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Roles of cancer stem cells in the development and progression of cancer metastasis to bone

Research Project

Project/Area Number 21390505
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionMatsumoto Dental University

Principal Investigator

HIRAGA Toru  松本歯科大学, 歯学部, 准教授 (70322170)

Co-Investigator(Kenkyū-buntansha) HOSOYA Akihiro  松本歯科大学, 歯学部, 講師 (70350824)
NINOMIYA Tadashi  松本歯科大学, 総合歯科医学研究所, 講師 (00360222)
KOBAYASHI Yasuhiro  松本歯科大学, 総合歯科医学研究所, 准教授 (20264252)
Project Period (FY) 2009 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2012: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Keywords癌 / 癌幹細胞 / 骨転移
Research Abstract

Bone is one of the most preferential sites for cancer metastasis; however, the precise mechanisms are still unclear. An increasing body of evidence suggests that cancers contain a small subset of their own stem-like cells called cancer stem cells (CSCs), which play critical roles in the initiation, maintenance and relapse of tumors. In this study, we studied the role of CSCs in cancer metastasis to bone. Flow cytometric analysis revealed the existence of CSC marker-positive cells in several kinds of cancer cell lines. Those cells exhibited some of the CSC-like properties in vitro and in vivo. However, the bone-metastatic potential of side population (SP) cells, which has been shown to enrich CSCs in several types of cancer, was similar to that of non-SP cells. Further studies are required to clarify the contribution of CSCs to cancer bone metastasis.

Report

(5 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (178 results)

All 2013 2012 2011 2010 2009 Other

All Journal Article (83 results) (of which Peer Reviewed: 79 results,  Open Access: 3 results) Presentation (92 results) Book (3 results)

  • [Journal Article] Localization of SUMOylation factors and Osterix in odontoblast lineage cells during dentin formation and regeneration.2013

    • Author(s)
      Hosoya A, Yukita A, Ninomiya T, Hiraga T, Yoshiba K, Yoshiba N, Kasahara E, Nakamura H.
    • Journal Title

      Histochem Cell Biol

      Volume: (in press) Issue: 2 Pages: 201-211

    • DOI

      10.1007/s00418-013-1076-y

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced bone-forming activity of side population cells in the periodontal ligament2013

    • Author(s)
      Ninomiya T, Hiraga T, Hosoya A, Ohnuma K, Ito Y, Takahashi M, Ito S, Asashima M, Nakamura H.
    • Journal Title

      Cell Transplant

      Volume: 23 Issue: 6 Pages: 691

    • DOI

      10.3727/096368913x663587

    • URL

      http://dx.doi.org/

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Osteoprotegerin-deficient male mice as a model for severe alveolar bone loss: Comparison with RANKL-overexpressing transgenic male mice.2013

    • Author(s)
      Koide M et al.
    • Journal Title

      Endocrinology

      Volume: 190 Issue: 2 Pages: 773-782

    • DOI

      10.1210/en.2012-1928

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Roles of Wnt signals in bone resorption during physiological and pathological states.2013

    • Author(s)
      Maeda K et al.
    • Journal Title

      J Mol Med (Berl)

      Volume: 91 Issue: 1 Pages: 15-23

    • DOI

      10.1007/s00109-012-0974-0

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of heparan sulfate proteoglycans surrounding osteoblast lineage cells.2012

    • Author(s)
      Nakamura H, Yukita A, Ninomiya T, HosoyaA, Hiraga T.
    • Journal Title

      J Oral Biosci

      Volume: 54(1) Issue: 1 Pages: 43-47

    • DOI

      10.1016/j.job.2012.01.005

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thy-1-positive cells in the subodontoblastic layer possess high potential to differentiate into hard tissue-forming cells.2012

    • Author(s)
      Hosoya A, Hiraga T, Ninomiya T, Yukita A, Yoshiba K, Yoshiba N, Takahashi M, Ito S, Nakamura H.
    • Journal Title

      Histochem Cell Biol

      Volume: 137(6) Issue: 6 Pages: 733-42

    • DOI

      10.1007/s00418-012-0928-1

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 25-Dihydroxyvitamin D3 inhibits osteoblastic differentiation of mouse periodontal fibroblasts.2012

    • Author(s)
      Chen YC, Ninomiya T, Hosoya A, Hiraga T, Miyazawa H, Nakamura H.1
    • Journal Title

      Arch Oral Biol

      Volume: 57(5) Issue: 5 Pages: 453-9

    • DOI

      10.1016/j.archoralbio.2011.10.005

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone-derived IGF mediates crosstalk between bone and breast cancer cells in bony metastases.2012

    • Author(s)
      Hiraga T, Myoui A, Hashimoto N, Sasaki A, Hata K, Morita Y, Yoshikawa H, Rosen CJ, Mundy GR, Yoneda T.
    • Journal Title

      Cancer Res

      Volume: 72(16) Pages: 4238-49

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Wnt5a-Ror2 signaling between osteoblasts and osteoclast precursors enhances osteoclastogenesis2012

    • Author(s)
      Maeda, K., Kobayashi, Y., Udagawa, N., Uehara, S., Ishihara, A., Mizoguchi, T., Kikuchi, Y., Takada, I., Kato, S., Kani, S., Nishita, M., Marumo, K., Martin, T.J., Minami, Y., Takahashi, N.
    • Journal Title

      Nat.Med.

      Volume: (印刷中) Issue: 3 Pages: 405-12

    • DOI

      10.1038/nm.2653

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expressional alterations of fibrillin-1 during wound healing of human dental pulp2012

    • Author(s)
      Yoshiba N, et al
    • Journal Title

      J Endodont

      Volume: 37 Issue: 2 Pages: 177-184

    • DOI

      10.1016/j.joen.2011.09.016

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular chaperone Hsp47 is essential for cartilage and endochondral bone formation2012

    • Author(s)
      Y. Masago, A. Hosoya, S. Kawano, A. Nasu, J. Toguchida, K. Fujita, H. Nakamura, G. Kondoh and K. Nagata
    • Journal Title

      J. Cell Sci.

      Volume: 125(5) Issue: 5 Pages: 1118-1128

    • DOI

      10.1242/jcs.089748

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ubc9 negatively regulates BMP-mediated osteoblastic differentiation in cultured cells2012

    • Author(s)
      Yukita A, Hosoya A, Ito Y, Katagiri T, Asashima M, Nakamura H
    • Journal Title

