(株), 中央研究所・第7研究室
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2010: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
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| Keywords | 周術期管理学 / 近赤外時間分解分光システム / 脳障害モニタリング / チトクロームオキシダーゼ / ヘモグロビン酸素飽和度 / 光路長 |
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| Research Abstract |
The purpose of this study is the development of the quantitative measurement of the cerebral cyt. aa3 by near-infrared time-resolved spectroscopy(TRS). Firstly, the algorithms of the redox state of cyt. aa3 in 3-wavelength or 6-wavelength TRS system were developed by the absorption coefficient values of oxy-and deoxy-Hb, which were obtained by the study of blood phantom models. Furthermore, the algorithms in 3-wavelength or 6-wavelength TRS system were evaluated by the dog model with cardiopulmonary bypass or the pig model with cardiac arrest. We concluded that the algorithms in 6-wavelength TRS system rather than 3-wavelength are capable of reliably measuring changes in the redox state of cerebral cyt. aa3 during severe conditions such as cardiac arrest.
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