A comprehensive study on periodontal regeneration using induced pluripotent stem(iPS) cells
| Project/Area Number |
21390525
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUYAMA Takashi 鹿児島大学, 大学院・医歯学総合研究科, 准教授 (40253900)
SAKODA Kenji 鹿児島大学, 大学院・医歯学総合研究科, 助教 (70419654)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2011: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Keywords | iPS細胞 / 歯周組織再生 / 移植・再生医療 / 再生・組織 / 歯学 / 細胞・組織 / 発生・分化 |
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| Research Abstract |
The purpose of this study was to investigate the possibility of the periodontal regeneration by iPS cell transplantation and to establish human gingival fibroblast derived iPS cell.
Culturing iPS cells in osteogenic medium, we observed calcium diposition by Alizarin Red S staining and osteocalcin positive immunostaining cells. In rat periodontal fenestration model, transplantation of the iPS cells encouraged not only new bone formation but also cementum formation on the denuded dentin surface.
Mouse iPS cells stimulated with osteogenic medium promote periodontal regeneration in rat periodontal fenestration model.
Moreover, we established human gingival fibroblast derived iPS cell. The results of this study may underlie new periodontal therapy.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Effectable application of vascular endothelial growth factor to critical sized rat calvaria defects2010
Author(s)
Yonamine Y, Matsuyama T, Sonomura T, Takeuchi H, Furuichi Y, Uemura M, Izumi Y, Noguchi K.
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Journal Title
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 109(2)
Pages: 225-231
Related Report
Peer Reviewed
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[Journal Article] Involvement of the endocannabinoid system in periodontal healing2010
Author(s)
Kozono S, Matsuyama T, Biwasa KK, Kawahara K, Nakajima Y, Yoshimoto T, Yonamine Y, Kadomatsu H, Tancharoen S, Hashiguchi T, Noguchi K, Maruyama I.
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Journal Title
Biochemical and biophysical research communications 394(4)
Pages: 928-933
Related Report
Peer Reviewed
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