      Bone

      Volume: 50 Issue: 5 Pages: 1092

    • DOI

      10.1016/j.bone.2012.02.008

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two distinct processes of bone-like tissue formation by dental pulp cells after tooth transplantation.2012

    • Author(s)
      Hosoya A et al.
    • Journal Title

      J Histochem Cytochem

      Volume: 60 Issue: 11 Pages: 861-873

    • DOI

      10.1369/0022155412459741

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical analysis of two stem cell markers of α-smooth muscle actin and STRO-1 during wound healing of human dental pulp.2012

    • Author(s)
      Yoshiba N et al.
    • Journal Title

      Histochem Cell Biol

      Volume: 138 Issue: 4 Pages: 583-592

    • DOI

      10.1007/s00418-012-0978-4

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tetracyclines convert the osteoclastic-differentiation pathway of orogenitor cells to produce dendritic cell-like cells2012

    • Author(s)
      Kinugawa S, et al
    • Journal Title

      J Immunol

      Volume: 188 Issue: 4 Pages: 1772-1781

    • DOI

      10.4049/jimmunol.1101174

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Daily administration of Eldecalcitol (ED-71), an active vitamin Danalog, increases bone mineral density by suppressing RANKL expression in mouse trabecular bone2012

    • Author(s)
      Harada S, et al
    • Journal Title

      J Bone Miner Res

      Volume: 27 Issue: 2 Pages: 461-473

    • DOI

      10.1002/jbmr.555

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Carbon nanotubes induce bone calcification by bidirectional interaction with osteoblasts2012

    • Author(s)
      Shimizu M, Kobayashi Y, Mizoguchi T, Nakamura H, Kawahara I, Narita N, Usui Y, Aoki K, Hara K, Haniu H, Ogihara N, Ishigaki N, Nakamura K, Kato H, Kawakubo M, Dohi Y, Taruta S, Kim YA, Endo M, Ozawa H, Udagawa N, Takahashi N, Saito N
    • Journal Title

      Advanced Materials

      Volume: 24 Issue: 16 Pages: 2176-2185

    • DOI

      10.1002/adma.201103832

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] c-Fos plays an essential role in the up-regulation of RANK expression in osteoclast precursors within the bone microenvironment2012

    • Author(s)
      Arai A, et al
    • Journal Title

      J Cell Sci

      Volume: (印刷中) Pages: 2910-2917

    • DOI

      10.1242/jcs.099986

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spleen serves as a reservoir of osteoclast precursors through vitamin D-induced IL-34 expression in osteopetrotic op/op mice.2012

    • Author(s)
      Nakamichi Y et al.
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 109 Issue: 25 Pages: 10006-10011

    • DOI

      10.1073/pnas.1207361109

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recent advances in intravital imaging of dynamic biological systems.2012

    • Author(s)
      菊田 順一
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: vol.119 Issue: 2 Pages: 193-197

    • DOI

      10.4049/jimmunol.1201345

    • NAID

      10030986703

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polarized osteoclasts put marks of tartate-resistant acid phosphatase on dentine slices-a simple method for identifying polarized osteoclasts2012

    • Author(s)
      Nakayama T, et al
    • Journal Title

      Bone

      Volume: 49 Issue: 6 Pages: 1331-1339

    • DOI

      10.1016/j.bone.2011.09.045

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Side population in MDA-MB-231 human breast cancer cells exhibits cancer stem cell-like properties without higher bone-metastatic potential.2011

    • Author(s)
      Hiraga T, Ito S, Nakamura H.
    • Journal Title

      Oncol Rep

      Volume: 25(1) Issue: 1 Pages: 289-96

    • DOI

      10.3892/or_00001073

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin E(2) receptor EP(4)-selective agonist (ONO-4819) increases bone formation by modulating mesenchymal cell differentiation.2011

    • Author(s)
      Ninomiya T, Hosoya A, Hiraga T, Koide M, Yamaguchi K, Oida H, Arai Y, Sahara N, Nakamura H, Ozawa H.
    • Journal Title

      Eur J Pharmacol

      Volume: 650(1) Issue: 1 Pages: 396-402

    • DOI

      10.1016/j.ejphar.2010.10.021

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of acidic microenvironment in the pathophysiology of cancer-associated bone pain.2011

    • Author(s)
      Yoneda T, Hata K, Nakanishi M, Nagae M, Nagayama T, Wakabayashi H, Nishisho T, Sakurai T, Hiraga T.
    • Journal Title

      Bone

      Volume: 48(1) Issue: 1 Pages: 100-5

    • DOI

      10.1016/j.bone.2010.07.009

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular events of acid-induced bone pain2011

    • Author(s)
      Yoneda T, Hata K, Nakanishi M, Nagae M, Nagayama T, Wakabayashi H, Nishisho T, Sakurai T, Hiraga T.
    • Journal Title

      IBMS BoneKEy

      Volume: 8(4) Issue: 4 Pages: 195-204

    • DOI

      10.1138/20110507

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Harmine, a b-carboline alkaloid, inhibits osteoclast differentiation and bone resorption in vitro and in vivo2011

    • Author(s)
      Yonezawa T, et al
    • Journal Title

      Eur J Pharmcol

      Volume: 650 Issue: 2-3 Pages: 511-518

    • DOI

      10.1016/j.ejphar.2010.10.048

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulatory mechanism of osteoclastogenesis by RANKL and Wnt signals2011

    • Author(s)
      Takahashi N, et al
    • Journal Title

      Front Biosci

      Volume: 16 Issue: 1 Pages: 21-30

    • DOI

      10.2741/3673

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of osteoclasts in culture2011

    • Author(s)
      Udagawa N, et al
    • Journal Title

      Methods Mol Biol

      Volume: 690 Pages: 273-284

    • DOI

      10.1007/978-1-60761-962-8_18

    • ISBN
      9781607619611, 9781607619628
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rab27a and Rab27b are involved in stimulation-dependent RANKL release from secretory lysosomes in osteoblastic2011

    • Author(s)
      Kariya Y, et al
    • Journal Title

      J Bone Miner Res

      Volume: 26 Issue: 4 Pages: 689-703

    • DOI

      10.1002/jbmr.268

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hyergravity suppresses bone resorption in ovariectomized rat2011

    • Author(s)
      Ikawa T, et al
    • Journal Title

      Adv Space Res

      Volume: 47 Issue: 7 Pages: 1214-1224

    • DOI

      10.1016/j.asr.2010.12.004

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Runx3 is a crucial regulator of alveolar differentiation and lung tumorigenesis in mice2011

