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Characterization of mouse models for glaucoma

Research Project

Project/Area Number 21390471
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research Institution独立行政法人国立病院機構東京医療センター(臨床研究センター) (2011)
独立行政法人国立病院機構(東京医療センター臨床研究センター) (2009-2010)

Principal Investigator

IWATA Takeshi  独立行政法人国立病院機構東京医療センター(臨床研究センター), 分子細胞生物学研究部, 部長 (90374157)

Co-Investigator(Renkei-kenkyūsha) MIZOTA Atsushi  帝京大学, 眼科学講座, 教授 (10239262)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2009: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Keywords緑内障 / オプチニュリン / WDR36 / Vav2 / Vav3 / トランスジェニックマウス
Research Abstract

Glaucoma is a multifactorial disease influenced by genetic and environment factors. The molecular mechanism of the glaucoma onset still remains unclear. In this study we focused on 4 genes, optineurin, WDR36, vav2, and vav3 to develop and characterize the mouse model for glaucoma.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (66 results)

All 2011 2010 2009 2008 Other

All Journal Article (18 results) (of which Peer Reviewed: 12 results) Presentation (27 results) Book (7 results) Remarks (4 results) Patent(Industrial Property Rights) (10 results) (of which Overseas: 1 results)

  • [Journal Article] Processing of optineurin in neuronal cells2011

    • Author(s)
      Shen X, Ying H, Qiu Y, Park J-S, Shyam R, Chi Z-L, Iwata T, Yue BYJT.
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 286 Pages: 3618-29

    • Related Report
      2011 Final Research Report
  • [Journal Article] Analysis of LOXL1 gene variants in Japanese patients with branch retinal vein occlusion2011

    • Author(s)
      Hara K, Akahori M, Tanito M, Kaidzu S, Ohira A, Iwata T.
    • Journal Title

      Molecular Vision

      Volume: 17 Pages: 3309-13

    • Related Report
      2011 Final Research Report
  • [Journal Article] Processing of optineurin in neuronal cells2011

    • Author(s)
      Shen X, et al
    • Journal Title

      J Biol Chem

      Volume: 286 Pages: 3618-3629

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modeling retinal degeneration using patient-specific induced pluripotent stem cells2011

    • Author(s)
      Jin ZB, et al
    • Journal Title

      PLoS One

      Volume: 6

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of LOXL1 gene variants in Japanese patients with branch retinal vein occlusion2011

    • Author(s)
      Hara K, et al
    • Journal Title

      Mol Vis

      Volume: 17 Pages: 3309-3313

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vav2 and Vav3 as candidate disease gene for spontaneous glaucoma in mice and human2010

    • Author(s)
      Fujikawa K, Iwata T, Inoue K, Akahori M, Kadotani H, Fukaya M, Watanabe M, Chang Q, Barnett EM, and Swat W.
    • Journal Title

      PLOS One

      Volume: 5

    • NAID

      120001896679

    • Related Report
      2011 Final Research Report
  • [Journal Article] Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice2010

    • Author(s)
      Chi Z-L, Akahori, A, Obazawa M, Minami M, Noda T, Nakaya N, Tomarev S, Kawase K, Yamamoto T, Noda S, Sasaoka M, Shimazaki A, Takada Y, and Iwata T.
    • Journal Title

      Human Molecular Genetics

      Volume: 19 Pages: 2605-2615

    • Related Report
      2011 Final Research Report
  • [Journal Article] Mutant WDR36 directly affects axon growth of retinal ganglion cells leading to progressive retinal degeneration in mice2010

    • Author(s)
      Chi Z-L, Yasumoto F, Sergeev Y, Minami M, Obazawa M, Kimura I, Takada Y, and Iwata T.
    • Journal Title

      Human Molecular Genetics

      Volume: 19 Pages: 3806-3815

    • Related Report
      2011 Final Research Report
  • [Journal Article] Vav2 and Vav3 as candidate disease gene for spontaneous glaucoma in mice and human.2010

    • Author(s)
      Fujikawa K, et al.
    • Journal Title

      PLoS ONE

      Volume: 5

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice.2010

    • Author(s)
      Chi Z, et al.
    • Journal Title

      Human Molecular Genetics

      Volume: 19 Pages: 2606-2615

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutant WDR36 directly affects axon growth of retinal ganglion cells leading to progressive retinal degeneration in mice.2010

