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Disruption of the blood-labyrinthine barrier and related genes in sudden sensorineural hearing loss

Research Project

Project/Area Number 21390460
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionNagoya University

Principal Investigator

NAKASHIMA Tsutomu  名古屋大学, 医学系研究科, 教授 (30180277)

Co-Investigator(Kenkyū-buntansha) NAGANAWA Shinji  名古屋大学, 大学院・医学系研究科, 教授 (50242863)
SHIMOKATA Hiroshi  国立長寿医療センター, 国立長寿医療センター研究所, 疫学研究部長 (10226269)
TERANISHI Masaaki  名古屋大学, 大学院・医学系研究科, 講師 (20335037)
Co-Investigator(Renkei-kenkyūsha) UCHIDA Yasue  愛知医科大学, 医学部, 講師 (80313998)
Project Period (FY) 2009 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2009: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Keywords突発性難聴 / 血液迷路関門 / MRI / 遺伝子多型 / 急性低音障害型感音難聴 / メニエール病 / 内リンパ水腫 / 血管透過性 / 炎症 / インターロイキン / CFH / 内耳
Research Abstract

Disruption of the blood-labyrinthine barrier was evaluated by the degree of Gd contrast enhancement of the inner ear in suddensensorineural hearing loss. There were ears with significant Gd enhancenment but there were also ears without Gd enhancement. Disruption of the blood-labyrinthine barrier may be associated with impairment of the blood vessels, inflammation and oxidative stress. The relevant gene polymorphisms were investigated in patients with sudden sensorineural hearing loss and in controls. Polymorphisms of interleukin-1A (rs1800587), interleukin-6 (rs1061170), complement factor H (rs1061170), aquaporin5 (rs3736309) and NO synthase 3 (rs1799983) seemed to be related to onset of sudden sensorineural hearing loss.交付決定額

Report

(5 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (118 results)

All 2013 2012 2011 2010 2009 Other

All Journal Article (74 results) (of which Peer Reviewed: 71 results) Presentation (38 results) Book (5 results) Remarks (1 results)

  • [Journal Article] Polymorhisms in genes involved in the free-radical process in patients with sudden sensorineural hearing loss and Meniere's disease.2013

    • Author(s)
      Teranishi M, Uchida Y, Nishio N, Kato K, Otake H, Yoshida T, Suzuki H, Sone M, Sugiura S, Ando F, Shimokata H, Nakashima T.
    • Journal Title

      Free Radic Res

      Volume: (Epub ahead of print)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Magnetic resonance imaging of the inner ear after both intratympanic and intravenous gadolinium injections.2013

    • Author(s)
      Iida T, Teranishi M, Yoshida T, Otake H, Sone M, Kato M, Shimono M, Yamazaki M, Naganawa S, Nakashima T.
    • Journal Title

      Acta Otolaryngol

      Volume: 133 Pages: 434-438

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polymorphisms in genes encoding aquaporins 4 and 5 and estrogen receptor α in patients with Meniere's disease and sudden sensorineural hearing loss.2013

    • Author(s)
      Nishio N, Teranishi M, Uchida Y, Sugiura S, Ando F, Shimokata H, Sone M, Otake H,Kato K, Yoshida T, Tagaya M, Hibi T, Nakashima T.
    • Journal Title

      Life Sci

      Volume: 92 Pages: 541-546

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polymorphisms in genes encoding aquaporins 4 and 5 and estrogen receptor α in patients with Ménière's disease and sudden sensorineural hearing loss.2013

    • Author(s)
      Nishio N
    • Journal Title

      Life Sci

      Volume: 92 Issue: 10 Pages: 541-546

    • DOI

      10.1016/j.lfs.2013.01.019

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Meniere's disease: a reappraisal supported by a variable latency of symptoms and the MRI visualisation of endolymphatic hydrops.2013

    • Author(s)
      Pyykko I
    • Journal Title

      BMJ Open.

      Volume: 3 Issue: 2 Pages: 1-10

    • DOI

      10.1136/bmjopen-2012-001555

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gadolinium distribution in cochlear perilymph: differences between intratympanic and intravenous gadolinium injection.2013

    • Author(s)
      Yamazaki M
    • Journal Title

      Neuroradiology.

