New treatment using gene induction and regenerative medicinefor diaphragmatic agenesis
| Project/Area Number |
21390475
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MASUMOTO Koji 筑波大学, 医学医療系, 教授 (20343329)
NONAKA Kazuaki 九州大学, 歯学研究院, 教授 (90128067)
NAGATA Koji 九州大学, 大学病院, 助教 (20419568)
IEIRI Satoshi 九州大学, 大学病院, 講師 (00363359)
TAJIRI Tatsuro 京都府立医科大学, 医学研究科, 教授 (80304806)
KINOSHITA Yoshiaki 九州大学, 医学研究院, 准教授 (80345529)
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| Project Period (FY) |
2009 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2011: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Keywords | 小児呼吸器外科学 / 横隔膜ヘルニア / 肺低形成 / 成長因子 / SNP-array / 責任遺伝子 / 幹細胞 / 再生医療 |
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| Research Abstract |
Intrapulmonary mesenchymal stem cells (MSC) were administered to the rat with nitrophen-induced diaphragmatic hernia. As a result, PCNA positive cells are increased.DNA was extracted from the 20 patients and parents of congenital diaphragmatic hernia. The microdeletion of TCTE3 was detected. This might be the responsible gene for congenital diaphragmatic hernia.Abdominal muscle flap method was performed for the reconstructive surgery in 11 cases with recurrent diaphragmatic hernia. All of the patients showed good outcome.Liver-like cells were induced from SHED. We are just starting to make the sheet of the striated muscle cells derived from SHED.
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Report
(5 results)
Research Products
(83 results)
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[Journal Article] Association of lymphocyte crossmatch and the outcome of intestinal transplantaion in swine2011
Author(s)
Hayashida M, Matsuura T, Saeki I, Yanagi Y, Yoshimaru K, Nishimoto, Y, Takahashi Y, Fujita K, Takada N, Taguchi S, Uesugi T, Hirose R, Nakamura M, Nakao M, Taguchi T
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Journal Title
Pediatr Surg Int
Volume: 27(3)
Pages: 279-281
Related Report
Peer Reviewed
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[Journal Article] EGFR Tyrosine Kinase Inhibition Worsens Acute Lung Injury in Mice with Repairing Airway Epithelium2011
Author(s)
Harada C, Kawaguchi T, Ogata-Suetsugu S, Yamada M, Hamada N, Maeyama T, Souzaki R, Tajiri T, Taguchi T, Kuwano K, Nakanishi Y
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Journal Title
J Respir Crit Care Med
Volume: 183
Pages: 743-751
Related Report
Peer Reviewed
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[Journal Article] Successful treatment of an infected wound in infants by a combination of negative pressure wound therapy and arginine supplementation2011
Author(s)
Masumoto K, Nagata K, Oka Y, Kai H, Yamaguchi S, Wada M, Kusuda T, Hara T, Hirose S, Iwasaki A, Taguchi T
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Journal Title
Nutrition
Volume: 27(11-12)
Pages: 1141-1145
Related Report
Peer Reviewed
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[Journal Article] Effectiveness of basic endoscopic surgical skill training for pediatric surgeons.2010
Author(s)
Ieiri S, Nakatsuji T, Higashi M, Akiyoshi J, Uemura M, Konishi K, Onimaru, M, Ohuchida K, Hong J, Tomikawa M, Tanoue K, Hashizume M, Taguchi T
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Journal Title
Pediatr Surg Int
Volume: 26(10)
Pages: 947-954
Related Report
Peer Reviewed
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[Journal Article] Improvement in the outcome of patients with antenatally diagnosed congenital diaphragmatic hernia using gentle ventilation and circulatory stabilization2009
Author(s)
Masumoto K, Teshiba R, Esumi G, Nagata K, Takahata Y, Hikino S, Hara T, Hojo S, Tsukimori K, Wake N, Kinukawa N, Taguchi T
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Journal Title
Pediatr Surg Int 25(6)
Pages: 487-492
NAID
Related Report
Peer Reviewed
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