    • Author(s)
      Chi Z, et al.
    • Journal Title

      Human Molecular Genetics

      Volume: 19 Pages: 3806-3815

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of drusen formation by compstatin, a peptide inhibitor of complement C3 activation, on Cynomolgus monkey with early-onset macular degeneration2010

    • Author(s)
      Chi Z, et al.
    • Journal Title

      Current Topics on Complement and Eye Disease, Advances in Experimental Medicine and Biology(Springer)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative proteomic analyses of macular versus peripheral retina in Cynomolgus monkeys(Macaca fascicularis)2010

    • Author(s)
      Okamoto H, et al.
    • Journal Title

      Experimental Animal 59

      Pages: 171-182

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice2010

    • Author(s)
      Chi Z, et al.
    • Journal Title

      Human Molecular Genetics ddg146

      Pages: 1-10

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stargardt disease with preserved central vision : identification of a putative novel mutation in ATP-binding cassette transporter gene2010

    • Author(s)
      Fujinami K, et al.
    • Journal Title

      Acta Ophthalmologica

      Pages: 1-2

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vav2 and Vav3 as candidate disease gene for spontaneous glaucoma in mice and human2010

    • Author(s)
      Fujikawa K, et al.
    • Journal Title

      PLOS One5 : e9050 5

      Pages: 1-11

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic analysis of typical wet-type age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese population2009

    • Author(s)
      Goto A, et al.
    • Journal Title

      Journal of Ocular Biology, Disease, and In formatics

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 緑内障遺伝子改変動物の基礎2009

    • Author(s)
      岩田岳
    • Journal Title

      眼薬理

    • NAID

      10027119510

    • Related Report
      2009 Annual Research Report
  • [Presentation] Dominant mutations in RP1L1 are responsible for occult macular dystrophy2011

    • Author(s)
      Akahori, et al
    • Organizer
      ARVO
    • Place of Presentation
      Fort Lauderdale, FL
    • Related Report
      2011 Annual Research Report
  • [Presentation] Microarray analysis of RPE cells isolated from cynomolgus monkey with early-onset drusen formation2011

    • Author(s)
      Chi, et al
    • Organizer
      ARVO
    • Place of Presentation
      Fort Lauderdale, FL
    • Related Report
      2011 Annual Research Report
  • [Presentation] Plasma proteome analysis on cynomolgus monkey pedigrees with early onset drusen formation2011

    • Author(s)
      Kobayashi, et al
    • Organizer
      ARVO
    • Place of Presentation
      Fort Lauderdale, FL
    • Related Report
      2011 Annual Research Report
  • [Presentation] Inhibition of drusen formation by Compstatin in cynomolgus monkey with early-onset macular degeneration2011

    • Author(s)
      Iwata, et al
    • Organizer
      Aegean Conferences
    • Place of Presentation
      Rhodes, Greece
    • Related Report
      2011 Annual Research Report
  • [Presentation] Dominant mutations in RP1L1 are responsible for occult macular dystrophy (Miyake's Disease)2011

    • Author(s)
      Iwata, et al
    • Organizer
      ASHG
    • Place of Presentation
      Montreal, Canada
    • Related Report
      2011 Annual Research Report
  • [Presentation] Suppression of drusen formation by compstatin (POT-4), a peptide inhibitor of C3 activation, on cynomolgus monkey with early-onset macular degeneration2010

    • Author(s)
      Chi ZL, et al.
    • Organizer
      19th International Congress for Eye Research
    • Place of Presentation
      Montreal
    • Year and Date
      2010-07-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Analysis of Colocalization of Rab8 and ERM Family in the Ocular Body2010

    • Author(s)
      I. Kimura, H. Okamoto, Z. L. Chi, M. Akahori, M. T. Suzuki, T. Iwata
    • Organizer
      Association for Research in Vision and Ophthalmology
    • Related Report
      2011 Final Research Report
  • [Presentation] CHARACTERIZATION OF GLIA CELLS IN OPTN AND WDR36 TRANSGENIC MICE2010

    • Author(s)
      T. Iwata. Z. L. Chi, M. Akahori, Y. Takada, N. Nakaya, S. Tomarev, Y. Sergeev
    • Organizer
      19th International Congress for Eye Research
    • Related Report
      2011 Final Research Report
  • [Presentation] Overexpression of mutant OPTN and WDR36 leads to a progressive retinal degeneration in mice2010

