| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2011: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Research Abstract |
The purpose of this study was to investigate the possibility of the periodontal regeneration by iPS cell transplantation and to establish human gingival fibroblast derived iPS cell.
Culturing iPS cells in osteogenic medium, we observed calcium diposition by Alizarin Red S staining and osteocalcin positive immunostaining cells. In rat periodontal fenestration model, transplantation of the iPS cells encouraged not only new bone formation but also cementum formation on the denuded dentin surface.
Mouse iPS cells stimulated with osteogenic medium promote periodontal regeneration in rat periodontal fenestration model.
Moreover, we established human gingival fibroblast derived iPS cell. The results of this study may underlie new periodontal therapy.
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