      Volume: 54 Issue: 10 Pages: 1161-1169

    • DOI

      10.1007/s00234-012-1078-9

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endolymphatic hydrops revealed by magnetic resonance imaging in patients with acute low-tone sensorineural hearing loss2013

    • Author(s)
      Shimono M
    • Journal Title

      Otol Neurotol

      Volume: in press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contrast enhancement of the inner ear in magnetic resonance images taken at 10 minutes or 4 hours after intravenous gadolinium injection.2012

    • Author(s)
      Sano R, Teranishi M, Yamazaki M, Isoda H, Naganawa S, Sone M, Hiramatsu M, Yoshida T, Suzuki H, Nakashima T.
    • Journal Title

      Acta Otolaryngol

      Volume: 132 Pages: 241-246

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polymorphisms in Genes Involved in Oxidative Stress Response in Patients with Sudden Sensorineural Hearing Loss and Meniere's Disease in a Japanese Population.2012

    • Author(s)
      Teranishi M, Uchida Y, Nishio N, Kato K, Otake H, Yoshida T, Suzuki H, Sone M, Sugiura S, Ando F, Shimokata H, Nakashima T.
    • Journal Title

      DNA Cell Biol

      Volume: 31 Pages: 1555-1562

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polymorphisms in Genes Involved in Inflammatory Pathways in Patients with Sudden Sensorineural Hearing Loss.2012

    • Author(s)
      Hiramatsu M, Teranishi M, Uchida Y, Nishio N, Suzuki H, Kato K, Otake H, Yoshida T, Tagaya M, Suzuki H, Sone M, Sugiura S, Ando F, Shimokata H, Nakashima T.
    • Journal Title

      J Neurogenet.

      Volume: 26 Pages: 387-396

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Contribution of complement factor H Y402H polymorphism to sudden sensorineural hearing loss risk and possible interaction with diabetes.2012

    • Author(s)
      Nishio N, Teranishi M, Uchida Y, Sugiura S, Ando F, Shimokata H, Sone M, Otake H, Kato K, Yoshida T, Tagaya M, Hibi T, Nakashima T.
    • Journal Title

      Gene

      Volume: 499(1) Pages: 226-230

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polymorphisms in genes involved in inflammatory pathways in patients with sudden sensorineural hearing loss2012

    • Author(s)
      Hiramatsu M, et al
    • Journal Title

      J Neurogenet

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of computed tomography and magnetic resonance imaging for evaluation of cholesteatoma with labsyrinthine fistulae2012

    • Author(s)
      Sone M., et al
    • Journal Title

      Laryngoscope

      Volume: (印刷中) Issue: 5 Pages: 1121-1125

    • DOI

      10.1002/lary.23204

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contrast enhancement of the inner ear in magnetic resonance images taken at 10 minutes or 4 hours after intravenous gadolinium injection2012

    • Author(s)
      Sano R., et al
    • Journal Title

      Acta Otolaryngol

      Volume: 132 Pages: 241-246

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cochlear blood flow and speech perception ability in cochlear implant users2012

    • Author(s)
      Nakashima T., et al
    • Journal Title

      Otol Neurotol

      Volume: 33 Issue: 2 Pages: 165-168

    • DOI

      10.1097/mao.0b013e318241c0db

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Audiological signs in pediatric cases with dehiscence of the bony labyrinth caused by a high jugular bulb2012

    • Author(s)
      Sone M, et al
    • Journal Title

      Int J Pediatr Otorhinolaryngol

      Volume: 76 Pages: 447-451

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of interleukin-1 gene polymorphisms with sudden sensirineral hearing loss and Meniere's disease2011

    • Author(s)
      Furuta T, Teranishi M, Uchida Y, Nishio N, Kato K, Otake H, Yoshida T, Tagaya M, Suzuki H, Sugiura M, Sone M, Hiramatsu M, Sugiura S, Ando F, Shimokata H, Nakashima T.
    • Journal Title

      Int Journal Immunogenet

      Volume: 38 Pages: 249-254

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A perspective from magnetic resonance imaging findings of the inner ear : Relationships among cerebrospinal, ocular and inner ear fluids2011

    • Author(s)
      Nakashima T, et al
    • Journal Title

      Auris Nasus Larynx

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of interleukin-1 gene polymorphisms with sudden sensorineural hearing loss and Meniere's disease2011

    • Author(s)
      Furuta T., et al
    • Journal Title

      Int J Immunogenet

      Volume: 131 Issue: 3 Pages: 249-254

    • DOI

      10.1111/j.1744-313x.2011.01004.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Accuracy of 3.0 Tesla magnetic resonance imaging in the diagnosis of intracochlear schwannoma2011

