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Functional analysis of oral sensation on the basis of signalplexes

Research Project

Project/Area Number 21390494
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional basic dentistry
Research InstitutionTohoku University

Principal Investigator

WAKAMORI Minoru  東北大学, 大学院・歯学研究科, 教授 (50222401)

Co-Investigator(Kenkyū-buntansha) YOSHIDA Takashi  東北大学, 大学院・歯学研究科, 助教 (30455795)
Co-Investigator(Renkei-kenkyūsha) MORI Yasuo  京都大学, 大学院・工学研究科, 教授 (80212265)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2011: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2010: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2009: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Keywordsパッチクランプ法 / TRPM5 / TRPV1 / チャネル / 口腔感覚 / カプサイシン受容体
Research Abstract

Fat is one of the three major nutrients but it is not a sapid substance which activates one of the five basic tastes, sweet, bitter, sour, salt, and umami. However, we have experience that fat changes the taste of dishes largely. Transient receptor potential M5(TRPM5)channel is not a receptor of the five basic tastes but it is gated after stimulation of the gustducin-coupled receptors for sweet, bitter, and umami. We analyzed the electrophysiological and pharmacological properties of TRPM5 channel. TRPM5 channel was not activated by fatty acids, but modulated by fatty acids.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (34 results)

All 2012 2011 2010 2009 Other

All Journal Article (13 results) (of which Peer Reviewed: 10 results) Presentation (13 results) Book (7 results) Remarks (1 results)

  • [Journal Article] Rab3-interacting moleculeγisoforms lacking the Rab3-binding domain induce long lasting currents but block neurotransmitter vesicle anchoring in voltage-dependent P/Q-type Ca2+ channels2010

    • Author(s)
      Uriu Y, Kiyonaka S, Miki T, Yagi M, Akiyama S, Mori E, Nakao A, Beedle AM, Campbell KP, Wakamori M, Mori Y.
    • Journal Title

      J Biol Chem

      Volume: 285 Pages: 21750-21767

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A missense mutation of the gene encoding voltage-dependent sodium channel (Nav1. 1)confers susceptibility to febrile seizures in rats2010

    • Author(s)
      Mashimo T, Ohmori I, Ouchida M, Ohno Y, Tsurumi T, Miki T, Wakamori M, Ishihara S, Yoshida T, Takizawa A, Kato M, Hirabayashi M, Sasa M, Mori Y, Serikawa T.
    • Journal Title

      J Neurosci

      Volume: 30 Pages: 5744-5753

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuraonal Ca2+-sensitive non-selective cation channels and TRPC52010

    • Author(s)
      Wakamori M.
    • Journal Title

      J Oral Biosci

      Volume: 52 Pages: 352-357

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 痛覚(侵害受容)とは何か? ユージノールはなぜ効くのか?2010

    • Author(s)
      若森実、近藤大祐、荒木健太郎.
    • Journal Title

      日本歯科評論

      Volume: 70 Pages: 135-142

    • Related Report
      2011 Final Research Report
  • [Journal Article] A missense mutation of the gene encoding voltage-dependent sodium channel (Nav1.1) confers susceptibility to febrile seizures in rats2010

    • Author(s)
      Mashimo T, Ohmori I, Ouchida M, Ohno Y, Tsurumi T, Miki T, Wakamori M, Ishihara S, Yoshida T, Takizawa A, Kato M, Hirabayashi M, Sasa M, Mori Y, Serikawa T
    • Journal Title

      J Neurosci

      Volume: 30 Pages: 5744-5753

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rab3-interacting molecule γ isoforms lacking the Rab3-binding domain induce long lasting currents but block neurotransmitter vesicle anchoring in voltage-dependent P/Q-type Ca^<2+> channels2010

    • Author(s)
      Uriu Y, Kiyonaka S, Miki T, Yagi M, Akiyama S, Mori E, Nakao A, Beedle AM, Campbell KP, Wakamori M, Mori Y
    • Journal Title

      J Biol Chem

      Volume: 285 Pages: 21750-21767

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuraonal Ca^<2+>-sensitive non-selective cation channels and TRPC52010

    • Author(s)
      Wakamori M
    • Journal Title

      J Oral Biosci

      Volume: 52 Pages: 352-357

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 痛覚(侵害受容)とは何か?ユージノールはなぜ効くのか?2010

    • Author(s)
      若森実、近藤大祐、荒木健太郎
    • Journal Title

      日本歯科評論

      Volume: 70 Pages: 135-142

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Knockdown of Cav2.1 calcium channels is sufficient to induce neurological disorders observed in natural occurring Cacna1a mutants in mice2009

    • Author(s)
      Saito H, Okada M, Miki T, Wakamori M, Futatsugi A, Mori Y, Mikoshiba K, Suzuki N.
    • Volume
      390
    • Pages
      1029-1033
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A pathogenic C terminus-truncated polycystin-2 mutant enhances receptor-activated Ca2+ entry via association with TRPC3 and TRPC72009

    • Author(s)
      Miyagi K, Kiyonaka S, Yamada K, Miki T, Mori E, Kato K, Numata T, Sawaguchi Y, Numaga T, Kimura T, Kanai Y, Kawano M, Wakamori M, Nomura H, Koni I, Yamagishi M, Mori Y
    • Journal Title

      J Biol Chem

      Volume: 284 Pages: 34400-34412

    • NAID

      120006334914

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A pathogenic C terminus-truncated polycystin-2 mutant enhances receptor-activated Ca^<2+> entry via association with TRPC3 and TRPC7.2009

