Basic Research on the Inner Ear Protection During Partial Destruction of the Inner Ear

• Project/Area Number: 21390457
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Tohoku University
• Principal Investigator: KOBAYASHI Toshimitsu 東北大学, 大学院・医学系研究科, 教授 (80133958)
• Co-Investigator(Kenkyū-buntansha): KAWASE Tetsuaki 東北大学, 大学院・医工学研究科, 教授 (50169728) ; OSHIMA Takeshi 東北大学, 大学院・医学系研究科, 准教授 (40241608) ; KAMAKURA Shinji 東北大学, 大学院・医工学研究科, 教授 (80224640) ; NAKAYA Kazuhiro 東北大学, 病院, 助教 (60466563) ; HIDAKA Hiroshi 東北大学, 病院, 講師 (40302103)
• Project Period (FY): 2009 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000); Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2010: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2009: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
• Keywords: 内耳切断 / 内耳保護 / 内耳電位 / イオン / モルモット / 耳毒性 / ダプトマシシン / ABR / 内リンパ電位 / イオン濃度 / 半規管瘻孔 / 半規管 / 半規管膨大部 / 前庭 / 内耳電

Research Abstract

1)Disturbance of the mechanism of cochlear function caused by vestibular labyrinth destruction may involve reduction in the [K(+)] concentration in the endolymph.
2) Stopping endolymphatic leakage may be the most important factor to prevent acute phasehearing impairment.

