Genome-wide association study identifies two susceptibility loci for agerelated macular degeneration in the Japanese population

• Project/Area Number: 21390468
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kyushu University
• Principal Investigator: ISHIBASHI Tatsuro 九州大学, 医学研究院, 教授 (30150428)
• Co-Investigator(Kenkyū-buntansha): KIYOHARA Yutaka 九州大学, 大学院・医学研究院, 教授 (80161602) ; KUBO Mitsuaki 独立法人理化学研究所, チームリーダー (30442958)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000); Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2009: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
• Keywords: 加齢黄斑変性 / 遺伝子解析 / ゲノムワイドアプローチ

Research Abstract

Our data showed that TNFRSFIOALOC389641 on chromosome 8p21 and RESTC4orf14POLR2BIGFBP7 on chromosome 4q12 are new susceptibility loci for exudative AMD in the Japanese population. Futher functional studies are neccesary to clarify the mechanisms of these loci on the susceptibility to exudative AMD

Research Products

• [Journal Article] et al. Genome-wide association stud y identifies two susceptibility loci for exudative ageralated macular degeneration i n the Japanese population (2011)
  • Author(s): Arakawa S, Kiyohara Y, Kubo M, Ishib ashi T
  • Journal Title: Nature genetics Volume: 43 Pages: 10001-1004
  • Peer Reviewed
• [Journal Article] Genome-wide association study identifies two susceptibility loci for exudative age-ralated macular degeneration in the Japanese population (2011)
  • Author(s): Arakawa S, Kiyohara Y, Kubo M, Ishibashi T, et al
  • Journal Title: Nature genetics Volume: 43 Pages: 1001-1004
  • Peer Reviewed
• [Journal Article] Nine-year incidence and risk factors for retinal vein occlusion in ageneral Japanese population : ths Hisayama Study (2011)
  • Author(s): Arakawa S, Kiyohara Y, Ishibashi T, et al
  • Journal Title: Investigative Ophthalmology & Visual Science Volume: 52 Pages: 5905-5909
  • Peer Reviewed
• [Journal Article] High serum bilirubin levels and diabetic retinopathy : The Hisayama Study (2011)
  • Author(s): Yasuda M, Kiyohara Y, Ishibashi T, et al
  • Journal Title: Ophthalmology Volume: 118 Pages: 1423-1428
  • Peer Reviewed
• [Journal Article] Pigment Epithelium-Derived Factor Gene Therapy Targeting Retinal Ganglion Cell Injuries : Neuroprotection Against Loss of Function in Two Animal Models (2011)
  • Author(s): Miyazaki M, Ishibashi T, et al
  • Journal Title: HUMAN GENE THERAPY Volume: 22 Pages: 559-565
  • NAID: 120005007890
  • Peer Reviewed
• [Journal Article] Establishment of a New Animal Model of Focal Subretinal Fibrosis That Resembles Disciform Lesion in Advancsd Age-Related Macular Degeneration (2011)
  • Author(s): Jo Y-J, Ishibashi T, et al
  • Journal Title: IOVS Volume: 52(8) Pages: 6089-6095
  • Peer Reviewed
• [Journal Article] Hyalocytes : Essential Cell of the Vitreous Cavity in Vitreoretinal Pathophysiology? (2011)
  • Author(s): Sakamoto T, Ishibashi T, et al
  • Journal Title: Retina Volume: 31 Pages: 222-228
  • Peer Reviewed