    • Author(s)
      Lee J-M, et al
    • Journal Title

      Differentiation

      Volume: 81 Issue: 4 Pages: 261-268

    • DOI

      10.1016/j.diff.2011.02.001

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased bone mass in mice after a single injection of an anti-RANKL neutralizing antibody : evidence for a bone anabolic effect of PTH in mice with few osteoclasts2011

    • Author(s)
      Furuya Y, et al
    • Journal Title

      J Biol Chem

      Volume: 286 Issue: 42 Pages: 37023-37031

    • DOI

      10.1074/jbc.m111.246280

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lineage-Committed Osteoclast Precursors Circulate in Blood and Settle Down Into Bone2011

    • Author(s)
      Muto, A, Mizoguchi, T, Udagawa, N., Ito, S, Kawahara, I, Abiko, Y, Arai, A., Harada, S., Kobayashi, Y., Nakamichi, Y, Penninger, JM, Noguchi, T, Takahashi, N.
    • Journal Title

      Journal of Bone and Mineral Research

      Volume: 26 Issue: 12 Pages: 2978-2990

    • DOI

      10.1002/jbmr.490

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Side population in MDA-MB-231 human breast cancer cells exhibits cancer stem cell-like properties without higher bone metastatic potential.2011

    • Author(s)
      Hiraga T, et al.
    • Journal Title

      Oncol Rep

      Volume: 25 Pages: 289-296

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin E2 receptor EP4-selective agonist (ONO-4819) increases bone formation by modulating mesenchymal cell differentiation.2011

    • Author(s)
      Ninomiya T, et al.
    • Journal Title

      Eur J Pharmcol

      Volume: 650 Pages: 396-402

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Harmine, a b-carboline alkaloid, inhibits osteoclast differentiation and bone resorption in vitro and in vivo.2011

    • Author(s)
      Yonezawa T, et al.
    • Journal Title

      Eur J Pharmcol

      Volume: 650 Pages: 511-518

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of acidic microenvironment in the pathophysiology of cancer-associated bone pain.2011

    • Author(s)
      Yoneda T, et al.
    • Journal Title

      Bone

      Volume: 48 Pages: 100-105

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulatory mechanism of osteoclastogenesis by RANKL and Wnt signals.2011

    • Author(s)
      Takahashi N, et al.
    • Journal Title

      Front Biosci

      Volume: 16 Pages: 21-30

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of osteoclasts in culture.2011

    • Author(s)
      Udagawa N, et al.
    • Journal Title

      Methods Mol Biol

      Volume: 690 Pages: 273-284

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ab27a and Rab27b are involved in stimulation-dependent RANKL release from secretory lysosomes in osteoblastic cells.2011

    • Author(s)
      Kariya Y, et al.
    • Journal Title

      J Bone Miner Res

      Volume: 26 Pages: 689-703

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypergravity suppresses bone resorption in ovariectomized rat.2011

    • Author(s)
      Ikawa T, et al.
    • Journal Title

      Adv Space Res

      Volume: 47 Pages: 1214-1224

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Administration of the bisphosphonate zoledronic acid during tooth development inhibits tooth eruption and formation and induces dental abnormalities in rats.2010

    • Author(s)
      Hiraga T, Ninomiya T, Hosoya A, Nakamura H.
    • Journal Title

      Calcif Tissue Int

      Volume: 86(6) Issue: 6 Pages: 502-10

    • DOI

      10.1007/s00223-010-9366-z

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Localization of Thy-1-positive cells in the perichondrium during endochondral ossification.2010

    • Author(s)
      Nakamura H, Yukita A, Ninomiya T, Hosoya A, Hiraga T, Ozawa H.
    • Journal Title

      J Histochem Cytochem

      Volume: 58(5) Issue: 5 Pages: 455-462

    • DOI

      10.1369/jhc.2010.955393

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Potential of Periodontal Ligament Cells to Regenerate Alveolar Bone2010

    • Author(s)
      Hosoya A, Ninomiya T, Hiraga T, Yoshiba K, Yoshiba N, Kasahara E, Ozawa H, Nakamura H.
    • Journal Title

      Journal of Oral Biosciences

      Volume: 52 Issue: 2 Pages: 72-80

    • DOI

      10.2330/joralbiosci.52.72

    • NAID

      10027105411

    • ISSN
      1349-0079, 1880-3865
    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Zoledronic acid delays wound healing of the tooth extraction socket, inhibits oral epithelial cell migration, and promotes proliferation and adhesion to hydroxyapatite of oral bacteria, without causing osteonecrosis of the jaw, in mice.2010

    • Author(s)
      Kobayashi Y, Hiraga T, Ueda A, Wang L, Matsumoto-Nakano M, Hata K, Yatani H, Yoneda T.
    • Journal Title

      J Bone Miner Metab

      Volume: 28(2) Issue: 2 Pages: 165-75

    • DOI

      10.1007/s00774-009-0128-9

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acid activation of Trpv1 leads to an up-regulation of calcitonin gene-related peptide expression in dorsal root ganglion neurons via the CaMK-CREB cascade: a potential mechanism of inflammatory pain.2010

    • Author(s)
      Nakanishi M, Hata K, Nagayama T, SakuraiT, Nishisho T, Wakabayashi H, Hiraga T, Ebisu S, Yoneda T.
    • Journal Title

      Mol Biol Cell

      Volume: 21(15) Issue: 15 Pages: 2568-77

    • DOI

      10.1091/mbc.e10-01-0049

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Administration of the bisphosphonate Zoledronic Acid during tooth development inhibits tooth eruption and formation, and induces dental abnormalities in rats.2010

    • Author(s)
      Hiraga T, et al.
    • Journal Title

      Calcified Tissue Int

      Volume: 56 Pages: 502-510

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Function of OPG as a traffic regulator for RANKL is crucial for controlled osteoclastogenesis.2010

    • Author(s)
      Aoki S, et al.
    • Journal Title

      J Bone Miner Res

      Volume: 25 Pages: 1907-1921

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deficiency of vitamin A delays bone healing process in association with reduced BMP2 expression after drill-hole injury in mice.2010

    • Author(s)
      Tanaka K, et al.
    • Journal Title

      Bone

      Volume: 47 Pages: 1006-1012

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Localization of Thy-1-positive cells in the perichondrium during endochondral ossification.2010

