Cellular mechanism of maintaining bone minerals by osteocyte lacunar-canalicular system
| Project/Area Number |
21390488
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Morphological basic dentistry
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
AMIZUKA Nirio 北海道大学, 大学院・歯学研究科, 教授 (30242431)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
LI Minqi 北海道大学, 大学院・歯学研究科, 助教 (60447612)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
ODA Kimimitsu 新潟大学, 大学院・医歯学総合研究科, 教授 (10122681)
UDAGAWA Nobuyuki 松本歯科大学, 歯学部, 教授 (70245801)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2009: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
|
|---|
| Keywords | 細胞・組織 / 解剖学 / 骨細胞 / 骨 / 歯学 / 遺伝子 |
|---|
| Research Abstract |
The aim of this research project is to clarify whether osteocyte lacunar canalicular system (OLSC) would maintain bone minerals and affect bone remodeling in vivo. Our findings demonstrated that 1) OLCS is geometrically well-distributed in mature cortical bone, but not, in immature trabecular bone. Sclerostin and fibroblast growth factor (FGF) 23, which are osteocyte-derived factors, are abundantly synthesized in osteocytes in the well-arranged OLSC, 2)osteoprotegerin deficient mice and klotho deficient mice bearing abnormal bone remodeling showed irregularly distributed OLCS, which affects the synthesis of sclerostin and dentin matrix protein-1 (DMP-1), and 3) the administration of parathyroid hormone induced enlarged osteocytic lacunae, i.e., release of bone minerals, indicating osteocytic osteolysis.
|
Report
(4 results)
Research Products
(44 results)
-
-
-
-
[Journal Article] The distribution of osteocytic lacunar-canalicular system, and immunolocalization of FGF23 and sclerostin in osteocytes2012
Author(s)
Amizuka N., Hongo H., Sasaki M., Hasegawa T., Suzuki R., Tabata C., Ubaidus S., Masuki H., Guo Y., Freitas PHL., Oda K., Li M
-
Journal Title
J Oral Biosci
Volume: 54
Pages: 37-42
Related Report
-
-
-
[Journal Article] Eldecalcitol, a second-generation vitamin D analog, drives bone minimodeling and reduces osteoclastic number in trabecular bone of ovariectomized rats2011
Author(s)
Freitas PHL., Hasegawa T., Takeda S., Sasaki M., Tabata C., Oda K., Li M., Saito H., Amizuka N
-
Journal Title
Bone
Volume: 49(3)
Pages: 335-342
Related Report
-
[Journal Article] Morphological assessment of bone mineralization in tibial metaphyses of ascorbic acid-deficient ODS rats2011
Author(s)
Hasegawa T., Li M., Hara K., Sasaki M., Tabata C., Freitas PHL., Hongo H., Suzuki R., Kobayashi M., Inoue K., Yamamoto T., Oohata N., Oda K., Akiyama Y., Amizuka N
-
Journal Title
Biomed Res
Volume: 32(4)
Pages: 259-269
NAID
Related Report
-
-
-
-
[Journal Article] FGFR3 down-regulates PTH/PTHrP receptor gene expression by mediating JAK/STAT signaling in chondrocytic cell line2010
Author(s)
Li M., Seki Y., Freitas PHL., Nagata M., Kojima T., Sultana S., Ubaidus S., Maeda T., Shimomura-Kuroki J., Henderson J., Tamura M., Liu Z., Guo Y., Yamamoto T., Oda K., Takagi R., Amizuka N
-
Journal Title
J Electron Microsc
Volume: 59(3)
Pages: 227-236
NAID
Related Report
-
[Journal Article] Ultrastructural observation on cells meeting the histological criteria for preosteoblasts . a study in the mouse tibial metaphysis2010
Author(s)
Narimatsu K., Li M., Freitas PHL., Sultana S., Ubaidus S., Kojima T., Liu Z., Guo Y., Suzuki R., Yamamoto T., Oda K., Amizuka N
-
Journal Title
J Electron Microsc
Volume: 59(5)
Pages: 427-436
Related Report
-
-
-
-
-
-
-
[Journal Article] Type IIc sodium-dependent phosphate transporter regulates calcium metabolism2009
Author(s)
Segawa H., Onitsuka A., Kuwahata M., Hanabusa E., Furutani J., Kaneko I., Tomoe Y., Aranami F., Matsumoto N., Ito M., Matsumoto M., Li M., Amizuka N., Miyamoto K
-
Journal Title
J Am Soc Nephrol
Volume: 20(1)
Pages: 104-113
Related Report
-
[Journal Article] Npt2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development2009
Author(s)
Segawa H., Onitsuka A., Furutani J., Kaneko I., Aranami F., Matsumoto N., Tomoe Y., Kuwahata M., Ito M., Matsumoto M., Li M., Amizuka N., Miyamoto K
-
Journal Title
Am J Physiol Renal Physiol
Volume: 297(3)
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
