| Project/Area Number |
21390488
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
AMIZUKA Nirio 北海道大学, 大学院・歯学研究科, 教授 (30242431)
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| Co-Investigator(Kenkyū-buntansha) |
LI Minqi 北海道大学, 大学院・歯学研究科, 助教 (60447612)
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| Co-Investigator(Renkei-kenkyūsha) |
ODA Kimimitsu 新潟大学, 大学院・医歯学総合研究科, 教授 (10122681)
UDAGAWA Nobuyuki 松本歯科大学, 歯学部, 教授 (70245801)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2009: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Keywords | 細胞・組織 / 解剖学 / 骨細胞 / 骨 / 歯学 / 遺伝子 |
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| Research Abstract |
The aim of this research project is to clarify whether osteocyte lacunar canalicular system (OLSC) would maintain bone minerals and affect bone remodeling in vivo. Our findings demonstrated that 1) OLCS is geometrically well-distributed in mature cortical bone, but not, in immature trabecular bone. Sclerostin and fibroblast growth factor (FGF) 23, which are osteocyte-derived factors, are abundantly synthesized in osteocytes in the well-arranged OLSC, 2)osteoprotegerin deficient mice and klotho deficient mice bearing abnormal bone remodeling showed irregularly distributed OLCS, which affects the synthesis of sclerostin and dentin matrix protein-1 (DMP-1), and 3) the administration of parathyroid hormone induced enlarged osteocytic lacunae, i.e., release of bone minerals, indicating osteocytic osteolysis.
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