|Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2012: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Bone is one of the most preferential sites for cancer metastasis; however, the precise mechanisms are still unclear. An increasing body of evidence suggests that cancers contain a small subset of their own stem-like cells called cancer stem cells (CSCs), which play critical roles in the initiation, maintenance and relapse of tumors. In this study, we studied the role of CSCs in cancer metastasis to bone. Flow cytometric analysis revealed the existence of CSC marker-positive cells in several kinds of cancer cell lines. Those cells exhibited some of the CSC-like properties in vitro and in vivo. However, the bone-metastatic potential of side population (SP) cells, which has been shown to enrich CSCs in several types of cancer, was similar to that of non-SP cells. Further studies are required to clarify the contribution of CSCs to cancer bone metastasis.