    • Author(s)
      Miyagi K, Kiyonaka S, Yamada K, Miki T, Mori E, Kato K, Numata T, Sawaguchi Y, Numaga T, Kimura T, Kanai Y, Kawano M, Wakamori M, Nomura H, Koni I, Yamagishi M, Mori Y.
    • Journal Title

      J Biol Chem 284

      Pages: 34400-34412

    • NAID

      120006334914

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Knockdown of Cav2.1 calcium channels is sufficient to induce neurological disorders observed in natural occurring Cacnala mutants in mice.2009

    • Author(s)
      Saito H, Okada M, Miki T, Wakamori M, Futatsugi A, Mori Y, Mikoshiba K, Suzuki N.
    • Journal Title

      Biochem Biophys Res Commun. 390

      Pages: 1029-1033

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      Wakamori M, Imoto K
    • Journal Title

      Handbook of Neurochemistry and Molecular Neurobiology 3^<rd> Ed(Voltage-Gated Calcium Channels)

      Pages: 543-558

    • Related Report
      2009 Annual Research Report
  • [Presentation] 鎮静薬ユージノールのTRPV1チャネルに対する効果2012

    • Author(s)
      吉田卓史、菊池尚、高橋かおり、若森実
    • Organizer
      日本薬理学年会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 鎮静薬ユージノールのTRPV1チャネルに対する効果2012

    • Author(s)
      吉田卓史、菊池尚、高橋かおり、若森実
    • Organizer
      第83回日本薬理学年会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 電位依存性カルシウムチャネルの生物物理学的解析2011

    • Author(s)
      若森実
    • Organizer
      新薬理学セミナー
    • Place of Presentation
      仙台
    • Year and Date
      2011-09-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 電位依存性カルシウムチャネルの生物物理学的解析2011

    • Author(s)
      若森実
    • Organizer
      新薬理学セミナー2011
    • Place of Presentation
      仙台(招待講演)
    • Year and Date
      2011-09-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] TRP channels play a role in the mouse osteoblast cell line MC3T3-E1 under shear stress2011

    • Author(s)
      Yoshida T、Wakamori M
    • Organizer
      Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2011-03-23
    • Related Report
      2011 Final Research Report
  • [Presentation] TRP channels play a role in the mouse osteoblast cell line MC3T3-E1 under shear stress2011

    • Author(s)
      Yoshida T, Wakamori M
    • Organizer
      The 84^<th> Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2011-03-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Facilitation of TRPM5 channel activities by fatty acids2011

    • Author(s)
      Wakamori M、Kondoh D、Yoshida T, Kikuchi H、Komatsu M
    • Organizer
      Harvard-Tohoku-Forsyth Symposium
    • Place of Presentation
      USA
    • Year and Date
      2011-01-06
    • Related Report
      2011 Final Research Report
  • [Presentation] Facilitation of TRPM5 channel activities by fatty acids2011

    • Author(s)
      Wakamori M, Kondoh D, Yoshida T, Kikuchi H, Komatsu M
    • Organizer
      Harvard-Tohoku-Forsyth Symposium
    • Place of Presentation
      Boston, USA(招待講演)
    • Year and Date
      2011-01-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] TRPM5チャネル活性の脂肪酸による修飾2010

    • Author(s)
      近藤大祐、吉田卓史、菊池尚、小松正志、若森実
    • Organizer
      日本薬理学会北部会
    • Place of Presentation
      札幌
    • Year and Date
      2010-09-10
    • Related Report
      2011 Final Research Report
  • [Presentation] TRPM5チャネル活性の脂肪酸による修飾2010

    • Author(s)
      近藤大祐、吉田卓史、菊池尚、小松正志、若森実
    • Organizer
      第61回日本薬理学会北部会
    • Place of Presentation
      札幌
    • Year and Date
      2010-09-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] TRPM5チャネルの脂肪酸による修飾2010

    • Author(s)
      若森実、吉田卓史、菊地尚
    • Organizer
      日本薬理学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-17
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 神経や口腔内組織に発現する細胞外環境センサーとしてのTRPチャネル2009

    • Author(s)
      若森実
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-09
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] FACILITATION OF TRPC5 CHANNEL BY CALCIUM2009

    • Author(s)
      Wakamori M、Yoshida T、Yamamoto S、Mori Y
    • Organizer
      国際生理学会
    • Place of Presentation
      京都
    • Year and Date
      2009-07-30
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Book] 歯学英和辞典2012

    • Author(s)
      若森実
    • Publisher
      研究社
    • Related Report
      2011 Final Research Report
  • [Book] 現代歯科薬理学第5版2012

    • Author(s)
      若森実
    • Publisher
      医歯薬出版
    • Related Report
      2011 Final Research Report
  • [Book] 歯学英和辞典(分担執筆、生理学・薬理学担当)2012

    • Author(s)
      五十嵐薫、越後成志、若森実、渡邉誠, 他
    • Publisher
      研究社
    • Related Report
      2011 Annual Research Report
  • [Book] 現代歯科薬理学第5版(加藤有三、篠田壽監修)2012

    • Author(s)
      若森実、篠田壽, 他
    • Publisher
      医歯薬出版
    • Related Report
      2011 Annual Research Report
  • [Book] Interface Oral Health Science 20112011

    • Author(s)
      Wakamori M
    • Related Report
      2011 Final Research Report
  • [Book] Interface Oral Health Science 20112011

    • Author(s)
      Wakamori M, Yoshida T, Kikuchi T, Kondoh D, Komatsu M
    • Publisher
      Springer
    • Related Report
      2011 Annual Research Report
  • [Book] Imoto K、Voltage-Gated Calcium Channels2009

    • Author(s)
      Wakamori M
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.bsc.tohoku.ac.jp/contents/c2_32/c2_32_wakamori_m

    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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