    • Author(s)
      Nakamura H, et al.
    • Journal Title

      J Histochem Cytochem

      Volume: 58 Pages: 455-462

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potential of periodontal ligament cells to regenerate alveolar bone.2010

    • Author(s)
      Hosoya A, et al.
    • Journal Title

      J Oral Biosci

      Volume: 52 Pages: 72-80

    • NAID

      10027105411

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Zoledronic acid delays wound healing of the tooth extraction socket in mice : Insights into the pathogenesis of bisphosphonate-related osteonecrosis of the jaw.2010

    • Author(s)
      Kobayashi Y, et al.
    • Journal Title

      J Bone Miner Metab

      Volume: 28 Pages: 165-175

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acid activation of Trpv1 leads to an up-regulation of calcitonin gene related peptide expression in dorsal root ganglion neurons via the CaMK-CREB cascade : A potential mechanism of inflammatory pain.2010

    • Author(s)
      Nakanishi M, et al.
    • Journal Title

      Mol Biol Cell

      Volume: 21 Pages: 2568-2577

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical localization of cytokeratins in the junctional region of ectoderm and endoderm.2010

    • Author(s)
      Hosoya A, et al.
    • Journal Title

      Anat Rec (Hoboken)

      Volume: 293 Pages: 1864-1872

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Runx3 is required for the differentiation of lung epithelial cells and suppression of lung cancer.2010

    • Author(s)
      Lee KS, et al.
    • Journal Title

      Oncogene

      Volume: 29 Pages: 3349-3361

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Temporomandibular joint response to mandibular deviation in rabbits detected by 3D micro-CT imaging.2010

    • Author(s)
      Zhao C, et al.
    • Journal Title

      Arch Oral Biol

      Volume: 55 Pages: 929-937

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alisol-B, a novel phyto-steroid, suppresses the RANKL-induced osteoclast formation and prevents bone loss in mice.2010

    • Author(s)
      Lee JW, et al.
    • Journal Title

      Biochem Pharmacol

      Volume: 80 Pages: 352-361

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 軟骨内骨化過程におけるThy-1(CD90)陽性細胞の役割2010

    • Author(s)
      中村浩彰, ら
    • Journal Title

      THE BONE

      Volume: 24 Pages: 205-208

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 癌の骨転移2010

    • Author(s)
      平賀徹
    • Journal Title

      骨粗鬆症治療

      Volume: 9 Pages: 197-200

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Zoledronic acid delays wound healing of the tooth extraction socket in mice : Insights into the pathogenesis of bisphosphonate-related osteonecrosis of the jaw.2010

    • Author(s)
      Kobayashi Y, et al.
    • Journal Title

      J Bone Miner Metab (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Localization of Thy-1-positive cells in the perichondrium during endochondral ossification.2010

    • Author(s)
      Nakamura H, et al.
    • Journal Title

      J Histochem Cytochem (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Formation of bone-like mineralized matrix by periodontal ligament cells in vivo: a morphological study in rats.2009

    • Author(s)
      Hiraga T, Ninomiya T, Hosoya A, Takahashi M, Nakamura H.
    • Journal Title

      J Bone Miner Metab

      Volume: 27(2) Issue: 2 Pages: 149-57

    • DOI

      10.1007/s00774-009-0039-9

    • NAID

      10025336621

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Imatinib mesylate suppresses bone metastases of breast cancer by inhibiting osteoclasts through the blockade of c-Fms signals.2009

    • Author(s)
      Hiraga T, Nakamura H.
    • Journal Title

      Int J Cancer.

      Volume: 124(1) Pages: 215-22

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of cell cycle-arrested quiescent osteoclast precursors in vivo.2009

    • Author(s)
      Mizoguchi T, Muto A, Udagawa N, Arai A, Yamashita T, Hosoya A, Ninomiya T, Nakamura H, Yamamoto Y, Kinugawa S, Nakamura M, Nakamichi Y, Kobayashi Y, Nagasawa S, Oda K, Tanaka H, Tagaya M, Penninger JM, Ito M, Takahashi N.
    • Journal Title

      J Cell Biol

      Volume: 184(4) Issue: 4 Pages: 541-54

    • DOI

      10.1083/jcb.200806139

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Light and Dark Side of Bisphosphonates2009

    • Author(s)
      Jimi E, Takami M, Hiraga T, Nakamura I, Urade M, Miyamoto Y.
    • Journal Title

      Journal of Oral Biosciences

      Volume: 51 Issue: 4 Pages: 177-187

    • DOI

      10.2330/joralbiosci.51.177

    • NAID

      10027104865

    • ISSN
      1349-0079, 1880-3865
    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Formation of bone-like mineralized matrix by periodontal ligament cells in vivo : a morphological study in rats.2009

    • Author(s)
      Hiraga T, et al.
    • Journal Title

      J Bone Miner Metab 27

      Pages: 149-157

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Imatinib mesylate suppresses bone metastases of breast cancer by inhibiting osteoclasts through the blockade of c-Fms signals.2009

    • Author(s)
      Hiraga T, et al.
    • Journal Title

      Int J Cancer 124

      Pages: 215-222

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of cell cycle-arrested quiescent osteoclast precursors in vivo.2009

    • Author(s)
      Mizoguchi T, et al.
    • Journal Title

      J Cell Biol 184

      Pages: 541-554

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diphenylhydantoin inhibits osteoclast differentiation and function through suppression of NFATc1 signaling.2009

    • Author(s)
      Koide M, et al.
    • Journal Title

      J Bone Miner Res 24

      Pages: 1469-1480

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The light and dark side of bisphosphonates.2009

    • Author(s)
      Jimi E, et al.
    • Journal Title

      J Oral Biosci 51

      Pages: 177-187

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of p^<63> during early craniofacial development of the mouse embryo.2009

    • Author(s)
      Hosoya A, et al.
    • Journal Title

      Dev Reprod 13

      Pages: 89-95

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chick tooth induction revisited.2009

    • Author(s)
      Cai J, et al.
    • Journal Title

      J Exp Zoolog B Mol Dev Evol 312

      Pages: 465-472

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ERK activation is involved in tooth development via FGF10 signaling.2009

    • Author(s)
      Cho KW, et al.
    • Journal Title

      J Exp Zoolog B Mol Dev Evol 312

      Pages: 901-911

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intermittent parathyroid hormone administration stimulates preosteoblastic proliferation without leading to enhanced bone formation in osteoclast-less c-fos(-/-)mice.2009

