Systematical investigations on the neurological control and its disorder of the larynx

• Project/Area Number: 21390463
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: HISA Yasuo 京都府立医科大学, 医学研究科, 教授 (50181087)
• Co-Investigator(Kenkyū-buntansha): SHIMADA Taketoshi 京都府立医科大学, 医学研究科, 講師 (30275226) ; NAKANO Hiroshi 京都府立医科大学, 医学研究科, 助教 (00405309) ; 馬場 均 京都府立医科大学, 医学研究科, 客員講師 (30360035)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000); Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2009: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
• Keywords: 喉頭 / 神経機構 / 嚥下 / 発声 / アクアポリン / TDP-43 / 神経制御機構 / 喉頭腺分泌 / ALS / 概日リズム / 腺分泌 / 時計遺伝子

Research Abstract

Important subjects on the neurological control and its disorder were clarified with present highest manners. Clarified matters were as follows;brainstem vocalization area, axonal projections of medullary swallowing neurons, regulation of aquaporins in the larynx and transient redistribution of TDP-43 in brainstem motor neurons after axonal ligation.

Research Products

• [Journal Article] Localization and regulation of aquaporins in the murine larynx (2012)
  • Author(s): Ahmed Mel-R, Bando H, Hirota R, Sakaguchi H, Koike S, El-Adawy AA, Kotby MN, Hisa Y
  • Journal Title: Acta Otolaryngol Volume: 132(4) Pages: 439-46
  • Peer Reviewed
• [Journal Article] Localization and regulation of aquaporins in the murine larynx (2012)
  • Author(s): Ahmed M El-Rabie
  • Journal Title: Acta Otolaryngologica Volume: Vol.132(Epub) Pages: 439-446
  • Peer Reviewed
• [Journal Article] Axonal projections of medullary swallowing neurons in guinea pigs (2011)
  • Author(s): Sugiyama Y, Shiba K, Nakazawa K, Suzuki T, Umezaki T, Ezure K, Abo N, Yoshihara T, Hisa Y
  • Journal Title: J Comp Neurol Volume: 519(11) Pages: 2193-2211
  • Peer Reviewed
• [Journal Article] Axonal projections of medullary swallowing neurons in guinea pigs (2011)
  • Author(s): Sugiyama Y, Shiba K, Nakazawa K, Suzuki T, Umezaki T, Ezure K Abo N, Yoshihara T, Hisa Y.
  • Journal Title: J Comp Neurol Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Brainstem vocalization area in guinea pigs (2010)
  • Author(s): Sugiyama Y, Shiba K, Nakazawa K, Suzuki T, Hisa Y
  • Journal Title: Neurosci Res Volume: 66(4) Pages: 359-365
  • Peer Reviewed
• [Journal Article] Brainstem vocalization area in guinea pigs (2010)
  • Author(s): Sugiyama Y, Shiba K, Nakazawa K, Suzuki T, Hisa Y.
  • Journal Title: Neurosci Res Volume: 66 Pages: 359-365
  • Peer Reviewed
• [Journal Article] Axonal ligation induces transient redistribution of TDP-43 in brainstem motor neurons (2009)
  • Author(s): Sato T, Takeuchi S, Saito A, Ding W, Bamba H, Matsuura H, Hisa Y, Tooyama I, Urushitani M
  • Journal Title: Neuroscience Volume: 164(4) Pages: 1565-1578
  • Peer Reviewed
• [Presentation] Localization of aquaporins in the murine larynx(poster) (2011)
  • Author(s): Hisa Y
  • Organizer: Collegium Oto-Rhino-Laryngologicum Amicitiae Sacrum
  • Place of Presentation: Bruges, Belgium
  • Year and Date: 2011-09-07
• [Presentation] Localization of aquaporins in the murine larynx (2011)
  • Author(s): Yasuo Hisa
  • Organizer: Collegium Oto-Rhino-Laryngologicum Amicitiae Sacrum
  • Place of Presentation: Oud Sint-Jan (Bruges, Belgium)
  • Year and Date: 2011-09-07
• [Presentation] Developments in Basic Neurolaryngology. Panel Discussion : Neurolaryngology (2011)
  • Author(s): Hisa Y
  • Organizer: 12th Asia-Oceania ORL-HNS Congress
  • Place of Presentation: Auckland, New Zealand
  • Year and Date: 2011-03-03
• [Presentation] Aquaporins expression in the murine larynx(poster) (2010)
  • Author(s): Bando H, Ahmed ME, Nabieh AA, Nishio T, Hirota R, Kotby MN, Hisa Y
  • Organizer: The 7th East Asian Conference on Phonosurgery
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2010-11-26
• [Presentation] Recent advances in basic neurolaryngology. Panel Discussion 102.Neural mechanism of phonation (2010)
  • Author(s): Hisa Y
  • Organizer: Voice 2010 The 4th World Voice Congress
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2010-09-09
• [Presentation] Vocal sites in guinea pig brainstem(poster) (2010)
  • Author(s): Hisa Y, Sugiyama Y, Shiba K
  • Organizer: Collegium Oto-Rhino-Laryngologicum Amicitiae Sacrum
  • Place of Presentation: Budapest, Hungary
  • Year and Date: 2010-08-25
• [Presentation] Vocal Sites in guinea pig brainstem (2010)
  • Author(s): Hisa Y, Sugiyama Y, Shiba K.
  • Organizer: Collegium Oto-Rhino-Laryngologicum Amicitiae Sacrum
  • Place of Presentation: Budapest, Hungary
  • Year and Date: 2010-08-25
• [Presentation] Brainstem vocalization regions in guinea pigs(poster) (2010)
  • Author(s): Sugiyama Y, Suzuki T, Nakazawa K, Shiba K, Hisa Y
  • Organizer: European Neuroscience
  • Place of Presentation: Amsterdam, The Netherlands
  • Year and Date: 2010-07-07