Down regulation of antigen presentation pathway plays an important role in metastasis and progression of advanced stage of epithelial ovarian cancer.

• Project/Area Number: 21390449
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Niigata University
• Principal Investigator: TANAKA Kenichi 新潟大学, 医歯学系, 教授 (10126427)
• Co-Investigator(Kenkyū-buntansha): YAHATA Tetsuro 新潟大学, 医歯学系, 准教授 (90293232) ; YOSHIHARA Kousuke 新潟大学, 医歯学系, 助教 (40547535) ; SEKINE Masayuki 新潟大学, 医歯学総合病院, 助教 (70345502)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000); Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2009: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
• Keywords: 卵巣がん / EMT / 抗原提供 / 遺伝子発現プロファイル / 上皮性卵巣がん / 予後予測 / 腫瘍内浸潤リンパ球 / 上皮性卵巣癌 / 分子標的治療薬 / 上皮間葉移行

Research Abstract

High-grade serous ovarian cancers are heterogeneous not only in terms of clinical outcome but also at the molecular level. Our aim was to establish a novel risk classification system based on a gene expression signature for predicting overall survival, leading to suggesting novel therapeutic strategies using EMT molecules for high-risk patients. This risk classification based on the gene expression signature is an accurate predictor of clinical outcome in patients with advanced stage high-grade serous ovarian cancer and has the potential to develop new therapeutic strategies for high-grade serous ovarian cancer patients.

Research Products

• [Journal Article] High risk ovarian cancer based on 126-gene expression signeture is uniquely charcterized by down-regulation of antigen presentation passway Clin (2012)
  • Author(s): Yoshihara K, Tanaka K, 他27名
  • Journal Title: Cancer Res Volume: 18(5) Pages: 1374-85
  • Peer Reviewed
• [Journal Article] High-Risk Ovarian Cancer Based on 126-Gene Expression Signature Is Uniquely Characterized by Downregulation of Antigen Presentation Pathway (2012)
  • Author(s): Kosuke Yoshihara
  • Journal Title: Clinical Cancer Research Volume: 18 Issue: 5 Pages: 1374-1385
  • DOI: 10.1158/1078-0432.ccr-11-2725
  • Peer Reviewed
• [Journal Article] Germline Copy Number Variations in BRCA1-Associated Ovarian Cancer Patients Genes (2011)
  • Author(s): Yoshihara K, Tanaka K, 他7名
  • Journal Title: Chromosomes and Cancer Volume: 50 Pages: 167-177
  • Peer Reviewed
• [Journal Article] Germline Copy Number Variations in BRCA1-Associated Ovarian Cancer Patients (2011)
  • Author(s): K.Yoshihara, K Tanaka, 他7名
  • Journal Title: Genes, Chromosomes and Cancer Volume: 50 Issue: 3 Pages: 167-177
  • DOI: 10.1002/gcc.20841
  • Peer Reviewed
• [Journal Article] Identification of Receptor Tyrosine Kinase, Discoidin Domain Receptor 1 (DDR1), as a Potential Biomarker for Serous Ovarian Cancer (2011)
  • Author(s): Quan J, Yahata T, Adachi S, Yoshihara K, Tanaka K
  • Journal Title: Int J Mol Sci Volume: 12 Issue: 2 Pages: 971-982
  • DOI: 10.3390/ijms12020971
  • Peer Reviewed
• [Journal Article] Germ line copy number valiations in BRCA1 associated ovarian cancerpatients (2011)
  • Author(s): Yoshihara, K., Tanaka, Mitt, 他7名
  • Journal Title: Genes Chromosomes Cancer Volume: 50 Pages: 167-177
  • Peer Reviewed
• [Journal Article] Gene expression profile for predicting survival in advanced-stage serous ovarian cancer across two independent datasets. (2010)
  • Author(s): K Yoshihara K Yoshihara K Yoshihara K Yoshihara K Yoshihara K Yoshihara K Yoshihara K Yoshihara K Yoshihara K Yoshihara K, Tanaka K Tanaka K Tanaka K Tanaka K Tanaka K Tanaka K Tanaka K Tanaka K., 他14名
  • Journal Title: PLoS One Volume: 5
  • Peer Reviewed
• [Journal Article] Meta analysis of genome wide association scans for genetic susceptibility to endometriosis in Japanese population (2010)
  • Author(s): Adachi, S.Tanaka, K., 他15
  • Journal Title: J Hum Genet Volume: 55 Pages: 816-821
  • NAID: 10030737956
  • Peer Reviewed
• [Journal Article] Gene expression profiling for predicting survival in advanced-stage serous ovarian cancer across two independent data sets (2010)
  • Author(s): Yoshihara, K., Tanaka, K., 他15名
  • Journal Title: Plos one 5
  • Peer Reviewed
• [Journal Article] Gene expression profiling of advanced-stage serous ovarian cancers distinguishes novel subclasses and implicates ZEB2 in tumor progression and prognosis. (2009)
  • Author(s): Yoshihara, K., Tanaka, K., 他12名
  • Journal Title: Cancer Sci 100(8) Pages: 1421-8
  • NAID: 10027193229
  • Peer Reviewed
• [Presentation] 家族性卵巣がんの基礎と臨床 (2011)
  • Author(s): 田中憲一
  • Organizer: 第51回日本婦人科腫瘍学会学術集会
  • Place of Presentation: ホテルマリターレ創生(福岡県)(招待講演)
  • Year and Date: 2011-11-25
• [Presentation] 個別化医療を目的とした漿液性卵巣癌の予後予測プロファイルの同定 (2011)
  • Author(s): 吉原弘祐、田中憲一、他2名
  • Organizer: 第62回日本産科婦人科学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2011-08-29
• [Presentation] Geneexpression profile for predicting survival in ovarian cancer across two independent datasets (2011)
  • Author(s): Yoshihara K. Tanaka K., 他4名
  • Organizer: 第101回アメリカ癌学会
  • Place of Presentation: Washington D. C. U. S. A
  • Year and Date: 2011-04-12
• [Presentation] Germ line copy number variations in BRCA1 mutation carriers (2010)
  • Author(s): Yoshihara Kosuke
  • Organizer: American Society Human Genetics
  • Place of Presentation: アメリカ合衆国ワシントンD.C.
• [Presentation] 進行漿液性卵巣癌におけるZEB2高発現は独立した予後不良因子である (2009)
  • Author(s): Yoshihara, K., Tanaka, K, 他5名
  • Organizer: 第68回日本癌学会
  • Place of Presentation: 横浜、パシフィコ横浜
  • Year and Date: 2009-10-02
• [Presentation] Gene expression profile identified novel subclasses in advanced-stage serous ovarian cancers and revealed ZEB2 expression as the prognostic marker. (2009)
  • Author(s): Yoshihara, K., Tanaka, K, 他13名
  • Organizer: 第100回米国癌学会(American association for Cancer research)
  • Place of Presentation: 米国、Dennver
  • Year and Date: 2009-04-20