Analysis of regeneration ability of periodontal ligament by ADAMTSL4 and development of novel therapeutic for conservative dentistry
| Project/Area Number |
21390509
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
SAITO Masahiro 東京理科大学, 基礎工学部・生物工学科, 准教授 (40215562)
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| Co-Investigator(Kenkyū-buntansha) |
TERANAKA Toshio 神奈川歯科大学, 歯学部, 教授 (60104460)
TSUJI Takashi 東京理科大学, 基礎工学部・生物工学科, 教授 (50339131)
須田 直人 明海大学, 歯学部形態機能成育学講座歯科矯正学, 教授 (90302885)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
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| Keywords | 保存修復学 / 再生 / 歯根膜 / マイクロフィブリル / 創傷治癒 / 発生 / 弾性繊維 / 結合組織 / マルファン病 / マイクロフィブル / 弾性線維 |
|---|
| Research Abstract |
Marfan's syndrome(MFS) is a systemic disorder of the connective tissues including periodontal ligament(PDL) by insufficiency of fibrillin-1 microfibril formation and can cause severe periodontal disease. ADAMTSL6β, a microfibril-associated extracellular matrix protein that has been implicated in fibrillin-1 microfibril assembly is able to improve microfibril insufficiency of PDL in MFS mice model. These findings suggest ADAMTSL6β-mediated fibrillin-1 microfibril assembly develop as a new therapeutic of conservative dentistry for the treatment of periodontal disease in MFS.
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Report
(4 results)
Research Products
(75 results)
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[Journal Article] Role of epithelial-stem cell interactions during dental cell differentiation2012
Author(s)
M. Arakaki, M. Ishikawa, T. Nakamura, T. Iwamoto, A. Yamada, E. Fukumoto, M. Saito, K. Otsu, H. Harada, Y. Yamada, and S. Fukumoto
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Journal Title
J Biol Chem
Volume: 287(13)
Pages: 10590-601
Related Report
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[Journal Article] ADAMTSL6β rescues fibrillin-1 microfibril disorder in Marfan syndrome mouse model through the promotion of fibrillin-1 assembly2011
Author(s)
M. Saito, M. Kurokawa, M. Oda, M. Oshima, K. Tsutsui, K. Kosaka, K. Nakao, M. Ogawa, R. Manabe, N. Suda, G. Ganjargal, Y. Hada, T. Noguchi, T. Teranaka, K. Sekiguchi, T. Yoneda and T. Tsuji
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Journal Title
J Biol Chem
Volume: 286(44)
Pages: 38602-38613
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[Journal Article] Functional tooth regeneration using a bioengineered tooth unit as a mature organ replacement regenerative therapy2011
Author(s)
M. Oshima, M. Mizuno, A. Imamura, M. Ogawa, M. Yasukawa, H. Yamazaki, R. Morita, E. Ikeda, K. Nakao, T. Takano-Yamamoto, S. Kasugai, M. Saito and T. Tsuji
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Related Report
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[Journal Article] Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis2009
Author(s)
A. Saito, S. Hino, T. Murakami, S. Kanemoto, S. Kondo, M. Saito, R. Nishimura, T. Yoneda, T. Furuichi, S. Ikegawa, M. Ikawa, M. Okabe, K. Imaizumi
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Journal Title
Nat Cell Biol.
Volume: 11(10)
Pages: 1197-1204
Related Report
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[Journal Article] Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation2009
Author(s)
T. Murakami, A. Saito, S. Hino, S. Kondo, S. Kanemoto, K. Chihara, H. Sekiya, K. Tsumagari, K. Ochiai, K. Yoshinaga, M. Saito, R. Nishimura, T. Yoneda, I. Kou, T. Furuichi, S. Ikegawa, M. Ikawa, M. Okabe, A. Wanaka, K. Imaizumi
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Journal Title
Nat Cell Biol.
Volume: 11(10)
Pages: 1205-1211
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