Matrix metalloproteinase-3 in a stable form, a novel medicament for pulpitis
| Project/Area Number |
21390512
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKASHIMA Misako 国立長寿医療研究センター, 口腔疾患研究部, 室長 (20207773)
NAKATA Kazuhiko 愛知学院大学, 歯学部, 講師 (70261013)
EGUCHI Takanori 国立長寿医療研究センター, 口腔疾患研究部, 室長 (20457229)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2011: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Keywords | 再生歯学 / MMP3(マトリックスメタロプロテアーゼ3) / 抗炎症作用 / 歯髄炎治療薬 / 歯髄再生 / 覆髄剤 / MMP3 / 歯髄炎治療 |
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| Research Abstract |
In this study, the canine model of irreversible pulpitis was established to examine the effect of MMP-3 in the inflamed pulp tissues. Regeneration of pulp tissue with vasculature and nerves was observed in this pulpitis model 14 days after MMP-3 treatment, followed by dentin matrix formation on the exposed pulp tissues by day 28.In the absence of MMP-3, whole pulp necrosis was observed on day 14 to 28.Infiltration of macrophage and antigen-presenting cells was significantly inhibited in MMP-3 treated pulp tissues compared with control on day 3 to 7.IL-6 expression was significantly decreased as early as day 3 in MMP-3 treated pulp. These results suggest that MMP-3 has anti-inflammatory effect and is promising drug candidates for irreversible pulpitis.
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Report
(4 results)
Research Products
(20 results)