    • Author(s)
      Yoshida T., et al
    • Journal Title

      Auris Nasus Larynx

      Volume: 38 Issue: 4 Pages: 551-554

    • DOI

      10.1016/j.anl.2010.12.011

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contribution of 1425G/A polymorphism in protein kinase C-Eta (PRKCH) gene and brain white matter lesions to the risk of sudden sensorineural hearing loss in a Japanese nested case-control study2011

    • Author(s)
      Uchida Y, et al
    • Journal Title

      J Neurogenet

      Volume: 25 Pages: 82-87

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anatomical details of the brainstem and cranial nerves visualized by high resolution readout-segmented multi-shot echo-planar diffusion-weighted images using unidirectional MPG at 3T2011

    • Author(s)
      Naganawa S., et al
    • Journal Title

      Magn Reson Med Sci

      Volume: 10 Pages: 269-275

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contrast enhancement of the anterior eye segment and subarachnoid space : detection in the normal state by heavily T2-weighted 3D FLAIR2011

    • Author(s)
      Naganawa S., et al
    • Journal Title

      Magn Reson Med Sci

      Volume: 10 Pages: 193-199

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contrast enhancement of the inner ear after intravenous administration of a standard or double dose of gadolinium contrast agents2011

    • Author(s)
      Suzuki H., et al
    • Journal Title

      Acta Otolaryngol

      Volume: 131 Issue: 10 Pages: 1025-1031

    • DOI

      10.3109/00016489.2011.598552

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visualization of endolymphatic hydrops after intratympanic injection of Gd-DTPA : comparison of 2D and 3D real inversion recovery imaging2011

    • Author(s)
      Naganawa S., et al
    • Journal Title

      Magn Reson Med Sci

      Volume: 10 Pages: 101-106

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of Contrast Effect on the Cochlear Perilymph after Intratympanic and Intravenous Gadolinium Injection2011

    • Author(s)
      Yamazaki M., et al
    • Journal Title

      AJNR Am J Neuroradiol

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between endolymphatic hydrops as revealed by magnetic resonance imaging and caloric response2011

    • Author(s)
      Kato M., et al
    • Journal Title

      Otol Neurotol

      Volume: 32 Issue: 9 Pages: 1480-1485

    • DOI

      10.1097/mao.0b013e318235568d

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endolympathic hydrops in patients with vestibular schwannoma : visualization by non-contrast-enhanced 3D FLAIR2011

    • Author(s)
      Naganawa S., et al
    • Journal Title

      Neuroradiology

      Volume: 53 Issue: 12 Pages: 1009-1015

    • DOI

      10.1007/s00234-010-0834-y

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 内耳の炎症性疾患2011

    • Author(s)
      吉田忠雄, 他
    • Journal Title

      ENTONI

      Volume: 131号 Pages: 39-45

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 私の処方箋耳科学領域急性感音難聴2011

    • Author(s)
      吉田忠雄, 他
    • Journal Title

      JOHNS

      Volume: 27 Pages: 1342-1344

    • Related Report
      2011 Annual Research Report
  • [Journal Article] めまいの新しい疾患概念MRIによる内リンパ水腫の画像診断2011

    • Author(s)
      中島務, 他
    • Journal Title

      Equilibrium Research

      Volume: 70 Pages: 197-203

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MR画像からみた鼓室内薬剤投与療法の評価2011

    • Author(s)
      中島務, 他
    • Journal Title

      Otology Japan

      Volume: 21 Pages: 161-167

    • NAID

      10029699562

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 診断・治療をマスターする内耳炎2011

    • Author(s)
      大竹宏直, 他
    • Journal Title

      耳鼻咽喉科・頭頸部外科

      Volume: 83 Pages: 229-234

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Association of Interleukin-1 Gene polymorphisms with Sudden Sensorineural Hearing Loss and Meniere's disease.2011

    • Author(s)
      Furuta T., et al.
    • Journal Title

      Int J Immunogenet.

      Volume: (In press,In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endolympathic hydrops in patients with vestibular schwannoma : visualization by non-contrast-enhanced 3D FLAIR.2011

    • Author(s)
      Naganawa S., et al.
    • Journal Title

      Neuroradiology.