Research Products

• [Journal Article] Risk factors for aggravation of bone conduction hearing in cases withlabyrinthine fistula caused by middle ear cholesteatomas (2012)
  • Author(s): Ikeda R, Kobayashi T, Kawase T, Oshima T, Sato T.
  • Journal Title: Ann Otol RhinolLaryngol Volume: 121(3) Pages: 162-167
  • Peer Reviewed
• [Journal Article] Risk factors for aggravation of bone conduction hearing in cases with labyrinthine fistula caused by middle ear cholesteatomas (2012)
  • Author(s): Ikeda R, Kobayashi T, Kawase T, Oshima T, Sato T
  • Journal Title: Annals of Otology, Rhinology & Laryngology Volume: 121 Pages: 162-167
  • Peer Reviewed
• [Journal Article] Effect of aspiration of perilymph during stapes surgery on the endocochlear potential of guinea pig (2011)
  • Author(s): Ikeda R, Nakaya K, Oshima H, Oshima T, Kawase T, Kobayashi T.
  • Journal Title: Otolaryngol Head Neck Surg Volume: 145(5) Pages: 801-805
  • Peer Reviewed
• [Journal Article] Preventative effect of various fluids used in the epitympanic bulla on deterioration of cochlear function during labyrinthectomy (2011)
  • Author(s): Ikeda R, Nakaya K, Oshima T, Kawase T, Kobayashi T.
  • Journal Title: Acta Otolaryngol Volume: 131(6) Pages: 572-578
  • Peer Reviewed
• [Journal Article] 耳科・神経耳科手術における内耳操作-特に聴力保存的部分的迷路切除術について- (2011)
  • Author(s): 池田怜吉、小林俊光
  • Journal Title: 耳鼻咽喉科臨床 Volume: 104 Pages: 759-769
  • Peer Reviewed
• [Journal Article] Effect of vestibular labyrinth destruction on endocochlear potential and potassium concentration of the cochlea (2010)
  • Author(s): Ikeda R, Nakaya K, Yamazaki M, Oshima T, Kawase T, Kobayashi T.
  • Journal Title: Hear Res Volume: 265(1-2) Pages: 90-95
  • Peer Reviewed
• [Journal Article] Calcium concentration in cochlear endolymph after vestibular labyrinth injury (2010)
  • Author(s): Ikeda R, Nakaya K, Oshima T, Kawase T, Kobayashi T.
  • Journal Title: Neuroreport. Volume: 9 Pages: 651-655
  • Peer Reviewed
• [Journal Article] Preventative effect of various fluids used in the epitympanic bulla on deterioration of cochlear function during labyrinthectomy. (2010)
  • Author(s): Ikeda R, Nakaya K, Oshima T, Kawase T, Kobayashi T.
  • Journal Title: Acta Otolaryngol.
  • Peer Reviewed
• [Journal Article] Calcium concentration in cochlear endolymph after vestibular labyrinth injury. (2010)
  • Author(s): Ikeda R, Nakaya K, Oshima T, Kawase T, Kobayashi T.
  • Journal Title: Neuroreport. Volume: 9 Pages: 651-655
  • Peer Reviewed
• [Journal Article] Effect of vestibular labyrinth destruction on endocochlear potential and potassium concentration of the cochlea (2010)
  • Author(s): Ryoukichi Ikeda, Kazuhiro Nakaya, Muneharu Yamazaki, Takeshi Oshima, Tetsuaki Kawase, Toshimitsu Kobayashi
  • Journal Title: Hearing Research (in press)
  • Peer Reviewed
• [Presentation] Ototoxic effect of daptomycin applied to the guinea pig middle ear (2012)
  • Author(s): Muneharu Yamazaki, Hidetoshi Oshima, Kazuhiro Nomura, Takeshi Oshima, Tetsuaki Kawase, Toshimitsu Kobayashi
  • Organizer: Inner ear biology
  • Place of Presentation: Germany(Tibingen)
  • Year and Date: 2012-10-02
• [Presentation] Effect of Aspiration of Perilymph During Stapes Surgery on the Endocochlear Potential in the Guinea Pig (2012)
  • Author(s): Ryoukichi Ikeda, Kazuhiro Nakaya, Takeshi Oshima, Tetsuaki Kawase, Toshimitsu Kobayashi
  • Organizer: ARO
  • Place of Presentation: USA(San Diego)
  • Year and Date: 2012-02-25
• [Presentation] Effect of Aspiration of Perilymph During Stapes Surgery on the Endocochlear Potential in the Guinea Pig (2012)
  • Author(s): Ikeda R, Nakaya K, Oshima T, Kawase T, Kobayashi T
  • Organizer: ARO
  • Place of Presentation: USA (San Diego)
  • Year and Date: 2012-02-25
• [Presentation] Ototoxic effect of daptomycin applied to the guinea pig middle ear (2012)
  • Author(s): M. Yamazaki, H. Oshima, *K. Nomura, T. Oshima, T. Kawase, T. Kobayashi
  • Organizer: 49th Workshop on Inner Ear Biology
  • Place of Presentation: Tübingen, Germany
• [Presentation] Preventative Effect of Various Fluids Filled in the Epitympanic Bulla on Deterioration of Cochlear Function During Labyrinthectomy (2011)
  • Author(s): Ryoukichi Ikeda, *Kazuhiro Nakaya (presentation), Takeshi Oshima, Tetsuaki Kawase, Toshimitsu Kobayashi.
  • Organizer: ARO 2011 MidWinter Meeting
  • Place of Presentation: Baltimore, USA
  • Year and Date: 2011-02-20
• [Presentation] Preventative effect of various fluids filled in the epitympanic bulla on deterioration of cochlear function during labyrinthectomy (2010)
  • Author(s): Ryoukichi Ikeda, Kazuhiro Nakaya, Muneharu Yamazaki, Takeshi Oshima, Tetsuaki Kawase, Toshimitsu Kobayashi
  • Organizer: Joint Meeting of Otorhinolaryngology-Head and Neck Surgery
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2010-09-09
• [Presentation] Preventative effect of various fluids filled in the epitympanic bulla on deterioration of cochlear function during labyrinthectomy. (2010)
  • Author(s): Ryoukichi Ikeda, Kazuhiro Nakaya, Muneharu Yamazaki, Takeshi Oshima, Tetsuaki Kawase, Toshimitsu Kobayashi.
  • Organizer: Joint Meeting of Otorhinolaryngology-Head and Neck Surgery
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2010-09-09
• [Presentation] Potassium and calcium concentration in cochlear endolymph after vestibular labyrinth injury (2010)
  • Author(s): Ryoukichi Ikeda, Kazuhiro Nakaya (presentation), Muneharu Yamazaki, Takeshi Oshima, Tetsuaki Kawase, Toshimitsu Kobayashi
  • Organizer: Inner ear biology
  • Place of Presentation: Prague, Czech Republic
  • Year and Date: 2010-08-30
• [Presentation] Potassium and calcium concentration in cochlear endolymph after vestibular labyrinth injury. (2010)
  • Author(s): Ryoukichi Ikeda, Kazuhiro Nakaya (presentation), Muneharu Yamazaki, Takeshi Oshima, Tetsuaki Kawase, Toshimitsu Kobayashi.
  • Organizer: Inner ear biology
  • Place of Presentation: Prague, Czech Republic
  • Year and Date: 2010-08-30
• [Presentation] Effect of Vestibular Labyrinth Destruction on Endocochlear Potential and Potassium Concentration of the Cochlea (2010)
  • Author(s): Ryoukichi Ikeda, Kazuhiro Nakaya, Muneharu Yamazaki, Takeshi Oshima, Tetsuaki Kawase, Toshimitsu Kobayashi
  • Organizer: The Thirty-Third Annual MidWinter Research Meeting of the Association for Research in Otolaryngology
  • Place of Presentation: Anaheim,USA
• [Presentation] Effect of Vestibular Labyrinth Destruction on Endocochlear Potential and Potassium Concentration of the Cochlea (2010)
  • Author(s): Ryoukichi Ikeda, Kazuhiro Nakaya, Muneharu Yamazaki, Takeshi Oshima, Tetsuaki Kawase, Toshimitsu Kobayashi
  • Organizer: The Thirty-Third Annual MidWinter Research Meeting of the Association for Research in Otolaryngology
  • Place of Presentation: Anaheim、米国
• [Presentation] Effect of Vestibular Labyrinth Destruction on Endocochlear Potential and Potassium Concentration of the Cochlea (2009)
  • Author(s): Ryoukichi Ikeda, Kazuhiro Nakaya, Muneharu Yamazaki, Takeshi Oshima, Tetsuaki Kawase, Toshimitsu Kobayashi
  • Organizer: 10th Taiwan-Japan Otolaryngology Head & Neck Conference
  • Place of Presentation: Yilan,Taiwan
• [Presentation] Effect of Vestibular Labyrinth Destruction on Endocochlear Potential and Potassium Concentration of the Cochlea (2009)
  • Author(s): Ryoukichi Ikeda, Kazuhiro Nakaya, Muneharu Yamazaki, Takeshi Oshima, Tetsuaki Kawase, Toshimitsu Kobayashi
  • Organizer: 10th Taiwan-Japan Otolaryngology Head & Neck Conference
  • Place of Presentation: Yilan、台湾