Novel trial to control acute lung injury by regulating neutrophil function targeting for A3 adenosine receptor
| Project/Area Number |
21390485
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Juntendo University |
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Principal Investigator |
INOUE Yoshiaki 順天堂大学, 医学部, 先任准教授 (60379196)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Hiroshi 順天堂大学, 医学研究科, 教授 (90252676)
OKAMOTO Ken 順天堂大学, 医学部, 教授 (40347076)
MATSUDA Shigeru 順天堂大学, 医学部, 先任准教授 (00317471)
SUMI Yuka 順天堂大学, 医学部, 准教 (40403084)
IWABUCHI Kazuhisa 順天堂大学, 医療看護学部, 教授 (10184897)
YAMADA Yoshiyasu 順天堂大学, 医学研究科, 教授 (30459028)
OODE Yasymasa 順天堂大学, 医学部, 講師 (70437424)
TAKEMOTO Masaaki 順天堂大学, 医学部, 助教 (60551801)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2011: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2009: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
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| Keywords | A3 adenosine receptor / 好中球 / 高張塩化ナトリウム溶液 / Systemic Inflammatory Response Syndrome / 急性肺障害 / SIRS / 高張塩化ナトリウム溶液(HS) / Biomarker / 過剰酸素(dROM) / 抗酸化能(dROM) / 好中球エラスターゼ |
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| Research Abstract |
We focused on Adenosine Receptor that has been reported as a trigger of Polymorphonuclear Leukocyte(PMN) activation on the scene of inflammation, especially for A3 subtype(A3ADR) that works as a negative feedback for PMN activation. Through measuring A3ADR expression on PMN for the patients with systemic inflammatory response syndrome(SIRS), we tried to evaluate the possibility of A3ADR as a target of SIRS and Acute Lung Injury(ALI).
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Purinergic signaling : a fundamental mechanism in neutrophil activation2010
Author(s)
Chen Y, Yao Y, Sumi Y, Li A, To UK, Elkhal A, Inoue Y, Woehrle T, Zhang Q, Hauser C, Junger WG
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Journal Title
Science Signaling
Volume: 125
Pages: 45-45
Related Report
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[Journal Article] Purinergic signaling : a fundamental mechanism in neutrophil activation.2010
Author(s)
Chen Y, Yao Y, Sumi Y, Li A, To UK, Elkhal A, Inoue Y, Woehrle T, Zhang Q, Hauser C, Junger WG
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Journal Title
Science Signaling
Volume: 125
Related Report
Peer Reviewed
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