    • Author(s)
      de Freitas PH, et al.
    • Journal Title

      J Bone Miner Res 24

      Pages: 1586-1597

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A local bone anabolic effect of rhFG2-impregnated gelatin hydrogel by promoting cell proliferation and coordinating osteoblastic differentiation.2009

    • Author(s)
      Koide N, et al.
    • Journal Title

      Bone 44

      Pages: 699-707

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of pharmaceuticals with a novel fifty-hour animal model of bone loss.2009

    • Author(s)
      Yoshiya T, et al.
    • Journal Title

      J Bone Miner Res 24

      Pages: 1194-1205

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An in vivo 3D micro-CT evaluation of tooth movement after the application of different force magnitudes in rat molar.2009

    • Author(s)
      Gonzales C, et al.
    • Journal Title

      Angle Orthodontist 79

      Pages: 703-714

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multiwalled carbon nanotubes specifically inhibit osteoclast differentiation and function.2009

    • Author(s)
      Narita N, et al.
    • Journal Title

      Nano Lett 9

      Pages: 1406-1413

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Action of RANKL and OPG for osteoclastogenesis.2009

    • Author(s)
      Kobayashi Y, et al.
    • Journal Title

      Crit Rew Eukaryot Gene Expr 19

      Pages: 61-72

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Docetaxel inhibits bone resorption through suppression of osteoclast for mation and function in different manners.2009

    • Author(s)
      Takahashi M, et al.
    • Journal Title

      J Bone Miner Metab 27

      Pages: 24-35

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 歯の形態形成を制御する分子に関する最近の知見2009

    • Author(s)
      平賀徹
    • Journal Title

      歯界展望 114

      Pages: 610-611

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 歯根膜幹細胞を用いた歯周組織再生2009

    • Author(s)
      細矢明宏
    • Journal Title

      THE BONE 23

      Pages: 108-109

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 歯髄を用いた再生療法の試み2009

    • Author(s)
      細矢明宏
    • Journal Title

      歯界展望 113

      Pages: 1174-1175

    • Related Report
      2009 Annual Research Report
  • [Presentation] The cancer stem cell marker CD44 promotes bone metastasis of breast cancer by enhancing tumorigenicity, cell motility, and matrix production.2012

    • Author(s)
      Hiraga T, Ito S, Nakamura H.
    • Organizer
      34th Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Minneapolis, Minnesota, USA
    • Year and Date
      2012-10-12
    • Related Report
      2012 Final Research Report
  • [Presentation] 癌幹細胞マーカーCD44 の乳癌 骨転移に対する機能的役割2012

    • Author(s)
      平賀 徹
    • Organizer
      第71回 日本癌学会学術総会
    • Place of Presentation
      札幌 市教育文化会館(北海道)
    • Year and Date
      2012-09-20
    • Related Report
      2012 Final Research Report
  • [Presentation] 癌幹細胞マーカーCD44 は癌細胞の造腫瘍能,細胞運動能, 基質形成能の亢進を介して骨転移を促進する2012

    • Author(s)
      平賀 徹、中村浩彰
    • Organizer
      第30回 日本骨代謝学会学術集会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2012-07-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Eldecalcitol(ED-71)は海綿骨におけるRANKLの発現を抑制し骨密度を増加させる2011

    • Author(s)
      原田卓, ら
    • Organizer
      第73回松本歯科大学学会例会
    • Place of Presentation
      松本歯科大学(長野県)
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] Thy-1陽性歯髄細胞の局在および硬組織形成能2011

    • Author(s)
      細矢明宏, ら
    • Organizer
      第133回日本歯科保存学会・秋季学会
    • Place of Presentation
      長良川国際会議場(岐阜県)
    • Year and Date
      2011-10-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] ラット臼歯培養系における歯髄組織の変化に関する免疫組織化学的観察2011

    • Author(s)
      吉羽邦彦, ら
    • Organizer
      第133回日本歯科保存学会・秋季学会
    • Place of Presentation
      長良川国際会議場(岐阜県)
    • Year and Date
      2011-10-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Daily administration of Eldecalcitol (ED-71), an active vitamin Danalog, increases bone mineral density by suppressing RANKL expression in mouse trabecular bone2011

    • Author(s)
      Harada S, et al
    • Organizer
      33th American Society for Bone and Mineral Research Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Thy-1陽性subodontoblastic layer細胞の高い硬組織形成能2011

    • Author(s)
      細矢明宏, ら
    • Organizer
      第9回日本再生歯科医学会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2011-09-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒト間葉系幹細胞を用いた歯科用インプラント体表面への細胞接着実験2011

    • Author(s)
      隈部俊二, ら
    • Organizer
      第9回日本再生歯科医学会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2011-09-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒト間葉系幹細胞を用いた硬組織形成実験2011

    • Author(s)
      中塚美智子, ら
    • Organizer
      第9回日本再生歯科医学会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2011-09-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] c-Fos plays an essential role in up-regulation of RANK expression in osteoclast precursors2011

    • Author(s)
      Arai A, et al
    • Organizer
      IOF Regionals 2nd Asia-Pacific Osteoporosis and Bone Meeting ANZBMS Annual Scientific Meeting, with JSBMR
    • Place of Presentation
      Queensland, Australia
    • Year and Date
      2011-09-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] BMP-induced ectopic bone formation in c-Fos-deficient mice2011

    • Author(s)
      Nakamura M, et al
    • Organizer
      IOF Regionals 2nd Asia-Pacific Osteoporosis and Bone Meeting ANZBMS Annual Scientific Meeting, with JSBMR
    • Place of Presentation
      Queensland, Australia
    • Year and Date
      2011-09-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] SUMO化修飾によるBMP応答能の制御2011

    • Author(s)
      雪田聡, ら
    • Organizer
      第18回BMP研究会
    • Place of Presentation
      大阪大学中ノ島センター(大阪府)
    • Year and Date
      2011-07-31
    • Related Report
      2011 Annual Research Report
  • [Presentation] アルクチゲニンはNFATc1の核移行を促進するが転写活性を抑制する2011

    • Author(s)
      山下照仁, ら
    • Organizer
      第29回日本骨代謝学会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2011-07-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] c-fos遺伝子欠損マウスを用いたBMP誘導性異所性骨形成に関する解析2011

    • Author(s)
      中村美どり, ら
    • Organizer
      第29回日本骨代謝学会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2011-07-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 生体内における破骨細胞分化機構の解明-M-CSFはc-Fosを介して破骨細胞前駆細胞のRANK発現を上昇する-2011

