| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2011: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Research Abstract |
In this study, the canine model of irreversible pulpitis was established to examine the effect of MMP-3 in the inflamed pulp tissues. Regeneration of pulp tissue with vasculature and nerves was observed in this pulpitis model 14 days after MMP-3 treatment, followed by dentin matrix formation on the exposed pulp tissues by day 28.In the absence of MMP-3, whole pulp necrosis was observed on day 14 to 28.Infiltration of macrophage and antigen-presenting cells was significantly inhibited in MMP-3 treated pulp tissues compared with control on day 3 to 7.IL-6 expression was significantly decreased as early as day 3 in MMP-3 treated pulp. These results suggest that MMP-3 has anti-inflammatory effect and is promising drug candidates for irreversible pulpitis.
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