| Project/Area Number |
21390532
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HOSHI Kazuto 東京大学, 医学部附属病院, 特任准教授 (30344451)
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| Co-Investigator(Kenkyū-buntansha) |
TAKATO Tsuyoshi 東京大学, 医学部附属病院, 教授 (90171454)
MORI Yoshiyuki 東京大学, 医学部附属病院, 准教授 (70251296)
FUJIHARA Yuko 東京大学, 医学(系)研究科(研究院), 特任助教 (50466744)
飯野 光喜 山形大学, 医学部, 教授 (50212717)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Keywords | 再生軟骨 / インプラント / スカフォールド / 顎顔面 / 軟骨細胞 |
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| Research Abstract |
We have produced complex regenerative cartilage or regenerative joints that consist of two layers of cartilage and bone to apply them to the repair of cleft lip-nose or temporomandibular joint reconstruction. Regarding every regenerative cartilage which we have invented, a large amount of cell pellets were produced, and then physical strength and resistance to hypoxia or undernutrition were added to them. After that, 3D shape was formed by accumulating and fusing those pellets together. At transplantation, tissue tension relief was attempted in the transplantation site. Based on the techniques, we have realized scaffold-free 3D regenerative cartilage.
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