    • Author(s)
      荒井敦, ら
    • Organizer
      第29回日本骨代謝学会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2011-07-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Eldecalcitol(ED-71)は海綿骨におけるRANKLの発現を抑制し、骨密度を増加させる2011

    • Author(s)
      原田卓, ら
    • Organizer
      第29回日本骨代謝学会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2011-07-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 破骨細胞の極性化指標TRAP-markは分泌痕跡である2011

    • Author(s)
      中山貴裕, ら
    • Organizer
      第29回日本骨代謝学会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2011-07-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] in vivoにおける破骨細胞分化機構の解析-M-CSFはc-Fosを介し前駆細胞のRANKを上昇する2011

    • Author(s)
      荒井敦, ら
    • Organizer
      第72回松本歯科大学学会例会
    • Place of Presentation
      松本歯科大学(長野県)
    • Year and Date
      2011-07-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] ラット炎症歯髄に対する薬物輸送担体の遺伝子発現解析2010

    • Author(s)
      大倉直人, ら
    • Organizer
      第133回 日本歯科保存学会・秋季学会
    • Place of Presentation
      長良川国際会議場(岐阜県)
    • Year and Date
      2010-10-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 半導体レーザー照射後のラット臼歯における非コラーゲンタンパクの遺伝子発現2010

    • Author(s)
      重谷佳見, ら
    • Organizer
      第133回 日本歯科保存学会・秋季学会
    • Place of Presentation
      長良川国際会議場(岐阜県)
    • Year and Date
      2010-10-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラット臼歯培養系における歯髄組織の変化に関する免疫組織化学的観察2010

    • Author(s)
      吉羽邦彦, ら
    • Organizer
      第133回 日本歯科保存学会・秋季学会
    • Place of Presentation
      長良川国際会議場(岐阜県)
    • Year and Date
      2010-10-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] OPG rather than RANKL regulates alveolar bone loss.2010

    • Author(s)
      Koide M, et al.
    • Organizer
      32th American Society for Bone and Mineral Research Annual Meeting
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2010-10-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Function of OPG as a traffic regulator for RANKL is crucial for controlled osteoclastogenesis.2010

    • Author(s)
      Aoki A, et al.
    • Organizer
      32th American Society for Bone and Mineral Research Annual Meeting
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2010-10-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Side population in human breast cancer cells exhibits cancer stem cell-like properties but does not have higher bone-metastatic potential.2010

    • Author(s)
      Hiraga T, Ito S, Nakamura H.
    • Organizer
      32th Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2010-10-17
    • Related Report
      2012 Final Research Report
  • [Presentation] Side population in human breast cancer cells exhibits cancer stem cell-like properties but does not have higher bone-metastatic potential.2010

    • Author(s)
      Hiraga T, et al.
    • Organizer
      32th American Society for Bone and Mineral Research Annual Meeting
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2010-10-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Osteogenic potential of side population cells in periodontal ligament.2010

    • Author(s)
      Ninomiya T, et al.
    • Organizer
      32th American Society for Bone and Mineral Research Annual Meeting
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2010-10-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] A novel murine model of osteopetrosis by administration of a denosumab-like anti-murine RANKL neutralizing monoclonal antibody.2010

    • Author(s)
      Yasuda H, et al.
    • Organizer
      32th American Society for Bone and Mineral Research Annual Meeting
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2010-10-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Rab27a and Rab27b are involved in stimulation-dependent RANKL release form secretory lysosomes in osteoblastic cells.2010

    • Author(s)
      Kariya Y, et al.
    • Organizer
      32th American Society for Bone and Mineral Research Annual Meeting
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2010-10-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] 乳癌 side population 細胞の骨転 移能2010

    • Author(s)
      平賀 徹
    • Organizer
      第69回 日本癌学会総会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2010-09-24
    • Related Report
      2012 Final Research Report
  • [Presentation] 乳癌side population細胞の骨転移能2010

    • Author(s)
      平賀徹
    • Organizer
      第69回 日本癌学会総会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 歯根膜におけるビタミンDレセプターの局在とビタミンD3の作用について2010

    • Author(s)
      陳彦呈, ら
    • Organizer
      第52回 歯科基礎医学会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Thy-1陽性歯髄細胞の硬組織形成能に関する形態学的研究2010

    • Author(s)
      細矢明宏, ら
    • Organizer
      第52回 歯科基礎医学会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] BMPによる分化制御機構におけるSUMO化修飾の役割2010

    • Author(s)
      雪田聡, ら
    • Organizer
      第52回 歯科基礎医学会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒト歯髄組織においてFibrillin-1はMMP-3により分解され細胞分化と石灰化を誘導する2010

    • Author(s)
      吉羽永子, ら
    • Organizer
      第52回 歯科基礎医学会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 骨芽細胞におけるRab27aおよびRab27bを介したRANKL放出制御2010

    • Author(s)
      苅谷嘉顕, ら
    • Organizer
      第28回 日本骨代謝学会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2010-07-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 抗マウスRANKL中和抗体OYC1の単回投与による4週間の持続的な骨量増加2010

    • Author(s)
      古屋優里子, ら
    • Organizer
      第28回 日本骨代謝学会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2010-07-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 骨芽細胞分化におけるSUMO化修飾の役割2010

    • Author(s)
      雪田聡, ら
    • Organizer
      第28回 日本骨代謝学会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2010-07-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 細胞は高い骨転移能を有するか2010

    • Author(s)
      平賀 徹 、中村浩彰 乳癌 side population
    • Organizer
      第28回 日本骨代謝学会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2010-07-22
    • Related Report
      2012 Final Research Report
  • [Presentation] 乳癌side population細胞は高い骨転移能を有するか?2010

    • Author(s)
      平賀徹, ら
    • Organizer
      第28回 日本骨代謝学会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2010-07-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] OPGによるRANKL細胞内選別輸送制御機構の解析2010

    • Author(s)
      青木重樹, ら
    • Organizer
      第28回 日本骨代謝学会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2010-07-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Expressional alterations of fibrillin-1 during wound healing of dental pulps.2010

    • Author(s)
      Yoshiba N, et al.
    • Organizer
      88th General Session & Exhibition of the International Association for Dental Research
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-07-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] Tissue Alteration of Rat Dental Pulp in Whole Tooth Culture.2010

    • Author(s)
      Yoshiba K, et al.
    • Organizer
      88th General Session & Exhibition of the International Association for Dental Research
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-07-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒト歯髄創傷治癒過程で生じるFibrillin-1の分解は細胞分化と石灰化を誘導する2010

