| Co-Investigator(Kenkyū-buntansha) |
ISAKA Yoshitaka 大阪大学, 医学(系)研究科, 准教授 (00379166)
ASAHI Michio 大阪医科大学, 医学部, 教授 (10397614)
LI Xiaokang 国立成育医療センター(研究所), 移植, 外科研究部, 室長 (60321890)
TAKAHARA Siro 大阪大学, 医学(系)研究科(研究院), 寄附講座教授 (70179547)
勝岡 洋治 大阪医科大学, 医学部, 教授 (10051757)
|
|---|
| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
|
|---|
| Research Abstract |
We have developed a novel approach of highly effective gene transfection technique using lenti-virus vector combined with ultrasound mediated gene transfection procedure. We have performed successful gene transfection of metron factor, which is the engineered chimeric factors containing selected functional domains of HGF and MSP, into the transplanted kidney tissue. Local production of MF-1, which may enhance the expansion of Treg cells in vivo, combined with .the adoptive transfer of Treg cells, successfully induced the donor specific immune tolerance in more than 70% of recipients in our rat kidney transplant model.
|
