| Project/Area Number |
21390439
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Urology
|
|---|
| Research Institution | Hyogo Medical University (2011)
Kyoto University (2009-2010) |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OGAWA Osamu 京都大学, 医学研究科, 教授 (90260611)
YOSHIMURA Koji 京都大学, 医学研究科, 准教授 (40397542)
OKUBO Kazutoshi 京都大学, 医学研究科, 講師 (20511877)
INOUE Takahiro 関西医科大学, 医学部, 助教 (80511881)
NISHIYAMA Hiroyuki 筑波大学, 人間健康科学研究科, 教授 (20324642)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
OKAMURA Hitoshi 京都大学, 薬学研究科, 教授 (60158813)
TABATA Yasuhiko 京都大学, 再生医科学研究所, 教授 (50211371)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2011: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
|
|---|
| Keywords | 時計遺伝子 / コネキシン43 / ギャップジャンクション / Rev-erbalpha / Sp-1 / 日内排尿リズム / PTH-rP / 排尿発達 |
|---|
| Research Abstract |
We discovered circadian oscillation of Connexin43(Cx43), a molecule controlling functional bladder capacity, is regulated thorough interaction by Rev-erbα, a gene related with the circadian clock, and Sp-1, a molecule unrelated with the clock. As a result, circadian rhythm is generated in gap junction activity among bladder smooth muscle cells and contributes to micturition rhythm, with bladder capacity larger during sleep phase than during active phase. Thus, circadian clock is a regulator of micturition rhythm.
|