    • Author(s)
      吉羽永子, ら
    • Organizer
      第132回 日本歯科保存学会・春季学会
    • Place of Presentation
      熊本市国際交流会館(熊本県)
    • Year and Date
      2010-06-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラクトフェリンは細胞分化を制御し、卵巣摘出ラットの骨量減少を抑制する2010

    • Author(s)
      二宮禎, ら
    • Organizer
      第30回 日本骨形態計測学会
    • Place of Presentation
      米子コンベンションセンター(鳥取県)
    • Year and Date
      2010-05-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] 卵巣摘出マウスの骨密度低下に対するホノキオールの抑制効果2010

    • Author(s)
      浅井みどり, ら
    • Organizer
      日本農芸化学会 2010年度大会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 卵巣摘出マウスの骨密度低下に対するエピガロカテキンガレートの抑制効果2010

    • Author(s)
      李順燕, ら
    • Organizer
      日本農芸化学会 2010年度大会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] OPG遺伝子欠損マウスの歯槽骨吸収に対する骨吸収抑制剤の効果2009

    • Author(s)
      小出雅則, ら
    • Organizer
      第69回 松本歯科大学学会
    • Place of Presentation
      長野
    • Year and Date
      2009-11-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] in-vivo Micro CTの骨研究における有用性2009

    • Author(s)
      二宮禎
    • Organizer
      第9回 日本外傷歯学会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] Rapid evaluation of a denosumab-like anti-human RANKL neutralizing monoclonal antibody with sRANKL treated bone loss model.2009

    • Author(s)
      Yasuda H, et al.
    • Organizer
      31st Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Colorado, USA
    • Year and Date
      2009-09-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] Treatment with bisphosphonate during tooth development inhibits tooth formation and eruption, and induces odontomas.2009

    • Author(s)
      Hiraga T, Ninomiya T, Hosoya A, Nakamura H.
    • Organizer
      31st Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Denver, Colorado, USA
    • Year and Date
      2009-09-12
    • Related Report
      2012 Final Research Report
  • [Presentation] Treatment with bisphosphonate during tooth development inhibits tooth formation and eruption, and induces odontomas2009

    • Author(s)
      Hiraga T, et al.
    • Organizer
      31st Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Colorado, USA
    • Year and Date
      2009-09-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 歯根膜組織の歯槽骨再生能2009

    • Author(s)
      細矢明宏
    • Organizer
      第51回 歯科基礎医学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 骨芽細胞分化におけるSUMO化修飾因子UBC9役割2009

    • Author(s)
      雪田聡, ら
    • Organizer
      第51回 歯科基礎医学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト歯髄組織におけるFibrillin-1の分解が細胞分化および石灰化に及ぼす影響2009

    • Author(s)
      吉羽永子, ら
    • Organizer
      第51回 歯科基礎医学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] OPG遺伝子欠損マウスにおいては著しい歯槽骨吸収を呈する2009

    • Author(s)
      小出雅則, ら
    • Organizer
      第51回 歯科基礎医学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] in-vivo Micro CTの骨研究における有用性2009

    • Author(s)
      二宮禎
    • Organizer
      第1回 In-vivo micro CT forum
    • Place of Presentation
      長野
    • Year and Date
      2009-08-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 骨膜のThy-1(CD90)陽性細胞の骨原性細胞としての役割2009

    • Author(s)
      中村浩彰, ら
    • Organizer
      第27回 日本骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-07-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] RANKL投与骨量減少症モデルマウスによるdenosumab様抗ヒトRANKL中和抗体の迅速評価2009

    • Author(s)
      富盛賀也, ら
    • Organizer
      第27回 日本骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-07-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 歯胚形成期のビスフォスフォネート投与は歯の形成・萌出を生害し,歯牙腫様病変を 誘発する2009

    • Author(s)
      平賀 徹、二宮 禎、細 矢 明 宏 、中村浩彰
    • Organizer
      第27回日本骨代謝学会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2009-07-24
    • Related Report
      2012 Final Research Report
  • [Presentation] 歯胚形成期のビスフォスフォネート投与は歯の形成・萌出を生害し,歯牙腫様病変を誘発する2009

    • Author(s)
      平賀徹, ら
    • Organizer
      第27回 日本骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-07-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] 骨吸収関連遣伝子改変マウスにおける歯槽骨吸収及びビスフォスフォネートの効果2009

    • Author(s)
      小出雅則, ら
    • Organizer
      第27回 日本骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-07-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト歯髄組織におけるFibrillin-1の局在に関する免疫組織化学的研究-石灰化および細胞分化との関連性について-2009

    • Author(s)
      吉羽永子, ら
    • Organizer
      第130回 日本歯科保存学会・春季学会
    • Place of Presentation
      北海道
    • Year and Date
      2009-06-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] In vivo マイクロCTを用いた骨形態解析2009

    • Author(s)
      二宮禎
    • Organizer
      第29回 日本骨形態計測学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-05-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Molecular chaperone Hsp47 is essential for cartilage and endochondral bone formation.

    • Author(s)
      Masago Y et al.
    • Organizer
      Join Meeting of The 45th Annual Meeting of the Japanese Society of Developmental Biologists & The 64th Annual Meeting of the Japan Society for Cell Biology
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Spleen serves as a reservoir of osteoclast precursors through IL-34 expression in op/op mice.

    • Author(s)
      Nakamichi Y et al.
    • Organizer
      4th International Conference on Osteoimmunology
    • Place of Presentation
      Corfu, Greece
    • Related Report
      2012 Annual Research Report
  • [Presentation] 象牙芽細胞分化過程におけるSUMO化修飾因子とOsterixの局在

    • Author(s)
      細矢 明宏ら
    • Organizer
      第136回 日本歯科保存学会 平成24年度春季大会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ダイナミン阻害剤は破骨細胞のアクチンリング形成を抑制する

    • Author(s)
      上原 俊介ら
    • Organizer
      第74回 松本歯科大学学会
    • Place of Presentation
      松本歯科大学(長野県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ラクトフェリンの細胞分化調節機能

    • Author(s)
      二宮 禎ら
    • Organizer
      第30回 日本骨代謝学会学術集会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Wnt5a-Ror2シグナルは関節炎に伴う骨破壊を増悪する

    • Author(s)
      小林 泰浩ら
    • Organizer
      第30回 日本骨代謝学会学術集会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ダイナミン阻害剤ダイナソアはアクチンリング形成を阻害する