      Volume: (In press,In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endolymphatic hydrops and blood-labyrinth barrier in Meniere's disease.2011

    • Author(s)
      Tagaya M., et al.
    • Journal Title

      Acta Otolaryngol.

      Volume: (In press,In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contrast-enhanced MRI of the inner ear after intratympanic injection of meglumine gadopentetate or gadodiamide hydrate.2011

    • Author(s)
      Suzuki H., et al.
    • Journal Title

      Acta Otolaryngol

      Volume: 131 Pages: 130-135

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Morphological observation of the stria vascularis in midkine and pleiotrophin knockout mice.2011

    • Author(s)
      Sone M., et al.
    • Journal Title

      Auris Nasus Larynx

      Volume: 38 Pages: 41-45

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relevance and characteristics of gastroesophageal reflux in adult patients with otitis media with effusion.2011

    • Author(s)
      Sone M., et al.
    • Journal Title

      Auris Nasus Larynx

      Volume: 38 Pages: 203-207

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 3 Tesla magnetic resonance imaging obtained 4 hours after intravenous gadolinium injection in patients with sudden deafness2010

    • Author(s)
      Tagaya M, Teranishi M, Naganawa S, Iwata T, Yoshida T, Otake H, Nakata S, Sone M, Nakashima T.
    • Journal Title

      Acta Otolaryngol

      Volume: 130 Pages: 665-669

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endolymphatic hydrops revealed by intravenous gadolinium injection in patients with Meniere's disease.2010

    • Author(s)
      Nakashima T., et al.
    • Journal Title

      Acta Otolaryngol.

      Volume: 130 Pages: 338-343

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Accuracy of 3.0 Tesla magnetic resonance imaging in the diagnosis of intracochlear schwannoma.2010

    • Author(s)
      Yoshida T., et al.
    • Journal Title

      Auris Nasus Larynx

      Volume: (Epub ahead of print,Epub ahead of print)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visualization of endolymphatic hydrops in Meniere's disease with single-dose intravenous gadolinium-based contrast media using heavily T(2)-weighted 3D-FLAIR.2010

    • Author(s)
      Naganawa S., et al.
    • Journal Title

      Magn Reson Med Sci.

      Volume: 9 Pages: 237-242

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diabetes reduces auditory sensitivity in middle-aged listeners more thanin elderly listeners : a population-based study of age-related hearing loss.2010

    • Author(s)
      Uchida Y., et al.
    • Journal Title

      Med Sci Mont

      Volume: 16 Pages: 63-68

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simultaneous three-dimensional visualization of the intra-parotid facial nerve and parotid duct using a three-dimensional reversed FISP sequence with diffusion weighting.2010

    • Author(s)
      Naganawa S., et al.
    • Journal Title

      Magn Reson Med Sci

      Volume: 9 Pages: 153-158

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased sensitivity to low concentration gadolinium contrastby optimized heavily T2-weighted 3D-FLAIR to visualize endolymphatic space.2010

    • Author(s)
      Naganawa S., et al.
    • Journal Title

      Magn Reson Med Sci

      Volume: 9 Pages: 73-80

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Signal alteration of the cochlear perilymph on 3 different sequences after intratympanic Gd-DTPA administration at 3 tesla : comparison of 3D-FLAIR, 3D-T1-weighted imaging, and 3D-CISS.2010

    • Author(s)
      Yamazaki M., et al.
    • Journal Title

      Magn Reson Med Sci

      Volume: 9 Pages: 65-71

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The impact of arterial sclerosis on hearing with and without occupational noise exposure : a population-based aging study in males.2010

    • Author(s)
      Yoshioka M., et al.
    • Journal Title

      Auris Nasus Larynx

      Volume: 37 Pages: 558-564

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MR imaging of the cochlear modiolus after intratympanic administration of Gd-DTPA.2010

    • Author(s)
      Kawai H., et al.
    • Journal Title

      Magn Reson Med Sci

      Volume: 9 Pages: 23-29

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estimation of gadolinium-induced T1-shortening with measurement of simple signal intensity ratio between the cochlea and brain parenchyma on 3D-FLAIR : correlation with T1 measurement by TI scout sequence.2010

    • Author(s)
      Naganawa S., et al.
    • Journal Title

      Magn Reson Med Sci

      Volume: 9 Pages: 17-22

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of the C677T polymorphism in the methylenetetrahydropholate reductase gen with sudden sensorineural hearing loss.2010

