Dose a novel biomarker, RM2-Haptoglobin-beta, has the possibility to exceed PSA in predicting outcome of prostate cancer?
| Project/Area Number |
21390437
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Tohoku University |
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Principal Investigator |
ARAI Yoichi 東北大学, 大学院・医学系研究科, 教授 (50193058)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Akihiro 東北大学, 病院, 講師 (70344661)
MITSUZUKA Koji 東北大学, 大学院・医学系研究科, 助教 (80568171)
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| Co-Investigator(Renkei-kenkyūsha) |
SAITO Eiichi 琉球大学, 医学部, 教授 (80235043)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2011: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Keywords | 前立腺癌 / PSA / RM2 / ハプトグロビンβ鎖 / 糖鎖マーカー / ハプトグロビンss鎖 |
|---|
| Research Abstract |
In our previous study, haptoglobin-beta chain defined by RM2 is a novel serum marker that may be useful for detection of early prostate cancer when coupled with PSA as or gan-specific marker because it is not specific to prostate cancer. In current study, we tried to establish the assay system of detecting haptoglobin-beta chain defined by RM2 from sera of prostate cancer patients.
There were no correlation between concentrations of haptoglobin and PSA. And more, there were no differences in concentrations of haptoglobin between sera of prostate cancer and sera of benign prostate disease. So it is necessary to improve the quality of detecting system of haptoglobin-beta chain defined by RM2.
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Report
(4 results)
Research Products
(73 results)
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[Journal Article] 副腎疾患最近の話題2010
Author(s)
石戸谷滋人, 荒井陽一, 佐藤文俊, 伊藤貞嘉, 高瀬圭, 石橋忠司, 中村保宏, 笹野公伸
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Journal Title
原発性アルドステロン症診療の新たな流れ各科連携の成果内分泌外科
Volume: 27(4)
Pages: 235-240
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