    • Author(s)
      Chi ZL. Akahori M, Obazawa M, Minami M, Noda T, Nakaya N, Tomarev S, Kawase K, Yamamoto T, Noda S, Sasaoka M, Shimazaki A, Sergeev Y, Takada Y, Iwata T.
    • Organizer
      50th American Society for Cell Biology
    • Related Report
      2011 Final Research Report
  • [Presentation] Overexpression of mutant OPTN and WDR36 leads to a progressive retinal degeneration in mice.2010

    • Author(s)
      Chi ZL, et al.
    • Organizer
      50th American Society for Cell Biology
    • Place of Presentation
      Philadelphia
    • Related Report
      2010 Annual Research Report
  • [Presentation] 「失明に至る眼の疾患に挑む」加齢黄斑変性の霊長類モデル、遺伝子解析からの創薬ターゲット2009

    • Author(s)
      岩田岳
    • Organizer
      第34回ヒューマンサイエンス総合研究セミナー
    • Place of Presentation
      砂防会館(東京)
    • Year and Date
      2009-09-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Overexpression of Mutated Optineurin and WDR36 Leads to Normal Tension Glaucoma in Mice2009

    • Author(s)
      Takeshi Iwata, et al.
    • Organizer
      Association for Research in Vision and Ophthalmology
    • Related Report
      2011 Final Research Report
  • [Presentation] 遺伝情報を応用した病態解析とモデル作成2009

    • Author(s)
      岩田岳, 他
    • Organizer
      第113回日本眼科学会総会
    • Related Report
      2011 Final Research Report
  • [Presentation] 緑内障遺伝子WDR36トランスジェニックマウスの解析2009

    • Author(s)
      池在龍, 他
    • Organizer
      第113回日本眼科学会総会
    • Related Report
      2011 Final Research Report
  • [Presentation] 毛様体におけるRab8とERM Familyの局在についての検討2009

    • Author(s)
      木村至, 他
    • Organizer
      第113回日本眼科学会総会
    • Related Report
      2011 Final Research Report
  • [Presentation] Susceptibility genes and animal models of glaucoma2009

    • Author(s)
      Takeshi Iwata, et al.
    • Organizer
      Asia Association for Research in Vision and Ophthalmology
    • Related Report
      2011 Final Research Report
  • [Presentation] 遺伝情報を応用した病態解析とモデル作成2009

    • Author(s)
      岩田岳
    • Organizer
      第113回日本眼科学会総会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 日本人における滲出型加齢黄斑変性のゲノムワイド相関解析2009

    • Author(s)
      関麻子
    • Organizer
      第113回日本眼科学会総会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 緑内障遺伝子WDR36トランスジェニックマウスの解析2009

    • Author(s)
      池在龍
    • Organizer
      第113回日本眼科学会総会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 毛様体におけるRab8とERM Family の局在についての検討2009

    • Author(s)
      木村至
    • Organizer
      第113回日本眼科学会総会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 加齢黄斑変性の発症機序とモデル動物を用いた予防・治療法の開発2009

    • Author(s)
      岩田岳
    • Organizer
      第63回国立病院総合医学会
    • Place of Presentation
      仙台国際センター(仙台)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Susceptibility genes and animal models of glaucoma. Asia Association for Research in Vision and Ophthalmology2009

    • Author(s)
      岩田岳
    • Organizer
      Asia Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Hyderabad, India
    • Related Report
      2009 Annual Research Report
  • [Presentation] Japanese contribution to the global eye research-past, present and future2009

    • Author(s)
      岩田岳
    • Organizer
      Asia Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Hyderabad, India
    • Related Report
      2009 Annual Research Report
  • [Presentation] Proteomic analysis of low molecular weight plasma proteins from patients with ocular diseases2009

    • Author(s)
      岩田岳
    • Organizer
      Asia Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Hyderabad, India
    • Related Report
      2009 Annual Research Report
  • [Presentation] Overexpression of Mutated Optineurin and WDR36 Leads to Norm al Tension Glaucoma in Mice2009

    • Author(s)
      岩田岳
    • Organizer
      Association for Research in Vision and Ophthalmology
    • Place of Presentation
      USA, Fort Lauderdale
    • Related Report
      2009 Annual Research Report
  • [Presentation] Characterization of RPE Cells Isolated From Cynomolgus Monkey With Early-Onset Macular Degeneration2009