    • Author(s)
      Uchida Y., et al.
    • Journal Title

      Laryngoscope

      Volume: 120 Pages: 791-795

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Ala54Thr polymorphism in the fatty acid-binding protein 2 (FABP2) gene is associated with hearing impairment : a preliminary report.2010

    • Author(s)
      Uchida Y., et at
    • Journal Title

      Auris Nasus Larynx

      Volume: 37 Pages: 496-499

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The association between gene polymorphisms in uncoupling proteins and hearing impairment in Japanese elederly.2010

    • Author(s)
      Sugiura S., et al.
    • Journal Title

      Acta Otolaryngol

      Volume: 130 Pages: 487-492

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Imaging findings in a case with cholesteatoma in complete aural atresia.2010

    • Author(s)
      Sone M., et al.
    • Journal Title

      Am J Otolaryngol

      Volume: 31 Pages: 297-299

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anatomy-based surgery to remove thyroglossal duct cyst : two anomalous cases.2010

    • Author(s)
      Iwata T., et al.
    • Journal Title

      J Laryngol Otol

      Volume: 124 Pages: 443-446

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 3D-FLAIR MRI in facial nerve paralysis with and without audio-vestibular disorder.2010

    • Author(s)
      Nakata S., et al.
    • Journal Title

      Acta Otolaryngol.

      Volume: 130 Pages: 632-636

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Three-dimensional (3D) visualization of endolymphatic hydrops after intratympanic injection of Gd-DTPA : optimization of a 3D-real inversion-recovery turbo spin-echo (TSE) sequence and application of a 32-channel head coil at 3T2010

    • Author(s)
      Naganawa S., et al.
    • Journal Title

      J Magn Reson Imaging 31

      Pages: 210-214

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between endolymphatic hydrops and vestibular-evoked myogenic potential2010

    • Author(s)
      Katayama N., et al.
    • Journal Title

      Acta Otolaryngol

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in endolymphatic hydrops in a patient with Meniere's disease observed using magnetic resonance imaging2010

    • Author(s)
      Sone M., et al.
    • Journal Title

      Auris Nasus Larynx 37

      Pages: 220-222

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 3 Tesla magnetic resonance imaging obtained 4 hours after intravenous gadolinium injection in patients with sudden deafness2009

    • Author(s)
      Tagaya M., et al.
    • Journal Title

      Acta Otolaryngol

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of presumed hemorrhage in the ampullar endolymph of the semicircular canal : a case report2009

    • Author(s)
      Naganawa S., et al.
    • Journal Title

      Magn Reson Med Sci 8

      Pages: 187-191

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Imaging findings in a case with cholesteatoma in complete aural atresia2009

    • Author(s)
      Sone M., et al.
    • Journal Title

      Am J Otolaryngol

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between the Degree of Endolymphatic Hydrops and Electrocochleography2009

    • Author(s)
      Yamamoto M., et al.
    • Journal Title

      Audiol Neurootol 15

      Pages: 254-260

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 3D-FLAIR MRI in facial nerve paralysis with and without audio-vestibular disorder2009

    • Author(s)
      Nakata S., et al.
    • Journal Title

      Acta Otolaryngol

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The association between gene polymorphisms in uncoupling proteins and hearing impairment in Japanese elderly2009

    • Author(s)
      Sugiura S., et al.
    • Journal Title

      Acta Otolaryngol

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endolymphatic space imaging in patients with delayed endolymphatic hydrops2009

    • Author(s)
      Kasai S., et al.
    • Journal Title

      Acta Otolaryngol 129

      Pages: 1169-1174

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased signal intensity of the cochlea on pre- and post-contrast enhanced 3D-FLAIR in patients with vestibular schwannoma2009

    • Author(s)
      Yamazaki M., et al.
    • Journal Title

      Neuroradiology 51

      Pages: 855-863

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endolymphatic hydrops revealed by intravenous gadolinium injection in patients with Meniere's disease2009

    • Author(s)
      Nakashima T., et al.
    • Journal Title

      Acta Otolaryngol

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Image evaluation of endolymphatic space in fluctuating hearing loss without vertigo2009

    • Author(s)
      Teranishi M., et al.
    • Journal Title

      Eur Arch Otorhinolaryngol 266

      Pages: 1871-1877

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Individual differences in the permeability of the round window : evaluating the movement of intratympanic gadolinium into the inner ear2009

