The analysis of Ni allergy development and the therapeutic strategy in prosthodontics
| Project/Area Number |
21390518
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Prosthetic dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
ICHIKAWA Tetsuo 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (90193432)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIMARU Naozumi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (60314879)
WATANABE Megumi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (40380050)
KASHIWABARA Toshiya 徳島大学, 病院, 助教 (90274232)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2009: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Keywords | 金属アレルギー / 樹状細胞 / MAPキナーゼ / ニッケル / T細胞 |
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| Research Abstract |
We analyzed Ni allergy symptoms in the mouse model which we produced. The major populations of infiltrated immune cells around the allergic region in skin were CD3 positive cells(T cells) and CD11c/ MHC classII positive cells(dendritic cells). p38/ MKK6 pathway in dendritic cells was activated by Ni stimulation both in vivo and in vitro.
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Report
(4 results)
Research Products
(20 results)
