| Project/Area Number |
21390476
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
TACHI Masahiro 東北大学, 大学院・医学系研究科, 教授 (50312004)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAKAMI Kazuyoshi 東北大学, 大学院・医学系研究科, 教授 (10253973)
KANNO Emi 東北大学, 大学院・医学系研究科, 助教 (10431595)
牛尾 茂子 東北大学, 病院, 医員 (80509604)
鳥谷部 荘八 東北大学, 病院, 助教 (90375006)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2011: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Keywords | バイオフィルム / 創傷治癒 / 慢性創傷 / 糖尿病性足潰瘍 |
|---|
| Research Abstract |
Quorum-sensing(QS)systems regulate virulence factors in Pseudomonas aeruginosa, which produces autoinducers. Accerelations of wound healing were not observed when inoculated with ΔlasI or ΔrhlI in place of PAO1 and cancelled when co-treated with these anti HSL antisera, respectively, but not with control rabbit serum. By contrast, administration of HSL significantly accelerated the re-epithelialization. These results suggest that HSL may be deeply involved in the skin wound healing during P. aeruginosa infection.
Low-energy extracorporeal shockwave treatment(LE-ESWT)has been demonstrated to accelerate wound repair. E-NOS is induced at the wound tissues by LE-ESWT and plays a critical role in the therapeutic effects of this treatment accelerating the wound healin g through promoting VEGF expression and neo-vascularization.
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