    • Author(s)
      Yoshioka M., et al.
    • Journal Title

      Otol Neurotol 30

      Pages: 645-648

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 3D computerized model of endolymphatic hydrops from specimens of temporal bone2009

    • Author(s)
      Teranishi M., et al.
    • Journal Title

      Acta Otolaryngol Sup. 560

      Pages: 43-47

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intratympanic membrane congenital cholesteatoma2009

    • Author(s)
      Yoshida T., et al.
    • Journal Title

      Int J Pediatr Otorhinolaryngol 73

      Pages: 1003-1005

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endothelin-1 gene polymorphism and hearing impairment in elderly Japanese2009

    • Author(s)
      Uchida Y., et al.
    • Journal Title

      Laryngoscope 119

      Pages: 938-943

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endolymphatic hydrops of the labyrinth visualized on noncontrast MR imaging : a case report2009

    • Author(s)
      Naganawa S., et al.
    • Journal Title

      Magn Reson Med Sci 8

      Pages: 43-46

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 内耳画像診断の臨床2012

    • Author(s)
      中島務
    • Organizer
      第74回奈良県耳鼻咽喉科研修会
    • Place of Presentation
      奈良
    • Year and Date
      2012-02-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] 内耳疾患における画像診断2012

    • Author(s)
      中島務
    • Organizer
      第2回慶耳会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2012-02-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 内耳疾患におけるMRIについて2012

    • Author(s)
      中島務
    • Organizer
      第17回みなみ名古屋耳鼻咽喉科懇話会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-01-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Magnetic resonance imaging of the inner ear after intratympanic and intravenous gadolinium injections2012

    • Author(s)
      Nakashima T, Iida T, Teranishi M, Yoshida T, Kato M, Sone M, Yamazaki M, Naganawa S.
    • Organizer
      49th Inner Ear Bioloby Workshop
    • Place of Presentation
      Tubingen, Germany
    • Related Report
      2012 Final Research Report
  • [Presentation] Polymorphic analysis in patients with Meniere's disease and sudden sensorineural hearing loss2012

    • Author(s)
      Teranishi M, Uchida Y, Nishio N, Kao K, Otake H, Yoshida T, Sone M, Sugiura S, Ando F, Shimokata H, Nakashima T.
    • Organizer
      49th Inner Ear Bioloby Workshop
    • Place of Presentation
      Tubingen, Germany
    • Related Report
      2012 Final Research Report
  • [Presentation] Magnetic resonance imaging of the inner ear after intratympanic and intravenous gadolinium injections2012

    • Author(s)
      Nakashima T
    • Organizer
      49th Inner Ear Bioloby Workshop
    • Place of Presentation
      チュービンゲン(ドイツ)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Polymorphic analysis in patients with Meniere’s disease and sudden sensorineural hearing loss2012

    • Author(s)
      Teranishi M
    • Organizer
      49th Inner Ear Bioloby Workshop
    • Place of Presentation
      チュービンゲン(ドイツ)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 突発性難聴・メニエール病におけるアクアポリン4,5の遺伝子多型の検討2012

    • Author(s)
      寺西正明, 他
    • Organizer
      第30回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      大津
    • Related Report
      2011 Annual Research Report
  • [Presentation] Contribution of complement factor H Y402H polymorphism to sudden sensorineural hearing loss risk and possible interaction with diabetes2011

    • Author(s)
      Nishio N, Teranishi M, Uchida Y, Sugiura S, Ando F, Shimokata H, Sone M, Otake H, Kato K, Yoshida T, Tagaya M, Hibi T, Nakashima T.
    • Organizer
      11th Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2011-12-08
    • Related Report
      2012 Final Research Report
  • [Presentation] 内リンパ水腫のMRIを使った画像診断2011

    • Author(s)
      中島務
    • Organizer
      第7回静岡めまい研究会
    • Place of Presentation
      静岡
    • Year and Date
      2011-10-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] 片頭痛・めまい・突発性難聴の臨床-その周辺をめぐって-内耳性めまい・難聴の臨床2011

    • Author(s)
      中島務
    • Organizer
      第14回日本病院脳神経外科学会
    • Place of Presentation
      松山
    • Year and Date
      2011-07-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Polymorphisms in genes involved in inflammatory pathways in patients with sudden sensorineural hearing loss2011