• [Journal Article] Morphologic and Functional Advantages of Macular Hole Surgery with Brilliant Blue G-Assisted Internal Limiting Membrane Peeling (2011)
  • Author(s): Fukuda K, Ishibashi T, et al
  • Journal Title: Retina Volume: 31(8) Pages: 1720-1725
  • Peer Reviewed
• [Journal Article] Prevalence and systemic risk factors of retinal vein occlusion in a general Japanese population : The Hisayama Study (2010)
  • Author(s): Yasuda M, Ishibashi T, et al
  • Journal Title: Investigative Ophthalmology & Visual Science Volume: 51 Pages: 3205-3209
  • Peer Reviewed
• [Journal Article] Prevalence and systemic risk factors of retinal vein occlusion in a general Japanese population : The Hisayama Study. (2010)
  • Author(s): Yasuda M, Ishibashi T, et al
  • Journal Title: Investigative Ophthalmology & Visual Science (in press)
  • Peer Reviewed
• [Journal Article] Nine-year incidence and risk factors for age-related macular degeneration in a defined Japanese population : The Hisayama Study. (2009)
  • Author(s): Yasuda M, Ishibashi T, et al
  • Journal Title: Ophthalmology 116 Pages: 2135-2140
  • Peer Reviewed
• [Presentation] 加齢黄斑変性:最近の話題 (2011)
  • Author(s): 石橋達朗
  • Organizer: 第228回山口県眼科医会秋季集談会
  • Place of Presentation: 山口市(特別講演)
  • Year and Date: 2011-11-27
• [Presentation] 加齢黄斑変性:最近の話題 (2011)
  • Author(s): 石橋達朗
  • Organizer: 第73回香川大学眼科研究会
  • Place of Presentation: 高松市(特別講演)
  • Year and Date: 2011-11-26
• [Presentation] 加齢黄斑変性治療の現状と未来 (2011)
  • Author(s): 石橋達朗
  • Organizer: 第5回Midland Seminar of Ophthalmology
  • Place of Presentation: 名古屋市(招待講演)
  • Year and Date: 2011-10-29
• [Presentation] 加齢黄斑変性 (2011)
  • Author(s): 石橋達朗
  • Organizer: 日本学術会議感覚器分科会市民公開講座加齢と目と耳の病気
  • Place of Presentation: 京都市(招待講演)
  • Year and Date: 2011-05-21
• [Presentation] 網膜の包括的神経保護～臨床応用への挑戦～ (2011)
  • Author(s): 石橋達朗
  • Organizer: 第115回日本眼科学会
  • Place of Presentation: 東京都(特別講演)
  • Year and Date: 2011-05-14
• [Presentation] 眼科領域における抗VEGF治療 (2011)
  • Author(s): 石橋達朗
  • Organizer: 第36回日本微小循環学会総会
  • Place of Presentation: 名古屋市
• [Presentation] 網膜の包括的神経保護～臨床応用への挑戦～ (2011)
  • Author(s): 石橋達朗
  • Organizer: 第115回日木眼科学会特別講演
  • Place of Presentation: 東京都
• [Presentation] ポリープ状脈絡膜血管症の有病率～久山町研究 (2010)
  • Author(s): 安田美穂、清原裕、石橋達朗, ら
  • Organizer: 第64回日本臨床眼科学会
  • Place of Presentation: 神戸市
  • Year and Date: 2010-11-11
• [Presentation] 加齢黄斑変性およびドルーゼンにおける高感度CRP値の検討 (2010)
  • Author(s): 安田美穂、清原裕、石橋達朗, ら
  • Organizer: 第114回日本眼科学会総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2010-04-23
• [Presentation] 糖尿病網膜症の疫学と予防戦略 (2010)
  • Author(s): 安田美穂、清原裕、石橋達朗, ら
  • Organizer: 第114回日本眼科学会総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2010-04-22
• [Presentation] 久山町研究からわかる眼科疾患の危険因子・予防因子 (2010)
  • Author(s): 安田美穂
  • Organizer: 関西眼疾患研究会
  • Place of Presentation: 京都市
  • Year and Date: 2010-01-05
• [Presentation] 加齢黄斑変性の疫学 (2009)
  • Author(s): 安田美穂、石橋達朗, ら
  • Organizer: 第63回 日本臨床眼科学会
  • Place of Presentation: 福岡市
  • Year and Date: 2009-10-09
• [Presentation] 加齢黄斑変性患者における高感度CRP値の検討 (2009)
  • Author(s): 安田美穂
  • Organizer: 第47回 六大学合同眼科研究会
  • Place of Presentation: 福岡市
  • Year and Date: 2009-09-05