    • Author(s)
      Chi Z
    • Organizer
      Association for Research in Vision and Ophthalmology
    • Place of Presentation
      USA, Fort Lauderdale
    • Related Report
      2009 Annual Research Report
  • [Presentation] Suppression of drusen formation by Compstatin(POT-4), a peptide inhibitor of complement component C3 activation, on cynomolgus monkey with early-onset macular degeneration2009

    • Author(s)
      岩田岳
    • Organizer
      Aegean Conference
    • Place of Presentation
      Crete, Greece
    • Related Report
      2009 Annual Research Report
  • [Book] 眼科と補体、補体への招待2011

    • Author(s)
      岩田岳
    • Publisher
      メディカルビュー社
    • Related Report
      2011 Final Research Report
  • [Book] 視力・資格を司る黄斑の生理機能と黄斑変性の分子メカニズム、実験医学2011

    • Author(s)
      岩田岳
    • Publisher
      羊土社
    • Related Report
      2011 Final Research Report
  • [Book] 実験医学2011

    • Author(s)
      岩田岳
    • Total Pages
      5
    • Publisher
      羊土社
    • Related Report
      2011 Annual Research Report
  • [Book] 補体への招待2011

    • Author(s)
      岩田岳
    • Total Pages
      5
    • Publisher
      メディカルビュー社
    • Related Report
      2011 Annual Research Report
  • [Book] 眼科と補体、補体への2011

    • Author(s)
      岩田岳
    • Total Pages
      5
    • Publisher
      メディカルビュー社(招待)
    • Related Report
      2010 Annual Research Report
  • [Book] 視力・色覚を司る黄斑の生理機能と黄斑変性の分子メカニズム、視覚・聴覚のNeuro science、実験医学2011

    • Author(s)
      岩田岳
    • Total Pages
      12
    • Publisher
      羊土社
    • Related Report
      2010 Annual Research Report
  • [Book] 緑内障遺伝子改変動物の基礎、眼薬理2009

    • Author(s)
      岩田岳
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.eye.go.jp

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.kankakuki.go.jp/lab_e.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.eye.go.jp/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.kankakuki.go.jp/lab_e.html

    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 神経障害の検定のための組成物、キットおよび方法2009

    • Inventor(s)
      岩田岳
    • Industrial Property Rights Holder
      東京医療センター
    • Industrial Property Number
      2008-091522
    • Filing Date
      2009-03-31
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 代謝障害を伴う疾患の検定のための組成物、キットおよび方法2009

    • Inventor(s)
      岩田岳
    • Industrial Property Rights Holder
      東京医療センター
    • Industrial Property Number
      2008-092021
    • Filing Date
      2009-03-31
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 老化、および血管障害を伴う疾患の検定のための組成物、キットおよび方法2009

    • Inventor(s)
      岩田岳
    • Industrial Property Rights Holder
      東京医療センター
    • Industrial Property Number
      2008-092245
    • Filing Date
      2009-03-31
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] コラーゲン線維の萎縮による組織障害の検査のための方法、組成物及びキット2009

    • Inventor(s)
      岩田岳
    • Industrial Property Rights Holder
      東京医療センター
    • Industrial Property Number
      2008-257469
    • Filing Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 糖尿病性末梢血管障害の検査のための方法、組成物およびキット2009

    • Inventor(s)
      岩田岳
    • Industrial Property Rights Holder
      東京医療センター
    • Industrial Property Number
      2008-257430
    • Filing Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 細胞増殖を伴う糖尿病合併症の検査のための方法、組成物およびキット2009

    • Inventor(s)
      岩田岳
    • Industrial Property Rights Holder
      東京医療センター
    • Industrial Property Number
      2008-257691
    • Filing Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 神経障害の検定のための組成物、キットおよび方法2008

    • Inventor(s)
      岩田岳
    • Industrial Property Rights Holder
      国立病院機構東京医療センター
    • Filing Date
      2008
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 代謝障害を伴う疾患の検定のための組成物、キットおよび方法2008

    • Inventor(s)
      岩田岳
    • Industrial Property Rights Holder
      国立病院機構東京医療センター
    • Filing Date
      2008
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 緑内障のリスクの予測方法2008

    • Inventor(s)
      岩田岳
    • Industrial Property Rights Holder
      国立病院機構東京医療センター
    • Filing Date
      2008
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] コラーゲン線維の萎縮による組織障害の検査のための方法、組成物及びキット2008

    • Inventor(s)
      岩田岳
    • Industrial Property Rights Holder
      東京医療センター
    • Industrial Property Number
      2008-257469
    • Filing Date
      2008-10-02
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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