| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2009: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Research Abstract |
The pathways regulated by p53 and RB tumor suppressors and TGF-βsignaling play important roles in tumor suppression in human. In this study, we investigated the functional roles of DRIL1 and its closely related DRIL2, family members of ARID(AT-rich interaction domain) DNA-binding proteins, in three major tumor suppressor pathways. We found that DRIL1 cooperates with p53 to activate pro-arrest p21^<WAF1> transcription, and that DRIL1 and DRIL2 play important roles in E2F-target gene expression and cell cycle progression. In addition, our results suggest that DRIL2 function is required for osteogenic differentiation. These results provide important insights in the regulation of human tumor suppressor pathways.
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