| Project/Area Number |
21390510
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MAEDA Hidefumi 九州大学, 大学病院, 講師 (10284514)
WADA Naohisa 九州大学, 大学病院, 講師 (60380466)
TOMOKIYO Atsushi 九州大学, 大学院・歯学研究院, 助教 (20507777)
藤井 慎介 九州大学, 大学病院, 助教 (60452786)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2009: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
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| Keywords | 歯内療法学 / 未分化なヒト歯根膜細胞 / ヒト歯根膜細胞 / ハイドロキシアパタイト / 象牙質タンパク / 未分化な歯根膜細胞株 / 炭酸アパタイト / TGF-β1 / 歯根膜幹細胞 / 足場材 / 表面抗原 |
|---|
| Research Abstract |
As periodontal ligament(PDL) is a fibrous connective tissue connecting tooth root to bone, it plays an important role in retaining tooth. In this research, we aimed to identify stem cells, signaling elements, and scaffolds suitable for the regeneration of PDL tissue that is severely damaged by deep caries, serious periodontitis, and trauma. Here we report that for PDL stem cells, the cells expressing the same markers as mesenchymal stem cell basically meet the criteria of PDL stem cells ; as candidates suitable as signaling elements, TGF-beta1, bFGF, serial treatment of TGF-beta1 after bFGF, NGF, GDNF, EGF, mechanical stress, Angiotensin II, Interleukin-11, and calcium are enumerated ; materials including calcium and the resin such as Superbond showed efficacy as scaffolds for PDL stem cells.
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