    • Author(s)
      Teranishi M, Hiramatsu M, Uchida Y, Nishio N, Suzuki H, Kato K, Otake H, Yoshida T, Tagaya M, Suzuki H, Sone M, Sugiura S, Ando F, Shimokata H, Nakashima T.
    • Organizer
      48th Inner Ear Biology Workshop
    • Place of Presentation
      Lisbon, Portugal
    • Related Report
      2012 Final Research Report
  • [Presentation] EDN1(エンドセリン1遺伝子)Lys198Asn多型に関する突発性難聴ケースコントロール研究について2011

    • Author(s)
      内田育恵, 他
    • Organizer
      第112回日本耳鼻咽喉科学会
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] 突発性難聴とメニエール病におけるUCP2遺伝子多型の影響2011

    • Author(s)
      杉浦彩子, 他
    • Organizer
      日本耳鼻咽喉科学会
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] メニエール病に対するゲンタマイシン鼓室内注入療法とMEIによる評価2011

    • Author(s)
      竹内晋平, 他
    • Organizer
      第73回耳鼻咽喉科臨床学会
    • Place of Presentation
      松本
    • Related Report
      2011 Annual Research Report
  • [Presentation] Endolymphatic hydrops of the labyrinth visualized by intravenous gadlinium injection in Meniere's disease2011

    • Author(s)
      Otake H., et al
    • Organizer
      1st Congress of CEORL-HNS
    • Place of Presentation
      Barcelona Spain
    • Related Report
      2011 Annual Research Report
  • [Presentation] Polymorphisms in Genes Involved in Inflammatory Pathways in Patients with Sudden Sensorineural Hearing Loss2011

    • Author(s)
      Teranishi M., et al
    • Organizer
      48th Inner Ear Biology Workshop
    • Place of Presentation
      Lisbon
    • Related Report
      2011 Annual Research Report
  • [Presentation] Dehiscence of the bony labyrinth caused by a high jugular bulb in children2011

    • Author(s)
      Sone M., et al
    • Organizer
      28th Politzer Society Meeting
    • Place of Presentation
      Athens Greece
    • Related Report
      2011 Annual Research Report
  • [Presentation] Visualization of inner ear hydrops in a pendred syndrome mouse model by using microcomputed tomography2011

    • Author(s)
      Yoshida T., et al
    • Organizer
      28th Politzer Society Meeting
    • Place of Presentation
      Athens Greece
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cochlear blood flow and speech perception ability in cochlear implant users2011

    • Author(s)
      Nakashima T, et al
    • Organizer
      The 8^<th> Asia Pacific Symposium on Cochlear Implant and Related Sciences
    • Place of Presentation
      Daegu, Korea
    • Related Report
      2011 Annual Research Report
  • [Presentation] 特発性両側性難聴、老人性難聴においてMRIにより内リンパ水腫を検出した症例2011

    • Author(s)
      寺西正明, 他
    • Organizer
      第56回日本聴覚医学会
    • Place of Presentation
      福岡
    • Related Report
      2011 Annual Research Report
  • [Presentation] 内リンパ水腫症例における連続周波数ティンパノメトリーとMRI画像所見の比較(第2報)2011

    • Author(s)
      加藤健, 他
    • Organizer
      第56回日本聴覚医学会
    • Place of Presentation
      福岡
    • Related Report
      2011 Annual Research Report
  • [Presentation] 前庭型メニエール病における内耳MRI所見2011

    • Author(s)
      加藤正大, 他
    • Organizer
      第70回日本めまい平衡医学会
    • Place of Presentation
      千葉
    • Related Report
      2011 Annual Research Report
  • [Presentation] 高位頸静脈球に伴う小児骨迷路欠損症例2011

    • Author(s)
      曾根三千彦, 他
    • Organizer
      第21回日本耳科学会
    • Place of Presentation
      沖縄
    • Related Report
      2011 Annual Research Report
  • [Presentation] 突発性難聴における炎症性サイトカインの遺伝子多型の検討2011

    • Author(s)
      寺西正明, 他
    • Organizer
      第21回日本耳科学会
    • Place of Presentation
      沖縄
    • Related Report
      2011 Annual Research Report
  • [Presentation] メニエール病およびその周辺疾患における内リンパ腔MRI画像2011

    • Author(s)
      吉田忠雄, 他
    • Organizer
      第21回日本耳科学会
    • Place of Presentation
      沖縄
    • Related Report
      2011 Annual Research Report
  • [Presentation] ファブリー病における聴覚障害と酵素補充療法の効果2011