    • Author(s)
      上原 俊介ら
    • Organizer
      第30回 日本骨代謝学会学術集会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 癌幹細胞マーカーCD44は癌細胞の造腫瘍能,細胞運動能,基質形成能の亢進を介して骨転移を促進する

    • Author(s)
      平賀 徹ら
    • Organizer
      第30回 日本骨代謝学会学術集会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] M-CSF欠損op/opマウスにおいて、脾臓は破骨細胞前駆細胞の貯蔵庫として機能する:破骨細胞形成におけるIL-34の新しい役割

    • Author(s)
      中道 裕子ら
    • Organizer
      第30回 日本骨代謝学会学術集会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 抗RANKL抗体によるOPG遺伝子欠損マウスの歯槽骨吸収の抑制効果

    • Author(s)
      小出 雅則ら
    • Organizer
      第30回 日本骨代謝学会学術集会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] FKBP5の骨組織における局在とデキサメタゾン応答に対する制御

    • Author(s)
      雪田 聡ら
    • Organizer
      第30回 日本骨代謝学会学術集会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] コラーゲンゲルを用いたヒト間葉系幹細胞HMS0014の分化誘導実験

    • Author(s)
      中塚 美智子ら
    • Organizer
      第10回 日本再生歯科医学会
    • Place of Presentation
      ニチイ学館 神戸ポートアイランドセンター(兵庫県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] SUMO化修飾因子の象牙質形成および再生過程における局在

    • Author(s)
      細矢 明宏ら
    • Organizer
      第10回 日本再生歯科医学会
    • Place of Presentation
      ニチイ学館 神戸ポートアイランドセンター(兵庫県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Wnt5a-Ror2 signals boosts bone destruction in arthritis

    • Author(s)
      Kobayashi Y et al.
    • Organizer
      1st Asia-pacific bone and mineral research meeting, 22nd Annual scientific meeting Austrian & New Zealand bone & mineral Society
    • Place of Presentation
      Perth, Australia
    • Related Report
      2012 Annual Research Report
  • [Presentation] Wnt5a-Ror2シグナルによる破骨細胞分化制御機構

    • Author(s)
      小林 泰浩ら
    • Organizer
      第54回 歯科基礎医学会学術大会
    • Place of Presentation
      奥羽大学(福島県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] マウス歯髄におけるプロテオグリカン局在の検討

    • Author(s)
      雪田 聡ら
    • Organizer
      第54回 歯科基礎医学会学術大会
    • Place of Presentation
      奥羽大学(福島県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 分化直後の象牙芽細胞に局在するSUMO化修飾因子とOsterix

    • Author(s)
      細矢 明宏ら
    • Organizer
      第54回 歯科基礎医学会学術大会
    • Place of Presentation
      奥羽大学(福島県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ラット炎症歯髄に対する薬物輸送担体の遺伝子発現解析

    • Author(s)
      大倉 直人ら
    • Organizer
      第54回 歯科基礎医学会学術大会
    • Place of Presentation
      奥羽大学(福島県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ラクトフェリンは細胞分化を制御し、卵巣摘出ラットの骨量減少を抑制する

    • Author(s)
      二宮 禎ら
    • Organizer
      第54回 歯科基礎医学会学術大会
    • Place of Presentation
      奥羽大学(福島県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] コラーゲンゲルにおけるHMS0014間葉系細胞の三次元培養による硬組織形成能の評価

    • Author(s)
      中塚 美智子ら
    • Organizer
      第54回 歯科基礎医学会学術大会
    • Place of Presentation
      奥羽大学(福島県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 癌幹細胞マーカーCD44の乳癌骨転移に対する機能的役割

    • Author(s)
      平賀 徹
    • Organizer
      第71回 日本癌学会学術総会
    • Place of Presentation
      札幌市教育文化会館 (北海道)
    • Related Report
      2012 Annual Research Report
  • [Presentation] The cancer stem cell marker CD44 promotes bone metastasis of breast cancer by enhancing tumorigenicity, cell motility, and matrix production.

    • Author(s)
      Hiraga T et al.
    • Organizer
      34th Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Minneapolis, MN, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] c-Fos plays an essential role in up-regulation of RANK expression in osteoclast precursors.

    • Author(s)
      Arai A et al.
    • Organizer
      34th Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Minneapolis, MN, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Tetracyclines inhibit osteoclast differentiation by converting the differentiation pathway from osteoclasts to dendritic cells.

    • Author(s)
      Koide M et al.
    • Organizer
      34th Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Minneapolis, MN, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Dynasore rapidly disrupts podosome belts in polarized osteoclasts.

    • Author(s)
      Uehara S et al.
    • Organizer
      34th Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Minneapolis, MN, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] An experiment on in vitro bone tissue formation by HMS0014 human mesenchymal cells cultured on surface modified titanium plates.

    • Author(s)
      Nakatsuka M et al.
    • Organizer
      International Conference on Progress in Bone and Mineral Research
    • Place of Presentation
      Vienna, Austria
    • Related Report
      2012 Annual Research Report
  • [Presentation] 破骨細胞形成におけるM-CSF/RANKL/IL-34のそれぞれの役割

    • Author(s)
      中道 裕子ら
    • Organizer
      第75回松本歯科大学学会
    • Place of Presentation
      松本歯科大学(長野県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Origin of bone-like tissues in dental pulp after tooth transplantation.

    • Author(s)
      Hosoya A et al.
    • Organizer
      The 60th Annual Meeting of Japanese Association for Dental Research
    • Place of Presentation
      新潟コンベンションセンター(新潟)
    • Related Report
      2012 Annual Research Report
  • [Book] がん骨転移治 療 -ビスホスホネート治療による Bone Management-2012

    • Author(s)
      平賀 徹骨転移進行抑制と疼痛緩和
    • Publisher
      先端医学社、東京
    • Related Report
      2012 Final Research Report
  • [Book] がん骨転移治療 -ビスホスホネート治療によるBone Management-2012

    • Author(s)
      平賀 徹 (高橋 俊二 編、分担執筆)
    • Total Pages
      242
    • Publisher
      先端医学社
    • Related Report
      2012 Annual Research Report
  • [Book] 骨転移進行抑制と疼痛緩和2012

    • Author(s)
      高橋俊二編
    • Publisher
      先端医学社(印刷中)
    • Related Report
      2011 Annual Research Report

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Published: 2009-04-01   Modified: 2019-07-29  

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