| Project/Area Number |
21390516
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Kyushu University (2010-2011)
Hiroshima University (2009) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NIKAWA Hiroki 広島大学, 大学院・医歯薬学総合研究科, 教授 (10228140)
SATODA Takahiro 広島大学, 大学院・医歯薬学総合研究科, 教授 (80170801)
YUGE Lois 広島大学, 大学院・保健学研究科, 教授 (20263676)
TERADA Yoshihiro 九州大学, 大学院・歯学研究院, 教授 (30038898)
SHINOHARA Yoshinori 九州大学, 大学院・歯学研究院, 助教 (00423533)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2011: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Keywords | 骨吸収 / 破骨細胞 / 補綴処置 / NHA2 / メカニカルストレス / NHE10 / RANKL / モノクローナル抗体 |
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| Research Abstract |
The functions of NHA2 during osteoclast differentiation were investigated using the monoclonal antibodies(anti-NHA2 mAb). The data suggest that NHA2 is involved in cell-cell fusion during osteoclast differentiation. On the other hand, mechanical loading conditions result in alveolar bone resorption. Therefore, we investigated the effects of anti-NHA2 mAb on osteoblast and osteoclast differentiation under mechanical loading. However, the data was not enough for conclusion.。
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