    • Author(s)
      山本浩志, 他
    • Organizer
      第21回日本耳科学会
    • Place of Presentation
      沖縄
    • Related Report
      2011 Annual Research Report
  • [Presentation] Contribution of Complement Factor H Y402H Polymorphism to Sudden Sensorineural Hearing Loss Risk and Possible Interaction with Diabetes2011

    • Author(s)
      Nishio N., et al
    • Organizer
      11th Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery
    • Place of Presentation
      神戸
    • Related Report
      2011 Annual Research Report
  • [Presentation] MRIによる内リンパ水腫の画像診断2010

    • Author(s)
      中島務
    • Organizer
      第69回日本めまい平衡医学会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2010-11-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Image Evaluation of Endolymphatic Space in Patients with Meniere's Disease2010

    • Author(s)
      Nakashima T., et al.
    • Organizer
      Sixth International Symposium on Meniere's Disease and Inner Ear Disorders.
    • Place of Presentation
      Kyoto International Conference Center (Kyoto)
    • Year and Date
      2010-11-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 突発性難聴に対するデキサメゾン鼓室内注入療法の効果2010

    • Author(s)
      内田育恵, 他
    • Organizer
      第55回日本聴覚医学会
    • Place of Presentation
      奈良県新公会堂(奈良県)
    • Year and Date
      2010-11-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] 画像評価からみた鼓室内薬剤投与療法の有効性2010

    • Author(s)
      中島務
    • Organizer
      第20回日本耳科学会
    • Place of Presentation
      ひめぎんホール(松山市)
    • Year and Date
      2010-10-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] 加齢による難聴の危険因子と予防策2010

    • Author(s)
      中島務
    • Organizer
      第10回日本抗加齢医学会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2010-06-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 術前診断に高解像度MRIが有用であった蝸牛内神経鞘腫の1例2010

    • Author(s)
      吉田忠雄, 他
    • Organizer
      第111回日本耳鼻咽喉科学会
    • Place of Presentation
      仙台国際センター(仙台市)
    • Year and Date
      2010-05-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 内リンパ水腫のMRIによる程度分類2009

    • Author(s)
      中島務, 他
    • Organizer
      XIX World Congress of Oto-Rhino-Laryngology
    • Place of Presentation
      サンパウロ (ブラジル)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 後天性サイトメガロウィルス感染後に発症した進行性難聴の一例2009

    • Author(s)
      大竹宏直, 他
    • Organizer
      第54回日本聴覚医学会
    • Place of Presentation
      横浜市
    • Related Report
      2009 Annual Research Report
  • [Presentation] 静注Gdによるメニエール病による内リンパ水腫の描出2009

    • Author(s)
      長縄慎二, 他
    • Organizer
      第37回日本磁気共鳴医学会大会
    • Place of Presentation
      横浜市
    • Related Report
      2009 Annual Research Report
  • [Presentation] 内リンパ水腫と前庭誘発筋原電位 (VEMP) の関係2009

    • Author(s)
      片山直美, 他
    • Organizer
      第68回めまい平衡医学会総会
    • Place of Presentation
      徳島市
    • Related Report
      2009 Annual Research Report
  • [Book] 「紹介の最適のタイミングは?」急性難聴の鑑別とその対処2012

    • Author(s)
      寺西正明、中島務
    • Publisher
      中山書店
    • Related Report
      2012 Final Research Report
  • [Book] 「予後診断は可能か?」 急性難聴の鑑別とその対処2012

    • Author(s)
      寺西正明、中島務
    • Publisher
      中山書店
    • Related Report
      2012 Final Research Report
  • [Book] 急性難聴の鑑別とその対処(分担)2012

    • Author(s)
      寺西正明
    • Total Pages
      7
    • Publisher
      中山書店
    • Related Report
      2012 Annual Research Report
  • [Book] 耳鼻咽喉科・頭頸部外科研修ノート2011

    • Author(s)
      山岨達也, 他
    • Total Pages
      580
    • Publisher
      (株)診断と治療社
    • Related Report
      2010 Annual Research Report
  • [Book] よくわかる聴覚障害 -難聴と耳鳴のすべて-2010

    • Author(s)
      中島務, 他
    • Publisher
      永井書店(未定)
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等 (研究代表者 Researcher ID)

    • URL

      http://www.researcherid.com/rid/B-8259-2012

    • Related Report
      2012 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2019-07-29  

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