| Budget Amount *help |
¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Fiscal Year 2011: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Research Abstract |
In this study, we examined if persistent hyperglycemia elicited alterations of gut barrier function in a critical ill model. Short-term hyperglycemia augmented gut mucosal permeability in an endotoxemic model, while long-term hyperglycemia for 24hr resulted in the up-regulation of inflammatory cytokines such as IL-1β and IL-6 in mesenteric lymph nodes, and of T lymphocyte subset such as helper T2 and regulatory T cells in gut. The present study shed light on the significant effects of clinically relevant level of persistent hyperglycemia on gut barrier function and immune system in critical ill.
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